Carcinogenicity of triethanolamine in mice and its mutagenicity after reaction with sodium nitrite in bacteria.

abstract：:The acute hemorrhagic necrosis of tumor nodules caused by the systemic administration of recombinant human tumor necrosis factor alpha (rhTNF-alpha) has been partially attributed to changes in tumor neovascularity. In this study, the effects of rhTNF-alpha were tested on primary autochthonous sarcomas induced in C57BL...

journal_title：Cancer research

authors： McIntosh JK,Mulé JJ,Travis WD,Rosenberg SA

更新日期：1990-04-15 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death for women in the United States. Of the different subtypes, estrogen receptor-negative (ER(-)) tumors, which are ErbB2+ or triple-negative, carry a relatively poor prognosis. In this study, we used system-wide analysis of breast cancer proteomes to identify prot...

journal_title：Cancer research

authors： Geiger T,Madden SF,Gallagher WM,Cox J,Mann M

更新日期：2012-05-01 00:00:00

abstract：:Of 20,000 plant extracts submitted to the National Cancer Institute antitumor screens from 1960 to 1980, over 95% exhibited inadequate tumor-inhibiting activity or promoted tumor growth. Of these, 50 extracts representing 42 species showed significant levels of tumor growth enhancement compared to controls on the basi...

journal_title：Cancer research

authors： Caldwell ME,Brewer WR

更新日期：1983-12-01 00:00:00

abstract：:LMO2 is a transcription regulator involved in human T-cell leukemia, including some occurring in X-SCID gene therapy trials, and in B-cell lymphomas and prostate cancer. LMO2 functions in transcription complexes via protein-protein interactions involving two LIM domains and causes a preleukemic T-cell development bloc...

journal_title：Cancer research

authors： Appert A,Nam CH,Lobato N,Priego E,Miguel RN,Blundell T,Drynan L,Sewell H,Tanaka T,Rabbitts T

更新日期：2009-06-01 00:00:00

abstract：:Thirteen patients with metastatic breast carcinoma were given injections of 50-1593 micrograms of 131I-monoclonal antibody (MAb) B6.2 immunoglobulin G and F(ab')2 for pharmacokinetic evaluation and radioimmunoimaging. Blood clearance of the 131I-MAb-B6.2 was biphasic. The mean half-times (t 1/2 alpha, t 1/2 beta) for ...

journal_title：Cancer research

authors： Hayes DF,Zalutsky MR,Kaplan W,Noska M,Thor A,Colcher D,Kufe DW

更新日期：1986-06-01 00:00:00

abstract：:The regulation of urokinase secretion and receptor display in a well-differentiated colon carcinoma cell line, GEO, adapted to serum-free conditions was examined. In protein-free medium, the cell line secreted 0.8 +/- 0.1 ng/ml/10(6) cells of urokinase in a 3-day period as determined by an enzyme-linked immunosorbent ...

journal_title：Cancer research

authors： Boyd D,Brattain M

更新日期：1989-04-15 00:00:00

abstract：:We have established two new epithelial cell lines (NRP-152, NRP-154), with markedly different properties, from the dorsal-lateral prostate of Lobund/Wistar rats treated with N-methyl-N-nitrosourea and testosterone propionate. NRP-152 cells do not form tumors in athymic mice and retain many of the properties of normal ...

journal_title：Cancer research

authors： Danielpour D,Kadomatsu K,Anzano MA,Smith JM,Sporn MB

更新日期：1994-07-01 00:00:00

abstract：:The liver represents a major and frequently sole site of metastases for many types of cancer, particularly gastrointestinal cancers. We showed previously that coadministration of an engineered hepatic-targeting Listeria monocytogenes (LM) with a cancer vaccine enhanced the antitumor effect of vaccine-induced T cells s...

journal_title：Cancer research

authors： Yoshimura K,Laird LS,Chia CY,Meckel KF,Slansky JE,Thompson JM,Jain A,Pardoll DM,Schulick RD

更新日期：2007-10-15 00:00:00

abstract：:Serial pulmonary function tests including single-breath carbon monoxide-diffusing capacity (DLCO), forced vital capacity (FVC), and forced expiratory volume in 1 sec were performed in a relatively homogeneous group of male patients with germ cell tumors treated with vinblastine, bleomycin, and cis-diamminedichloroplat...

journal_title：Cancer research

authors： Comis RL,Kuppinger MS,Ginsberg SJ,Crooke ST,Gilbert R,Auchincloss JH,Prestayko AW

更新日期：1979-12-01 00:00:00

abstract：:Fluorescein-labeled dextrans (FITC-D) from 3 to 5000 kDa (Stokes' radii from 1 to 40 nm) were used to study influx from the plasma into the peritoneum and efflux from the peritoneal cavity into the plasma in normal and ascites tumor-bearing mice and in mice whose peritoneal vessels had been rendered hyperpermeable by ...

journal_title：Cancer research

authors： Nagy JA,Herzberg KT,Masse EM,Zientara GP,Dvorak HF

更新日期：1989-10-01 00:00:00

abstract：:Chronic myelogenous leukemia is characterized by a specific chromosomal translocation, t(9;22), in which the ABL protooncogene and the BCR gene become juxtaposed. The chimeric BCR/ABL gene produces a P210 fusion protein with deregulated tyrosine kinase activity. We have recently isolated a complementary DNA, CRKL, whi...

journal_title：Cancer research

authors： ten Hoeve J,Kaartinen V,Fioretos T,Haataja L,Voncken JW,Heisterkamp N,Groffen J

更新日期：1994-05-15 00:00:00

abstract：:The ability of glucocorticoids (GCs) to induce death in lymphoid-origin cells is the basis for their frequent use in the therapy of various human hematological malignancies. However, the occurrence of primary or secondary GC resistance limits their clinical usefulness. Prior investigations into the mechanism of GC res...

journal_title：Cancer research

authors： Geley S,Hartmann BL,Hala M,Strasser-Wozak EM,Kapelari K,Kofler R

更新日期：1996-11-01 00:00:00

abstract：:Administration of nerve growth factor (NGF) to the offspring of Sprague-Dawley rats transplacentally exposed to 50 mg/kg ethylnitrosourea on the 20th day of gestation resulted in a significant reduction of trigeminal and peripheral nerve neurinomas. Forty, 60, and 80 micrograms of NGF was administered in five s.c. dos...

journal_title：Cancer research

authors： Raju NR,Koestner A,Marushige K,Lovell KL,Okazaki D

更新日期：1989-12-15 00:00:00

abstract：:Although immunotherapies of tumors have demonstrated promise for altering the progression of malignancies, immunotherapies have been limited by an immunosuppressive tumor microenvironment (TME) that prevents infiltrating immune cells from performing their anticancer functions. Prominent among immunosuppressive cells a...

journal_title：Cancer research

authors： Cresswell GM,Wang B,Kischuk EM,Broman MM,Alfar RA,Vickman RE,Dimitrov DS,Kularatne SA,Sundaram CP,Singhal S,Eruslanov EB,Crist SA,Elzey BD,Ratliff TL,Low PS

更新日期：2020-11-17 00:00:00

abstract：:Approximately 10% of gastric adenocarcinomas worldwide are associated with human EBV. These carcinomas generally do not express the latent membrane protein 1 (LMP1), the major known EBV oncogene. Recently, another EBV gene [ie., BARF1 (BamHI A rightward open reading frame)] was shown to have transforming and immortali...

journal_title：Cancer research

authors： zur Hausen A,Brink AA,Craanen ME,Middeldorp JM,Meijer CJ,van den Brule AJ

更新日期：2000-05-15 00:00:00

abstract：:Thmidine (TdR) incorporation into DNA increased in the livers and spleens of rats bearing Yoshida sarcoma (solid type) or AH130 (solid type). TdR kinase and DNA polymerase activities increased in the serum, liver, and spleen of these rats, while thymidine monophosphate kinase activity increased appreciably only in the...

journal_title：Cancer research

authors： Shirasaka T,Fujii S

更新日期：1975-03-01 00:00:00

abstract：:The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tumorigenesis. Using ...

journal_title：Cancer research

authors： Ohm JE,Mali P,Van Neste L,Berman DM,Liang L,Pandiyan K,Briggs KJ,Zhang W,Argani P,Simons B,Yu W,Matsui W,Van Criekinge W,Rassool FV,Zambidis E,Schuebel KE,Cope L,Yen J,Mohammad HP,Cheng L,Baylin SB

更新日期：2010-10-01 00:00:00

abstract：:Myc transcriptional activity is frequently deregulated in human cancers, but a Myc-driven gene signature with prognostic ability across multiple tumor types remains lacking. Here, we selected 18 Myc-regulated genes from published studies of Myc family targets in epithelial ovarian cancer (EOC) and neuroblastoma. A Myc...

journal_title：Cancer research

authors： Jung M,Russell AJ,Liu B,George J,Liu PY,Liu T,DeFazio A,Bowtell DD,Oberthuer A,London WB,Fletcher JI,Haber M,Norris MD,Henderson MJ

更新日期：2017-02-15 00:00:00

abstract：:Inbred rodent strains with differing sensitivity to experimental tumor induction provide model systems for the detection of genes that either are responsible for cancer predisposition or modify the process of carcinogenesis. Rats of the inbred BD strains differ in their susceptibility to the induction of neural tumors...

journal_title：Cancer research

authors： Kindler-Röhrborn A,Kölsch BU,Fischer C,Held S,Rajewsky MF

更新日期：1999-03-01 00:00:00

abstract：:Peritoneal exudate cells (PEC) from C57BL/6 mice were collected on different days following an i.p. injection of Adriamycin (10 mg/kg) as free drug (ADM) or encapsulated in multilamellar liposomes (ADM/Lip). Macrophages harvested from mice at various times (Days 4-14) after either drug treatment were responsive to in ...

journal_title：Cancer research

authors： Mace K,Mayhew E,Mihich E,Ehrke MJ

更新日期：1988-01-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) E7 is a viral oncoprotein that is believed to play a major role in cervical neoplasia. Anti-HPV16 E7 intracellular single-chain antibodies (scFvs) were constructed to down-regulate HPV16 E7 oncoprotein in HPV DNA-containing cell lines. In these studies, we transfected anti-E7 scFvs...

journal_title：Cancer research

authors： Wang-Johanning F,Gillespie GY,Grim J,Rancourt C,Alvarez RD,Siegal GP,Curiel DT

更新日期：1998-05-01 00:00:00

abstract：:Granulocyte macrophage colony-stimulating factor (GMCSF) can mediate antitumor effects by recruiting natural killer cells and by induction of tumor-specific cytotoxic T-cells through antigen-presenting cells. Oncolytic tumor cell-killing can produce a potent costimulatory danger signal and release of tumor epitopes fo...

journal_title：Cancer research

authors： Cerullo V,Pesonen S,Diaconu I,Escutenaire S,Arstila PT,Ugolini M,Nokisalmi P,Raki M,Laasonen L,Särkioja M,Rajecki M,Kangasniemi L,Guse K,Helminen A,Ahtiainen L,Ristimäki A,Räisänen-Sokolowski A,Haavisto E,Oksanen M,

更新日期：2010-06-01 00:00:00

abstract：:An experimental system designed for tracing the estradiol kinetics in target cells by specific antibodies has been applied to human breast cancer. Several major defects of the estradiol receptor mechanism have been demonstrated. The detected changes (lack of cytoplasmic receptors, impaired nuclear transfer of estradio...

journal_title：Cancer research

authors： Nenci I

更新日期：1978-11-01 00:00:00

abstract：:Tumor metastasis is one of the most important clinical aspects of neoplastic disease because patient mortality is frequently attributable to disseminated rather than primary tumors. However, it still is not possible to definitively distinguish those individuals at high risk for disseminated disease, who would benefit ...

journal_title：Cancer research

authors： Hunter KW,Broman KW,Voyer TL,Lukes L,Cozma D,Debies MT,Rouse J,Welch DR

更新日期：2001-12-15 00:00:00

abstract：:Chromosomal aberrations associated with lung cancer are frequently observed in the long arm of chromosome 6. A candidate susceptibility locus at 6q23-25 for lung cancer was recently identified; however, no tumor suppressor genes inactivated by mutation have been identified in this locus. Genetic, epigenetic, gene expr...

journal_title：Cancer research

authors： Tessema M,Willink R,Do K,Yu YY,Yu W,Machida EO,Brock M,Van Neste L,Stidley CA,Baylin SB,Belinsky SA

更新日期：2008-03-15 00:00:00

abstract：:Targeting dendritic cells in vivo by transcutaneous peptide immunization (TCI) represents an efficient immunization strategy to induce tumor-specific CTL because it reflects the physiologic conditions occurring during pathogen infection. Here we show that including a Th1 peptide in TCI can activate preexisting memory ...

journal_title：Cancer research

authors： Hosoi A,Takeda Y,Furuichi Y,Kurachi M,Kimura K,Maekawa R,Takatsu K,Kakimi K

更新日期：2008-05-15 00:00:00

abstract：:Chronic exposure to the hepatocellular carcinogen diethylnitrosamine (DEN) causes a dose-dependent accumulation of the promutagenic DNA adduct O4-ethyldeoxythymidine in hepatocytes and increases in the number of initiated hepatocytes as indicated by gamma-glutamyl transpeptidase positive foci. Initiation is thought to...

journal_title：Cancer research

authors： Deal FH,Richardson FC,Swenberg JA

更新日期：1989-12-15 00:00:00

abstract：:Certain ductal carcinoma in situ (DCIS) lesions overexpress the HER-2/neu receptor at this early stage of breast cancer development. Recently, we showed that a HER-2-targeted dendritic cell vaccine could be used to eliminate HER-2-overexpressing cells in patients that harbor these high-risk DCIS lesions. Our findings ...

journal_title：Cancer research

authors： Czerniecki BJ,Roses RE,Koski GK

更新日期：2007-07-15 00:00:00

abstract：:The expression of 8 oncogenes and the structures of 19 oncogenes were analyzed in 15 adenocarcinomas (12 primary and 3 metastatic), 18 adenomatous polyps, and 18 normal colonic mucosae derived from 19 patients with familial polyposis coli. The expression of c-myc gene was most elevated in carcinoma, and moderately ele...

journal_title：Cancer research

authors： Sugio K,Kurata S,Sasaki M,Soejima J,Sasazuki T

更新日期：1988-09-01 00:00:00

abstract：:Mutations in the p53 gene were identified in five of eight non-melanoma skin tumors in the sun-exposed areas of xeroderma pigmentosum patients by the polymerase chain reaction and single strand conformation polymorphism analysis followed by sequencing of the DNA. All mutations occurred at the dipyrimidine sites, indic...

journal_title：Cancer research

authors： Sato M,Nishigori C,Zghal M,Yagi T,Takebe H

更新日期：1993-07-01 00:00:00