Abstract：
:Granulocyte macrophage colony-stimulating factor (GMCSF) can mediate antitumor effects by recruiting natural killer cells and by induction of tumor-specific cytotoxic T-cells through antigen-presenting cells. Oncolytic tumor cell-killing can produce a potent costimulatory danger signal and release of tumor epitopes for antigen-presenting cell sampling. Therefore, an oncolytic adenovirus coding for GMCSF was engineered and shown to induce tumor-specific immunity in an immunocompetent syngeneic hamster model. Subsequently, 20 patients with advanced solid tumors refractory to standard therapies were treated with Ad5-D24-GMCSF. Of the 16 radiologically evaluable patients, 2 had complete responses, 1 had a minor response, and 5 had disease stabilization. Responses were frequently seen in injected and noninjected tumors. Treatment was well tolerated and resulted in the induction of both tumor-specific and virus-specific immunity as measured by ELISPOT and pentamer analysis. This is the first time that oncolytic virus-mediated antitumor immunity has been shown in humans. Ad5-D24-GMCSF is promising for further clinical testing.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Cerullo V,Pesonen S,Diaconu I,Escutenaire S,Arstila PT,Ugolini M,Nokisalmi P,Raki M,Laasonen L,Särkioja M,Rajecki M,Kangasniemi L,Guse K,Helminen A,Ahtiainen L,Ristimäki A,Räisänen-Sokolowski A,Haavisto E,Oksanen M,doi
10.1158/0008-5472.CAN-09-3567subject
Has Abstractpub_date
2010-06-01 00:00:00pages
4297-309issue
11eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-09-3567journal_volume
70pub_type
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