Abstract：
:Certain ductal carcinoma in situ (DCIS) lesions overexpress the HER-2/neu receptor at this early stage of breast cancer development. Recently, we showed that a HER-2-targeted dendritic cell vaccine could be used to eliminate HER-2-overexpressing cells in patients that harbor these high-risk DCIS lesions. Our findings suggest that vaccinating such patients might diminish the risk of recurrence, protect against the development of invasive breast cancer, and minimize morbidity associated with current treatments. We discuss several implications of this work for developing effective cancer vaccines.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Czerniecki BJ,Roses RE,Koski GKdoi
10.1158/0008-5472.CAN-07-0878subject
Has Abstractpub_date
2007-07-15 00:00:00pages
6531-4issue
14eissn
0008-5472issn
1538-7445pii
67/14/6531journal_volume
67pub_type
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