DNA synthesis in tumor-bearing rats.

Abstract:

:Thmidine (TdR) incorporation into DNA increased in the livers and spleens of rats bearing Yoshida sarcoma (solid type) or AH130 (solid type). TdR kinase and DNA polymerase activities increased in the serum, liver, and spleen of these rats, while thymidine monophosphate kinase activity increased appreciably only in the liver and spleen. On diethylaminoethyl cellulose column chromatography, 2 peaks of TdR dinase activity were separated from the serum and tumor tissues of rats bearing Yoshida sarcoma (solid type) while only 1 peak was obtained from the liver. TdR kinase activity in the serum decreased abruptly 7 hr after removal of the Yoshida sarcoma, while that in the liver decreased more slowly.

journal_name

Cancer Res

journal_title

Cancer research

authors

Shirasaka T,Fujii S

subject

Has Abstract

pub_date

1975-03-01 00:00:00

pages

517-20

issue

3

eissn

0008-5472

issn

1538-7445

journal_volume

35

pub_type

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