Functional characterization of filamin a interacting protein 1-like, a novel candidate for antivascular cancer therapy.

abstract：:The estimated growth rates for five lines of human fibroblasts (Human Genetic Mutant Cell Repository designations 0011, 2936B , 0038A , 2912A , and 3529), during the first few population doublings after establishment of the lines, were within the expected range, i.e., equivalent to doubling times from 16 to 28 hr, wit...

journal_title：Cancer research

authors： Tamm I,Kikuchi T,Wang E,Pfeffer LM

更新日期：1984-06-01 00:00:00

abstract：:The experimental antitumor activity of a new mitomycin derivative, 7-cysteaminomitosane (RR-150), was evaluated in mice. When administered i.p. to mice bearing i.p.-implanted tumors, RR-150 was superior to mitomycin C (MMC) in increasing the life span of animals bearing P388 leukemia, B16 melanoma, and a line of L1210...

journal_title：Cancer research

authors： Bradner WT,Rose WC,Schurig JE,Schlein A,Huftalen JB

更新日期：1984-12-01 00:00:00

abstract：:HL60 cells, human promyelocytic leukemia cells, can be induced to differentiate into more mature myeloid forms by dimethyl sulfoxide (DMSO) or retinoic acid (RA) and into macrophage-like cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) or related compounds. Macrophage differentiation of HL60 cells by TPA treatment ...

journal_title：Cancer research

authors： Hirai H,Murakami T,Urabe A,Takaku F

更新日期：1985-06-01 00:00:00

abstract：:One of the most promising new avenues for the development of more selective and efficacious cancer therapies relies on the antibody-mediated targeted delivery of bioactive agents (e.g., cytokines) to the tumor environment. The identification of quantitative differences in the expression of accessible vascular proteins...

journal_title：Cancer research

authors： Rybak JN,Roesli C,Kaspar M,Villa A,Neri D

更新日期：2007-11-15 00:00:00

abstract：:Pathologic conditions associated with hyperinsulinemia, such as obesity, metabolic syndrome, and diabetes, seem to increase the risk of breast cancer. Here, we studied molecular mechanisms by which insulin activates the expression of leptin, an obesity hormone that has been shown to promote breast cancer progression i...

journal_title：Cancer research

authors： Bartella V,Cascio S,Fiorio E,Auriemma A,Russo A,Surmacz E

更新日期：2008-06-15 00:00:00

abstract：:We have examined the time course and patterns of covalent aflatoxin B1:DNA adducts produced within the ribosomal RNA gene sequences isolated from the liver nuclear DNA of aflatoxin B1-treated animals. Liver nuclear DNA was initially enriched in ribosomal DNA by cesium salt density centrifugation, and incubated under a...

journal_title：Cancer research

authors： Irvin TR,Wogan GN

更新日期：1985-08-01 00:00:00

abstract：:Murine melanoma B16-F1 cells of low metastatic potential were transfected with the human gene for the prepro form of urokinase in an SV40 expression vector (plasmid pSV2-uPA), and cells expressing high amounts of the human urokinase gene product were selected for by an enzyme-linked immunosorbent assay specific for hu...

journal_title：Cancer research

authors： Yu HR,Schultz RM

更新日期：1990-12-01 00:00:00

abstract：:The development of androgen-independent growth in advanced carcinoma of the prostate (CaP) is associated with poor prognosis and few therapeutic options. Chemotherapeutic drugs offer the afflicted patient palliative benefits, but these are short-lived because of the chemoresistant nature of hormone-refractory prostate...

journal_title：Cancer research

authors： Lee JT Jr,Steelman LS,McCubrey JA

更新日期：2004-11-15 00:00:00

abstract：:In previous studies, we reported that key antioxidant and DNA repair genes are regulated differently in normal bronchial epithelial cells of lung cancer cases compared with non-lung cancer controls. In an effort to develop a biomarker for lung cancer risk, we evaluated the transcript expressions of 14 antioxidant, DNA...

journal_title：Cancer research

authors： Blomquist T,Crawford EL,Mullins D,Yoon Y,Hernandez DA,Khuder S,Ruppel PL,Peters E,Oldfield DJ,Austermiller B,Anders JC,Willey JC

更新日期：2009-11-15 00:00:00

abstract：:The macrophage content of spontaneous metastases has been quantified morphometrically for a panel of rodent tumors at different stages of metastatic tumor growth. Using a histochemical technique to selectively stain macrophages, we have evaluated the relative content of macrophages in spontaneous pulmonary metastases ...

journal_title：Cancer research

authors： Bugelski PJ,Corwin SP,North SM,Kirsh RL,Nicolson GL,Poste G

更新日期：1987-08-01 00:00:00

abstract：:Glycogen synthase kinase 3beta (GSK3beta) is a multifunctional serine/threonine kinase. We showed that the expression of GSK3beta was drastically down-regulated in human cutaneous squamous cell carcinomas and basal cell carcinomas. Due to its negative regulation of many oncogenic proteins, we hypothesized that GSK3bet...

journal_title：Cancer research

authors： Ma C,Wang J,Gao Y,Gao TW,Chen G,Bower KA,Odetallah M,Ding M,Ke Z,Luo J

更新日期：2007-08-15 00:00:00

abstract：:Gastric carcinoma is one of the most common cancers and lethal malignancies worldwide. Thus far, the regulatory mechanisms of its aggressiveness are still poorly understood. To understand the pathogenesis and to develop new therapeutic strategies, it is essential to dissect the molecular mechanisms that regulate progr...

journal_title：Cancer research

authors： Yeh TS,Wu CW,Hsu KW,Liao WJ,Yang MC,Li AF,Wang AM,Kuo ML,Chi CW

更新日期：2009-06-15 00:00:00

abstract：:Midkine is a heparin-binding growth factor highly expressed in various cancers, including neuroblastoma, the most common extracranial pediatric solid tumor. Prognosis of patients with neuroblastoma in which MYCN is amplified remains particularly poor. In this study, we used a MYCN transgenic model for neuroblastoma in...

journal_title：Cancer research

authors： Kishida S,Mu P,Miyakawa S,Fujiwara M,Abe T,Sakamoto K,Onishi A,Nakamura Y,Kadomatsu K

更新日期：2013-02-15 00:00:00

abstract：:Electron paramagnetic resonance imaging (EPRI) enables noninvasive spatial mapping of free radical metabolism and has recently been shown to provide in vivo physiologic information regarding alterations in the redox state of tumors and neoplastic tissues. With the use of nitroxide spin probes, it has been shown that c...

journal_title：Cancer research

authors： Mikuni T,He G,Petryakov S,Fallouh MM,Deng Y,Ishihara R,Kuppusamy P,Tatsuta M,Zweier JL

更新日期：2004-09-15 00:00:00

abstract：:Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called "oncogene addiction," provides a rationale for molecular targeted therapy. The efficacy of this strategy require...

journal_title：Cancer research

authors： Weinstein IB,Joe A

更新日期：2008-05-01 00:00:00

abstract：:The pattern of protein phosphorylation induced by phorbol-12-myristate-13-acetate (PMA) was analyzed by two-dimensional gel electrophoresis in human HL-60 leukemia cells, which are susceptible to induction of cell differentiation by PMA, and in cells from an HL-60 cell variant designated R-94 that are resistant to suc...

journal_title：Cancer research

authors： Anderson NL,Gemmell MA,Coussens PM,Murao S,Huberman E

更新日期：1985-10-01 00:00:00

abstract：:Genetic differences in metabolism of benzo(a)pyrene (BP) were investigated using cultured epidermal keratinocytes and dermal fibroblasts isolated from four inbred strains of mice: C3H/HeJms and C57BL/6J that are responsive; and DBA/2 and AKR/Jms that are nonresponsive in terms of inducibility of aryl hydrocarbon hydro...

journal_title：Cancer research

authors： Hosomi J,Nemoto N,Kuroki T

更新日期：1983-08-01 00:00:00

abstract：:Loss of imprinting (LOI) of the insulin-like growth factor II (IGFII) gene is a frequent phenomenon in colorectal tumor tissues. Previous reports indicated that subjects with colorectal neoplasias show LOI of IGFII in circulating lymphocytes. Furthermore, LOI of IGFII is strongly related to the methylation of a differ...

journal_title：Cancer research

authors： Kaaks R,Stattin P,Villar S,Poetsch AR,Dossus L,Nieters A,Riboli E,Palmqvist R,Hallmans G,Plass C,Friesen MD

更新日期：2009-07-01 00:00:00

abstract：:The selective ubiquitination of proteins by ubiquitin E3 ligases plays an important regulatory role in control of cell differentiation, growth, and transformation and their dysregulation is often associated with pathologic outcomes, including tumorigenesis. RNF5 is an E3 ubiquitin ligase that has been implicated in mo...

journal_title：Cancer research

authors： Bromberg KD,Kluger HM,Delaunay A,Abbas S,DiVito KA,Krajewski S,Ronai Z

更新日期：2007-09-01 00:00:00

abstract：:The effects of quinacrine, an antimetabolite which intercalates into DNA, on the ultrastructure of interphase nuclei and on RNA turnover were studied in primary cultures of rat hepatocytes. Procedures included ultrastructural cytochemical staining for ribonucleoprotein and DNA, autoradiography, and measurement of labe...

journal_title：Cancer research

authors： Leduc EH,Bernhard W,Viron A,Fain J,Puvion E

更新日期：1981-07-01 00:00:00

abstract：:We have found that reversible differentiation into the myoepithelial cells of a human salivary gland adenocarcinoma cell line (HSG) occurs in growth medium containing dibutyryl cAMP (dB-cAMP). In the current study, the relationship between intracellular cAMP levels and anchorage-dependent and -independent growth or ra...

journal_title：Cancer research

authors： Azuma M,Yoshida H,Kawamata H,Yanagawa T,Furumoto N,Sato M

更新日期：1988-05-15 00:00:00

abstract：:In cancer patients and in those at high risk, systemic exposure to agents for therapy or prevention is accompanied by undesirable side effects. We hypothesized that it is possible to prevent and treat breast cancer by introducing anticancer agents into the mammary ductal network. Here, we show the efficacy of intraduc...

journal_title：Cancer research

authors： Murata S,Kominsky SL,Vali M,Zhang Z,Garrett-Mayer E,Korz D,Huso D,Baker SD,Barber J,Jaffee E,Reilly RT,Sukumar S

更新日期：2006-01-15 00:00:00

abstract：:Tumor infiltrating lymphocytes (TIL) were isolated from 22 tumors obtained from 15 patients with metastatic melanoma. In 18 of the 22 tumors, a substantial number of lymphocytes was isolated with an average lymphoid cell:tumor cell ratio of 1.26. The TIL were predominantly cytotoxic/suppressor T-lymphocytes with an av...

journal_title：Cancer research

authors： Itoh K,Tilden AB,Balch CM

更新日期：1986-06-01 00:00:00

abstract：:In this study we describe the establishment of a leukemic cell line (BNML-CL/ara-C), originating from the 1-beta-D-arabinofuranosylcytosine (ara-C)-resistant brown Norway rat myelocytic leukemia model (BNML/ara-C), that retains the in vivo generated ara-C resistance. Its biological and biochemical characteristics have...

journal_title：Cancer research

authors： Richel DJ,Colly LP,Arkesteijn GJ,Arentsen-Honders MW,Kerster MG,ter Riet PM,Willemze R

更新日期：1990-10-15 00:00:00

abstract：:The novel antineoplastic drug taxol has been shown to be active clinically against several types of human tumors. With improvement in treatment strategy and the number of long-term survivors increasing, a question that needs to be addressed is the potential carcinogenic effect of the treatment in the induction of seco...

journal_title：Cancer research

authors： Hei TK,Hall EJ

更新日期：1993-03-15 00:00:00

abstract：:The tumor-associated antigen MUC1 is overexpressed and underglycosylated in human adenocarcinomas of diverse origins, such as breast, ovary, and colon. We isolated and describe five human single-chain (sc) Fv antibodies specific for the MUC1 variable number of tandem repeats region isolated by in vitro selection from ...

journal_title：Cancer research

authors： Henderikx P,Kandilogiannaki M,Petrarca C,von Mensdorff-Pouilly S,Hilgers JH,Krambovitis E,Arends JW,Hoogenboom HR

更新日期：1998-10-01 00:00:00

abstract：:Loss of expression of the E-cadherin cell-cell adhesion molecule is important in carcinoma development and progression. Because previous data suggest that loss of E-cadherin expression in breast carcinoma may result from a dominant transcriptional repression pathway acting on the E-cadherin proximal promoter, we pursu...

journal_title：Cancer research

authors： Hajra KM,Chen DY,Fearon ER

更新日期：2002-03-15 00:00:00

abstract：:Multidrug resistance (MDR) can be mediated, in part, by overexpression of P-glycoprotein (P-gp) and is characterized by broad resistance to several structurally, chemically, and pharmacologically distinct chemotherapeutic compounds. It has been hypothesized that immunological approaches to cytolysis may be used to ove...

journal_title：Cancer research

authors： McGrath MS,Rosenblum MG,Philips MR,Scheinberg DA

更新日期：2003-01-01 00:00:00

abstract：:We have previously shown that topotecan, a topoisomerase I poison, inhibits hypoxia-inducible factor (HIF)-1alpha protein accumulation by a DNA damage-independent mechanism. Here, we report that daily administration of topotecan inhibits HIF-1alpha protein expression in U251-HRE glioblastoma xenografts. Concomitant wi...

journal_title：Cancer research

authors： Rapisarda A,Zalek J,Hollingshead M,Braunschweig T,Uranchimeg B,Bonomi CA,Borgel SD,Carter JP,Hewitt SM,Shoemaker RH,Melillo G

更新日期：2004-10-01 00:00:00

abstract：:p21 (WAF1/CIP1; CDKN1a) is a universal cell-cycle inhibitor directly controlled by p53 and p53-independent pathways. Knowledge of the regulation and function of p21 in normal and cancer cells has opened up several areas of investigation and has led to novel therapeutic strategies. The discovery in 1993 and subsequent ...

journal_title：Cancer research

authors： El-Deiry WS

更新日期：2016-09-15 00:00:00