Increased glucocorticoid receptor concentration in macrophage differentiation of myeloid leukemia cells with 12-O-tetradecanoylphorbol-13-acetate.

Abstract:

:HL60 cells, human promyelocytic leukemia cells, can be induced to differentiate into more mature myeloid forms by dimethyl sulfoxide (DMSO) or retinoic acid (RA) and into macrophage-like cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) or related compounds. Macrophage differentiation of HL60 cells by TPA treatment induced a 3- to 4-fold increase in glucocorticoid receptor concentration per cell and a 2- to 3-fold increase in glucocorticoid receptor concentration per mg of protein. The ability of TPA derivatives to increase glucocorticoid receptor concentration paralleled their ability to induce macrophage differentiation. Macrophage differentiation of other myeloid leukemia cells by TPA treatment induced a 2- to 3-fold increase in glucocorticoid receptor concentration per cell. Exposure of T-lymphoblasts or erythroleukemia cells to TPA did not affect glucocorticoid receptor concentration. Myeloid differentiation of myeloid leukemia cells by DMSO or RA induced no significant change in glucocorticoid receptor concentration. The increase in glucocorticoid receptor concentration in macrophage differentiation of myeloid leukemia cells with TPA was considered to depend, not on TPA treatment, but on the process of macrophage differentiation. Further, glucocorticoid receptor concentration can be a sensitive marker of macrophage differentiation of myeloid leukemia cells.

journal_name

Cancer Res

journal_title

Cancer research

authors

Hirai H,Murakami T,Urabe A,Takaku F

subject

Has Abstract

pub_date

1985-06-01 00:00:00

pages

2456-61

issue

6

eissn

0008-5472

issn

1538-7445

journal_volume

45

pub_type

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