Abstract：
:The data of nine monolayer cultures, 48 multicellular spheroids, and 19 s.c. xenografts of LoVo cells were fitted, on an individual basis, by exponential and Gompertzian equations, respectively. The mean growth parameters alpha 0 (initial growth rate) and beta (retardation factor) of the three experimental systems presented a strong linear correlation alpha 0 = 6.88 beta + 0.56, r = 0.9843. This implies that, at the particular tumor size of 155 microns in diameter (mean +/- SD = 50-310 microns), the tumor growths described by Gompertzian curves (from spheroids as well as from s.c. xenografts) have the same growth rate as monolayer cultures. This occurrence strongly supports an exponential-Gompertzian growth model, where an exponential monolayer-like phase changes to a Gompertzian growth, controlled by environmental conditions, when the tumor size has reached a critical value.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Demicheli R,Foroni R,Ingrosso A,Pratesi G,Soranzo C,Tortoreto Msubject
Has Abstractpub_date
1989-12-01 00:00:00pages
6543-6issue
23eissn
0008-5472issn
1538-7445journal_volume
49pub_type
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