Effects of timing and type of tobacco in cigarette-induced bladder cancer.

abstract：:We have recently demonstrated that many cancer cell lines produce a novel trypsinogen isoenzyme called tumor-associated trypsinogen 2 (TAT-2). It was found during a search of the target protease for tumor-associated trypsin inhibitor (TATI). We now show that degradation of subendothelial cell extracellular matrix (ECM...

journal_title：Cancer research

authors： Koivunen E,Ristimäki A,Itkonen O,Osman S,Vuento M,Stenman UH

更新日期：1991-04-15 00:00:00

abstract：:The growth of solid tumors and the formation of metastases are dependent on neoangiogenesis. One of the most important factors in inducing the formation of new blood vessels is the vascular endothelial growth factor (VEGF), which acts specifically on endothelial cells. VEGF is expressed and secreted by almost all soli...

journal_title：Cancer research

authors： Barleon B,Siemeister G,Martiny-Baron G,Weindel K,Herzog C,Marmé D

更新日期：1997-12-01 00:00:00

abstract：:Three mouse monoclonal antibodies to distinct cell surface antigens were derived from immunizations with cells of Tera-1, a human teratocarcinoma cell line, and a membrane preparation of placental tissue. The distribution of the antigens on 165 cultured lines of various human tumors and normal cells was determined by ...

journal_title：Cancer research

authors： Rettig WJ,Cordon-Cardo C,Ng JS,Oettgen HF,Old LJ,Lloyd KO

更新日期：1985-02-01 00:00:00

abstract：:The Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling cascade enhances tumor cell proliferation in many cases. Here, we show that adenovirus type 5, a small DNA tumor virus used in experimental cancer therapy, strongly induces ERK phosphorylation during the late phase...

journal_title：Cancer research

authors： Schümann M,Dobbelstein M

更新日期：2006-02-01 00:00:00

abstract：:Calorie restriction has been shown to inhibit epithelial carcinogenesis and this method of dietary restriction reduces many circulating proteins, including insulin-like growth factor I (IGF-I). Previously, we identified a relationship between elevated tissue IGF-I levels and enhanced susceptibility to chemically induc...

journal_title：Cancer research

authors： Moore T,Carbajal S,Beltran L,Perkins SN,Yakar S,Leroith D,Hursting SD,Digiovanni J

更新日期：2008-05-15 00:00:00

abstract：:Although the cancer cell cytoskeleton is a clinically validated target, few new strategies have emerged for selectively targeting cell division by modulating the cytoskeletal structure, particularly ways that could avoid the cardiotoxic and neurotoxic effects of current agents such as taxanes. We address this gap by d...

journal_title：Cancer research

authors： Lash LL,Wallar BJ,Turner JD,Vroegop SM,Kilkuskie RE,Kitchen-Goosen SM,Xu HE,Alberts AS

更新日期：2013-11-15 00:00:00

abstract：:Matrix metalloproteinases have been traditionally linked to cancer dissemination through their ability to degrade most extracellular matrix components, thus facilitating invasion and metastasis of tumor cells. However, recent functional studies have revealed that some metalloproteases, including several members of the...

journal_title：Cancer research

authors： Viloria CG,Obaya AJ,Moncada-Pazos A,Llamazares M,Astudillo A,Capellá G,Cal S,López-Otín C

更新日期：2009-06-01 00:00:00

abstract：:SR31747A is a sigma ligand with potent antiproliferative activity against tumor cells and for which three binding proteins have been identified to date: (a) SRBP-1 (also called sigma 1); (b) HIS; and (c) sigma 2. In this study, we characterized an additional SR31747A binding site, i.e., SRBP-2 (SR31747A-binding protei...

journal_title：Cancer research

authors： Vidal H,Mondesert G,Galiègue S,Carrière D,Dupuy PH,Carayon P,Combes T,Bribes E,Simony-Lafontaine J,Kramar A,Loison G,Casellas P

更新日期：2003-08-15 00:00:00

abstract：:Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation of miRNAs has been associated with the pa...

journal_title：Cancer research

authors： Park EY,Chang E,Lee EJ,Lee HW,Kang HG,Chun KH,Woo YM,Kong HK,Ko JY,Suzuki H,Song E,Park JH

更新日期：2014-12-15 00:00:00

abstract：:The deregulated expression of cyclin E as measured by the overexpression of its low molecular weight (LMW) isoforms is a powerful predictor of poor outcome in patients with breast cancer. The mechanism by which these LMW forms give tumor cells a growth advantage is not known and is the subject of this article. In this...

journal_title：Cancer research

authors： Akli S,Zheng PJ,Multani AS,Wingate HF,Pathak S,Zhang N,Tucker SL,Chang S,Keyomarsi K

更新日期：2004-05-01 00:00:00

abstract：:Transgenic mice have been previously established that express v-rasHa or v-fos exclusively in the epidermis by means of a targeting vector based on the human keratin 1 gene (HK1). Epidermal expression of v-rasHa (HK1.ras) or v-fos (HK1.fos) resulted in hyperplasia, hyperkeratosis, and later, in benign tumors. To asses...

journal_title：Cancer research

authors： Greenhalgh DA,Quintanilla MI,Orengo CC,Barber JL,Eckhardt JN,Rothnagel JA,Roop DR

更新日期：1993-11-01 00:00:00

abstract：:3-(Iodoacetamido)-benzoylurea (3-IAABU) is a newly synthesized antitubulin compound with a molecular weight of 347. 3-IAABU exhibited anticancer activity in a variety of tumor cell lines with ID90 in the range of 0.015-0.29 microM for leukemic cells and 0.06-0.92 microM for solid tumors. Higher selectivity against mal...

journal_title：Cancer research

authors： Jiang JD,Davis AS,Middleton K,Ling YH,Perez-Soler R,Holland JF,Bekesi JG

更新日期：1998-12-01 00:00:00

abstract：:Retinoids are promising agents for cancer chemoprevention and therapy. Nuclear retinoic acid receptors (RARs; RARalpha, -beta, and -gamma) and retinoid X receptors (RXRs; RXRalpha, -beta, and -gamma) are thought to mediate most of retinoids' effects on cell growth and differentiation. Because the majority of human non...

journal_title：Cancer research

authors： Sun SY,Yue P,Dawson MI,Shroot B,Michel S,Lamph WW,Heyman RA,Teng M,Chandraratna RA,Shudo K,Hong WK,Lotan R

更新日期：1997-11-01 00:00:00

abstract：:Leucine-rich repeat-containing 3B (LRRC3B) is an evolutionarily highly conserved leucine-rich repeat-containing protein, but its biological significance is unknown. Using restriction landmark genomic scanning and pyrosequencing, we found that the promoter region of LRRC3B was aberrantly methylated in gastric cancer. G...

journal_title：Cancer research

authors： Kim M,Kim JH,Jang HR,Kim HM,Lee CW,Noh SM,Song KS,Cho JS,Jeong HY,Hahn Y,Yeom YI,Yoo HS,Kim YS

更新日期：2008-09-01 00:00:00

abstract：:For many solid tumors, surgical resection remains the gold standard and tumor-involved margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for in situ imaging during resection. However, for cancers with difficult imaging conditions, surg...

journal_title：Cancer research

authors： Gao RW,Teraphongphom NT,van den Berg NS,Martin BA,Oberhelman NJ,Divi V,Kaplan MJ,Hong SS,Lu G,Ertsey R,Tummers WSFJ,Gomez AJ,Holsinger FC,Kong CS,Colevas AD,Warram JM,Rosenthal EL

更新日期：2018-09-01 00:00:00

abstract：:The rat pancreatic carcinoma cell line AR4-2J was screened for growth-associated genes linked to the mitogenic effect of the novel gut brain hormone, pituitary adenylate cyclase activating polypeptide (PACAP). Using the mRNA differential display technique, we identified and sequenced an unknown rat gene, PACAP-respons...

journal_title：Cancer research

authors： Schäfer H,Trauzold A,Siegel EG,Fölsch UR,Schmidt WE

更新日期：1996-06-01 00:00:00

abstract：:It is becoming increasingly clear that tumor growth and progression is not entirely due to genetic aberrations but also reflective of tumor cell plasticity. It follows therefore that proteins contributing to tumor progression oscillate in their expression a contention yet to be shown. Because the urokinase-type plasmi...

journal_title：Cancer research

authors： Yang L,Avila H,Wang H,Trevino J,Gallick GE,Kitadai Y,Sasaki T,Boyd DD

更新日期：2006-08-15 00:00:00

abstract：:Using JM and MOLT3, two human T-cell acute lymphoblastic leukemia cell lines, we investigated the ability of 24-h thymidine exposures to enhance the cytotoxicity of cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) (carboplatin). Clinically achievable thymidine concentrations (for 24 h) significantly enhanced c...

journal_title：Cancer research

authors： Cohen JD,Robins HI,Schmitt CL,Tanner MA

更新日期：1989-11-01 00:00:00

abstract：:Bladder cancer progression is thought to be associated with sequential genetic events. To search for the specific genetic changes associated with the metastatic process, comparative genomic hybridization was performed on 22 primary tumors and 24 metastases (10 distant and 14 nodal metastases) from 17 patients with sta...

journal_title：Cancer research

authors： Hovey RM,Chu L,Balazs M,DeVries S,Moore D,Sauter G,Carroll PR,Waldman FM

更新日期：1998-08-15 00:00:00

abstract：:Low-dose cyclophosphamide (LDC) induces selective apoptosis of endothelial cells within the vascular bed of tumors. Here, we investigated a hypothesis that the effect of LDC is mediated by the pro-apoptotic action of endogenous inhibitors of angiogenesis. Tumors treated with LDC demonstrate similar expression of matri...

journal_title：Cancer research

authors： Hamano Y,Sugimoto H,Soubasakos MA,Kieran M,Olsen BR,Lawler J,Sudhakar A,Kalluri R

更新日期：2004-03-01 00:00:00

abstract：:Human CYP2A6 has been recognized as being involved in the mutagenic activation of promutagens such as the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Methoxsalen (8-methoxypsoralen) was reported to inhibit CYP2A6. In the present study, the inhibitory effects of methoxsalen on NN...

journal_title：Cancer research

authors： Takeuchi H,Saoo K,Yokohira M,Ikeda M,Maeta H,Miyazaki M,Yamazaki H,Kamataki T,Imaida K

更新日期：2003-11-15 00:00:00

abstract：:In the diagnosis of non-Hodgkin's lymphomas, the ready characterization of the neoplastic cell lineage by analysis of cell surface markers is of great importance. We present evidence for the existence of a human B-leukemia-associated antigen recognized by a complement-fixing monoclonal antibody (anti-Y 29/55). A hybri...

journal_title：Cancer research

authors： Forster HK,Gudat FG,Girard MF,Albrecht R,Schmidt J,Ludwig C,Obrecht JP

更新日期：1982-05-01 00:00:00

abstract：:Human mammary and other carcinoma cells secrete and express on their cell surfaces complex, mucin-like glycoproteins (Mr greater than 10(6] that are recognized as tumor-associated antigens by a variety of monoclonal antibodies (MAbs). One such MAb, B72.3, has been extensively studied as to range of reactivity for a va...

journal_title：Cancer research

authors： Sheer DG,Schlom J,Cooper HL

更新日期：1988-12-01 00:00:00

abstract：:In vitro tests of tumor cell drug sensitivity have been suggested as a means of selecting more appropriate clinical strategies against human cancer and improving preclinical drug development. The lack of biotransformation in these in vitro assays precludes the meaningful assessment of several major chemotherapeutic ag...

journal_title：Cancer research

authors： Kirkwood JM,Marsh JC

更新日期：1983-07-01 00:00:00

abstract：:Twenty-seven patients with advanced cancer were entered in a phase I study of bolus i.v. 5-fluorouracil at a dose of 370 mg/m2/day for 5 days combined with a continuous i.v. infusion of (6S)-folinic acid for 5.5 days, starting 24 h in advance of the first 5-fluorouracil dose. The dose of (6S)-folinic acid was escalate...

journal_title：Cancer research

authors： Newman EM,Akman SA,Harrison JS,Leong LA,Margolin KA,Morgan RJ,Raschko JW,Somlo G,Ahn CW,Doroshow JH

更新日期：1992-05-01 00:00:00

abstract：:Myeloproliferative disorders (MPD) are stem cell-derived clonal diseases arising as a consequence of acquired aberrations in c-ABL, Janus-activated kinase 2 (JAK2), and platelet-derived growth factor receptor (PDGFR) that generate oncogenic fusion tyrosine kinases (FTK), including BCR/ABL, TEL/ABL, TEL/JAK2, and TEL/P...

journal_title：Cancer research

authors： Cramer K,Nieborowska-Skorska M,Koptyra M,Slupianek A,Penserga ET,Eaves CJ,Aulitzky W,Skorski T

更新日期：2008-09-01 00:00:00

abstract：:We analyzed the immunohistochemical expression of three epitopes of the tumor-associated glycoprotein 72 (TAG-72) in whole cross-sections of primary colorectal carcinomas and in regional lymph node metastases using monoclonal antibodies (MAbs) B72.3, CC-49, and CC-83, which recognize distinct carbohydrate antigenic de...

journal_title：Cancer research

authors： Muraro R,Frati L,Bei R,Ficari F,Valli C,French D,Mammarella S,Caramia F,Fegiz G,Mariani-Costantini R

更新日期：1991-10-01 00:00:00

abstract：:The effect of dietary intake of different levels of Menhaden fish oil on azoxymethane-induced carcinogenesis was examined in male F344 rats fed the semipurified diets. Starting at 5 weeks of age, groups of animals were fed the 5% corn oil (low corn oil) diet. At 7 weeks of age, all animals except the vehicle-treated c...

journal_title：Cancer research

authors： Reddy BS,Maruyama H

更新日期：1986-07-01 00:00:00

abstract：:The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to increase their metabolism. ShcA signaling enhanced glucose catabolism through glycolysis and oxidative phosphorylation, rendering breast cancer cells critically depe...

journal_title：Cancer research

authors： Im YK,Najyb O,Gravel SP,McGuirk S,Ahn R,Avizonis DZ,Chénard V,Sabourin V,Hudson J,Pawson T,Topisirovic I,Pollak M,St-Pierre J,Ursini-Siegel J

更新日期：2018-09-01 00:00:00

abstract：:Decreased BRCA1 expression in the absence of genetic mutation is observed frequently in sporadic cancers of the breast and other sites, although little is known regarding the mechanisms by which the expression of this gene can be repressed. Here, we show that activating and repressive E2Fs simultaneously bind the BRCA...

journal_title：Cancer research

authors： Bindra RS,Gibson SL,Meng A,Westermark U,Jasin M,Pierce AJ,Bristow RG,Classon MK,Glazer PM

更新日期：2005-12-15 00:00:00