In Silico Modeling of Immunotherapy and Stroma-Targeting Therapies in Human Colorectal Cancer.

abstract：:Recently, we have shown that the p53 tumor suppressor gene product can inhibit expression of the bcl-2 gene. In this report, we explored the molecular basis for p53-mediated down-regulation of bcl-2 gene expression using a cotransfection approach involving p53 expression plasmids and chloramphenicol acetyltransferase ...

journal_title：Cancer research

authors： Miyashita T,Harigai M,Hanada M,Reed JC

更新日期：1994-06-15 00:00:00

abstract：:Cancers are initiated as a result of changes that occur in the genome. Identification of gains and losses in the structure and expression of tumor-suppressor genes and oncogenes lies at the root of the understanding of cancer cell biology. Here, we show that the mitogen-activated protein kinase (MAPK) MKK3 suppresses ...

journal_title：Cancer research

authors： MacNeil AJ,Jiao SC,McEachern LA,Yang YJ,Dennis A,Yu H,Xu Z,Marshall JS,Lin TJ

更新日期：2014-01-01 00:00:00

abstract：:The C3H/10T1/2 CL8 cell line (10T1/2) is being widely used as a quantitative assay system for chemical and physical carcinogens. 10T1/2 cells, but not their transformed counterparts, exhibit a decreased final saturation density with decreasing serum concentration. Exposure of carcinogen-treated cultures to 5% serum 8 ...

journal_title：Cancer research

authors： Bertram JS

更新日期：1977-02-01 00:00:00

abstract：:Prolactin, a pituitary hormone, exerts pleiotropic effects in various cells. These effects are mediated by a membrane receptor highly expressed in many tissues. To analyze prolactin effects on the thyroid gland, we first identified prolactin receptor (PRLR) mRNAs by in situ hybridization. To further evaluate the physi...

journal_title：Cancer research

authors： Kedzia C,Lacroix L,Ameur N,Ragot T,Kelly PA,Caillou B,Binart N

更新日期：2005-09-15 00:00:00

abstract：:A glomerulopathy in hamsters bearing human epithelial tumors is described. The tumors resulted from the s.c. implantation of human heteroploid cells (MA160) derived originally from a benign prostatic adenoma. The renal immunomorphological and ultrastructural changes include expansion of mesangial matrix and cellularit...

journal_title：Cancer research

authors： Richman AV,Alexander RW

更新日期：1979-02-01 00:00:00

abstract：:Vascular endothelial growth factor D has recently been linked to the control of lymphangiogenesis and lymphatic metastasis. The molecular determinants regulating vegf-D gene transcription, however, have not yet been identified. After isolation of 2 kb of 5'-flanking DNA of the human vegf-D gene, we identified a novel,...

journal_title：Cancer research

authors： Schäfer G,Wissmann C,Hertel J,Lunyak V,Höcker M

更新日期：2008-01-15 00:00:00

abstract：:The biosynthesis of distinct prostatic and lysosomal acid phosphatases is demonstrated using a human prostatic carcinoma cell line, PC-3SF12. The biosynthesis and maturation of the acid phosphatases was studied by metabolic labeling with radioactive leucine, specific immunoprecipitation, sodium dodecyl sulfate-polyacr...

journal_title：Cancer research

authors： Waheed A,Van Etten RL

更新日期：1986-09-01 00:00:00

abstract：:An accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high reexcision rates without resorting to the...

journal_title：Cancer research

authors： Kennedy BF,McLaughlin RA,Kennedy KM,Chin L,Wijesinghe P,Curatolo A,Tien A,Ronald M,Latham B,Saunders CM,Sampson DD

更新日期：2015-08-15 00:00:00

abstract：:Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of gamma-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC50 in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity with respect to 75 ot...

journal_title：Cancer research

authors： Luistro L,He W,Smith M,Packman K,Vilenchik M,Carvajal D,Roberts J,Cai J,Berkofsky-Fessler W,Hilton H,Linn M,Flohr A,Jakob-Røtne R,Jacobsen H,Glenn K,Heimbrook D,Boylan JF

更新日期：2009-10-01 00:00:00

abstract：:Estrogen independence and progression to a metastatic phenotype are hallmarks of therapeutic resistance and mortality in breast cancer patients. Metastasis has been associated with chemokine signaling through the SDF-1-CXCR4 axis. Thus, the development of estrogen independence and endocrine therapy resistance in breas...

journal_title：Cancer research

authors： Rhodes LV,Short SP,Neel NF,Salvo VA,Zhu Y,Elliott S,Wei Y,Yu D,Sun M,Muir SE,Fonseca JP,Bratton MR,Segar C,Tilghman SL,Sobolik-Delmaire T,Horton LW,Zaja-Milatovic S,Collins-Burow BM,Wadsworth S,Beckman BS,Wood CE

更新日期：2011-01-15 00:00:00

abstract：:Verapamil has been shown to enhance immunotoxin activity but only at concentrations that are too high for in vivo use. Therefore, four structural analogues of verapamil (D792, D595, D528, and Sz45) were evaluated for their ability to enhance the in vitro activity of immunotoxins made with either ricin A chain or Pseud...

journal_title：Cancer research

authors： Pirker R,FitzGerald DJ,Raschack M,Frank Z,Willingham MC,Pastan I

更新日期：1989-09-01 00:00:00

abstract：:Induction of mRNA for BIK proapoptotic protein by doxorubicin or gamma-irradiation requires the DNA-binding transcription factor activity of p53. In MCF7 cells, pure antiestrogen fulvestrant also induces BIK mRNA and apoptosis. Here, we provide evidence that, in contrast to doxorubicin or gamma-irradiation, fulvestran...

journal_title：Cancer research

authors： Hur J,Bell DW,Dean KL,Coser KR,Hilario PC,Okimoto RA,Tobey EM,Smith SL,Isselbacher KJ,Shioda T

更新日期：2006-10-15 00:00:00

abstract：:The effects of taxol on antitubulin immunofluorescent staining patterns, cellular DNA content, and labeling with [3H]thymidine were measured for the taxol-sensitive HL60 and taxol-resistant K562 cell lines after exposures for 0, 4, 12, and 24 h. Taxol caused a relative increase in the fraction of 4C interphase and met...

journal_title：Cancer research

authors： Roberts JR,Allison DC,Donehower RC,Rowinsky EK

更新日期：1990-02-01 00:00:00

abstract：:One of the major problems in the diagnosis of localized prostatic tumors is to predict the aggressiveness of an individual tumor, which is presumably associated with chance to progression. In an attempt to find molecular markers that are specific for aggressive prostatic cancer cells, we compared steady-state mRNA lev...

journal_title：Cancer research

authors： Bussemakers MJ,van de Ven WJ,Debruyne FM,Schalken JA

更新日期：1991-01-15 00:00:00

abstract：:The diagnostic value of elevated human chorionic gonadotropin (hCG) and its free alpha (hCG alpha) and beta (hCG beta) subunit serum levels as specific tumor markers for nongonadal malignancies is controversial. In the present report, different monoclonal based immunoradiometric assays specific for hCG and its free hC...

journal_title：Cancer research

authors： Marcillac I,Troalen F,Bidart JM,Ghillani P,Ribrag V,Escudier B,Malassagne B,Droz JP,Lhommé C,Rougier P

更新日期：1992-07-15 00:00:00

abstract：:The ability of four steroids and three bile acids to promote the appearance of hyperplastic foci and hyperplastic nodules initiated by diethylnitrosamine (DEN) in the liver of male Fischer rats was tested and compared with that of the known promoter phenobarbital (PB, 0.05%) as a standard value. Two weeks after a sing...

journal_title：Cancer research

authors： Cameron RG,Imaida K,Tsuda H,Ito N

更新日期：1982-06-01 00:00:00

abstract：:Medulloblastoma is frequently disseminated throughout the central nervous system by the time of diagnosis. Conventional therapeutic approaches have not reduced the high mortality associated with metastatic medulloblastoma and little is known regarding the molecular mechanisms that promote tumor invasion. Previously, w...

journal_title：Cancer research

authors： Hernan R,Fasheh R,Calabrese C,Frank AJ,Maclean KH,Allard D,Barraclough R,Gilbertson RJ

更新日期：2003-01-01 00:00:00

abstract：:Although apoptosis and necrosis are morphologically distinct manifestations of cell death, apoptosis and some necroses share common features in the death signaling pathway involving functional steps of death-driving interleukin 1beta-converting enzyme family proteases and anti-cell death protein Bcl-2. One evident phy...

journal_title：Cancer research

authors： Eguchi Y,Shimizu S,Tsujimoto Y

更新日期：1997-05-15 00:00:00

abstract：:High levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, suggesting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. To test this hypothesis in vivo, we generated transgenic mice with widespread expression of Mdm4. Two independe...

journal_title：Cancer research

authors： Xiong S,Pant V,Suh YA,Van Pelt CS,Wang Y,Valentin-Vega YA,Post SM,Lozano G

更新日期：2010-09-15 00:00:00

abstract：:Tumor antigen-induced inhibition of leukocyte adherence was adapted and modified for use in glass test tubes for the study of cell-mediated antitumor immunity to human adenocarcinoma of the breast. Peripheral blood leukocytes from 40 to 47 patients with proven breast cancer responded to an antigenic extract of breast ...

journal_title：Cancer research

authors： Grosser N,Thomson DM

更新日期：1975-09-01 00:00:00

abstract：:Gonadotropin-releasing hormone-I (GnRH-I) is known to directly regulate prostate cancer cell proliferation. However, the role of GnRH-II in prostate cancer is unclear. Here, we investigated the effect of the GnRH-II antagonist trptorelix-1 (Trp-1) on growth of PC3 prostate cancer cells. Trp-1 induced growth inhibition...

journal_title：Cancer research

authors： Kim DK,Yang JS,Maiti K,Hwang JI,Kim K,Seen D,Ahn Y,Lee C,Kang BC,Kwon HB,Cheon J,Seong JY

更新日期：2009-02-01 00:00:00

abstract：:The adoptive transfer of recombinant-methionyl human interleukin 2 (rIL-2)-activated autologous peripheral blood mononuclear lymphokine-activated killer (LAK) cells to cancer patients is being evaluated as an alternative to conventional cancer therapy. We have independently developed an alternative regimen to previous...

journal_title：Cancer research

authors： Schoof DD,Gramolini BA,Davidson DL,Massaro AF,Wilson RE,Eberlein TJ

更新日期：1988-09-01 00:00:00

abstract：:Rous sarcoma virus-transformed hamster BHK fibroblasts express a virus-induced cell surface antigen undetectable in cells either transformed by unrelated viruses or infected by transformation-defective strains of Rous sarcoma virus. To clarify whether this antigen plays any role in the process of malignant transformat...

journal_title：Cancer research

authors： Comoglio PM,Pani B,Prat M,Tarone G,Monti-Bragadin C

更新日期：1979-11-01 00:00:00

abstract：:Methylglyoxal-bis(guanylhydrazone) (MGBG) is a polycationic drug which is useful in the chemotherapy of lymphoid and myeloid proliferative disorders. The drug has recently been shown to produce selective ultrastructural damage to the mitochondria of proliferating cell populations. It is important to understand the mol...

journal_title：Cancer research

authors： Feuerstein B,Porter CW,Dave C

更新日期：1979-10-01 00:00:00

abstract：:Our recent study found that activation of signal transducer and activator of transcription 3 (Stat3) is up-regulated in human brain metastatic cells and contributes to brain metastasis of melanoma. However, the molecular mechanisms underlying this increased Stat3 activation and effect on brain metastasis are unknown. ...

journal_title：Cancer research

authors： Huang FJ,Steeg PS,Price JE,Chiu WT,Chou PC,Xie K,Sawaya R,Huang S

更新日期：2008-12-01 00:00:00

abstract：:Although significant advances in radiotherapy have increased its effectiveness in many cancer settings, general strategies to widen the therapeutic window between normal tissue toxicity and malignant tumor destruction would still offer great value. CD47 blockade has been found to confer radioprotection to normal tissu...

journal_title：Cancer research

authors： Soto-Pantoja DR,Terabe M,Ghosh A,Ridnour LA,DeGraff WG,Wink DA,Berzofsky JA,Roberts DD

更新日期：2014-12-01 00:00:00

abstract：:Tumor-associated macrophages (TAM) are a major inflammatory infiltrate in tumors and a major component of the protumor function of inflammation. TAM in established tumors generally have an M2 phenotype with defective production of interleukin-12 (IL-12) and high IL-10. Here, we report that defective responsiveness of ...

journal_title：Cancer research

authors： Saccani A,Schioppa T,Porta C,Biswas SK,Nebuloni M,Vago L,Bottazzi B,Colombo MP,Mantovani A,Sica A

更新日期：2006-12-01 00:00:00

abstract：:The expression of the mucin-bound sialyl-Lewisx epitope is increased in the tissue of most colorectal carcinomas and in the sera of about 30% of tumor patients. In colon cancer, a portion of the sialyl-Lex groups detectable with the monoclonal antibody AM-3 is located on MUC1 (C. Hanski et al., Cancer Res., 53: 4082-4...

journal_title：Cancer research

authors： Hanski C,Hanski ML,Zimmer T,Ogorek D,Devine P,Riecken EO

更新日期：1995-02-15 00:00:00

abstract：:The soybean-derived Bowman Birk inhibitor (BBI) has been shown to inhibit carcinogenesis in both in vitro and in vivo model systems. In the present study, we have utilized a BBI affinity column to determine whether cellular enzymes, present in C3H/10T1/2 cells, specifically interact with this inhibitor. Using this tec...

journal_title：Cancer research

authors： Billings PC,St Clair W,Owen AJ,Kennedy AR

更新日期：1988-04-01 00:00:00

abstract：:O6-Benzylguanine is an inactivator of O6-alkylguanine-DNA alkyltransferases (AGT) which is currently entering clinical trials as an agent improving the cancer chemotherapeutic activity of chloroethylnitrosoureas and other alkylating agents. O6-Benzylguanine acts by virtue of its ability to serve as a substrate for the...

journal_title：Cancer research

authors： Crone TM,Goodtzova K,Edara S,Pegg AE

更新日期：1994-12-01 00:00:00