Abstract：
:An accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high reexcision rates without resorting to the removal of excess healthy tissue. Optical coherence microelastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to microscale variations of the mechanical properties of tissue. As the tumor modifies the mechanical properties of breast tissue, OCME has the potential to identify, on the microscale, involved regions of fresh, unstained tissue. OCME is based on the use of optical coherence tomography (OCT) to measure tissue deformation in response to applied mechanical compression. In this feasibility study on 58 ex vivo samples from patients undergoing mastectomy or wide local excision, we demonstrate the performance of OCME as a means to visualize tissue microarchitecture in benign and malignant human breast tissues. Through a comparison with corresponding histology and OCT images, OCME is shown to enable ready visualization of features such as ducts, lobules, microcysts, blood vessels, and arterioles and to identify invasive tumor through distinctive patterns in OCME images, often with enhanced contrast compared with OCT. These results lay the foundation for future intraoperative studies. Cancer Res; 75(16); 3236-45. ©2015 AACR.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Kennedy BF,McLaughlin RA,Kennedy KM,Chin L,Wijesinghe P,Curatolo A,Tien A,Ronald M,Latham B,Saunders CM,Sampson DDdoi
10.1158/0008-5472.CAN-14-3694subject
Has Abstractpub_date
2015-08-15 00:00:00pages
3236-45issue
16eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-14-3694journal_volume
75pub_type
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