Abstract：
:Cancer cells often fail to respond to stimuli that normally activate their intrinsic apoptotic machinery. Moreover, they are able to adapt to hypoxia by changing their glycolytic rate. Pyruvate kinase (PK) is a rate-limiting enzyme in glycolysis that is converted to a less active dimer form of PKM2 isoenzyme during oncogenesis. Here, we show that both somatostatin and the structural analogue TT-232 interact with the PKM subtype. We further show that the PKM2 is translocated to the nucleus in response to TT-232 and different apoptotic agents. Nuclear translocation of PKM2 is sufficient to induce cell death that is caspase independent, isoform specific, and independent of its enzymatic activity. These results show that the tumor marker PKM2 plays a general role in caspase-independent cell death of tumor cells and thereby defines this glycolytic enzyme as a novel target for cancer therapy development.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Steták A,Veress R,Ovádi J,Csermely P,Kéri G,Ullrich Adoi
10.1158/0008-5472.CAN-06-2870subject
Has Abstractpub_date
2007-02-15 00:00:00pages
1602-8issue
4eissn
0008-5472issn
1538-7445pii
67/4/1602journal_volume
67pub_type
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