Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis.

abstract：:A unique electrophoretic form of lactate dehydrogenase (LDH-Z), formerly observed in a choriocarcinoma cell line (JEG-3) and first-trimester placenta, has been shown to be the same as that produced in hydatidiform mole and term placenta. We have also observed LDH-Z in second-trimester placenta, choriocarcinoma metasta...

journal_title：Cancer research

authors： Siciliano MJ,Bordelon-Riser ME,Freedman RS,Kohler PO

更新日期：1980-02-01 00:00:00

abstract：:Cellular senescence is a potent tumor-suppressive program that prevents neoplastic events. Paradoxically, senescent cells develop an inflammatory secretome, termed the senescence-associated secretory phenotype, which is implicated in age-related pathologies including cancer. Here, we report that senescent cells active...

journal_title：Cancer research

authors： Han L,Long Q,Li S,Xu Q,Zhang B,Dou X,Qian M,Jiramongkol Y,Guo J,Cao L,Chin YE,Lam EW,Jiang J,Sun Y

更新日期：2020-08-15 00:00:00

abstract：:12-O-Tetradecanoylphorbol-13-acetate (TPA) is widely used as a tumor promoter with organotropy in skin and esophagus. TPA-induced, organ-specific tumor promotion is not correlated with the distribution of its receptor, protein kinase C (PKC). Using five administration methods (painting, drinking, gavage feeding, i.p. ...

journal_title：Cancer research

authors： Zhong S,Quealy JA,Bode AM,Nomura M,Kaji A,Ma WY,Dong Z

更新日期：2001-05-15 00:00:00

abstract：:We have screened 57 cases of primary, nonfunctional, pituitary adenomas for loss of heterozygosity of markers on chromosome 9p. Using a panel of 11 microsatellite markers, we found hemizygous deletion with at least one of the markers in 18 tumors (31.5%). The frequency of loss was similar in both noninvasive (8 of 26;...

journal_title：Cancer research

authors： Farrell WE,Simpson DJ,Bicknell JE,Talbot AJ,Bates AS,Clayton RN

更新日期：1997-07-01 00:00:00

abstract：:Progression of prostate cancer is believed to be dependent on angiogenesis induced by tumor cells. 3,3'-Diindolylmethane (DIM) has been shown to repress neovascularization in a Matrigel plug assay and inhibit cell proliferation, migration, invasion, and capillary tube formation of cultured human umbilical vein endothe...

journal_title：Cancer research

authors： Kong D,Li Y,Wang Z,Banerjee S,Sarkar FH

更新日期：2007-04-01 00:00:00

abstract：:Inhibin is a heterodimeric TGFβ family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the α subunit of inhibin (INHA), which is critical for the functionality of dimeric inhibin A/B, correlates w...

journal_title：Cancer research

authors： Singh P,Jenkins LM,Horst B,Alers V,Pradhan S,Kaur P,Srivastava T,Hempel N,Győrffy B,Broude EV,Lee NY,Mythreye K

更新日期：2018-06-01 00:00:00

abstract：:Sputum samples obtained during the screening phase of a chemoprevention trial in heavy smokers were evaluated independently by trained cytotechnologists and classified for degree of cellular atypia according to the method of Saccommano et al. (G. Saccommano et al., Cancer (Phila.), 33: 256-270, 1974). The level of agr...

journal_title：Cancer research

authors： Browman GP,Arnold A,Levine MN,D'Souza T,Turner-Smith LM,Cayco R,Johnstone B,Birse R

更新日期：1990-02-15 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. However, clinical trials targeting the VEGF pathway are often ineffective, suggesting that other factors/pathways are also important in tumor angiogenesis. We have previously shown that the Notch ligand Delta-like 4 (DLL4) is up-regu...

journal_title：Cancer research

authors： Li JL,Sainson RC,Shi W,Leek R,Harrington LS,Preusser M,Biswas S,Turley H,Heikamp E,Hainfellner JA,Harris AL

更新日期：2007-12-01 00:00:00

abstract：:The regulation of urokinase secretion and receptor display in a well-differentiated colon carcinoma cell line, GEO, adapted to serum-free conditions was examined. In protein-free medium, the cell line secreted 0.8 +/- 0.1 ng/ml/10(6) cells of urokinase in a 3-day period as determined by an enzyme-linked immunosorbent ...

journal_title：Cancer research

authors： Boyd D,Brattain M

更新日期：1989-04-15 00:00:00

abstract：:Camptothecin, which induces an unusual type of DNA damage by trapping cellular topoisomerase I on chromosomal DNA in the form of drug-enzyme-DNA cleavable complexes, inhibits DNA synthesis and specifically kills S-phase cells. Cotreatment of L1210 cells with aphidicolin, which is an inhibitor of replicative DNA polyme...

journal_title：Cancer research

authors： Hsiang YH,Lihou MG,Liu LF

更新日期：1989-09-15 00:00:00

abstract：:Myc oncoproteins exert tumorigenic effects by regulating expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes...

journal_title：Cancer research

authors： Wong M,Tee AEL,Milazzo G,Bell JL,Poulos RC,Atmadibrata B,Sun Y,Jing D,Ho N,Ling D,Liu PY,Zhang XD,Hüttelmaier S,Wong JWH,Wang J,Polly P,Perini G,Scarlett CJ,Liu T

更新日期：2017-05-01 00:00:00

abstract：:Activation of the matrix metalloproteinase 2 (MMP-2) has been shown to play a major role in the proteolysis of extracellular matrix (ECM) associated with tumor invasion. Although the precise mechanism of this activation remains elusive, levels of the membrane type 1-MMP (MT1-MMP) at the cell surface and of the tissue ...

journal_title：Cancer research

authors： Gilles C,Bassuk JA,Pulyaeva H,Sage EH,Foidart JM,Thompson EW

更新日期：1998-12-01 00:00:00

abstract：:Radiolabeled antibodies have produced encouraging remissions in patients with chemotherapy-resistant hematological malignancies; however, the selection of therapeutic radionuclides for clinical trials remains controversial. In this study, we compared the internalization, lysosomal targeting, metabolism, and cellular r...

journal_title：Cancer research

authors： Press OW,Shan D,Howell-Clark J,Eary J,Appelbaum FR,Matthews D,King DJ,Haines AM,Hamann P,Hinman L,Shochat D,Bernstein ID

更新日期：1996-05-01 00:00:00

abstract：:12-O-Tetradecanoylphorbol-13-acetate (TPA) is an effective comitogen in phytohemagglutinin-treated bovine lymphocytes. Concurrent addition of 10(-8) M TPA gives a greater than 6-fold increase in DNA synthesis over cultures treated with the lectin alone. The delayed addition of phorbol ester, relative to the start of t...

journal_title：Cancer research

authors： Kensler TW,Mueller GC

更新日期：1978-03-01 00:00:00

abstract：:Heterozygous mutations in the BRCA1 gene predispose women to breast and ovarian cancer, while biallelic BRCA1 mutations are a cause of Fanconi anemia (FA), a rare genetic disorder characterized by developmental abnormalities, early-onset bone marrow failure, increased risk of cancers, and hypersensitivity to DNA-cross...

journal_title：Cancer research

authors： Park D,Bergin SM,Jones D,Ru P,Koivisto CS,Jeon YJ,Sizemore GM,Kladney RD,Hadjis A,Shakya R,Ludwig T

更新日期：2020-10-01 00:00:00

abstract：:The DNA damage response kinase ATR and its effector kinase CHEK1 are required for cancer cells to survive oncogene-induced replication stress. ATR inhibitors exhibit synthetic lethal interactions, with deficiencies in the DNA damage response enzymes ATM and XRCC1 and with overexpression of the cell cycle kinase cyclin...

journal_title：Cancer research

authors： Mohni KN,Kavanaugh GM,Cortez D

更新日期：2014-05-15 00:00:00

abstract：:The metabolic changes in rat hepatoma cell line, AH70 cells, after coculturing with Kupffer cells were visualized using a silicon-intensified target camera and subsequent processing with a computer-assisted digital imaging processor. In cocultured tumor cells, nonactivated Kupffer cells reduced mitochondrial energizat...

journal_title：Cancer research

authors： Kurose I,Miura S,Fukumura D,Yonei Y,Saito H,Tada S,Suematsu M,Tsuchiya M

更新日期：1993-06-01 00:00:00

abstract：:Serially cultivated keratinocytes of human and rat epidermis and esophagus were compared with respect to their sensitivity to toxic effects of 3-methylcholanthrene and ability to metabolize benzo(a)pyrene. 3-Methylcholanthrene was highly toxic to the human keratinocytes and to early-passage rat epidermal keratinocytes...

journal_title：Cancer research

authors： Heimann R,Rice RH

更新日期：1983-10-01 00:00:00

abstract：:A significant impediment to the success of cancer chemotherapy is multidrug resistance (MDR). A typical form of MDR is attributable to the overexpression of membrane transport proteins, such as P-glycoprotein, resulting in an increased drug efflux. In this study, we show that adenovirus-mediated enhancement of the c-J...

journal_title：Cancer research

authors： Zhou J,Liu M,Aneja R,Chandra R,Lage H,Joshi HC

更新日期：2006-01-01 00:00:00

abstract：:A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genome-scale expression profiling has identified new subtypes of cancer based on consistent patterns of variation in gene expression, leading to improved prognostic predictions. However, how these new genetic subtypes of can...

journal_title：Cancer research

authors： Wong DJ,Nuyten DS,Regev A,Lin M,Adler AS,Segal E,van de Vijver MJ,Chang HY

更新日期：2008-01-15 00:00:00

abstract：:We have used culture conditions which simulate the microenvironment of breast tumors for the isolation and propagation of primary breast tumor cells in vitro. In this monolayer setup, the mixture of cells dissociated from primary breast tumors is subjected to self-created gradients of oxygen and nutrients as well as m...

journal_title：Cancer research

authors： Dairkee SH,Deng G,Stampfer MR,Waldman FM,Smith HS

更新日期：1995-06-15 00:00:00

abstract：:The increase of interleukin-4 (IL-4) level in tumor environment and the up-regulation of IL-4 receptor (IL-4R) on tumor cells have been long observed. However, their significance for tumor development has not been investigated. Here, we found that endogenous IL-4 promotes tumor growth because neutralizing IL-4 by 11B1...

journal_title：Cancer research

authors： Li Z,Jiang J,Wang Z,Zhang J,Xiao M,Wang C,Lu Y,Qin Z

更新日期：2008-11-01 00:00:00

abstract：:A new form of therapy of experimental tumors, utilizing lymphokine-activated killer (LAK) cells and high doses of interleukin 2, has recently been applied in the treatment of human neoplasms. Severe side effects, suggestive of a diffuse vascular injury of unknown etiology, have prevented a more widespread application ...

journal_title：Cancer research

authors： Kotasek D,Vercellotti GM,Ochoa AC,Bach FH,White JG,Jacob HS

更新日期：1988-10-01 00:00:00

abstract：:Hematogenous carcinoma metastasis is supported by aggregated platelets and leukocytes, forming tumor cell emboli. Early tumor cell-platelet interactions can be mediated by P-selectin binding to tumor cell surface ligands and this process is blocked by heparin. We previously showed that L-selectin deficiency also atten...

journal_title：Cancer research

authors： Läubli H,Stevenson JL,Varki A,Varki NM,Borsig L

更新日期：2006-02-01 00:00:00

abstract：:The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tumorigenesis. Using ...

journal_title：Cancer research

authors： Ohm JE,Mali P,Van Neste L,Berman DM,Liang L,Pandiyan K,Briggs KJ,Zhang W,Argani P,Simons B,Yu W,Matsui W,Van Criekinge W,Rassool FV,Zambidis E,Schuebel KE,Cope L,Yen J,Mohammad HP,Cheng L,Baylin SB

更新日期：2010-10-01 00:00:00

abstract：:HER-2/neu (neu-N) transgenic mice, which express the nontransforming rat proto-oncogene, develop spontaneous focal mammary adenocarcinomas beginning at 5-6 months of age. The development and histology of these tumors bears a striking resemblance to what is seen in patients with breast cancer. We have characterized the...

journal_title：Cancer research

authors： Reilly RT,Gottlieb MB,Ercolini AM,Machiels JP,Kane CE,Okoye FI,Muller WJ,Dixon KH,Jaffee EM

更新日期：2000-07-01 00:00:00

abstract：:We have previously shown that N-cadherin expression is associated with tumor invasion, and that some cancer cells respond to specific extracellular matrix molecules by up-regulating N-cadherin. Pancreatic cancer is characterized by excessive deposition of type I collagen. Here, we show that human pancreatic cancer cel...

journal_title：Cancer research

authors： Shintani Y,Hollingsworth MA,Wheelock MJ,Johnson KR

更新日期：2006-12-15 00:00:00

abstract：:Frequent loss of heterozygosity (LOH) on the long arm of chromosome 5 (5q) has been reported in many types of human malignancies, including gastric carcinoma. One of the targets of 5q-LOH in colorectal carcinoma is certainly the adenomatous polyposis coli (APC) gene on 5q21. However, other evidence has suggested the p...

journal_title：Cancer research

authors： Tamura G,Ogasawara S,Nishizuka S,Sakata K,Maesawa C,Suzuki Y,Terashima M,Saito K,Satodate R

更新日期：1996-02-01 00:00:00

abstract：:We analyzed the mRNA expression of the FHIT gene by reverse transcription-PCR (RT-PCR) in 54 cases of acute lymphoblastic leukemia (ALL; 11 cases of T-cell ALL [T-ALL] and 43 cases of non-T-ALL) and 40 cases of acute myeloid leukemia (AML). In 46% of the ALL cases and 55% of the AML cases, FHIT expression was absent o...

journal_title：Cancer research

authors： Iwai T,Yokota S,Nakao M,Nakazawa N,Taniwaki M,Kimura T,Sonoda Y,Kaneko H,Okuda T,Azuma H,Oka T,Takeda T,Watanabe A,Kikuta A,Asami K,Sekine I,Matsushita T,Tsuchiya T,Mimaya J,Koizumi S,Ohta S,Miyake M,Takaue Y

更新日期：1998-11-15 00:00:00

abstract：:The chemopreventive effects of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) on oral carcinogenesis induced by 4-nitroquinoline 1-oxide (4-NQO) was investigated in male F344 rats. Rats were given 20 ppm of 4-NQO in their drinking water for 8 weeks to induce oral neoplasms or preneoplasms. Animals were fed ...

journal_title：Cancer research

authors： Tanaka T,Makita H,Ohnishi M,Mori H,Satoh K,Hara A

更新日期：1995-09-15 00:00:00