Critical role of Smad2 in tumor suppression and transforming growth factor-beta-induced apoptosis of prostate epithelial cells.

abstract：:Ubiquitination and ubiquitin-like posttranslational modifications (PTM) regulate activity and stability of oncoproteins and tumor suppressors. This implicates PTMs as antineoplastic targets. One way to alter PTMs is to inhibit activity of deubiquitinases (DUB) that remove ubiquitin or ubiquitin-like proteins from subs...

journal_title：Cancer research

authors： Mustachio LM,Lu Y,Kawakami M,Roszik J,Freemantle SJ,Liu X,Dmitrovsky E

更新日期：2018-02-01 00:00:00

abstract：:Cancer cells with germline deleterious mutations of BRCA1 or BRCA2 are deficient in homologous recombination repair and therefore sensitive to PARP inhibitor treatment. However, wild-type BRCA1/2-expressing cells with defects in other DNA damage repair pathway components may also exhibit "BRCAness," which in combinati...

journal_title：Cancer research

authors： Cai C

更新日期：2020-07-15 00:00:00

abstract：:This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107. After a brief analysis of the established structural and functional similarities among the three genes, the main purp...

journal_title：Cancer research

authors： Paggi MG,Giordano A

更新日期：2001-06-15 00:00:00

abstract：:A case-control study of 229 ovarian cancer cases (including 172 epithelial tumors) and an equal number of population-based controls was conducted during 1984 to 1986 in Shanghai, China, a low-risk area for ovarian cancer. Similar to studies in high-risk areas, the risk of epithelial tumors was high for nulliparous wom...

journal_title：Cancer research

authors： Shu XO,Brinton LA,Gao YT,Yuan JM

更新日期：1989-07-01 00:00:00

abstract：:PR-104, currently in phase II clinical trials, is a phosphate ester pre-prodrug which is converted in vivo to its cognate alcohol, PR-104A, a prodrug designed to exploit tumor hypoxia. Bioactivation occurs via one-electron reduction to DNA crosslinking metabolites in the absence of oxygen. However, certain tumor cell ...

journal_title：Cancer research

authors： Guise CP,Abbattista MR,Singleton RS,Holford SD,Connolly J,Dachs GU,Fox SB,Pollock R,Harvey J,Guilford P,Doñate F,Wilson WR,Patterson AV

更新日期：2010-02-15 00:00:00

abstract：:The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate inhibitors of CBP/p300 are of clinical value. We developed a specific and potent acetyl-lysine competitive protein-protein interaction i...

journal_title：Cancer research

authors： Picaud S,Fedorov O,Thanasopoulou A,Leonards K,Jones K,Meier J,Olzscha H,Monteiro O,Martin S,Philpott M,Tumber A,Filippakopoulos P,Yapp C,Wells C,Che KH,Bannister A,Robson S,Kumar U,Parr N,Lee K,Lugo D,Jeffrey P

更新日期：2015-12-01 00:00:00

abstract：:Lectin binding [concanavalin A, biotinylated ricinus communis agglutinin, and biotinylated succinylated wheat germ agglutinin (B-SWGA)] was used to detect the glycosylated proteins associated with a residual protein fraction [insoluble in 4% sodium dodecyl sulfate and termed the nuclear residual fraction (NRF)] or wit...

journal_title：Cancer research

authors： Burrus GR,Schmidt WN,Briggs JA,Hnilica LS,Briggs RC

更新日期：1988-02-01 00:00:00

abstract：:Continued monitoring of a family for new malignant tumors has revealed diverse immunological and neoplastic disorders during a 15-year period. In 1966, the proband developed lymphoma. In 1975, his antibody titers to Epstein-Barr virus (EBV) became elevated, and again, he developed a malignant lymphoma. He also had bor...

journal_title：Cancer research

authors： Purtilo DT,Liao SA,Sakamoto K,Snyder LM,DeFlorio D Jr,Bhawan J,Paquin L,Yang JP,Hutt-Fletcher LM,Muralidharan K,Raffa P,Saemundsen AK,Klein G

更新日期：1981-11-01 00:00:00

abstract：:Tumorigenic activities of the (+)- and (-)-enantiomers of the diastereomeric, bay-region benzo(c)phenanthrene 3,4-diol-1,2-epoxides were evaluated in two mouse tumor models. In an initiation-promotion experiment on mouse skin, a single topical application of 10, 25, or 75 nmol of the compounds was followed by 20 weeks...

journal_title：Cancer research

authors： Levin W,Chang RL,Wood AW,Thakker DR,Yagi H,Jerina DM,Conney AH

更新日期：1986-05-01 00:00:00

abstract：:Subcellular localization of von Hippel-Lindau (VHL) tumor suppressor may clarify its role in tumorigenesis. In rat kidney, we observed a granular cytoplasmic immunostaining of VHL, as seen in human tissues. The green fluorescent protein (GFP)-tagged VHL also appeared as cytoplasmic granules in vitro and was colocalize...

journal_title：Cancer research

authors： Shiao YH,Resau JH,Nagashima K,Anderson LM,Ramakrishna G

更新日期：2000-06-01 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) family of cytokines regulates cell proliferation, morphogenesis, and specialized cell functions in metazoans. Herein, we screened a compound library for modifiers of TGF-beta signaling in NMuMG epithelial cells using a cell-based assay to measure Smad2/3 nuclear transloca...

journal_title：Cancer research

authors： Park HJ,Partridge E,Cheung P,Pawling J,Donovan R,Wrana JL,Dennis JW

更新日期：2006-04-01 00:00:00

abstract：:There is still insufficient knowledge of the distribution of drinking habits in human populations, and more descriptive surveys are needed. Both prospective and retrospective epidemiological studies indicate that alcohol consumption is a cancer hazard. Prospective studies on excessive drinkers have shown an increased ...

journal_title：Cancer research

authors： Tuyns AJ

更新日期：1979-07-01 00:00:00

abstract：:Electron paramagnetic resonance imaging (EPRI) enables noninvasive spatial mapping of free radical metabolism and has recently been shown to provide in vivo physiologic information regarding alterations in the redox state of tumors and neoplastic tissues. With the use of nitroxide spin probes, it has been shown that c...

journal_title：Cancer research

authors： Mikuni T,He G,Petryakov S,Fallouh MM,Deng Y,Ishihara R,Kuppusamy P,Tatsuta M,Zweier JL

更新日期：2004-09-15 00:00:00

abstract：:WT1 encodes a zinc finger transcription factor that is expressed in the developing kidney and the inactivation of which leads to Wilms' tumor, a pediatric kidney cancer. We have recently shown that inducible expression of WT1 in osteosarcoma cells triggers programmed cell death, an effect that is associated with trans...

journal_title：Cancer research

authors： Englert C,Maheswaran S,Garvin AJ,Kreidberg J,Haber DA

更新日期：1997-04-15 00:00:00

abstract：:Barrett's esophagus, a columnar metaplasia of the lower esophagus epithelium related to gastroesophageal reflux disease, is the strongest known risk factor for the development of esophageal adenocarcinoma (EAC). Understanding the signal transduction events involved in esophageal epithelium carcinogenesis may provide i...

journal_title：Cancer research

authors： Yen CJ,Izzo JG,Lee DF,Guha S,Wei Y,Wu TT,Chen CT,Kuo HP,Hsu JM,Sun HL,Chou CK,Buttar NS,Wang KK,Huang P,Ajani J,Hung MC

更新日期：2008-04-15 00:00:00

abstract：:An investigation was carried out to determine the potential for activating tumor-inhibitory macrophages with the cytotoxic antitumor agent, bisantrene. Macrophages prepared from peritoneal exudates of mice treated i.p. with bisantrene were extremely active in inhibiting the growth of tumor cells. The minimal effective...

journal_title：Cancer research

authors： Wang BS,Lumanglas AL,Ruszala-Mallon VM,Durr FE

更新日期：1984-06-01 00:00:00

abstract：:Chemotherapy is an important treatment for ovarian cancer. However, conventional chemotherapy has inevitable drawbacks due to side effects from nonspecific biodistribution of the chemotherapeutic drugs. To solve such problem, targeted delivery approaches were developed. The targeted delivery approaches combine drug ca...

journal_title：Cancer research

authors： Zhang XY,Chen J,Zheng YF,Gao XL,Kang Y,Liu JC,Cheng MJ,Sun H,Xu CJ

更新日期：2009-08-15 00:00:00

abstract：:Lymphocytes can be stimulated to proliferate in vitro by mitogens such as concanavalin A. The tumor-promoting phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) can enhance this proliferation, partly because of an increase in interleukin 2 (IL-2) production. However, if lymphocytes are treated with TPA for 24 h...

journal_title：Cancer research

authors： Grove DS,Mastro AM

更新日期：1991-01-01 00:00:00

abstract：:The tumor suppressor gene in lung cancer (TSLC1) encodes a membrane glycoprotein containing extensive homology in the extracellular domain with the immunoglobulin-superfamily cell adhesion molecules. The intracellular cytoplasmic domain (CT) contains a protein 4.1 (FERM) binding motif, and a PDZ-interacting motif. Exp...

journal_title：Cancer research

authors： Mao X,Seidlitz E,Ghosh K,Murakami Y,Ghosh HP

更新日期：2003-11-15 00:00:00

abstract：:A transplanted rat lymphosarcoma (SGT-4), induced by Gross virus and inoculated s.c. into the foot of a normal syngeneic rat, initially grew but ultimately regressed. The tumor cells metastasized to the regional popliteal, lumbar, and inguinal lymph nodes and formed massive metastatic foci there. These lymph node meta...

journal_title：Cancer research

authors： Kodama T,Gotohda E,Takeichi N,Kuzumaki N,Kobayashi H

更新日期：1975-07-01 00:00:00

abstract：:The effects of vascular endothelial growth factor-A (VEGF-A/VEGF) and its receptors on endothelial cells function have been studied extensively, but their effects on tumor cells are less well defined. Studies of human colorectal cancer cells where the VEGF gene has been deleted suggest an intracellular role of VEGF as...

journal_title：Cancer research

authors： Bhattacharya R,Ye XC,Wang R,Ling X,McManus M,Fan F,Boulbes D,Ellis LM

更新日期：2016-05-15 00:00:00

abstract：:Squamous cell carcinoma of the head and neck (SCCHN) metastasizes predictably to cervical lymph nodes, with low rates of distant metastases. Tumor cells can express various receptors that facilitate such metastatic spread to lymph nodes and other nonlymphoid organs. Chemokine receptors (CCR), normally expressed on lym...

journal_title：Cancer research

authors： Wang J,Xi L,Hunt JL,Gooding W,Whiteside TL,Chen Z,Godfrey TE,Ferris RL

更新日期：2004-03-01 00:00:00

abstract：:Expression of the c-Myc oncoprotein is affected by conserved threonine 58 (T58) and serine 62 (S62) phosphorylation sites that help to regulate c-Myc protein stability, and altered ratios of T58 and S62 phosphorylation have been observed in human cancer. Here, we report the development of 3 unique c-myc knock-in mice ...

journal_title：Cancer research

authors： Wang X,Cunningham M,Zhang X,Tokarz S,Laraway B,Troxell M,Sears RC

更新日期：2011-02-01 00:00:00

abstract：:In order to test the contention that metastasis is a selective process and that therefore metastases might show a more restricted pattern of phenotypic and genotypic characteristics than primary tumors, we compared the expression of carcinoembryonic antigen, Ca 19-9, secretory component, serotonin, and mucin productio...

journal_title：Cancer research

authors： Arends JW,Schutte B,Wiggers T,Verstijnen CP,Blijham GH,Bosman FT

更新日期：1987-08-15 00:00:00

abstract：:The expression of epidermal growth factor receptor and transglutaminase type I, polyamine (putrescine, spermidine, and spermine) levels, ornithine decarboxylase activity, and micronuclei occurrence were assessed in the 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch model to elucidate the role and t...

journal_title：Cancer research

authors： Shin DM,Gimenez IB,Lee JS,Nishioka K,Wargovich MJ,Thacher S,Lotan R,Slaga TJ,Hong WK

更新日期：1990-04-15 00:00:00

abstract：:Retinoids are promising agents for cancer chemoprevention and therapy. Nuclear retinoic acid receptors (RARs; RARalpha, -beta, and -gamma) and retinoid X receptors (RXRs; RXRalpha, -beta, and -gamma) are thought to mediate most of retinoids' effects on cell growth and differentiation. Because the majority of human non...

journal_title：Cancer research

authors： Sun SY,Yue P,Dawson MI,Shroot B,Michel S,Lamph WW,Heyman RA,Teng M,Chandraratna RA,Shudo K,Hong WK,Lotan R

更新日期：1997-11-01 00:00:00

abstract：:Numerous studies show that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in chemoprevention or treatment of cancer. Nevertheless, the mechanisms underlying these antineoplastic effects remain poorly understood. Here, we report that induction of the cancer-specific proapoptotic cytokine melanoma different...

journal_title：Cancer research

authors： Zerbini LF,Czibere A,Wang Y,Correa RG,Otu H,Joseph M,Takayasu Y,Silver M,Gu X,Ruchusatsawat K,Li L,Sarkar D,Zhou JR,Fisher PB,Libermann TA

更新日期：2006-12-15 00:00:00

abstract：:The complement system is important in immunosurveillance against tumors. However, malignant cells are usually resistant to complement-mediated lysis. In this study, we examine the expression of factor H, an inhibitor of complement activation, and factor H-like protein 1 (FHL-1), its alternatively spliced form, in lung...

journal_title：Cancer research

authors： Ajona D,Castaño Z,Garayoa M,Zudaire E,Pajares MJ,Martinez A,Cuttitta F,Montuenga LM,Pio R

更新日期：2004-09-01 00:00:00

abstract：:Apoptosis is a mode of cell death that is carefully regulated based on cellular and environmental signals. The ability to modulate the individual cellular machinery and thereby to promote apoptosis is an important strategy in cancer therapy. It has previously been shown that overexpression of the transcription factor ...

journal_title：Cancer research

authors： Hunt KK,Deng J,Liu TJ,Wilson-Heiner M,Swisher SG,Clayman G,Hung MC

更新日期：1997-11-01 00:00:00

abstract：:Although accumulating evidence indicates that chronic lymphocytic leukemia (CLL) is a disease with appreciable cell dynamics, it remains uncertain whether this also applies to patients with stable disease. In this study, (2)H(2)O was administered to a clinically homogeneous cohort of nine stable, untreated CLL patient...

journal_title：Cancer research

authors： van Gent R,Kater AP,Otto SA,Jaspers A,Borghans JA,Vrisekoop N,Ackermans MA,Ruiter AF,Wittebol S,Eldering E,van Oers MH,Tesselaar K,Kersten MJ,Miedema F

更新日期：2008-12-15 00:00:00