A Novel Mechanism to Induce BRCAness in Cancer Cells.

abstract：:The biological activity of two novel 14-epi-analogues of 1,25(OH)2D3, 19-nor-14-epi-23-yne-1,25(OH)2D3 (TX 522) and 19-nor-14,20-bisepi-23-yne-1,25(OH)2D3 (TX 527), is described. Both analogues were at least 10 times more potent than 1,25(OH)2D3 in inhibiting in vitro cell proliferation and had much lower in vivo calc...

journal_title：Cancer research

authors： Verlinden L,Verstuyf A,Van Camp M,Marcelis S,Sabbe K,Zhao XY,De Clercq P,Vandewalle M,Bouillon R

更新日期：2000-05-15 00:00:00

abstract：:MicroRNAs (miRNAs) are a new class of short noncoding regulatory RNAs (18-25 nucleotides) that are involved in diverse developmental and pathologic processes. Altered miRNA expression has been associated with several types of human cancer. However, most studies did not establish whether miRNA expression changes occurr...

journal_title：Cancer research

authors： Sempere LF,Christensen M,Silahtaroglu A,Bak M,Heath CV,Schwartz G,Wells W,Kauppinen S,Cole CN

更新日期：2007-12-15 00:00:00

abstract：:The EphA2 receptor tyrosine kinase is overexpressed in many different types of human cancers where it functions as a powerful oncoprotein. Dramatic changes in the subcellular localization and function of EphA2 have also been linked with cancer, and in particular, unstable cancer cell-cell contacts prevent EphA2 from s...

journal_title：Cancer research

authors： Coffman KT,Hu M,Carles-Kinch K,Tice D,Donacki N,Munyon K,Kifle G,Woods R,Langermann S,Kiener PA,Kinch MS

更新日期：2003-11-15 00:00:00

abstract：:7-Hydroxystaurosporine (UCN-01) is a protein kinase inhibitor that is under development as an anticancer agent in the United States and Japan. Long-term exposure of human A549 non-small cell lung cancer cells to UCN-01 furnished cells (A549/UCN) with acquired resistance against UCN-01. In this study, the sensitivity o...

journal_title：Cancer research

authors： Sugiyama K,Akiyama T,Shimizu M,Tamaoki T,Courage C,Gescher A,Akinaga S

更新日期：1999-09-01 00:00:00

abstract：:Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated proteins that both function in tumor suppression. p16(INK4a) maintains the retinoblastoma protein in its growth-suppressive state through inhibition of cyclin D-dependent kinase activity, whereas ARF binds with MDM2 and stabilizes p53. T...

journal_title：Cancer research

authors： Yarbrough WG,Bessho M,Zanation A,Bisi JE,Xiong Y

更新日期：2002-02-15 00:00:00

abstract：:Cancer patients and tumor-bearing animals excrete high levels of modified purines and pyrimidines some of which, e.g., N2,N2-dimethylguanosine, can originate only from transfer RNA (tRNA). Until recently, it could not be ascertained whether the high level of excretion of such compounds is due to cell death or specific...

journal_title：Cancer research

authors： Borek E,Baliga BS,Gehrke CW,Kuo CW,Belman S,Troll W,Waalkes TP

更新日期：1977-09-01 00:00:00

abstract：:Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diver...

journal_title：Cancer research

authors： Lin DC,Mayakonda A,Dinh HQ,Huang P,Lin L,Liu X,Ding LW,Wang J,Berman BP,Song EW,Yin D,Koeffler HP

更新日期：2017-05-01 00:00:00

abstract：:The parent line of cultured "Nb2 node" lymphoma cells is dependent on the hormone prolactin (PRL) for growth and is widely used for the in vitro bioassay of lactogenic hormones. As reported previously, PRL-independent sublines have been developed in vitro from the parental line by lactogen deprivation. The present stu...

journal_title：Cancer research

authors： Horsman DE,Masui S,Gout PW

更新日期：1991-01-01 00:00:00

abstract：:A large number of poor prognosis neuroblastoma (NB) tumors constitutively express brain-derived neurotrophic factor (BDNF) and variably express the gene for its tyrosine kinase (Trk) receptor TrkB. Good prognosis NB tumors typically express high levels of TrkA mRNA, which encodes the signal transducing receptor for ne...

journal_title：Cancer research

authors： Matsumoto K,Wada RK,Yamashiro JM,Kaplan DR,Thiele CJ

更新日期：1995-04-15 00:00:00

abstract：:The evolution of immune blockades in tumors limits successful antitumor immunity, but the mechanisms underlying this process are not fully understood. Depletion of regulatory T cells (Treg), a T-cell subset that dampens excessive inflammatory and autoreactive responses, can allow activation of tumor-specific T cells. ...

journal_title：Cancer research

authors： Hindley JP,Jones E,Smart K,Bridgeman H,Lauder SN,Ondondo B,Cutting S,Ladell K,Wynn KK,Withers D,Price DA,Ager A,Godkin AJ,Gallimore AM

更新日期：2012-11-01 00:00:00

abstract：:In an attempt to better understand breast tumors sensitivity or resistance to anticancer drugs, the main drug-metabolizing enzyme systems were evaluated in both breast tumors and their corresponding peritumoral tissues in 12 patients. The following enzymes were assayed by Western blot: cytochromes P-450 (1A1/A2, 2B1/B...

journal_title：Cancer research

authors： Albin N,Massaad L,Toussaint C,Mathieu MC,Morizet J,Parise O,Gouyette A,Chabot GG

更新日期：1993-08-01 00:00:00

abstract：:A gastric choriocarcinoma cell line synthesizing human chorionic gonadotropin (HCG) was established in 1971 by Oboshi et al. and was found to possess human placental alkaline phosphatase. The present paper also deals with the relationship between the cell growth and HCG secretion and with cellular localization of HCG ...

journal_title：Cancer research

authors： Kameya T,Kuramoto H,Suzuki K,Kenjo T,Oshikiri T,Hayashi H,Itakura M

更新日期：1975-08-01 00:00:00

abstract：:Human intraepithelial lymphocytes (IEL), predominantly CD8+ T-lymphocytes located between intestinal epithelial cells (EC), may represent the first-line immune defense against colon cancer. The mechanism by which IEL bind to the colon cancer line, DLD-1, was evaluated. A larger fraction of IEL than peripheral blood mo...

journal_title：Cancer research

authors： Roberts AI,O'Connell SM,Ebert EC

更新日期：1993-04-01 00:00:00

abstract：:Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacologic inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity, and other diseases. Here, we report a previously unknown mechanism of FASN regulation involving ...

journal_title：Cancer research

authors： Lin HP,Cheng ZL,He RY,Song L,Tian MX,Zhou LS,Groh BS,Liu WR,Ji MB,Ding C,Shi YH,Guan KL,Ye D,Xiong Y

更新日期：2016-12-01 00:00:00

abstract：:Overexpression of PRL-3, an oncogenic phosphatase, was identified as a novel cluster in patients with newly diagnosed multiple myeloma. However, the regulation and oncogenic activities of PRL-3 in multiple myeloma warrant further investigation. Here, we report that IL6 activates STAT3, which acts as a direct transcrip...

journal_title：Cancer research

authors： Chong PSY,Zhou J,Lim JSL,Hee YT,Chooi JY,Chung TH,Tan ZT,Zeng Q,Waller DD,Sebag M,Chng WJ

更新日期：2019-09-15 00:00:00

abstract：:The signaling pathways that mediate the development of pancreatic ductal adenocarcinoma (PDAC) downstream of mutant Kras remain incompletely understood. Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer. Phosphorylation of rpS6 was increased in pancreatic acinar cells ...

journal_title：Cancer research

authors： Khalaileh A,Dreazen A,Khatib A,Apel R,Swisa A,Kidess-Bassir N,Maitra A,Meyuhas O,Dor Y,Zamir G

更新日期：2013-03-15 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) that arises in immune-deficient patients is an aggressive B-cell neoplasm that is universally associated with the EBV. Patients with EBV(+) PCNSL face a particularly poor prognosis with median survival times of 2-12 months despite aggressive management with radiation the...

journal_title：Cancer research

authors： Roychowdhury S,Peng R,Baiocchi RA,Bhatt D,Vourganti S,Grecula J,Gupta N,Eisenbeis CF,Nuovo GJ,Yang W,Schmalbrock P,Ferketich A,Moeschberger M,Porcu P,Barth RF,Caligiuri MA

更新日期：2003-03-01 00:00:00

abstract：:Distal enhancers have recently emerged as a common mode of gene regulation for several transcription factors, including estrogen and androgen receptors, the two key regulators of breast and prostate cancer major subtypes. Despite the rapid success in genome-wide annotation of estrogen receptor-alpha (ERalpha) binding ...

journal_title：Cancer research

authors： Chan CS,Song JS

更新日期：2008-11-01 00:00:00

abstract：:Sporadic prostate carcinoma is the most common male cancer in the Western world, yet many of the major genetic events involved in the progression of this often fatal cancer remain to be elucidated. Numerous cytogenetic and allelotype studies have reported frequent loss of heterozygosity on chromosomal arm 10q in spora...

journal_title：Cancer research

authors： Cairns P,Okami K,Halachmi S,Halachmi N,Esteller M,Herman JG,Jen J,Isaacs WB,Bova GS,Sidransky D

更新日期：1997-11-15 00:00:00

abstract：:Infection of the bone marrow-derived mast cell line PB-3c with a retrovirus carrying oncogenic c-Ha-ras or v-Ha-ras reduced the interleukin 3 (IL-3) growth requirement and induced a state of tumorigenicity. In contrast, normal c-Ha-ras had no effect on the IL-3 requirement of this cell line nor did the cells become tu...

journal_title：Cancer research

authors： Imber R,Fabbro D

更新日期：1991-01-15 00:00:00

abstract：:Using whole viable human colon carcinoma HT29 cells as immunogen, we produced a monoclonal antibody (mAb) termed 69-6-5. The antibody was functionally selected on its anti-cell-spreading activity. By immunoprecipitation of surface radiolabeled cell lysates from HT29-D4 cells (an HT29 cell clone), mAb 69-6-5 recognized...

journal_title：Cancer research

authors： Lehmann M,Rabenandrasana C,Tamura R,Lissitzky JC,Quaranta V,Pichon J,Marvaldi J

更新日期：1994-04-15 00:00:00

abstract：:Given the prevalence of Ras mutations in human cancer, it is critical to understand the effector pathways downstream of oncogenic Ras leading to transformation. To directly assess the requirement for Rac1 in K-ras-induced tumorigenesis, we employed a model of lung cancer in which an oncogenic allele of K-ras could be ...

journal_title：Cancer research

authors： Kissil JL,Walmsley MJ,Hanlon L,Haigis KM,Bender Kim CF,Sweet-Cordero A,Eckman MS,Tuveson DA,Capobianco AJ,Tybulewicz VL,Jacks T

更新日期：2007-09-01 00:00:00

abstract：:Recent studies have revealed that procaspase-8 has an important function in cell adhesion and motility. Src phosphorylation controls this function by preventing the conversion of procaspase-8, which is an adhesion/migration factor, to mature caspase-8, which is an apoptosis-inducing factor. This provides a mechanism t...

journal_title：Cancer research

authors： Frisch SM

更新日期：2008-06-15 00:00:00

abstract：:Methotrexate [(+) amethopterin, L-MTX] has two carboxyl groups in its structure and is eliminated mainly by excretion into urine and bile. To investigate the biliary excretion mechanism of L-MTX, we performed in vivo and in vitro studies using mutant rats, Eisai hyperbilirubinemic rats (EHBRs), whose canalicular multi...

journal_title：Cancer research

authors： Masuda M,I'izuka Y,Yamazaki M,Nishigaki R,Kato Y,Ni'inuma K,Suzuki H,Sugiyama Y

更新日期：1997-08-15 00:00:00

abstract：:Erythrocytes containing micronuclei serve as an indicator of genotoxic exposure in splenectomized individuals. Micronucleated erythrocytes, derived from cytogenetically damaged RBC precursors, are not selectively removed from peripheral blood in individuals who lack splenic function. The relationship between micronucl...

journal_title：Cancer research

authors： Smith DF,MacGregor JT,Hiatt RA,Hooper NK,Wehr CM,Peters B,Goldman LR,Yuan LA,Smith PA,Becker CE

更新日期：1990-08-15 00:00:00

abstract：:Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (...

journal_title：Cancer research

authors： Hecht SS,el-Bayoumy K,Rivenson A,Amin S

更新日期：1994-01-01 00:00:00

abstract：:Paclitaxel (Taxol) is a chemotherapeutic agent that prevents disassembly of microtubular polymers, causing a growth arrest in the G2-M phase of the cell cycle and leading to apoptotic death. Paclitaxel has remarkable efficacy against fast-growing tumors but possesses major drawbacks, such as poor solubility and lack o...

journal_title：Cancer research

authors： Guillemard V,Saragovi HU

更新日期：2001-01-15 00:00:00

abstract：:We have compared the rate and extent of adhesion of various types of mouse tumor cells to endothelial cells derived from different organ sources. Our panel of tumors has included sarcoma, bladder carcinoma, glioma, teratoma, hepatoma, endothelioma, mammary adenocarcinoma, and lymphoma cells. Endothelial cell monolayer...

journal_title：Cancer research

authors： Auerbach R,Lu WC,Pardon E,Gumkowski F,Kaminska G,Kaminski M

更新日期：1987-03-15 00:00:00

abstract：:Cancer patients showing local failure after radiation treatment have increased probability for developing metastatic disease. The mechanisms behind this observation have not been identified. In the present work, metastatic spread after inadequate radiation therapy was studied by using R-18 human melanoma xenografts as...

journal_title：Cancer research

authors： Rofstad EK,Mathiesen B,Galappathi K

更新日期：2004-01-01 00:00:00

abstract：:Epithelial to mesenchymal transition occurs during embryologic development to allow tissue remodeling and is proposed to be a key step in the metastasis of epithelial-derived tumors. The miR-200 family of microRNAs plays a major role in specifying the epithelial phenotype by preventing expression of the transcription ...

journal_title：Cancer research

authors： Bracken CP,Gregory PA,Kolesnikoff N,Bert AG,Wang J,Shannon MF,Goodall GJ

更新日期：2008-10-01 00:00:00