Main drug-metabolizing enzyme systems in human breast tumors and peritumoral tissues.

abstract：:The high uptake and prolonged renal retention of monoclonal antibody fragments that are conjugated with radiometal chelates precludes their routine clinical use due to high background counts, which may hinder detection of nearby lesions and/or cause renal radiotoxicity. We report on the potential use of Lys as a pharm...

journal_title：Cancer research

authors： DePalatis LR,Frazier KA,Cheng RC,Kotite NJ

更新日期：1995-11-15 00:00:00

abstract：:This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107. After a brief analysis of the established structural and functional similarities among the three genes, the main purp...

journal_title：Cancer research

authors： Paggi MG,Giordano A

更新日期：2001-06-15 00:00:00

abstract：:Myeloid cells are capable of promoting or eradicating tumor cells and the nodal functions that contribute to their different roles are still obscure. Here, we show that mice with myeloid-specific genetic loss of the NF-κB pathway regulatory kinase IKKβ exhibit more rapid growth of cutaneous and lung melanoma tumors. I...

journal_title：Cancer research

authors： Yang J,Hawkins OE,Barham W,Gilchuk P,Boothby M,Ayers GD,Joyce S,Karin M,Yull FE,Richmond A

更新日期：2014-12-15 00:00:00

abstract：:A complementary DNA (cDNA) clone (B4) encoding the catalytic subunit of a cAMP-dependent protein kinase (PKAc) was isolated from a lambda gt10 rat brain cDNA library, using a synthetic oligonucleotide probe whose sequence was based on the known amino acid sequence of a bovine cardiac PKAc. Sequence analysis of this cl...

journal_title：Cancer research

authors： Roth JS,Hsieh LL,Peraino C,Weinstein IB

更新日期：1990-03-15 00:00:00

abstract：:The nucleoside analogue 1-beta-D-arabinofuranosylcytosine (ara-C) is incorporated into herpes simplex virus type 1 (HSV-1) DNA, and this correlates with inhibition of virus replication. The technique of Weigle-type reactivation (WR) was used to compare the ability of induced cellular DNA repair pathways to recognize o...

journal_title：Cancer research

authors： Bubley GJ,Crumpacker CS,Schnipper LE

更新日期：1984-05-01 00:00:00

abstract：:Treatment of L1210 cells with glucose, 1-methyl-3-isobutylxanthine, theophylline, and prostaglandins E1 and E2 was used to increase to varying degrees the endogenous level of cyclic adenosine 3':5'-monophosphate (cAMP). In an inverse manner these agents decreased the rate of methotrexate (MTX) transport into the cells...

journal_title：Cancer research

authors： Henderson GB,Zevely EM,Huennekens FM

更新日期：1978-03-01 00:00:00

abstract：:Southern blot-hybridization analysis of DNAs from human tumors demonstrated amplification of the epidermal growth factor (EGF) receptor gene in 10 of 12 squamous cell carcinoma cell lines tested and in none of 18 tumor cell lines of nonsquamous cell carcinomas. The degree of amplification in the squamous cells varied ...

journal_title：Cancer research

authors： Yamamoto T,Kamata N,Kawano H,Shimizu S,Kuroki T,Toyoshima K,Rikimaru K,Nomura N,Ishizaki R,Pastan I

更新日期：1986-01-01 00:00:00

abstract：:Since the sodium salt of ascorbic acid (AA) promoted two-stage urinary bladder carcinogenesis in rats, whereas AA itself did not, the roles of the urinary sodium ion concentration and pH on urinary bladder carcinogenesis were investigated. Male F344 rats were given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine in their ...

journal_title：Cancer research

authors： Fukushima S,Shibata MA,Shirai T,Tamano S,Ito N

更新日期：1986-04-01 00:00:00

abstract：:The Notch ligand delta-like 4 (Dll4) has been identified as a promising target in tumor angiogenesis in preclinical studies, and Dll4 inhibitors have recently entered clinical trials for solid tumors, including ovarian cancers. In this study, we report the development of REGN421 (enoticumab), a fully human IgG1 monocl...

journal_title：Cancer research

authors： Kuhnert F,Chen G,Coetzee S,Thambi N,Hickey C,Shan J,Kovalenko P,Noguera-Troise I,Smith E,Fairhurst J,Andreev J,Kirshner JR,Papadopoulos N,Thurston G

更新日期：2015-10-01 00:00:00

abstract：:The gastrin gene is expressed widely in pancreatic adenocarcinomas and the study aimed to assess its role in both the resistance of cancer cells to apoptosis and the sensitivity of cells to chemotherapeutic agents. Two human pancreatic cell lines, PAN1 and BXPC3, expressed gastrin at both the RNA and protein levels an...

journal_title：Cancer research

authors： Harris JC,Gilliam AD,McKenzie AJ,Evans SA,Grabowska AM,Clarke PA,McWilliams DF,Watson SA

更新日期：2004-08-15 00:00:00

abstract：:In order to construct a multivariate model for predicting early recurrence and cancer death for patients with stage I non-small cell lung cancer, 271 consecutive patients (mean age, 63 +/- 8 years) who were diagnosed, treated, and followed at one institution were studied. All patients were clinical stage I with head a...

journal_title：Cancer research

authors： Harpole DH Jr,Herndon JE 2nd,Wolfe WG,Iglehart JD,Marks JR

更新日期：1995-01-01 00:00:00

abstract：:An in vitro cell line (SGT) derived from a mouse submaxillary gland adenocarcinoma (TGS) containing A and B viral particles maintained its oncogenicity only for newborn isogeneic hosts (C3H/He mice) immunosuppressed with antithymocyte serum. Inoculation into adult isogeneic animals did not cause tumor but provided par...

journal_title：Cancer research

authors： Castelli L,Neri G,Frigola A,Di Fava FM,Giuliano MC

更新日期：1975-09-01 00:00:00

abstract：:Autophagy is frequently activated in radioresistant cancer cells where it provides a cell survival strategy. The mTOR inhibitor rapamycin activates autophagy but paradoxically it also enhances radiosensitivity. In this study, we investigated the mechanisms of these opposing actions in radiation-resistant glioma or par...

journal_title：Cancer research

authors： Nam HY,Han MW,Chang HW,Lee YS,Lee M,Lee HJ,Lee BW,Lee HJ,Lee KE,Jung MK,Jeon H,Choi SH,Park NH,Kim SY,Kim SW

更新日期：2013-07-15 00:00:00

abstract：:O(6)-Alkylguanine-DNA alkyltransferase (AGT) plays a critical role in protection from the carcinogenic effects of simple alkylating agents by repairing O(6)-alkylguanine adducts via a direct transfer reaction. Nitric oxide (NO) or species derived from it are known to be able to initiate neoplastic growth and cannot on...

journal_title：Cancer research

authors： Liu L,Xu-Welliver M,Kanugula S,Pegg AE

更新日期：2002-06-01 00:00:00

abstract：:Histone demethylase LSD1 (also known as KDM1 and AOF2) is active in various cancer cells, but its biological significance in human carcinogenesis is unexplored. In this study, we explored hypothesized interactions between LSD1 and MYPT1, a known regulator of RB1 phosphorylation. We found that MYPT1 was methylated in v...

journal_title：Cancer research

authors： Cho HS,Suzuki T,Dohmae N,Hayami S,Unoki M,Yoshimatsu M,Toyokawa G,Takawa M,Chen T,Kurash JK,Field HI,Ponder BA,Nakamura Y,Hamamoto R

更新日期：2011-02-01 00:00:00

abstract：:The effect of dietary intake of different levels of Menhaden fish oil on azoxymethane-induced carcinogenesis was examined in male F344 rats fed the semipurified diets. Starting at 5 weeks of age, groups of animals were fed the 5% corn oil (low corn oil) diet. At 7 weeks of age, all animals except the vehicle-treated c...

journal_title：Cancer research

authors： Reddy BS,Maruyama H

更新日期：1986-07-01 00:00:00

abstract：:Snail is a key regulator of epithelial-mesenchymal transition (EMT), which is a major step in tumor metastasis. Although the induction of Snail transcription precedes EMT, posttranslational regulation, especially phosphorylation of Snail, is critical for determining Snail protein levels or stability, subcellular local...

journal_title：Cancer research

authors： Ryu KJ,Park SM,Park SH,Kim IK,Han H,Kim HJ,Kim SH,Hong KS,Kim H,Kim M,Yoon SJ,Asaithambi K,Lee KH,Park JY,Hah YS,Cho HJ,Yook JI,Yang JW,Ko GH,Lee G,Kang YJ,Hwangbo C,Kim KD,Park YJ,Yoo J

更新日期：2019-08-15 00:00:00

abstract：:12-O-Tetradecanoylphorbol-13-acetate (TPA) is an effective comitogen in phytohemagglutinin-treated bovine lymphocytes. Concurrent addition of 10(-8) M TPA gives a greater than 6-fold increase in DNA synthesis over cultures treated with the lectin alone. The delayed addition of phorbol ester, relative to the start of t...

journal_title：Cancer research

authors： Kensler TW,Mueller GC

更新日期：1978-03-01 00:00:00

abstract：:In Sarcoma 180 and L1210 ascites tumor models, the initial rate of methotrexate accumulation in tumor cells in the peritoneal cavity and in small intestine (intracellularly) after s.c. doses up to 800 mg/kg, showed saturation kinetics. These results and the fact that initial uptake in these tissues within this dosage ...

journal_title：Cancer research

authors： Sirotnak FM,Donsbach RC,Dorick DM,Moccio DM

更新日期：1976-12-01 00:00:00

abstract：:An estrogen-responsive mouse Leydig cell tumor line (Tumor 124958) has been shown to contain only a low-affinity binder for estradiol in the cytosol fraction. This differed from the putative estrogen receptor in terms of its hormone-binding specificity as well as affinity. In addition, the possibility that an estrogen...

journal_title：Cancer research

authors： Maeda Y,Sato B,Noma K,Kishimoto S,Koizumi K,Aono T,Matsumoto K

更新日期：1983-09-01 00:00:00

abstract：:In this issue of Cancer Research, Rozeveld and colleagues present intriguing evidence of the importance of lipid droplets and hormone-sensitive lipase (HSL) in regulating the aggressive nature of pancreatic cancer. Initially demonstrating a dependency of preloaded lipids on an invasive phenotype, the authors then esta...

journal_title：Cancer research

authors： Man J,Pajic M,Joshua AM

更新日期：2020-11-15 00:00:00

abstract：:The level of nonspecific lipid transfer protein in three Morris hepatomas of varying degrees of differentiation has been found to be less than 10% of the level in either host or control livers, whereas phosphatidylcholine transfer activity is slightly reduced for hepatomas compared to host livers (20 to 40%), though n...

journal_title：Cancer research

authors： Crain RC,Clark RW,Harvey BE

更新日期：1983-07-01 00:00:00

abstract：:The thymidylate synthase reaction remains an important target for widely used anticancer agents; however, the clinical utility of these drugs is limited by the occurrence of cellular resistance. Despite the considerable amount of information available regarding mechanisms of drug action, the relative significance of d...

journal_title：Cancer research

authors： Tinkelenberg BA,Hansbury MJ,Ladner RD

更新日期：2002-09-01 00:00:00

abstract：:Selectins bind to carbohydrate ligands in a calcium-dependent manner and play critical roles in host defense and possibly in tumor metastasis. To isolate peptides that mimic E-selectin ligands, we screened a phage peptide library using E-selectin as a target molecule. This attempt unexpectedly failed, probably because...

journal_title：Cancer research

authors： Fukuda MN,Ohyama C,Lowitz K,Matsuo O,Pasqualini R,Ruoslahti E,Fukuda M

更新日期：2000-01-15 00:00:00

abstract：:DNA damage response (DDR) pathways maintain genomic stability. A 657del5 mutation of NBS1, a key DDR component, causing the rare cancer-predisposing Nijmegen breakage syndrome has been reported nearly exclusively in Slavic populations. In this study, we describe the first identification in a Japanese population of an ...

journal_title：Cancer research

authors： Ebi H,Matsuo K,Sugito N,Suzuki M,Osada H,Tajima K,Ueda R,Takahashi T

更新日期：2007-12-01 00:00:00

abstract：:The lymphocytes from some Fanconi's anemia patients appeared to be more radiosensitive than normal as measured by the number of X-ray-(or bleomycin-) induced chromosome aberrations seen following G2 treatment. Fibroblasts from the same patients, however, all showed the same degree of colony survival as normals followi...

journal_title：Cancer research

authors： Duckworth-Rysiecki G,Taylor AM

更新日期：1985-01-01 00:00:00

abstract：:The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate inhibitors of CBP/p300 are of clinical value. We developed a specific and potent acetyl-lysine competitive protein-protein interaction i...

journal_title：Cancer research

authors： Picaud S,Fedorov O,Thanasopoulou A,Leonards K,Jones K,Meier J,Olzscha H,Monteiro O,Martin S,Philpott M,Tumber A,Filippakopoulos P,Yapp C,Wells C,Che KH,Bannister A,Robson S,Kumar U,Parr N,Lee K,Lugo D,Jeffrey P

更新日期：2015-12-01 00:00:00

abstract：:Various hormones and growth factors are involved in the growth regulation of breast (tumor) cells. In this report we show for the first time that an analogue of the neuropeptide somatostatin (Sandostatin) can also influence the proliferation of human breast cancer cells (MCF-7), namely, in an inhibitory fashion. With ...

journal_title：Cancer research

authors： Setyono-Han B,Henkelman MS,Foekens JA,Klijn GM

更新日期：1987-03-15 00:00:00

abstract：:We have compared the rate and extent of adhesion of various types of mouse tumor cells to endothelial cells derived from different organ sources. Our panel of tumors has included sarcoma, bladder carcinoma, glioma, teratoma, hepatoma, endothelioma, mammary adenocarcinoma, and lymphoma cells. Endothelial cell monolayer...

journal_title：Cancer research

authors： Auerbach R,Lu WC,Pardon E,Gumkowski F,Kaminska G,Kaminski M

更新日期：1987-03-15 00:00:00

abstract：:The cells' ability to proliferate in response to growth factor stimulation is significantly altered during cancer progression. To investigate the mechanisms underlying these alterations in prostate cancer, the role and expression of beta1A integrin and type 1 insulin-like growth factor receptor (IGF-IR), known to cont...

journal_title：Cancer research

authors： Goel HL,Breen M,Zhang J,Das I,Aznavoorian-Cheshire S,Greenberg NM,Elgavish A,Languino LR

更新日期：2005-08-01 00:00:00