Abstract：
:Various hormones and growth factors are involved in the growth regulation of breast (tumor) cells. In this report we show for the first time that an analogue of the neuropeptide somatostatin (Sandostatin) can also influence the proliferation of human breast cancer cells (MCF-7), namely, in an inhibitory fashion. With respect to dose-response relationship a bell-shaped curve was observed with the maximal inhibition of tumor cell growth at a sharply defined amount of Sandostatin (10 nM). The same effects were found with the natural hormone somatostatin-14 and another analogue (CGP 15-425). These results, together with the observation that high affinity binding sites for an iodinated derivative of Sandostatin are present in MCF-7 cells, support the conclusion that somatostatin and analogues act directly on breast cancer cells.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Setyono-Han B,Henkelman MS,Foekens JA,Klijn GMsubject
Has Abstractpub_date
1987-03-15 00:00:00pages
1566-70issue
6eissn
0008-5472issn
1538-7445journal_volume
47pub_type
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