Effect of high-fat diet on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine, methylazoxymethanol acetate, or methylnitrosourea.

abstract：:Smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor is driving metastatic progression. To identify smoking-induced alterations in human prostate cancer, we analyzed gene and protein expression patterns in tumors collected from current, past, and never sm...

journal_title：Cancer research

authors： Prueitt RL,Wallace TA,Glynn SA,Yi M,Tang W,Luo J,Dorsey TH,Stagliano KE,Gillespie JW,Hudson RS,Terunuma A,Shoe JL,Haines DC,Yfantis HG,Han M,Martin DN,Jordan SV,Borin JF,Naslund MJ,Alexander RB,Stephens RM,Loffr

更新日期：2016-03-01 00:00:00

abstract：:Identification and reversal of treatment resistance mechanisms of clinically refractory tumor cells is critical for successful cancer therapy. Here we show that ATP-binding cassette member B5 (ABCB5) identifies therapy-refractory tumor cells in colorectal cancer patients following fluorouracil (5-FU)-based chemoradiat...

journal_title：Cancer research

authors： Wilson BJ,Schatton T,Zhan Q,Gasser M,Ma J,Saab KR,Schanche R,Waaga-Gasser AM,Gold JS,Huang Q,Murphy GF,Frank MH,Frank NY

更新日期：2011-08-01 00:00:00

abstract：:IFN regulatory factor 8 (IRF8) is a key transcription factor for myeloid cell differentiation and its expression is frequently lost in hematopoietic cells of human myeloid leukemia patients. IRF8-deficient mice exhibit uncontrolled clonal expansion of undifferentiated myeloid cells that can progress to a fatal blast c...

journal_title：Cancer research

authors： Hu X,Yang D,Zimmerman M,Liu F,Yang J,Kannan S,Burchert A,Szulc Z,Bielawska A,Ozato K,Bhalla K,Liu K

更新日期：2011-04-15 00:00:00

abstract：:EBV-infected B-cell lymphomas are a potentially life-threatening complication in bone marrow and solid organ transplant recipients. Immunosuppressive drugs required to prevent allograft rejection also impair anti-EBV T-cell immunity, thereby increasing the risk of EBV-associated disease. Here we demonstrate that the i...

journal_title：Cancer research

authors： Nepomuceno RR,Balatoni CE,Natkunam Y,Snow AL,Krams SM,Martinez OM

更新日期：2003-08-01 00:00:00

abstract：:The expression of epidermal growth factor (EGF) receptor was examined immunohistochemically in a total of 122 gastric and 61 colonic carcinomas, out of which 16 gastric and 8 colonic carcinomas were also examined by 125I-labeled EGF binding analysis and Western blotting. The values of EGF binding were 12.68 +/- 1.98 (...

journal_title：Cancer research

authors： Yasui W,Sumiyoshi H,Hata J,Kameda T,Ochiai A,Ito H,Tahara E

更新日期：1988-01-01 00:00:00

abstract：:The ubiquitin proteasome system is responsible for the proteolysis of important cell cycle and apoptosis-regulatory proteins. In this paper we report that the dipeptidyl proteasome inhibitor, phthalimide-(CH2)8CH-(cyclopentyl) CO-Arg(NO2)-Leu-H (CEP1612), induces apoptosis and inhibits tumor growth of the human lung c...

journal_title：Cancer research

authors： Sun J,Nam S,Lee CS,Li B,Coppola D,Hamilton AD,Dou QP,Sebti SM

更新日期：2001-02-15 00:00:00

abstract：:Ionizing radiation is a major tool for cancer treatment. The response of eukaryotic cells to ionizing radiation includes apoptosis, a process which requires activation of multiple genes. We sought to determine whether radiation-induced gene expression plays a role in radiation-induced apoptosis. We found Apo2 ligand (...

journal_title：Cancer research

authors： Gong B,Almasan A

更新日期：2000-10-15 00:00:00

abstract：:Although the zinc finger transcription factor Krüppel-like factor 4 (KLF4) has been shown to be a negative regulator of cell proliferation, the mechanisms underlying the posttranslational modification of KLF4, especially at the level of protein degradation, are poorly understood. Here, we show that KLF4 protein levels...

journal_title：Cancer research

authors： Chen ZY,Wang X,Zhou Y,Offner G,Tseng CC

更新日期：2005-11-15 00:00:00

abstract：:GPRC5A is a G-protein-coupled receptor expressed in lung tissue but repressed in most human lung cancers. Studies in Gprc5a(-/-) mice have established its role as a tumor-suppressor function in this setting, but the basis for its role has been obscure. Here, we report that GPRC5A functions as a negative modulator of E...

journal_title：Cancer research

authors： Zhong S,Yin H,Liao Y,Yao F,Li Q,Zhang J,Jiao H,Zhao Y,Xu D,Liu S,Song H,Gao Y,Liu J,Ma L,Pang Z,Yang R,Ding C,Sun B,Lin X,Ye X,Guo W,Han B,Zhou BP,Chin YE,Deng J

更新日期：2015-05-01 00:00:00

abstract：:Nude mice bearing xenografts of HT-29 human colon cancer cell line were treated for 4 weeks with a [D-Trp6] agonist of luteinizing hormone releasing hormone (LH-RH), somatostatin analogue (RC-160), and bombesin/gastrin releasing peptide antagonist (RC-3095). Some inhibitory effect of [D-Trp6] LH-RH microcapsules relea...

journal_title：Cancer research

authors： Radulovic S,Miller G,Schally AV

更新日期：1991-11-01 00:00:00

abstract：:Frequent loss of heterozygosity (LOH) on the long arm of chromosome 5 (5q) has been reported in many types of human malignancies, including gastric carcinoma. One of the targets of 5q-LOH in colorectal carcinoma is certainly the adenomatous polyposis coli (APC) gene on 5q21. However, other evidence has suggested the p...

journal_title：Cancer research

authors： Tamura G,Ogasawara S,Nishizuka S,Sakata K,Maesawa C,Suzuki Y,Terashima M,Saito K,Satodate R

更新日期：1996-02-01 00:00:00

abstract：:Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CA...

journal_title：Cancer research

authors： Fultang L,Gamble LD,Gneo L,Berry AM,Egan SA,De Bie F,Yogev O,Eden GL,Booth S,Brownhill S,Vardon A,McConville CM,Cheng PN,Norris MD,Etchevers HC,Murray J,Ziegler DS,Chesler L,Schmidt R,Burchill SA,Haber M,De Sant

更新日期：2019-02-01 00:00:00

abstract：:17beta-Hydroxysteroid dehydrogenase type 12 (17beta-HSD12) has been shown to be involved in elongation of very long chain fatty acid (VLCFA) as well as in biosynthesis of estradiol (E2). 17beta-HSD12 expression was also reported in breast carcinomas but its functions have remained unknown. In this study, we examined t...

journal_title：Cancer research

authors： Nagasaki S,Suzuki T,Miki Y,Akahira J,Kitada K,Ishida T,Handa H,Ohuchi N,Sasano H

更新日期：2009-02-15 00:00:00

abstract：:Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified and highly expressed in lobular carcinomas of the breast. In this report, we evaluated the biological activity of FGFR1 in a wide range of in vitro assays. Conditional activation of FGFR1 in the nontransformed MCF10A human mammary cell line, MCF10A, r...

journal_title：Cancer research

authors： Xian W,Pappas L,Pandya D,Selfors LM,Derksen PW,de Bruin M,Gray NS,Jonkers J,Rosen JM,Brugge JS

更新日期：2009-03-15 00:00:00

abstract：:A naturally occurring human antibody potentiates dendritic cell function on cross-linking B7-DC (PD-L2), supporting robust T-cell responses in vitro. Moreover, treatment of dendritic cells with B7-DC cross-linking antibody resulted in secretion of interleukin-12, suggesting a TH1 polarization of this response. Here we...

journal_title：Cancer research

authors： Radhakrishnan S,Nguyen LT,Ciric B,Flies D,Van Keulen VP,Tamada K,Chen L,Rodriguez M,Pease LR

更新日期：2004-07-15 00:00:00

abstract：:Salvage of preformed nucleosides requires transport across the plasma membrane by sodium-dependent (concentrative) and sodium-independent (equilibrative) mechanisms. These transport systems are also the route of cellular uptake for nucleoside analogues, including gemcitabine (2',2'-difluorodeoxycytidine), a deoxycytid...

journal_title：Cancer research

authors： Rauchwerger DR,Firby PS,Hedley DW,Moore MJ

更新日期：2000-11-01 00:00:00

abstract：:Defects in antitumor immune responses have been associated with increased release of prostaglandin E(2) (PGE(2)) as a result of overexpression of cyclooxygenase (COX)-2 by tumors. In this report, we examine the effects of PGE(2) on antitumor CD8(+) T-cell responses generated both by cross-presenting dendritic cells an...

journal_title：Cancer research

authors： Ahmadi M,Emery DC,Morgan DJ

更新日期：2008-09-15 00:00:00

abstract：:Cyclins and cyclin-dependent kinases regulate the cell cycle. Cyclin A has a dual role in cell proliferation. It is essential in the S phase for DNA replication, and it is also involved in G2-M-phase transition, signifying actively dividing cells. The expression of cyclin A was determined by immunohistochemistry in pa...

journal_title：Cancer research

authors： Huuhtanen RL,Blomqvist CP,Böhling TO,Wiklund TA,Tukiainen EJ,Virolainen M,Tribukait B,Andersson LC

更新日期：1999-06-15 00:00:00

abstract：:Mutations in the p53 gene were identified in five of eight non-melanoma skin tumors in the sun-exposed areas of xeroderma pigmentosum patients by the polymerase chain reaction and single strand conformation polymorphism analysis followed by sequencing of the DNA. All mutations occurred at the dipyrimidine sites, indic...

journal_title：Cancer research

authors： Sato M,Nishigori C,Zghal M,Yagi T,Takebe H

更新日期：1993-07-01 00:00:00

abstract：:Modern cancer therapy/care involves the integration of basic, clinical, and population-based research professionals using state-of-the-art science to achieve the best possible patient outcomes. A well-integrated team of basic, clinical, and population science professionals and educators working with a fully engaged gr...

journal_title：Cancer research

authors： Welch DR,Antalis TM,Burnstein K,Vona-Davis L,Jensen RA,Nakshatri H,Riegel AT,Spitz DR,Watson DK,Weiner GJ,Cancer Biology Training Consortium.

更新日期：2015-12-15 00:00:00

abstract：:The MRP (multidrug resistance protein) gene, a member of the ubiquitous superfamily of ATP-binding cassette transporters, is associated with the multidrug resistance of mammalian cells to natural product anticancer agents. We have previously shown that abrogation of MRP expression by gene targeting leads to hypersensi...

journal_title：Cancer research

authors： Rappa G,Lorico A,Flavell RA,Sartorelli AC

更新日期：1997-12-01 00:00:00

abstract：:Cultures of human mammary epithelial cells (HMECs) contain a subpopulation of variant cells with the capacity to propagate beyond an in vitro proliferation barrier. These variant HMECs, which contain hypermethylated and silenced p16(INK4a) (p16) promoters, eventually accumulate multiple chromosomal changes, many of wh...

journal_title：Cancer research

authors： Holst CR,Nuovo GJ,Esteller M,Chew K,Baylin SB,Herman JG,Tlsty TD

更新日期：2003-04-01 00:00:00

abstract：:It has been shown in previous studies that a variety of estrogen receptor (ER) beta mRNA transcripts are expressed in human breast cancer cell lines and tumors. To complement the RNA expression studies, we have developed ER-beta-specific antibodies to characterize ER-beta protein expression in breast cancer cell lines...

journal_title：Cancer research

authors： Fuqua SA,Schiff R,Parra I,Friedrichs WE,Su JL,McKee DD,Slentz-Kesler K,Moore LB,Willson TM,Moore JT

更新日期：1999-11-01 00:00:00

abstract：:Previous cytogenetic analysis has revealed frequent losses of chromosome 1p21-22 in human malignant mesothelioma, suggesting that the loss or inactivation of a tumor suppressor gene's) residing at this site may contribute to the tumorigenic conversion of mesothelial cells. To more precisely define the location of the ...

journal_title：Cancer research

authors： Lee WC,Balsara B,Liu Z,Jhanwar SC,Testa JR

更新日期：1996-10-01 00:00:00

abstract：:The role of the immune system in tumor elimination has been shown to be increasingly ambiguous, as many tumors not only escape recognition by the adaptive immune response but also even prime the immune cells to promote tumor growth. This effect is achieved through a number of mechanisms, which include both direct inte...

journal_title：Cancer research

authors： Kareva I,Hahnfeldt P

更新日期：2013-05-01 00:00:00

abstract：:Huggins and Morii (J. Exp. Med., 114: 741, 1961) reported that massive adrenal necrosis occurs in 79 and 100% of female Sprague-Dawley rats receiving 20 and 30 mg, respectively, of the mammary carcinogen 7,12-dimethylbenz(a)anthracene (DMBA). Here, adrenal necrosis and regeneration were studied in 158 rats for up to 2...

journal_title：Cancer research

authors： Carter JH,Carter HW,Meade J

更新日期：1988-07-01 00:00:00

abstract：:This report describes and presents some preliminary results from a prospective clinical investigation to determine the ablative effect of thiotepa (N,N',N''-triethylene phosphoramide) on superficial low-stage bladder cancer and the effectiveness of this agent in the prevention of recurrent or new tumors. In the small ...

journal_title：Cancer research

authors：

更新日期：1977-08-01 00:00:00

abstract：:Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors from patients with hereditary nonpolyposis colon cancer and in a subset of patients with sporadic colorectal cancer (CRC). In sporadic CRC, three tumor phenotypes have been defined: microsatellite stable (MSS), low-frequency MS...

journal_title：Cancer research

authors： Cunningham JM,Christensen ER,Tester DJ,Kim CY,Roche PC,Burgart LJ,Thibodeau SN

更新日期：1998-08-01 00:00:00

abstract：:We have investigated the ability of tamoxifen to regulate members of the transforming growth factor beta (TGF-beta) family in human breast cancers in vivo. Using immunohistochemical techniques, we find that 3 months of tamoxifen treatment causes a consistent induction of extracellular TGF-beta 1 in breast cancer biops...

journal_title：Cancer research

authors： Butta A,MacLennan K,Flanders KC,Sacks NP,Smith I,McKinna A,Dowsett M,Wakefield LM,Sporn MB,Baum M

更新日期：1992-08-01 00:00:00

abstract：:In a search for the molecular basis of ABH status of tumors as correlated with malignancy, we studied various malignancy-related phenotypes of high H/Le(y)-expressing tumor cell lines in comparison with phenotypes of the same lines transfected with histo-blood group A or B genes. A and B gene transfectants, prepared i...

journal_title：Cancer research

authors： Ichikawa D,Handa K,Withers DA,Hakomori S

更新日期：1997-08-01 00:00:00