Essential Components of Cancer Education.

abstract：:Bleomycin inhibits cellular RNA synthesis and the inhibition is nonspecific. The ratio of polyadenylate- [poly(A)] containing RNA to non-poly(A)-containing RNA in the drug-treated human lymphocytic cells, line Wil2, was the same as that in untreated cells. Poly(A) RNA isolated from untreated cells was used as a templa...

journal_title：Cancer research

authors： Kuo MT,Auger LT,Saunders GF,Haidle CW

更新日期：1977-05-01 00:00:00

abstract：:A probabilistic analysis has been developed to assist the binary classification and risk assessment of members of familial colon cancer kindreds. The analysis is based on the microautoradiographic observation of [3H]thymidine-labeled epithelial cells in colonic mucosa of the kindred members. From biopsies of colonic m...

journal_title：Cancer research

authors： Lipkin M,Blattner WA,Gardner EJ,Burt RW,Lynch H,Deschner E,Winawer S,Fraumeni JF Jr

更新日期：1984-09-01 00:00:00

abstract：:Culturing DOV 13 ovarian carcinoma cells on three-dimensional collagen lattice but not on thin-layer collagen induces processing of promatrix metalloproteinase (MMP)-2 to a M(r) 62,000 form, suggesting that multivalent integrin aggregation may participate in proteinase regulation. To address the role of collagen-bindi...

journal_title：Cancer research

authors： Ellerbroek SM,Fishman DA,Kearns AS,Bafetti LM,Stack MS

更新日期：1999-04-01 00:00:00

abstract：:There is a great need for the development of novel chemotherapeutic agents that overcome the emergence of multidrug resistance (MDR) in cancer. We catalogued the National Cancer Institute's DTP drug repository in search of compounds showing increased toxicity in MDR cells. By comparing the sensitivity of parental cell...

journal_title：Cancer research

authors： Türk D,Hall MD,Chu BF,Ludwig JA,Fales HM,Gottesman MM,Szakács G

更新日期：2009-11-01 00:00:00

abstract：:Most patients' prostate cancers respond to androgen deprivation but relapse after periods of several months to years. Only two prostate cancer xenografts, LNCaP and PC-346, have been reported to be responsive to androgen deprivation and to relapse subsequently. Both of these tumors shrink slightly, if at all, and rela...

journal_title：Cancer research

authors： Nagabhushan M,Miller CM,Pretlow TP,Giaconia JM,Edgehouse NL,Schwartz S,Kung HJ,de Vere White RW,Gumerlock PH,Resnick MI,Amini SB,Pretlow TG

更新日期：1996-07-01 00:00:00

abstract：:The estrogen receptor (ER) is a nuclear protein with a hormone- and a DNA-binding domain. We examined the DNA binding of ER in MCF-7 cells and 79 primary breast cancers by gel mobility shift assay using as a probe the estrogen response element (ERE). The mobility shift assay showed saturable, specific binding of ER to...

journal_title：Cancer research

authors： Foster BD,Cavener DR,Parl FF

更新日期：1991-07-01 00:00:00

abstract：:Subcutaneous inoculation of Epstein-Barr virus (EBV) transformed peripheral blood B-lymphocytes (PBL) from an untreated chronic lymphocytic leukemia (CLL) patient produced progressively growing lethal tumors in 4 of 11 whole body irradiated (440 rads) nude mice. In one tumor bearing mouse there was splenomegaly and ge...

journal_title：Cancer research

authors： Lee CL,Uniyal S,Fernandez LA,Lee SH,Ghose T

更新日期：1986-05-01 00:00:00

abstract：:The INK4a/ARF locus encodes two distinct tumor suppressors, p16INK4a and p14ARF. Although the contribution of p16INK4a to human tumorigenesis through point mutation, deletion, and hypermethylation has been widely documented, little is known about specific p14ARF lesions and their consequences. Recent data indicate tha...

journal_title：Cancer research

authors： Esteller M,Cordon-Cardo C,Corn PG,Meltzer SJ,Pohar KS,Watkins DN,Capella G,Peinado MA,Matias-Guiu X,Prat J,Baylin SB,Herman JG

更新日期：2001-04-01 00:00:00

abstract：:Mitomycin C requires bioreduction in order to exert its cytotoxic action. Activation of mitomycin C to an electrophile was equally supported by NADPH and NADH in EMT6 tumor cell sonicates under hypoxia. No alkylation was observed under aerobic conditions. Purified NADH:cytochrome b5 reductase catalyzed the reduction o...

journal_title：Cancer research

authors： Hodnick WF,Sartorelli AC

更新日期：1993-10-15 00:00:00

abstract：:Morphine is used to treat pain in several medical conditions including cancer. Here we show that morphine, in a concentration typical of that observed in patients' blood, stimulates human microvascular endothelial cell proliferation and angiogenesis in vitro and in vivo. It does so by activating mitogen-activated prot...

journal_title：Cancer research

authors： Gupta K,Kshirsagar S,Chang L,Schwartz R,Law PY,Yee D,Hebbel RP

更新日期：2002-08-01 00:00:00

abstract：:Adaptive therapy seeks to exploit intra-tumoral competition to avoid, or at least delay, the emergence of therapy resistance in cancer. Motivated by promising results in prostate cancer, there is growing interest in extending this approach to other neoplasms. As such, it is urgent to understand the characteristics of ...

journal_title：Cancer research

authors： Strobl MAR,West J,Viossat Y,Damaghi M,Robertson-Tessi M,Brown JS,Gatenby RA,Maini PK,Anderson ARA

更新日期：2020-11-10 00:00:00

abstract：:Previous work showed that mice that had been thymectomized at 3 days of age tended, in later life, to develop a hyperplastic autoimmune gastritis and were also hypersusceptible to sarcogenesis by low dosages of 3-methylcholanthrene. In the present work, it was found that the hyperplastic autoimmune gastritis could be ...

journal_title：Cancer research

authors： Prehn LM

更新日期：1986-07-01 00:00:00

abstract：:MdmX and Mdm2 regulate p53 tumor suppressor functions by controlling p53 transcriptional activity and/or stability in cells exposed to DNA damage. Accumulating evidence indicates that ATM-mediated phosphorylation and degradation of Mdm2 and MdmX may be the initial driving force that induces p53 activity during the ear...

journal_title：Cancer research

authors： Zhang X,Lin L,Guo H,Yang J,Jones SN,Jochemsen A,Lu X

更新日期：2009-10-15 00:00:00

abstract：:The endoplasmic reticulum (ER) has been posited as a potential anticancer target. The synthetic antitumor alkyl-lysophospholipid analogue edelfosine accumulates in the ER of solid tumor cells. This ER accumulation of the drug leads to the inhibition of phosphatidylcholine and protein synthesis, G(2)-M arrest, depletio...

journal_title：Cancer research

authors： Nieto-Miguel T,Fonteriz RI,Vay L,Gajate C,López-Hernández S,Mollinedo F

更新日期：2007-11-01 00:00:00

abstract：:Noninvasive imaging techniques to image and characterize delivery and transport of macromolecules through the extracellular matrix (ECM) and supporting stroma of a tumor are necessary to develop treatments that alter the porosity and integrity of the ECM for improved delivery of therapeutic agents and to understand fa...

journal_title：Cancer research

authors： Pathak AP,Artemov D,Ward BD,Jackson DG,Neeman M,Bhujwalla ZM

更新日期：2005-02-15 00:00:00

abstract：:Blood vessels deliver oxygen and nutrients to tissues, and vascular networks are spatially organized to meet the metabolic needs for maintaining homeostasis. In contrast, the vasculature of tumors is immature and leaky, resulting in insufficient delivery of nutrients and oxygen. Vasculogenic processes occur normally i...

journal_title：Cancer research

authors： Sasajima J,Mizukami Y,Sugiyama Y,Nakamura K,Kawamoto T,Koizumi K,Fujii R,Motomura W,Sato K,Suzuki Y,Tanno S,Fujiya M,Sasaki K,Shimizu N,Karasaki H,Kono T,Kawabe J,Ii M,Yoshiara H,Kamiyama N,Ashida T,Bardeesy N,

更新日期：2010-08-01 00:00:00

abstract：:Untargeted effects of ionizing radiation (de novo effects in the unirradiated descendants or neighbors of irradiated cells) challenge widely held views about the mechanisms of radiation-induced DNA damage with implications for the health consequences of radiation exposures particularly in the context of the induction ...

journal_title：Cancer research

authors： Lorimore SA,McIlrath JM,Coates PJ,Wright EG

更新日期：2005-07-01 00:00:00

abstract：:Insulin receptor (IR) exists as two isoforms resulting from the alternative splicing of IR pre-mRNA. IR-B promotes the metabolic effects of insulin, whereas IR-A rather signals proliferative effects. IR-B is predominantly expressed in the adult liver. Here, we show that the alternative splicing of IR pre-mRNA is dysre...

journal_title：Cancer research

authors： Chettouh H,Fartoux L,Aoudjehane L,Wendum D,Clapéron A,Chrétien Y,Rey C,Scatton O,Soubrane O,Conti F,Praz F,Housset C,Rosmorduc O,Desbois-Mouthon C

更新日期：2013-07-01 00:00:00

abstract：:The anticancer oxazaphosphorine prodrugs cyclophosphamide and ifosfamide are activated in human liver by a 4-hydroxylation reaction catalyzed by multiple cytochrome P450 (CYP) enzymes. In the present study, we used a cultured human hepatocyte model to identify possible inducers of the CYP-catalyzed activation of these...

journal_title：Cancer research

authors： Chang TK,Yu L,Maurel P,Waxman DJ

更新日期：1997-05-15 00:00:00

abstract：:In cancer cell lines and rodent models, calcium and vitamin D favorably modulate cell proliferation, differentiation, and apoptosis in colonic epithelia. These effects may be modulated by local expression of the calcium receptor (CaR), the vitamin D receptor (VDR), and the P450 cytochromes, CYP27B1 and CYP24A1; howeve...

journal_title：Cancer research

authors： Ahearn TU,McCullough ML,Flanders WD,Long Q,Sidelnikov E,Fedirko V,Daniel CR,Rutherford RE,Shaukat A,Bostick RM

更新日期：2011-01-15 00:00:00

abstract：:The environmental contaminant 6-nitrochrysene (6-NC) has been shown to induce adenomas and adenocarcinomas in the colons of rats. The present study aimed at providing a better understanding of mechanisms that are responsible for this effect. Three female CD rats were injected i.p. with [3,4,9,10-3H]6-NC [9 mumol/rat (...

journal_title：Cancer research

authors： Chae YH,Delclos KB,Blaydes B,el-Bayoumy K

更新日期：1996-05-01 00:00:00

abstract：:MLH1 is an integral part of the mismatch repair complex, and the loss of this protein is associated with the acquisition of a mutator phenotype, microsatellite instability, and a predisposition to cancer. Deficiencies in the mismatch repair complex, including the loss of MLH1, result in elevated resistance to specific...

journal_title：Cancer research

authors： Hardman RA,Afshari CA,Barrett JC

更新日期：2001-02-15 00:00:00

abstract：:Pregnancy, parity, and circulating steroid hormone levels are associated with risk of breast cancer, but little is known about hormone concentrations during pregnancy and subsequent breast cancer risk. We evaluated early pregnancy (<140 days gestation) serum estradiol, estrone, progesterone, and testosterone and breas...

journal_title：Cancer research

authors： Fortner RT,Schock H,Kaaks R,Lehtinen M,Pukkala E,Lakso HÅ,Tanner M,Kallio R,Joensuu H,Grankvist K,Zeleniuch-Jacquotte A,Toniolo P,Lundin E,Surcel HM

更新日期：2014-12-01 00:00:00

abstract：:Oxidative stress exerted by superoxide-generating (redox-cycling) agents such as paraquat triggers the soxRS regulon of Escherichia coli. In this system, SoxR protein is the redox-sensitive activator of the soxS gene, the product of which then activates the approximately 10 promoters of this regulon. We found that 4-n...

journal_title：Cancer research

authors： Nunoshiba T,Demple B

更新日期：1993-07-15 00:00:00

abstract：:Structural and functional abnormalities in tumor blood vessels impact the delivery of oxygen and nutrients to solid tumors, resulting in chronic and cycling hypoxia. Although chronically hypoxic regions exhibit treatment resistance, more recently it has been shown that cycling hypoxic regions acquire prosurvival pathw...

journal_title：Cancer research

authors： Matsumoto S,Batra S,Saito K,Yasui H,Choudhuri R,Gadisetti C,Subramanian S,Devasahayam N,Munasinghe JP,Mitchell JB,Krishna MC

更新日期：2011-10-15 00:00:00

abstract：:In a recent study, we showed that the plant alkaloid camptothecin (CPT) and its derivatives 9-nitro-CPT (9NC) and 9-amino-CPT (9AC) inhibit growth of both human melanocytes (MEL cells) and their malignant counterparts, malignant melanoma (BRO) cells in vitro. This growth inhibition was accompanied by an increase in th...

journal_title：Cancer research

authors： Pantazis P,Early JA,Mendoza JT,DeJesus AR,Giovanella BC

更新日期：1994-02-01 00:00:00

abstract：:alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)beta(3) and produced erosion pits on bone substrates, whereas this effect was not observed by cells f...

journal_title：Cancer research

authors： Tucci M,De Palma R,Lombardi L,Rodolico G,Berrino L,Dammacco F,Silvestris F

更新日期：2009-08-15 00:00:00

abstract：:The presence of a valine (V) versus a phenylanaline (F) at position 158 of Fc gamma RIIIa/CD16a improves the affinity for IgG and is associated with higher therapeutic response to rituximab. Increased CD16 expression on natural killer (NK) cells from donors with the VV or VF versus FF genotype has recently been report...

journal_title：Cancer research

authors： Congy-Jolivet N,Bolzec A,Ternant D,Ohresser M,Watier H,Thibault G

更新日期：2008-02-15 00:00:00

abstract：:Chicken chondrocytes isolated from 11-day-old chicken vertebrate cartilage were transformed by Rous sarcoma virus ts LA24 of the Prague strain as well as by the wild-type Prague strain of Rous sarcoma virus. The morphology of chondrocytes transformed by Rous sarcoma virus ts LA 24 was dependent on the temperature, and...

journal_title：Cancer research

authors： Okayama M,Yoshimura M,Muto M,Chi J,Roth S,Kaji A

更新日期：1977-03-01 00:00:00

abstract：:In the present study, we report the characterization of the p53 tumor suppressor pathway in the 60 cell lines of the National Cancer Institute (NCI) anticancer drug screen, as well as correlations between the integrity of this pathway and the growth-inhibitory potency of 123 anticancer agents in this screen. Assessmen...

journal_title：Cancer research

authors： O'Connor PM,Jackman J,Bae I,Myers TG,Fan S,Mutoh M,Scudiero DA,Monks A,Sausville EA,Weinstein JN,Friend S,Fornace AJ Jr,Kohn KW

更新日期：1997-10-01 00:00:00