The role of intravesical thiotepa in the management of superficial bladder cancer. National Bladder Cancer Collaborative Group A.

Abstract:

:This report describes and presents some preliminary results from a prospective clinical investigation to determine the ablative effect of thiotepa (N,N',N''-triethylene phosphoramide) on superficial low-stage bladder cancer and the effectiveness of this agent in the prevention of recurrent or new tumors. In the small group of cases studied thus far, therapeutic thiotepa has destroyed superficial cancers in 33 to 36% of the cases, about the same results as those reported by others. It is too early in the study to assess the benefit from the prophylactic use of thiotepa.

journal_name

Cancer Res

journal_title

Cancer research

authors

subject

Has Abstract

pub_date

1977-08-01 00:00:00

pages

2916-7

issue

8 Pt 2

eissn

0008-5472

issn

1538-7445

journal_volume

37

pub_type

临床试验,杂志文章
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    authors: Wolff EA,Schreiber GJ,Cosand WL,Raff HV

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    abstract::Global blood flow (TBF), tumor vascular resistance, laser Doppler flow in superficial tumor areas, and mean arterial blood pressure were evaluated in rats bearing s.c. DS sarcomas. Measurements were performed before and after i.v. administration of rhTNF-alpha 2 or recombinant human lymphotoxin (rhLT) (1 mg/kg). Upon ...

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    authors: Kluge M,Elger B,Engel T,Schaefer C,Seega J,Vaupel P

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  • Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells.

    abstract::Nitromidazole and nitrofuran derivatives comprise a large family of compounds, some of which have been shown to be hypoxic cell specific radiosensitizers in vivo and in vitro. The effects of metronidazole (2-methyl-5-nitroimidazole-1-ethanol) and nitrofurazone (5-nitro-2-furaldehyde semicarbazone) were studied on cell...

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    authors: Mohindra JK,Rauth AM

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    abstract::5'-Deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine, which are metabolized to the methionine precursor, 5-methylthioribose-1-phosphate, by 5'-deoxy-5'-methylthioadenosine phosphorylase and purine nucleoside phosphorylase, respectively, can serve as sources of methionine for cultured HL-60 promyelocytic l...

    journal_title:Cancer research

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    doi:

    authors: Savarese TM,Ghoda LY,Dexter DL,Parks RE Jr

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  • Gonadal protection and fecundity rates in cyclophosphamide-treated rats.

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    authors: Montz FJ,Wolff AJ,Gambone JC

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  • A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5' regulatory region of BCL6 with a novel H4 histone gene.

    abstract::3q27 translocations affecting the BCL6 gene can involve not only immunoglobulin genes (IG) but also other as yet uncharacterized chromosomal loci as partners. Here, we describe cloning of the junctional area of a recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma of B-cell type and isolation of clones...

    journal_title:Cancer research

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    authors: Akasaka T,Miura I,Takahashi N,Akasaka H,Yonetani N,Ohno H,Fukuhara S,Okuma M

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  • New histochemical method for measuring intratumoral macrophages and macrophage recruitment into experimental metastases.

    abstract::A new double-label histochemical method is described which permits accurate quantitation of macrophage recruitment into neoplastic lesions in situ. Intratumoral macrophages are identified by their capacity to ingest colloidal iron particles from the interstitial fluid. Since colloidal iron is retained in a stable form...

    journal_title:Cancer research

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    authors: Bugelski PJ,Kirsh RL,Poste G

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  • Hypoxanthine concentrations in normal subjects and patients with solid tumors and leukemia.

    abstract::Mean plasma hypoxanthine (Hyp) concentrations determined by high-pressure liquid chromatography were 0.56 microM (range, 0.2 to 1.9 microM) in 16 normal subjects, 0.68 microM (range, 0.1 to 1.1 microM) in 10 untreated acute leukemic subjects, and 0.89 microM (range, 0.3 to 2.6 microM) in 14 solid tumor patients. Despi...

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    authors: Wung WE,Howell SB

    更新日期:1984-07-01 00:00:00

  • Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer.

    abstract::Myeloid-derived suppressor cells (MDSC) expand in tumor-bearing hosts and play a central role in cancer immune evasion by inhibiting adaptive and innate immunity. They therefore represent a major obstacle for successful cancer immunotherapy. Different strategies have thus been explored to deplete and/or inactivate MDS...

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    doi:10.1158/0008-5472.CAN-13-1545

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    pub_type: 杂志文章

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    authors: McLaughlin ME,Jacks T

    更新日期:2003-02-15 00:00:00

  • DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor.

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    journal_title:Cancer research

    pub_type: 杂志文章

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    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Horoszewicz JS,Leong SS,Kawinski E,Karr JP,Rosenthal H,Chu TM,Mirand EA,Murphy GP

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  • Mutation induction by 5-fluorodeoxyuridine in synchronous Chinese hamster cells.

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    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Aebersold PM

    更新日期:1979-03-01 00:00:00

  • Ligand responsiveness in human prostate cancer: structural analysis of mutant androgen receptors from LNCaP and CWR22 tumors.

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  • mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells.

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    pub_type: 杂志文章

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  • Intestinal intraepithelial lymphocytes bind to colon cancer cells by HML-1 and CD11a.

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    authors: Roberts AI,O'Connell SM,Ebert EC

    更新日期:1993-04-01 00:00:00

  • Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells.

    abstract::Iodide uptake in the thyroid and breast is mediated by the sodium/iodide symporter (NIS). NIS activation is used for radioiodide imaging and therapeutic ablation of thyroid carcinoma. NIS is expressed in >70% of breast cancers but at a level insufficient for radioiodine treatment. All-trans retinoic acid (tRA) induces...

    journal_title:Cancer research

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  • Ca2(+)-dependent binding of tamoxifen to calmodulin isolated from bovine brain.

    abstract::The interaction of the antiestrogen tamoxifen (Tx) with calmodulin (CaM) was investigated by cross-linking between the protein and [3H] tamoxifen aziridine. We observed that CaM binds Tx in a Ca2(+)-dependent manner and that two components are involved in the binding, with apparent dissociation constants (Kd) of about...

    journal_title:Cancer research

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  • Antitumor activity of a kinesin inhibitor.

    abstract::Several members of the kinesin family of microtubule motor proteins play essential roles in mitotic spindle function and are potential targets for the discovery of novel antimitotic cancer therapies. KSP, also known as HsEg5, is a kinesin that plays an essential role in formation of a bipolar mitotic spindle and is re...

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  • Role of amino acid depletion in combined treatment of neoplastic cells with methotrexate and L-asparaginase.

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  • Nonselective destruction of murine neoplastic cells by syngeneic tumoricidal macrophages.

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  • Androgen-dependent regulation of Her-2/neu in prostate cancer cells.

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    doi:

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    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Yeoman LC,Taylor CW,Jordan JJ,Busch H

    更新日期:1975-05-01 00:00:00