Abstract：
:Chinese hamster ovary cells synchronized by mitotic detachment were treated with 5-fluorodeoxyuridine (FdUrd), 0.2 micrograms/ml, at various times in the cell cycle. FdUrd treatment in the early S period induced resistance to 6-thioguanine. Treatment of asynchronous cells with FdUrd caused little increase in 6-thioguanine resistance over the spontaneous frequency. Mitotic selection thus enhances the probability of a cell being in the portion of S period receptive to mutation. These observations suggest that FdUrd treatment leads to mutagenesis at the growing points of DNA replication.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Aebersold PMsubject
Has Abstractpub_date
1979-03-01 00:00:00pages
808-10issue
3eissn
0008-5472issn
1538-7445journal_volume
39pub_type
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