Insertion of Myc into Igh accelerates peritoneal plasmacytomas in mice.

abstract：:The role of glutathione (GSH) as a determinant of cellular sensitivity to the cytotoxic and DNA-damaging effects of cyclophosphamide (CP) was studied in a dual culture system of rat hepatocytes and K562 human chronic myeloid leukemia cells, which have elevated aldehyde dehydrogenase activity with a corresponding insen...

journal_title：Cancer research

authors： Crook TR,Souhami RL,Whyman GD,McLean AE

更新日期：1986-10-01 00:00:00

abstract：:miR-31 inhibits breast cancer metastasis via the pleiotropic suppression of a cohort of prometastatic target genes that include integrin alpha(5) (ITGA5), radixin (RDX), and RhoA. We previously showed that the concomitant overexpression of ITGA5, RDX, and RhoA was capable of overriding the antimetastatic effects of ec...

journal_title：Cancer research

authors： Valastyan S,Chang A,Benaich N,Reinhardt F,Weinberg RA

更新日期：2010-06-15 00:00:00

abstract：:Multiple tobacco smoke-related premalignant and malignant lesions develop synchronously or metachronously in various organ sites, including the oral cavity. Both field cancerization and clonal migration seem to contribute to the occurrence of multiple tumors. Although the importance of endogenous factors (e.g., oncoge...

journal_title：Cancer research

authors： Du B,Leung H,Khan KM,Miller CG,Subbaramaiah K,Falcone DJ,Dannenberg AJ

更新日期：2007-09-15 00:00:00

abstract：:The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by MHC class I (MHC-I) molecules. Herein, we demonstrate that genetic or pharmacological inhibition of ERAP1 on human tumor cell lines perturbs their ability to engage several classes of ...

journal_title：Cancer research

authors： Cifaldi L,Romania P,Falco M,Lorenzi S,Meazza R,Petrini S,Andreani M,Pende D,Locatelli F,Fruci D

更新日期：2015-03-01 00:00:00

abstract：:Transforming growth factor betas (TGF-beta) play a dual role in carcinogenesis, functioning as tumor suppressors early in the process, and then switching to act as prometastatic factors in late-stage disease. We have previously shown that high molecular weight TGF-beta antagonists can suppress metastasis without the p...

journal_title：Cancer research

authors： Nam JS,Suchar AM,Kang MJ,Stuelten CH,Tang B,Michalowska AM,Fisher LW,Fedarko NS,Jain A,Pinkas J,Lonning S,Wakefield LM

更新日期：2006-06-15 00:00:00

abstract：:Hypoxia is a common feature of solid tumors. Prolyl hydroxylase enzymes (PHD1-3) are molecular oxygen sensors that regulate hypoxia-inducible factor activity, but their functions in metastatic disease remain unclear. Here, we assessed the significance of PHD enzymes during the metastatic spread of colorectal cancer. P...

journal_title：Cancer research

authors： Radhakrishnan P,Ruh N,Harnoss JM,Kiss J,Mollenhauer M,Scherr AL,Platzer LK,Schmidt T,Podar K,Opferman JT,Weitz J,Schulze-Bergkamen H,Koehler BC,Ulrich A,Schneider M

更新日期：2016-04-15 00:00:00

abstract：:Retinoids are promising agents for cancer chemoprevention and therapy. Nuclear retinoic acid receptors (RARs; RARalpha, -beta, and -gamma) and retinoid X receptors (RXRs; RXRalpha, -beta, and -gamma) are thought to mediate most of retinoids' effects on cell growth and differentiation. Because the majority of human non...

journal_title：Cancer research

authors： Sun SY,Yue P,Dawson MI,Shroot B,Michel S,Lamph WW,Heyman RA,Teng M,Chandraratna RA,Shudo K,Hong WK,Lotan R

更新日期：1997-11-01 00:00:00

abstract：:Host resistance to tumor growth was studied in athymic nude mice of C57BL background. Animals were pretreated in the left hind leg by local hyperthermia, local X-irradiation, or combined local hyperthermia and X-irradiation. Twenty-four hr posttreatment, the animals were inoculated with the metastatic Lewis lung carci...

journal_title：Cancer research

authors： Yerushalmi A,Weinstein Y

更新日期：1979-03-01 00:00:00

abstract：:WT1 encodes a zinc finger transcription factor that is expressed in the developing kidney and the inactivation of which leads to Wilms' tumor, a pediatric kidney cancer. We have recently shown that inducible expression of WT1 in osteosarcoma cells triggers programmed cell death, an effect that is associated with trans...

journal_title：Cancer research

authors： Englert C,Maheswaran S,Garvin AJ,Kreidberg J,Haber DA

更新日期：1997-04-15 00:00:00

abstract：:Whether the apparent efficacy of a specific kinase inhibitor is attributable solely to inhibition of its primary target, or to combined inhibition of additional unidentified kinases, is a critical issue in cancer therapy. We used a chemical genetic approach to generate a selective inhibitor of v-erbB [a transforming a...

journal_title：Cancer research

authors： Fan QW,Specht KM,Zhang C,Goldenberg DD,Shokat KM,Weiss WA

更新日期：2003-12-15 00:00:00

abstract：:Regional measurements of blood flow (F) were performed in transplanted intracerebral RG-2 rat gliomas using [14C]iodoantipyrine, Kety-Schmidt blood flow equations, and quantitative autoradiography. Twenty-nine intracranial tumors in ten rats were analyzed by location; 18 intraparenchymal, seven meningeal, two third-ve...

journal_title：Cancer research

authors： Groothuis DR,Pasternak JF,Fischer JM,Blasberg RG,Bigner DD,Vick NA

更新日期：1983-07-01 00:00:00

abstract：:The unresponsiveness of metastatic melanoma to conventional chemotherapeutic and biological agents is largely due to the development of resistance to apoptosis. Pyrimethamine belongs to the group of antifolate drugs, and in addition to antiprotozoan effects, it exerts a strong proapoptotic activity, which we recently ...

journal_title：Cancer research

authors： Giammarioli AM,Maselli A,Casagrande A,Gambardella L,Gallina A,Spada M,Giovannetti A,Proietti E,Malorni W,Pierdominici M

更新日期：2008-07-01 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). We observed similar effects of EGCG in esophageal squamous cell carcinoma KYSE 150 cells and epide...

journal_title：Cancer research

authors： Hou Z,Sang S,You H,Lee MJ,Hong J,Chin KV,Yang CS

更新日期：2005-09-01 00:00:00

abstract：:Thioether-lysophospholipids inhibited the in vitro incorporation of [3H]thymidine into blasts of 8 leukemias, lymphocytes of 3 chronic lymphocytic leukemias, and cells of 12 different solid tumors of human origin. This effect correlated with trypan blue dye exclusion, which was used to assess cell damage. Scanning ele...

journal_title：Cancer research

authors： Berdel WE,Fromm M,Fink U,Pahlke W,Bicker U,Reichert A,Rastetter J

更新日期：1983-11-01 00:00:00

abstract：:Precise diagnosis and subtyping of kidney tumors are imperative to optimize and personalize treatment decision for patients. Patients with the most common benign renal tumor, renal oncocytomas, may be overtreated with surgical resection because of limited preoperative diagnostic methods that can accurately identify th...

journal_title：Cancer research

authors： Zhang J,Li SQ,Lin JQ,Yu W,Eberlin LS

更新日期：2020-02-15 00:00:00

abstract：:Normal, viral transformed and tumor-derived cells grown in tissue culture and representing different species were tested for their ability to produce an extracellular tumor angiogenesis factor (TAF). TAF was assayed by measuring the host-mediated vascular response of the chorioallantoic membrane to TAF preparations. A...

journal_title：Cancer research

authors： Klagsbrun M,Knighton D,Folkman J

更新日期：1976-01-01 00:00:00

abstract：:Cancers of the upper aerodigestive tract (UADT) include malignant tumors of the oral cavity, pharynx, larynx, and esophagus and account for 6.4% of all new cancers in Europe. In the context of a multicenter case-control study conducted in 14 centers within 10 European countries and comprising 1,511 cases and 1,457 con...

journal_title：Cancer research

authors： Canova C,Hashibe M,Simonato L,Nelis M,Metspalu A,Lagiou P,Trichopoulos D,Ahrens W,Pigeot I,Merletti F,Richiardi L,Talamini R,Barzan L,Macfarlane GJ,Macfarlane TV,Holcátová I,Bencko V,Benhamou S,Bouchardy C,Kjaerheim

更新日期：2009-04-01 00:00:00

abstract：:The mammary carcinoma cell line MFM-223 is characterized by high androgen and low estrogen and progesterone receptor levels. With the dextran charcoal method, androgen binding was determined at 160 fmol/mg protein corresponding to approximately 100,000 binding sites per cell in whole cell binding assays. The estrogen ...

journal_title：Cancer research

authors： Hackenberg R,Lüttchens S,Hofmann J,Kunzmann R,Hölzel F,Schulz KD

更新日期：1991-10-15 00:00:00

abstract：:We recently identified the immunoglobulin-CAM CD155/PVR (the poliovirus receptor) as a regulator of cancer invasiveness and glioma migration, but the mechanism through which CD155/PVR controls these processes is unknown. Here, we show that expression of CD155/PVR in rat glioma cells that normally lack this protein enh...

journal_title：Cancer research

authors： Sloan KE,Stewart JK,Treloar AF,Matthews RT,Jay DG

更新日期：2005-12-01 00:00:00

abstract：:Recently, the cDNA encoding a novel candidate for prostate cancer-specific antigen, named prostate-specific membrane antigen (PSM), was cloned from the LNCaP prostate cancer cell line (R. S. Israeli, C. T. Powell, W. R. Fair, and W. D. W. Heston, Cancer Res., 53: 227-230,1993). More recently, they also identified an a...

journal_title：Cancer research

authors： Kawakami M,Nakayama J

更新日期：1997-06-15 00:00:00

abstract：:We have demonstrated the intracellular expression of sex hormone-binding globulin (SHBG) exon VII splicing variant mRNA in human uterine endometrial cancer using the reverse transcription-PCR-Southern blot and DNA sequencing analyses. Analysis of the missing base pairs proved that they corresponded to the entire exon ...

journal_title：Cancer research

authors： Misao R,Nakanishi Y,Fujimoto J,Tamaya T

更新日期：1997-12-15 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) is constitutively activated in many types of cancers and has been implicated in gene expression important for angiogenesis, tumor growth, progression, and metastasis. Here, we show that the NF-kappaB activator, IkappaB kinase-alpha (IKKalpha), but not IKKbeta,...

journal_title：Cancer research

authors： DeBusk LM,Massion PP,Lin PC

更新日期：2008-12-15 00:00:00

abstract：:The long-standing strategy for the treatment of metastatic prostate cancer has been to reduce androgenic stimulation of tumor growth by removal of the testes, the primary site of testosterone synthesis. However, a low level of androgenic stimulation may continue, even after castration, by the conversion of adrenal and...

journal_title：Cancer research

authors： Klus GT,Nakamura J,Li JS,Ling YZ,Son C,Kemppainen JA,Wilson EM,Brodie AM

更新日期：1996-11-01 00:00:00

abstract：:The p53 tumor suppressor gene product is known to be active in mediating radiation-induced G1-S cell cycle arrest and apoptosis in a number of normal cell lines. These functions are compromised by inactivation of p53, which promotes tumor progression. Because the p53 gene appears to play an important role in the cellu...

journal_title：Cancer research

authors： Gallardo D,Drazan KE,McBride WH

更新日期：1996-11-01 00:00:00

abstract：:ABBV-075 is a potent and selective BET family bromodomain inhibitor that recently entered phase I clinical trials. Comprehensive preclinical characterization of ABBV-075 demonstrated broad activity across cell lines and tumor models, representing a variety of hematologic malignancies and solid tumor indications. In mo...

journal_title：Cancer research

authors： Bui MH,Lin X,Albert DH,Li L,Lam LT,Faivre EJ,Warder SE,Huang X,Wilcox D,Donawho CK,Sheppard GS,Wang L,Fidanze S,Pratt JK,Liu D,Hasvold L,Uziel T,Lu X,Kohlhapp F,Fang G,Elmore SW,Rosenberg SH,McDaniel KF,Kati

更新日期：2017-06-01 00:00:00

abstract：:We report that tumor necrosis factor (TNF) alpha induced a strong antitumor immune reaction when it was produced in arteries leading to tumors by gene transfer in vivo. We used a mouse model carrying a sarcoma-180 tumor in the right footpad and injected the fusogenic liposomes encapsulating the human TNF-alpha gene in...

journal_title：Cancer research

authors： Mizuguchi H,Nakagawa T,Toyosawa S,Nakanishi M,Imazu S,Nakanishi T,Tsutsumi Y,Nakagawa S,Hayakawa T,Ijuhin N,Mayumi T

更新日期：1998-12-15 00:00:00

abstract：:Paclitaxel is a standard-of-care chemotherapy for breast cancer, despite the increasing recognition of its poor effectiveness in the treatment of patients with advanced disease. Here, we report that adenovirus-type 5 E1A-mediated elevation of the miRNA-processing enzyme Dicer is sufficient to enhance paclitaxel sensit...

journal_title：Cancer research

authors： Chang TY,Chen HA,Chiu CF,Chang YW,Kuo TC,Tseng PC,Wang W,Hung MC,Su JL

更新日期：2016-07-01 00:00:00

abstract：:BD-40, a pyridopyrroloisoquinoline analogue of ellipticines, has dose-dependent cytostatic and cytotoxic effects on cultures of Saccharomyces cerevisiae. These inhibitory effects take place only in growing cells and are enhanced in the presence of oxygen. Among the different repair-deficient mutants examined, a mutant...

journal_title：Cancer research

authors： Moustacchi E,Favaudon V,Bisagni E

更新日期：1983-08-01 00:00:00

abstract：:The characterization of radiation-induced fibrosarcoma cells (RIF-8A) which have been selected for resistance to Photofrin-mediated photodynamic therapy (PDT) is detailed in this report. Morphological and functional assessment of mitochondria in both the resistant RIF-8A and parental RIF-1 cells show distinct differen...

journal_title：Cancer research

authors： Sharkey SM,Wilson BC,Moorehead R,Singh G

更新日期：1993-10-15 00:00:00

abstract：:Transduction of mitogenic signals in cells can be mediated by molecules derived from the synthesis and breakdown of the major membrane phospholipid, phosphotidylcholine. Studies were performed on human mammary epithelial cells in culture to understand the impact of malignant transformation and progression on membrane ...

journal_title：Cancer research

authors： Aboagye EO,Bhujwalla ZM

更新日期：1999-01-01 00:00:00