Regional measurements of blood flow in experimental RG-2 rat gliomas.

abstract：:The adoptive transfer of recombinant-methionyl human interleukin 2 (rIL-2)-activated autologous peripheral blood mononuclear lymphokine-activated killer (LAK) cells to cancer patients is being evaluated as an alternative to conventional cancer therapy. We have independently developed an alternative regimen to previous...

journal_title：Cancer research

authors： Schoof DD,Gramolini BA,Davidson DL,Massaro AF,Wilson RE,Eberlein TJ

更新日期：1988-09-01 00:00:00

abstract：:Histopathological assessment of lymph node metastases (LNM) depends on subjective analysis of cellular morphology with inter-/intraobserver variability. In this study, LNM from esophageal adenocarcinoma was objectively detected using desorption electrospray ionization-mass spectrometry imaging (DESI-MSI). Ninety lymph...

journal_title：Cancer research

authors： Abbassi-Ghadi N,Golf O,Kumar S,Antonowicz S,McKenzie JS,Huang J,Strittmatter N,Kudo H,Jones EA,Veselkov K,Goldin R,Takats Z,Hanna GB

更新日期：2016-10-01 00:00:00

abstract：:Identification of factors that mediate visceral and bone metastatic spread and subsequent bone remodeling events is highly relevant to successful therapeutic intervention in advanced human prostate cancer. TBX2, a T-box family transcription factor that negatively regulates cell-cycle inhibitor p21, plays critical role...

journal_title：Cancer research

authors： Nandana S,Tripathi M,Duan P,Chu CY,Mishra R,Liu C,Jin R,Yamashita H,Zayzafoon M,Bhowmick NA,Zhau HE,Matusik RJ,Chung LW

更新日期：2017-03-15 00:00:00

abstract：:Genetic instability has been recognized as a hallmark of human cancers. Retinoblastoma (Rb) tumor suppressor protein has an essential role in modulating cell cycle progression. However, there is no direct evidence supporting its role in maintaining genetic stability. Here, we developed a sensitive method to examine th...

journal_title：Cancer research

authors： Zheng L,Flesken-Nikitin A,Chen PL,Lee WH

更新日期：2002-05-01 00:00:00

abstract：:We evaluated the cytotoxicity of the immunotoxin OKT1-SAP on fresh B-chronic lymphocytic leukemia (B-CLL) cells from 31 consecutive patients. OKT1-SAP comprised the OKT1 (CD5) monoclonal antibody disulfide linked to saporin-6 (SAP) ribosome-inactivating protein from the plant Saponaria officinalis. The effect of OKT1-...

journal_title：Cancer research

authors： Siena S,Bregni M,Formosa A,Brando B,Marenco P,Lappi DA,Bonadonna G,Gianni AM

更新日期：1989-06-15 00:00:00

abstract：:IA-1 is a recently isolated novel complementary DNA which encodes a protein of 510 amino acids that contains both a zinc finger DNA-binding domain and a putative prohormone domain. mRNA expression of IA-1 has been found thus far only in tumors of neuroendocrine origin. In this report we describe the expression of IA-1...

journal_title：Cancer research

authors： Lan MS,Russell EK,Lu J,Johnson BE,Notkins AL

更新日期：1993-09-15 00:00:00

abstract：:The effect of caffeine on the expression of murine endogenous virus in mouse cells induced by radiation and chemicals was studied. Postirradiation treatment of K-BALB cells with caffeine enhanced cell killing as well as the induction of xenotropic virus after ultraviolet light irradiation. The degree of enhancement fo...

journal_title：Cancer research

authors： Niwa O,Sugahara T

更新日期：1981-08-01 00:00:00

abstract：:The role of the immune system in tumor elimination has been shown to be increasingly ambiguous, as many tumors not only escape recognition by the adaptive immune response but also even prime the immune cells to promote tumor growth. This effect is achieved through a number of mechanisms, which include both direct inte...

journal_title：Cancer research

authors： Kareva I,Hahnfeldt P

更新日期：2013-05-01 00:00:00

abstract：:An accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high reexcision rates without resorting to the...

journal_title：Cancer research

authors： Kennedy BF,McLaughlin RA,Kennedy KM,Chin L,Wijesinghe P,Curatolo A,Tien A,Ronald M,Latham B,Saunders CM,Sampson DD

更新日期：2015-08-15 00:00:00

abstract：:The insulin-like growth factor receptor (IGF-IR) and insulin receptor are either overactivated and/or overexpressed in a wide range of tumor types and contribute to tumorigenicity, proliferation, metastasis, and drug resistance. Here, we show that BMS-554417, a novel small molecule developed as an inhibitor of IGF-IR,...

journal_title：Cancer research

authors： Haluska P,Carboni JM,Loegering DA,Lee FY,Wittman M,Saulnier MG,Frennesson DB,Kalli KR,Conover CA,Attar RM,Kaufmann SH,Gottardis M,Erlichman C

更新日期：2006-01-01 00:00:00

abstract：:Smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor is driving metastatic progression. To identify smoking-induced alterations in human prostate cancer, we analyzed gene and protein expression patterns in tumors collected from current, past, and never sm...

journal_title：Cancer research

authors： Prueitt RL,Wallace TA,Glynn SA,Yi M,Tang W,Luo J,Dorsey TH,Stagliano KE,Gillespie JW,Hudson RS,Terunuma A,Shoe JL,Haines DC,Yfantis HG,Han M,Martin DN,Jordan SV,Borin JF,Naslund MJ,Alexander RB,Stephens RM,Loffr

更新日期：2016-03-01 00:00:00

abstract：:Interleukin 2 (IL2) was injected peritumorally and intranodally in 36 patients with unresectable squamous cell carcinoma of the head and neck enrolled in an Eastern Cooperative Oncology Group-sponsored phase Ib trial (EST P-Z388). Groups of 6 patients received escalating doses(200, 2 x 10(3), 2 x 10(4), 2 x 10(5), 2 x...

journal_title：Cancer research

authors： Whiteside TL,Letessier E,Hirabayashi H,Vitolo D,Bryant J,Barnes L,Snyderman C,Johnson JT,Myers E,Herberman RB

更新日期：1993-12-01 00:00:00

abstract：:A naturally occurring human antibody potentiates dendritic cell function on cross-linking B7-DC (PD-L2), supporting robust T-cell responses in vitro. Moreover, treatment of dendritic cells with B7-DC cross-linking antibody resulted in secretion of interleukin-12, suggesting a TH1 polarization of this response. Here we...

journal_title：Cancer research

authors： Radhakrishnan S,Nguyen LT,Ciric B,Flies D,Van Keulen VP,Tamada K,Chen L,Rodriguez M,Pease LR

更新日期：2004-07-15 00:00:00

abstract：:We have previously shown that inoculation of human chromosome 3 (chr3)/A9 mouse fibrosarcoma microcell hybrids (MCHs) into severe combined immunodeficient (SCID) mice was followed by the regular elimination of some 3p regions whereas a 3q region was retained even after prolonged mouse passage. Using this approach, ref...

journal_title：Cancer research

authors： Kholodnyuk ID,Szeles A,Yang Y,Klein G,Imreh S

更新日期：2000-12-15 00:00:00

abstract：:Previous work in our laboratory has indicated that free fatty acids stimulate synthesis of fibrinogen by the liver. The effect of the hypolipidemic agent clofibrate on hyperfibrinogenemia associated with tumors was evaluated by monitoring clofibrate-induced changes in plasma fibrinogen concentration and biosynthesis o...

journal_title：Cancer research

authors： Pickart L,Thaler MM

更新日期：1979-10-01 00:00:00

abstract：:About 30% of all colorectal cancers are thought to have a genetic basis and the known predisposing genes can only account for a small fraction of cases. A previous report suggested that a colorectal cancer candidate gene, explaining at least 20% of colorectal cancer cases with family history, was located within a 25 c...

journal_title：Cancer research

authors： Kemp ZE,Carvajal-Carmona LG,Barclay E,Gorman M,Martin L,Wood W,Rowan A,Donohue C,Spain S,Jaeger E,Evans DG,Maher ER,Bishop T,Thomas H,Houlston R,Tomlinson I,Colorectal Tumour Gene Identification Study Consortium.

更新日期：2006-05-15 00:00:00

abstract：:Serial passages of the poorly differentiated, androgen-sensitive R3327-G prostatic adenocarcinoma were used to study the progressive changes that occur in tumor growth rate and androgen sensitivity. Different in vivo transplant generations (21st to 28th) were compared. The tumor doubling and animal survival times resu...

journal_title：Cancer research

authors： Pollack A,Block NL,Stover BJ,Irvin GL 3rd

更新日期：1985-03-01 00:00:00

abstract：:Inhibition of constitutive active signaling pathways, which are a characteristic phenomenon for many tumors, can be an effective therapeutic strategy. In contrast, oncogenic transcription factors, often activated by mutational events, are in general less amenable to small-molecule inhibition despite their obvious impo...

journal_title：Cancer research

authors： Amstutz R,Wachtel M,Troxler H,Kleinert P,Ebauer M,Haneke T,Oehler-Jänne C,Fabbro D,Niggli FK,Schäfer BW

更新日期：2008-05-15 00:00:00

abstract：:The Notch signaling pathway is required in both nonneoplastic neural stem cells and embryonal brain tumors, such as medulloblastoma, which are derived from such cells. We investigated the effects of Notch pathway inhibition on medulloblastoma growth using pharmacologic inhibitors of gamma-secretase. Notch blockade sup...

journal_title：Cancer research

authors： Fan X,Matsui W,Khaki L,Stearns D,Chun J,Li YM,Eberhart CG

更新日期：2006-08-01 00:00:00

abstract：:To understand the biological basis of resistance to endocrine therapy is of utmost importance in patients with steroid hormone receptor-positive breast cancer. Not only will this allow us prediction of therapy success, it may also lead to novel therapies for patients resistant to current endocrine therapy. DNA methyla...

journal_title：Cancer research

authors： Martens JW,Nimmrich I,Koenig T,Look MP,Harbeck N,Model F,Kluth A,Bolt-de Vries J,Sieuwerts AM,Portengen H,Meijer-Van Gelder ME,Piepenbrock C,Olek A,Höfler H,Kiechle M,Klijn JG,Schmitt M,Maier S,Foekens JA

更新日期：2005-05-15 00:00:00

abstract：:The objective of this investigation was to study the effects of maytansine on the cell cycle kinetics of HeLa cells. The results of this study indicate that maytansine is a very potent mitotic inhibitor and that it has no effect on macromolecular synthesis. Maytansine-induced cytotoxicity was dependent upon the positi...

journal_title：Cancer research

authors： Rao PN,Freireich EJ,Smith ML,Loo TL

更新日期：1979-08-01 00:00:00

abstract：:Four hundred and forty-seven human tumor specimens were accessioned and processed for clonogenic assay, yielding 374 specimens, representing 23 different histiotypes, adequate for culture. Different levels of viable cell inoculum density produced contrasting effects between 255 solid tumors as compared to 72 malignant...

journal_title：Cancer research

authors： Page RH,Tilchen EJ,Davis HL

更新日期：1988-07-15 00:00:00

abstract：:Mesothelin is a cell-surface tumor-associated antigen expressed in several human cancers. The limited expression of mesothelin on normal tissues and its high expression in many cancers make it an attractive candidate for targeted therapies using monoclonal antibodies, immunoconjugates, and immunotoxins. Mesothelin is ...

journal_title：Cancer research

authors： Zhang Y,Chertov O,Zhang J,Hassan R,Pastan I

更新日期：2011-09-01 00:00:00

abstract：:Metabolic activation may be a key step in determining the tissue specificity of carcinogenic nitrosamines. In previous work, we characterized P450IIE1 (an acetone/ethanol-inducible form of cytochrome P-450) as the major enzyme for the metabolic activation of N-nitrosodimethylamine. In this work, we investigated the me...

journal_title：Cancer research

authors： Lee M,Ishizaki H,Brady JF,Yang CS

更新日期：1989-03-15 00:00:00

abstract：:Chartreusin has exhibited significant therapeutic activity against three experimental mouse tumors (ascitic P388, L1210 leukemia, and B16 melanoma) when tumor cells were inoculated i.p. and drug was administered i.p. In further testing against P388 leukemia, no activity was observed when drug was administered p.o., s....

journal_title：Cancer research

authors： McGovren JP,Neil GL,Crampton SL,Robinson MI,Douros JD

更新日期：1977-06-01 00:00:00

abstract：:The human papillomavirus type 16 (HPV-16), the type most often associated with cervical cancer, immortalizes primary keratinocytes and inhibits serum/calcium-stimulated differentiation in culture. In this study, we have used a model of keratinocyte immortalization based upon HPV-16 to analyze perturbation of function ...

journal_title：Cancer research

authors： Wilding J,Vousden KH,Soutter WP,McCrea PD,Del Buono R,Pignatelli M

更新日期：1996-11-15 00:00:00

abstract：:The effects on Leydig cell tumorigenesis of surgical cryptorchidy, parabiotic union with a castrate male partner, and a combination on the two procedures as well as of the continuous exposure to a high level of diethylstilbestrol stimulation were studied in the high-tumor Fischer rat. Localized foci of adenomatous hyp...

journal_title：Cancer research

authors： Huseby RA

更新日期：1981-08-01 00:00:00

abstract：:Meningiomas are rich in progestin receptors, whereas estrogen receptors (ER) are virtually undetectable. The present experiments were performed to evaluate whether the absence of ER from the majority of human meningioma cytosols can be attributed to: occurrence of only a small number of ER-positive cells in an otherwi...

journal_title：Cancer research

authors： Blankenstein MA,Berns PM,Blaauw G,Mulder E,Thijssen JH

更新日期：1986-08-01 00:00:00

abstract：:A comprehensive description of genomic alterations in lung squamous cell carcinoma (lung SCC) has recently been reported, enabling the identification of genomic events that contribute to the oncogenesis of this disease. In lung SCC, one of the most frequently altered receptor tyrosine kinase families is the fibroblast...

journal_title：Cancer research

authors： Liao RG,Jung J,Tchaicha J,Wilkerson MD,Sivachenko A,Beauchamp EM,Liu Q,Pugh TJ,Pedamallu CS,Hayes DN,Gray NS,Getz G,Wong KK,Haddad RI,Meyerson M,Hammerman PS

更新日期：2013-08-15 00:00:00

abstract：:New sublines of Chinese hamster CHL cells stably expressing human NAT1 or NAT2 N-acetyltransferases or O-acetyltransferase of Salmonella typhimurium were established, and their sensitivities to carcinogenic nitroarenes and aromatic amines were compared using the in vitro micronucleus test. The subline expressing human...

journal_title：Cancer research

authors： Watanabe M,Matsuoka A,Yamazaki N,Hayashi M,Deguchi T,Nohmi T,Sofuni T

更新日期：1994-04-01 00:00:00