Effect of caffeine on induction of endogenous type C virus in mouse cells in vitro.

abstract：:The influence of cyclophosphamide (CY) on Friend virus leukemogenesis was studied in SJL/J, C57BL/10J, and C57BL/10J X SJL/J F1 (hereafter called B10SJF1) mice. All three differ in their susceptibility to the viral oncogenic effect. Immunosuppressive doses of CY, which by themselves produced no cancer, were followed 2...

journal_title：Cancer research

authors： Raikow RB,OKunewick JP,Buffo MJ,Kociban DL

更新日期：1985-02-01 00:00:00

abstract：:3,4-Dihydro-2,2-dimethyl-2H-naptho[1,2,-b]pyran-5,6-dione (beta-lapachone) is a novel DNA repair inhibitor. It was tested for synergistic X-ray-induced lethality in combination with several halogenated pyrimidine radiosensitizers. Logarithmic-phase growing human epidermoid laryngeal carcinoma (HEp-2) cells were allowe...

journal_title：Cancer research

authors： Boothman DA,Greer S,Pardee AB

更新日期：1987-10-15 00:00:00

abstract：:We have previously shown that mice simultaneously infected with the murine mammary tumor virus (MuMTV) and with certain slow murine leukemia viruses (MLV) have an increased resistance to the pathological effects of both agents. Here we report that milk-transmitted MuMTV also delays the development of the acute erythro...

journal_title：Cancer research

authors： Basolo F,Toniolo A,Bistocchi M,Fontanini G,Squartini F

更新日期：1986-08-01 00:00:00

abstract：:Cloned lines of Adriamycin (ADR)-sensitive and -resistant P388 leukemia have been established from single cell cultures. A marker chromosome M1 was found in all cells in the heterogeneous resistant P388/ADR parental line as well as in the cloned resistant lines P388/ADR/3 and P388/ADR/7; a different marker chromosome ...

journal_title：Cancer research

authors： Goldenberg GJ,Wang H,Blair GW

更新日期：1986-06-01 00:00:00

abstract：:Plasmids may have unique advantages as a gene delivery system. However, a major obstacle is the low in vivo transduction efficiency. In this study, an electroporation-based gene transduction approach was taken to study the effect of interleukin (IL)-2 or IL-12 gene transduction on the growth of experimental murine tum...

journal_title：Cancer research

authors： Lohr F,Lo DY,Zaharoff DA,Hu K,Zhang X,Li Y,Zhao Y,Dewhirst MW,Yuan F,Li CY

更新日期：2001-04-15 00:00:00

abstract：:Activation of the PI3K pathway occurs commonly in a wide variety of cancers. Experience with other successful targeted agents suggests that clinical resistance is likely to arise and may reduce the durability of clinical benefit. Here, we sought to understand mechanisms underlying resistance to PI3K inhibition in PTEN...

journal_title：Cancer research

authors： Nakanishi Y,Walter K,Spoerke JM,O'Brien C,Huw LY,Hampton GM,Lackner MR

更新日期：2016-03-01 00:00:00

abstract：:Antiangiogenic therapies like bevacizumab offer promise for cancer treatment, but acquired resistance, which often includes an aggressive mesenchymal phenotype, can limit the use of these agents. Upregulation of β1 integrin (ITGB1) occurs in some bevacizumab-resistant glioblastomas (BRG) whereby, mediating tumor-micro...

journal_title：Cancer research

authors： Carbonell WS,DeLay M,Jahangiri A,Park CC,Aghi MK

更新日期：2013-05-15 00:00:00

abstract：:The Rb/E2F pathway is deregulated in most human brain tumors, and the finding that loss of E2F1 reduced pituitary tumorigenesis in Rb(+/-) mice suggests that loss of pRb induces brain tumors by activating E2F1. We therefore investigated the role of E2F1 in the development and maintenance of brain cancer using a transg...

journal_title：Cancer research

authors： Olson MV,Johnson DG,Jiang H,Xu J,Alonso MM,Aldape KD,Fuller GN,Bekele BN,Yung WK,Gomez-Manzano C,Fueyo J

更新日期：2007-05-01 00:00:00

abstract：:As with many types of cancer, cell motility is an important factor in the progression and metastasis of hepatocellular carcinomas (HCC). HCC is associated with significant fibrosis in the liver. The fibrotic microenvironment in the liver is characterized by an altered composition of the extracellular matrix (ECM) and ...

journal_title：Cancer research

authors： Yang C,Zeisberg M,Lively JC,Nyberg P,Afdhal N,Kalluri R

更新日期：2003-12-01 00:00:00

abstract：:The increased proteolytic activity of membrane-bound and secreted proteases on the surface of cancer cells and in the transformed stroma is a common characteristic of aggressive metastatic prostate cancer. We describe here the development of an active site-specific probe for detecting a secreted peritumoral protease e...

journal_title：Cancer research

authors： LeBeau AM,Sevillano N,Markham K,Winter MB,Murphy ST,Hostetter DR,West J,Lowman H,Craik CS,VanBrocklin HF

更新日期：2015-04-01 00:00:00

abstract：:Decyl and phenyl disulfide derivatives of 6-mercaptopurine and 6-thioguanine (6-TG) were examined for antineoplastic activity under aerobic and hypoxic conditions toward EMT6 cells in culture. Although these derivatives did not display selective toxicity toward the hypoxic cells, they were significantly more toxic tha...

journal_title：Cancer research

authors： Kirkpatrick DL

更新日期：1987-08-15 00:00:00

abstract：:Previous studies have shown that the invasion of V2 carcinoma cells in the rabbit mesentery is associated with marked extracellular matrix synthesis leading eventually to an overall increase in mesenteric mass. The purpose of the present study was to investigate the structural and biochemical composition of the extrac...

journal_title：Cancer research

authors： Iozzo RV,Müller-Glauser W

更新日期：1985-11-01 00:00:00

abstract：:Fibrosarcomas produced by s.c. injection of 5 micrograms of 3-methylcholanthrene in Pgk-1a/Pgk-1b mice carrying X-chromosome inactivation mosaicism for the phosphoglycerate kinase (PGK-1) gene contained only one type of phosphoglycerate kinase in seven of eight cases (88%), as judged from its electrophoretic mobility,...

journal_title：Cancer research

authors： Tanooka H,Tanaka K

更新日期：1982-05-01 00:00:00

abstract：:Tumor hypoxia induces the up-regulation of a gene program associated with angiogenesis, glycolysis, adaptation to pH, and apoptosis via the hypoxia-inducible transcription factors (Hifs) 1 and 2. Disruption of this pathway has been proposed as a cancer therapy. Here, we use short interfering RNAs to compare specific i...

journal_title：Cancer research

authors： Sowter HM,Raval RR,Moore JW,Ratcliffe PJ,Harris AL

更新日期：2003-10-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by therapeutic resistance for which the basis is poorly understood. Here, we report that the DNA and p53-binding protein ATDC/TRIM29, which is highly expressed in PDAC, plays a critical role in DNA damage signaling and radioresistance in pancreatic cancer cells....

journal_title：Cancer research

authors： Wang L,Yang H,Palmbos PL,Ney G,Detzler TA,Coleman D,Leflein J,Davis M,Zhang M,Tang W,Hicks JK,Helchowski CM,Prasad J,Lawrence TS,Xu L,Yu X,Canman CE,Ljungman M,Simeone DM

更新日期：2014-03-15 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumor in children. Osteosarcoma patients who respond poorly to chemotherapy are at a higher risk of relapse and adverse outcome. Therefore, it was the aim of this study to identify prognostic factors at the time of diagnosis to characterize the genes predictive of poor su...

journal_title：Cancer research

authors： Mintz MB,Sowers R,Brown KM,Hilmer SC,Mazza B,Huvos AG,Meyers PA,Lafleur B,McDonough WS,Henry MM,Ramsey KE,Antonescu CR,Chen W,Healey JH,Daluski A,Berens ME,Macdonald TJ,Gorlick R,Stephan DA

更新日期：2005-03-01 00:00:00

abstract：:We have shown previously that the transduction of a number of human tumor cell lines with an adenovirus (AV1Y28) expressing a single-chain antibody fragment (scFv) directed against Ras proteins results in radiosensitization. Because Ras is involved in the regulation of a number of transcription factors, we have determ...

journal_title：Cancer research

authors： Russell JS,Raju U,Gumin GJ,Lang FF,Wilson DR,Huet T,Tofilon PJ

更新日期：2002-04-15 00:00:00

abstract：:The present study was designed to investigate the effect of selenium supplementation on dimethylbenz[a]anthracene-induced mammary tumorigenesis in female Sprague-Dawley rats fed either a 5 or 25% corn oil diet, denoted as low fat (LF) or high fat (HF), respectively. Selenium supplementation of LF and HF diets were beg...

journal_title：Cancer research

authors： Ip C

更新日期：1981-07-01 00:00:00

abstract：:The EphA2 receptor tyrosine kinase is found at low levels on nontransformed adult breast epithelial cells but is frequently overexpressed on aggressive breast cancer cells. Recent studies have documented an inverse relationship between EphA2 and estrogen receptor expression in breast cancer cell lines. In our present ...

journal_title：Cancer research

authors： Lu M,Miller KD,Gokmen-Polar Y,Jeng MH,Kinch MS

更新日期：2003-06-15 00:00:00

abstract：:Energy restriction (ER) inhibits mammary carcinogenesis and results in a marked reduction in tumor size, effects likely to be explained by ER-mediated induction of apoptosis. The goal of this study was to investigate the molecular mechanism(s) accounting for apoptosis induction. To do this, chemically induced mammary ...

journal_title：Cancer research

authors： Thompson HJ,Zhu Z,Jiang W

更新日期：2004-02-15 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA), initially defined by monoclonal antibody (mAb) 7E11, is a now well-characterized type 2 integral membrane glycoprotein expressed in a highly restricted manner by prostate epithelial cells. 7E11 has been shown to bind an intracellular epitope of PSMA that, in viable cells, is ...

journal_title：Cancer research

authors： Liu H,Moy P,Kim S,Xia Y,Rajasekaran A,Navarro V,Knudsen B,Bander NH

更新日期：1997-09-01 00:00:00

abstract：:It is well known that normal human diploid fibroblasts undergo a significant, p53-dependent arrest in the G1 phase of the cell cycle after exposure to ionizing radiation. The presence and magnitude of a G1 arrest in human tumor cell lines, however, has been controversial, particularly in cells derived from solid tumor...

journal_title：Cancer research

authors： Nagasawa H,Keng P,Maki C,Yu Y,Little JB

更新日期：1998-05-01 00:00:00

abstract：:Indomethacin, an inhibitor of prostaglandin (PG) synthesis, was investigated for its ability to increase radioresponse of two fibrosarcomas, FSA and NFSA, in C3Hf/Kam mice. In addition, the effect of indomethacin on radioresponse of hematopoietic tissue, jejunum, hair follicles, and tissues involved in the development...

journal_title：Cancer research

authors： Furuta Y,Hunter N,Barkley T Jr,Hall E,Milas L

更新日期：1988-06-01 00:00:00

abstract：:We have studied the cellular expression of NB/70K, a glycoprotein proposed to be human ovarian tumor associated described previously. Analysis of cells bearing this antigen in malignant ascites shows expression in tumor cells of gynecological origin (ovarian, endometrial) and to a limited degree in breast cancer cells...

journal_title：Cancer research

authors： Bizzari JP,Mackillop WJ,Buick RN

更新日期：1983-02-01 00:00:00

abstract：:Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first ...

journal_title：Cancer research

authors： Zhang K,Chu K,Wu X,Gao H,Wang J,Yuan YC,Loera S,Ho K,Wang Y,Chow W,Un F,Chu P,Yen Y

更新日期：2013-02-15 00:00:00

abstract：:Chemical and biological studies are presented for a new series of platinum(II) antitumor agents that violate the classical structure-activity relationships established for platinum complexes. These new agents, which have demonstrated activity against murine and human tumor systems, are cis-[Pt(NH3)2(Am)Cl]+ cations, i...

journal_title：Cancer research

authors： Hollis LS,Sundquist WI,Burstyn JN,Heiger-Bernays WJ,Bellon SF,Ahmed KJ,Amundsen AR,Stern EW,Lippard SJ

更新日期：1991-04-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer is associated with inherited defects in DNA mismatch repair. Clinical variation even in cases with identical predisposing mutations suggests the existence of other factors contributing to the phenotype. We addressed the modifying role of the common A/G polymorphism in exon 4 a...

journal_title：Cancer research

authors： Bala S,Peltomäki P

更新日期：2001-08-15 00:00:00

abstract：:A superinduction of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT) accompanies the phenotype-specific cytotoxic response to a class of antitumor polyamine analogues in several important human solid tumor models. A highly specific antiserum against the human SSAT protein has been develo...

journal_title：Cancer research

authors： Casero RA Jr,Gabrielson EW,Pegg AE

更新日期：1994-08-01 00:00:00

abstract：:2-Methoxyestradiol (2ME(2)), a physiologic metabolite of 17beta-estradiol (estrogen), has emerged as a promising cancer therapy because of its potent growth-inhibitory and proapoptotic effects on both endothelial and tumor cells. 2ME(2) also suppresses osteoclast differentiation and induces apoptosis of mature osteocl...

journal_title：Cancer research

authors： Cicek M,Iwaniec UT,Goblirsch MJ,Vrabel A,Ruan M,Clohisy DR,Turner RR,Oursler MJ

更新日期：2007-11-01 00:00:00