β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma.

abstract：:Three loci have been implicated in the etiology of familial breast cancer; the BRCA1 locus on 17q, the p53 gene on 17p, and the androgen receptor gene on the X chromosome. However, it has been estimated that in approximately 50% of all breast cancer families the predisposing genetic defect is not linked to any of thes...

journal_title：Cancer research

authors： Lindblom A,Skoog L,Rotstein S,Werelius B,Larsson C,Nordenskjöld M

更新日期：1993-09-15 00:00:00

abstract：:We have used culture conditions which simulate the microenvironment of breast tumors for the isolation and propagation of primary breast tumor cells in vitro. In this monolayer setup, the mixture of cells dissociated from primary breast tumors is subjected to self-created gradients of oxygen and nutrients as well as m...

journal_title：Cancer research

authors： Dairkee SH,Deng G,Stampfer MR,Waldman FM,Smith HS

更新日期：1995-06-15 00:00:00

abstract：:We have studied the cellular expression of NB/70K, a glycoprotein proposed to be human ovarian tumor associated described previously. Analysis of cells bearing this antigen in malignant ascites shows expression in tumor cells of gynecological origin (ovarian, endometrial) and to a limited degree in breast cancer cells...

journal_title：Cancer research

authors： Bizzari JP,Mackillop WJ,Buick RN

更新日期：1983-02-01 00:00:00

abstract：:Previous results have suggested that methotrexate (MTX) could interfere with the repair of spontaneous DNA damage. To determine its effects on induced DNA damage, MTX was compared to hydroxyurea and arabinofuranosylcytosine (H/A), a drug combination known to block the DNA polymerase step of excision repair, for its ab...

journal_title：Cancer research

authors： Borchers AH,Kennedy KA,Straw JA

更新日期：1990-03-15 00:00:00

abstract：:Previous studies have favored a basic difference in the regulation of specialized protein production by cells derived from the usual tissue of origin (eutopic) and cancer cells derived from a tissue not normally producing the protein (ectopic). Thus N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate was believed to...

journal_title：Cancer research

authors： Rosen SW,Calvert I,Weintraub BD,Tseng JS,Rabson AS

更新日期：1980-11-01 00:00:00

abstract：:Lectin binding [concanavalin A, biotinylated ricinus communis agglutinin, and biotinylated succinylated wheat germ agglutinin (B-SWGA)] was used to detect the glycosylated proteins associated with a residual protein fraction [insoluble in 4% sodium dodecyl sulfate and termed the nuclear residual fraction (NRF)] or wit...

journal_title：Cancer research

authors： Burrus GR,Schmidt WN,Briggs JA,Hnilica LS,Briggs RC

更新日期：1988-02-01 00:00:00

abstract：:C/EBPα is an essential transcription factor involved in regulating the expression or function of certain cell-cycle regulators, including in breast cancer cells. Although protein arginine methyltransferases have been shown to play oncogenic roles in a variety of cancers, little is known about the role of arginine meth...

journal_title：Cancer research

authors： Liu LM,Sun WZ,Fan XZ,Xu YL,Cheng MB,Zhang Y

更新日期：2019-06-01 00:00:00

abstract：:Mouse leukemia (P388) cells were incubated in cell culture medium containing nitrogen mustard [2-chloro-N-(2-chloroethyl)-N-methylethanamine] for 4 h. The nucleophosmin immunoband with a molecular weight of 37,000 (p37; other molecular weights are similarly designated) was observed in both control and nitrogen mustard...

journal_title：Cancer research

authors： Chan PK

更新日期：1989-06-15 00:00:00

abstract：:Centrosome amplification is a hallmark of virtually all types of cancers, including solid tumors and hematologic malignancies. Cancer cells with extra centrosomes use centrosome clustering (CC) to allow for successful division. Because normal cells do not rely on this mechanism, CC is regarded as a promising target to...

journal_title：Cancer research

authors： Konotop G,Bausch E,Nagai T,Turchinovich A,Becker N,Benner A,Boutros M,Mizuno K,Krämer A,Raab MS

更新日期：2016-11-15 00:00:00

abstract：:Maintenance of long term culture and conventional xenografting of early B-lineage acute lymphoblastic leukemia cells is most difficult. Matrigel, a solubilized attachment matrix shown to aid growth of anchorage dependent solid tumors, was studied in heterotransplantation. Material for xenografting was derived from 5 p...

journal_title：Cancer research

authors： Sterling-Levis K,White L,Trickett AE,Gramacho C,Pittman SM,Tobias V

更新日期：1993-03-15 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine nonmelanoma skin cancer, which is associated with the Merkel cell polyoma virus (MCPyV). Recently, expression of the terminal deoxynucleotidyl transferase (TdT) and the paired box gene 5 (PAX 5) has been consistently reported in the majority of MCCs. We ...

journal_title：Cancer research

authors： Zur Hausen A,Rennspiess D,Winnepenninckx V,Speel EJ,Kurz AK

更新日期：2013-08-15 00:00:00

abstract：:Critical roles played by some protein kinases in neoplastic transformation and progression provide a rationale for developing selective, small-molecule kinase inhibitors as antineoplastic drugs. Protein kinase Cepsilon (PKCepsilon) is a rational target for cancer therapy, because it is oncogenic and prometastatic in t...

journal_title：Cancer research

authors： Chu F,Koomen JM,Kobayashi R,O'Brian CA

更新日期：2005-11-15 00:00:00

abstract：:The possibility that the female sex steroid progesterone plays a role in meningioma proliferation has been suggested by a number of investigators; and it had been shown that many meningiomas have high affinity progesterone binding sites. The aim of this study was to examine the expression of progesterone receptor mRNA...

journal_title：Cancer research

authors： Carroll RS,Glowacka D,Dashner K,Black PM

更新日期：1993-03-15 00:00:00

abstract：:Dysregulation in patterns of alternative RNA splicing in cancer cells is emerging as a significant factor in cancer pathophysiology. In this study, we investigated the little known alternative splice isoform survivin-3B (S-3B) that is overexpressed in a tumor-specific manner. Ectopic overexpression of S-3B drove tumor...

journal_title：Cancer research

authors： Végran F,Mary R,Gibeaud A,Mirjolet C,Collin B,Oudot A,Charon-Barra C,Arnould L,Lizard-Nacol S,Boidot R

更新日期：2013-09-01 00:00:00

abstract：:Reversal of the drug resistance phenotype by the use of agents which induce cell differentiation offers an experimental approach to the study of chemoresistance. In numerous in vitro models, alpha-interferon (alpha-IFN) has been shown to induce phenotypical changes and to modulate the growth of cancer cells. The aim o...

journal_title：Cancer research

authors： Scala S,Pacelli R,Iaffaioli RV,Normanno N,Pepe S,Frasci G,Genua G,Tsuruo T,Tagliaferri P,Bianco AR

更新日期：1991-09-15 00:00:00

abstract：:N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) metabolism was examined in vitro using microsomes prepared from rat liver and renal cortex and from rabbit liver and renal cortex and outer and inner medulla. NFTA nitroreduction was observed with each tissue. Three mol of NADPH were used per mol of NFTA reduced. Sub...

journal_title：Cancer research

authors： Mattammal MB,Zenser TV,Palmier MO,Davis BB

更新日期：1985-01-01 00:00:00

abstract：:Estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to inactive estrogen sulfates, whereas steroid sulfatase (STS) hydrolyzes estrone sulfate to estrone. Both EST and STS have been suggested to play important roles in regulating the in situ production of estrogens in human breast carcinoma tissu...

journal_title：Cancer research

authors： Suzuki T,Nakata T,Miki Y,Kaneko C,Moriya T,Ishida T,Akinaga S,Hirakawa H,Kimura M,Sasano H

更新日期：2003-06-01 00:00:00

abstract：:We conjugated the chemotherapy agent daunorubicin to the anti-T-cell monoclonal antibody T101 using an active ester intermediate of the acid-labile linker cis-aconitate anhydride. By converting carbohydrate hydroxyl groups on the antibody to amines prior to conjugation, average drug to antibody ratios of 25:1 were ach...

journal_title：Cancer research

authors： Dillman RO,Johnson DE,Shawler DL,Koziol JA

更新日期：1988-11-01 00:00:00

abstract：:Genetic instability has been recognized as a hallmark of human cancers. Retinoblastoma (Rb) tumor suppressor protein has an essential role in modulating cell cycle progression. However, there is no direct evidence supporting its role in maintaining genetic stability. Here, we developed a sensitive method to examine th...

journal_title：Cancer research

authors： Zheng L,Flesken-Nikitin A,Chen PL,Lee WH

更新日期：2002-05-01 00:00:00

abstract：:To identify mechanisms of camptothecin (CPT) resistance/toxicity, sublines from a human KB cell line were made resistant to CPT by continuous selection in increasing concentrations of CPT. Two CPT-resistant lines, 100 and 300, were 32- and 54-fold resistant to the growth-inhibitory properties of CPT compared to the KB...

journal_title：Cancer research

authors： Beidler DR,Chang JY,Zhou BS,Cheng YC

更新日期：1996-01-15 00:00:00

abstract：:The hypothesis that microvesicle-mediated miRNA transfer converts noncancer stem cells into cancer stem cells (CSC) leading to therapy resistance remains poorly investigated. Here we provide direct evidence supporting this hypothesis, by demonstrating how microvesicles derived from cancer-associated fibroblasts (CAF) ...

journal_title：Cancer research

authors： Sansone P,Berishaj M,Rajasekhar VK,Ceccarelli C,Chang Q,Strillacci A,Savini C,Shapiro L,Bowman RL,Mastroleo C,De Carolis S,Daly L,Benito-Martin A,Perna F,Fabbri N,Healey JH,Spisni E,Cricca M,Lyden D,Bonafé M,Bromb

更新日期：2017-04-15 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) expression can induce mammary tumorigenesis in transgenic mice, and selective Cox-2 inhibitors are both chemopreventive and chemotherapeutic in rat models of breast cancer. We analyzed the expression of Cox-2 protein by immunohistochemistry in tissue array specimens of 1576 invasive breast can...

journal_title：Cancer research

authors： Ristimäki A,Sivula A,Lundin J,Lundin M,Salminen T,Haglund C,Joensuu H,Isola J

更新日期：2002-02-01 00:00:00

abstract：:The comparative metabolism of the enantiomers of cyclo phosphamide and of the racemate has been studied in humans. Four patients were each given, sequentially, the racemate, the (+)-enantiomer, and its (-)-antipode. The plasma levels of parent drug and the urinary output (24 hr) of unchanged drug and of two enzymatica...

journal_title：Cancer research

authors： Jarman M,Milsted RA,Smyth JF,Kinas RW,Pankiewicz K,Stec WJ

更新日期：1979-07-01 00:00:00

abstract：:Amplification and overexpression of erbB2 (Her-2/neu) proto-oncogene has been linked to human malignancies including tumors of the breast, ovary, and stomach. It has been implicated in tumor growth, sensitivity to standard chemotherapy, prognosis of patients, and disease-free survival. Although the clinical use of tra...

journal_title：Cancer research

authors： Jani JP,Finn RS,Campbell M,Coleman KG,Connell RD,Currier N,Emerson EO,Floyd E,Harriman S,Kath JC,Morris J,Moyer JD,Pustilnik LR,Rafidi K,Ralston S,Rossi AM,Steyn SJ,Wagner L,Winter SM,Bhattacharya SK

更新日期：2007-10-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a highly aggressive, heterogeneous disease with poor prognosis and no effective targeted therapies. EGFR is highly expressed in basal-like TNBC and is considered as a potential therapeutic target. However, EGFR targeting exerts only marginal clinical benefits, possibly due to ac...

journal_title：Cancer research

authors： Verma N,Müller AK,Kothari C,Panayotopoulou E,Kedan A,Selitrennik M,Mills GB,Nguyen LK,Shin S,Karn T,Holtrich U,Lev S

更新日期：2017-01-01 00:00:00

abstract：:SOX9 is a transcription factor that plays a critical role in the development of multiple tissues. We previously reported that SOX9 in normal human adult prostate was restricted to basal epithelium. SOX9 was also expressed in a subset of prostate cancer (PCa) cells and was increased in relapsed hormone-refractory PCa. ...

journal_title：Cancer research

authors： Wang H,Leav I,Ibaragi S,Wegner M,Hu GF,Lu ML,Balk SP,Yuan X

更新日期：2008-03-15 00:00:00

abstract：:Inoculation of the Soehner-Dmochowski isolate of the Moloney strain of murine sarcoma virus (MSV), designated MSV-SD, consistently leads to the development of bone tumors in the susceptible New Zealand black (NB) rats. Two separate cell cultures have been established from 2 individual MSV-SD-induced NB rat bone tumors...

journal_title：Cancer research

authors： Chan JC,East JL,Dmochowski L

更新日期：1975-09-01 00:00:00

abstract：:Cancer cell motility has been associated with metastatic potential of sublines of the Dunning R-3227 rat prostatic adenocarcinoma model. However, three sublines of high motility lacked the capacity for metastasis. In all previous works, motility has been studied upon plastic and only upon attached cells at least 18 h ...

journal_title：Cancer research

authors： Mohler JL,Levy F,Sharief Y

更新日期：1991-12-15 00:00:00

abstract：:We tested the ability of a serum-free medium containing insulin, transferrin, 17 beta-estradiol, dexamethasone, triiodothyronine, prostaglandin F2 alpha, and fibronectin (HBCA medium) to support the continuous growth and passage of five human breast carcinoma cell lines on a collagen matrix. Doubling times of the cell...

journal_title：Cancer research

authors： Calvo F,Brower M,Carney DN

更新日期：1984-10-01 00:00:00

abstract：:A putative tumor suppressor gene, p53, has been shown to be altered in a variety of human tumor types. The primary mechanism of p53 inactivation is believed to be mutation of one allele followed by loss of the second allele. Malignant mesothelioma is a tumor that has been highly associated with exposure to asbestos fi...

journal_title：Cancer research

authors： Cote RJ,Jhanwar SC,Novick S,Pellicer A

更新日期：1991-10-01 00:00:00