SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion.

abstract：:We have studied the effects of tamoxifen on the cell cycle kinetics of the endocrine-responsive MCF-7 human breast cancer cells. Tamoxifen inhibits proliferation of MCF-7 cells. The tritiated thymidine labeling index is markedly reduced by tamoxifen, indicating a reduction in the fraction of cells in S phase. Flow cyt...

journal_title：Cancer research

authors： Osborne CK,Boldt DH,Clark GM,Trent JM

更新日期：1983-08-01 00:00:00

abstract：:Neurofibromatosis type 2 (NF2) is a dominantly inherited cancer disorder caused by mutations at the NF2 gene locus. Merlin, the protein product of the NF2 gene, has been shown to negatively regulate Rac1 signaling by inhibiting its downstream effector kinases, the p21-activated kinases (Pak). Given the implication of ...

journal_title：Cancer research

authors： Yi C,Wilker EW,Yaffe MB,Stemmer-Rachamimov A,Kissil JL

更新日期：2008-10-01 00:00:00

abstract：:In vivo 31P nuclear magnetic resonance spectroscopy was used to examine the bioenergetics of the rat 9L gliosarcoma during untreated growth and in response to chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Tumor growth was associated with a decline in the phosphocreatine and nucleoside triphosphate resonances...

journal_title：Cancer research

authors： Steen RG,Tamargo RJ,McGovern KA,Rajan SS,Brem H,Wehrle JP,Glickson JD

更新日期：1988-02-01 00:00:00

abstract：:Carcinoma cells can transition from an epithelial-to-mesenchymal differentiation state through a process known as epithelial-mesenchymal transition (EMT). The process of EMT is characterized by alterations in the pattern of gene expression and is associated with a loss of cell polarity, an increase in invasiveness, an...

journal_title：Cancer research

authors： Bogachek MV,De Andrade JP,Weigel RJ

更新日期：2015-01-01 00:00:00

abstract：:There is a preclinical evidence that the oral administration of d,l-sulforaphane (SFN) can decrease the incidence or burden of early-stage prostate cancer [prostatic intraepithelial neoplasia (PIN)] and well-differentiated cancer (WDC) but not late-stage poorly differentiated cancer (PDC). Because SFN treatment induce...

journal_title：Cancer research

authors： Vyas AR,Hahm ER,Arlotti JA,Watkins S,Stolz DB,Desai D,Amin S,Singh SV

更新日期：2013-10-01 00:00:00

abstract：:Pemetrexed is a novel antifolate effective in the treatment of mesothelioma. Studies were undertaken to characterize the transport of this antifolate in this tumor. We report the presence of a novel, concentrative high-affinity transport activity in three human mesothelioma cell lines, characterized in detail in the N...

journal_title：Cancer research

authors： Wang Y,Zhao R,Chattopadhyay S,Goldman ID

更新日期：2002-11-15 00:00:00

abstract：:The mechanism of wasting, as it occurs in malignant diseases and various etiologically unrelated conditions, is still poorly understood. We have, therefore, studied putative cause/effect relationships in a murine model of cancer cachexia, C57BL/6 mice bearing the fibrosarcoma MCA-105. The plasma of these mice showed d...

journal_title：Cancer research

authors： Ushmorov A,Hack V,Dröge W

更新日期：1999-07-15 00:00:00

abstract：:A variety of heterologous mammalian cells were inoculated into nude mice and scored for tumorigenicity. The cells tested were from primary cell cultures, established cell lines of neoplastic origin, established cell lines of nontumor origin, and primary cell cultures transformed by oncogenic viruses. Regardless of the...

journal_title：Cancer research

authors： Stiles CD,Desmond W,Chuman LM,Sato G,Saier MH

更新日期：1976-04-01 00:00:00

abstract：:Genetically engineered mouse (GEM) models of lung tumorigenesis allow careful evaluation of lung tumor initiation, progression, and response to therapy. Using GEM models of oncogene-induced lung cancer, we show the striking similarity of the earliest stages of tumorigenesis induced by KRAS(G12D) or BRAF(V600E). Cre-me...

journal_title：Cancer research

authors： Trejo CL,Juan J,Vicent S,Sweet-Cordero A,McMahon M

更新日期：2012-06-15 00:00:00

abstract：:Studies involving transcriptomics have revealed multiple molecular subtypes of hepatocellular carcinoma (HCC). Positron emission tomography/computed tomography (PET/CT) has also identified distinct molecular imaging subtypes, including those with increased and decreased choline metabolism as measured by the tissue upt...

journal_title：Cancer research

authors： Kwee SA,Tiirikainen M,Sato MM,Acoba JD,Wei R,Jia W,Le Marchand L,Wong LL

更新日期：2019-04-01 00:00:00

abstract：:Antigens in human adult feces related to carcinoembryonic antigen (CEA) were analyzed with respect to their molecular masses, CEA domain compositions, and N-terminal amino acid sequences. By avoiding perchloric acid treatment, new fecal antigens related to CEA were identified. The fecal antigens revealed by Western bl...

journal_title：Cancer research

authors： Henslee JG,Vachula EJ,Paxton RJ,Matias MS,Shively JE,Rittenhouse HG,Tomita JT

更新日期：1992-08-01 00:00:00

abstract：:DNA of invasive ductal carcinomas from five women was analyzed for structural alterations in the purine nucleotides using gas chromatography-mass spectrometry with selected ion monitoring. The results were compared to those for a normal DNA control. The carcinoma DNA showed dramatically higher concentrations of the ba...

journal_title：Cancer research

authors： Malins DC,Haimanot R

更新日期：1991-10-01 00:00:00

abstract：:Immunohistochemical localization of CA 125 using murine monoclonal antibody OC 125 was performed on fresh frozen tissue from 44 endometrial adenocarcinomas and 26 benign endometria. Immunohistochemical evaluation incorporated both intensity and distribution of staining (CA 125 HSCORE). Thirty-seven cancers (84%) and 2...

journal_title：Cancer research

authors： Berchuck A,Soisson AP,Clarke-Pearson DL,Soper JT,Boyer CM,Kinney RB,McCarty KS Jr,Bast RC Jr

更新日期：1989-04-15 00:00:00

abstract：:Aberrant crypt foci (ACF) are microscopic lesions which have been postulated to precede the development of adenomatous polyps, the precursors to colorectal cancer. APC and ras gene mutations have been shown to be important early molecular events in the development of colorectal neoplasms. The objective of this study w...

journal_title：Cancer research

authors： Smith AJ,Stern HS,Penner M,Hay K,Mitri A,Bapat BV,Gallinger S

更新日期：1994-11-01 00:00:00

abstract：:5,6-Dimethylxanthenone-4-acetic acid (DMXAA) and combretastatin A4 phosphate (CA-4-P) markedly inhibit tumor blood flow in mice and are both currently in clinical trial. One of the challenges in clinical evaluation of antivascular agents is the monitoring of tumor blood flow inhibition in individual patients. This stu...

journal_title：Cancer research

authors： Siim BG,Laux WT,Rutland MD,Palmer BN,Wilson WR

更新日期：2000-08-15 00:00:00

abstract：:The immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Because of its lymphodepleting effects, chemotherapy has the potential to break this tol...

journal_title：Cancer research

authors： Park DS,Robertson-Tessi M,Luddy KA,Maini PK,Bonsall MB,Gatenby RA,Anderson ARA

更新日期：2019-10-15 00:00:00

abstract：:Exposure of mice to total body irradiation induces nuclear factor kappaB (NFkappaB) activation in a tissue-specific manner. In addition to the spleen, lymph nodes, and bone marrow, the tissues that exhibit NFkappaB activation now include the newly identified site of the intestinal epithelial cells. NFkappaB activated ...

journal_title：Cancer research

authors： Wang Y,Meng A,Lang H,Brown SA,Konopa JL,Kindy MS,Schmiedt RA,Thompson JS,Zhou D

更新日期：2004-09-01 00:00:00

abstract：:Resistance to anticancer therapeutics greatly affects the phenotypic and functional properties of tumor cells, but how chemoresistance contributes to the tumorigenic activities of cancer stem-like cells remains unclear. In this study, we found that a characteristic of cancer stem-like cells from chemoresistant tumors ...

journal_title：Cancer research

authors： Yamashina T,Baghdadi M,Yoneda A,Kinoshita I,Suzu S,Dosaka-Akita H,Jinushi M

更新日期：2014-05-15 00:00:00

abstract：:Because chronic intestinal inflammation is a risk factor for colorectal cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer susceptibility. Here, we report the association of 24 MBL2 single-nucleotide polymorphisms (SNP) and...

journal_title：Cancer research

authors： Zanetti KA,Haznadar M,Welsh JA,Robles AI,Ryan BM,McClary AC,Bowman ED,Goodman JE,Bernig T,Chanock SJ,Harris CC

更新日期：2012-03-15 00:00:00

abstract：:The effect of hydrocortisone on blood-borne tumor metastasis was studied in an i.v. inoculation experiment with Ehrlich hypotetraploid clone 1, Ehrlich hypotetraploid stock, and Ehrlich hyperdiploid stock tumors. The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced me...

journal_title：Cancer research

authors： Kodama M,Kodama T

更新日期：1975-04-01 00:00:00

abstract：:12-O-Tetradecanoylphorbol-13-acetate (TPA) is an effective comitogen in phytohemagglutinin-treated bovine lymphocytes. Concurrent addition of 10(-8) M TPA gives a greater than 6-fold increase in DNA synthesis over cultures treated with the lectin alone. The delayed addition of phorbol ester, relative to the start of t...

journal_title：Cancer research

authors： Kensler TW,Mueller GC

更新日期：1978-03-01 00:00:00

abstract：:Hypoxia is considered to be a major cause of tumor radioresistance. Reoxygenation of previously hypoxic areas after a priming dose of radiation is associated with an increase in tumor radiosensitivity. In a study of a hypoxic mammary carcinoma, 31P nuclear magnetic resonance spectra showed statistically significant in...

journal_title：Cancer research

authors： Koutcher JA,Alfieri AA,Devitt ML,Rhee JG,Kornblith AB,Mahmood U,Merchant TE,Cowburn D

更新日期：1992-09-01 00:00:00

abstract：:Nucleolar antigens of normal rat liver, regenerating liver, and Novikoff ascites hepatoma cells were transplanted in vitro from polyadenylic acid-containing messenger RNAs isolated from the respective tissues and immunoprecipitated with specific antinucleolar antibodies and Protein A. By two-dimensional gel electropho...

journal_title：Cancer research

authors： Satoh K,Busch H

更新日期：1983-05-01 00:00:00

abstract：:Solid tumors often contain poorly vascularized necrotic regions. In order to determine how such regions are formed within tumors and to identify substances which affect their formation, we have transformed nontumorigenic BALB/c 3T3 cells with an activated Ha-ras oncogene. Cells that were derived from independent clone...

journal_title：Cancer research

authors： Peretz D,Kimel N,Fujii DK,Neufeld G

更新日期：1993-01-01 00:00:00

abstract：:OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and ...

journal_title：Cancer research

authors： Curti BD,Kovacsovics-Bankowski M,Morris N,Walker E,Chisholm L,Floyd K,Walker J,Gonzalez I,Meeuwsen T,Fox BA,Moudgil T,Miller W,Haley D,Coffey T,Fisher B,Delanty-Miller L,Rymarchyk N,Kelly T,Crocenzi T,Bernstein E,

更新日期：2013-12-15 00:00:00

abstract：:SNS-032 is a potent inhibitor of cyclin-dependent kinases (Cdk) 2, 7, and 9 that regulate the cell cycle and transcription. Our studies in indolent primary chronic lymphocytic leukemia cells showed that SNS-032 inhibited transcription, diminished the antiapoptotic protein Mcl-1, and induced apoptosis. The present stud...

journal_title：Cancer research

authors： Chen R,Chubb S,Cheng T,Hawtin RE,Gandhi V,Plunkett W

更新日期：2010-08-15 00:00:00

abstract：:Cultured normal and malignant human lung cells were examined for their different sensitivities to the cytocidal action of nine antitumor and three non-antitumor agents. The malignant cells were killed preferentially at lower concentrations and in a shorter time with each antitumor agent, Adriamycin, neocarzinostatin, ...

journal_title：Cancer research

authors： Tsukeda H,Mizuno S,Nitta K

更新日期：1978-08-01 00:00:00

abstract：:Although the aromatase inhibitor anastrozole has been shown to be very effective in the treatment of hormone-dependent postmenopausal breast cancer, some patients with advanced disease will develop resistance to treatment. To investigate therapeutic strategies to overcome resistance to anastrozole treatment, we have u...

journal_title：Cancer research

authors： Macedo LF,Sabnis GJ,Goloubeva OG,Brodie A

更新日期：2008-05-01 00:00:00

abstract：:For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial cell marker, has remained elusive. Here, we used a combinatorial phage display-based approach ("epitope mapping") to select peptides binding to the original PAL-E antibo...

journal_title：Cancer research

authors： Jaalouk DE,Ozawa MG,Sun J,Lahdenranta J,Schlingemann RO,Pasqualini R,Arap W

更新日期：2007-10-15 00:00:00

abstract：:Epidemiological studies have shown a positive association of colon cancer with hyperlipidemia. Furthermore, signaling generated by peroxisome proliferator-activated receptor (PPAR) alpha and gamma ligands, suggested to be candidate tumor preventive agents, has been shown to lower serum triglyceride levels. In the pres...

journal_title：Cancer research

authors： Niho N,Takahashi M,Kitamura T,Shoji Y,Itoh M,Noda T,Sugimura T,Wakabayashi K

更新日期：2003-09-15 00:00:00