Abstract：
:DNA of invasive ductal carcinomas from five women was analyzed for structural alterations in the purine nucleotides using gas chromatography-mass spectrometry with selected ion monitoring. The results were compared to those for a normal DNA control. The carcinoma DNA showed dramatically higher concentrations of the base modifications 8-hydroxy-guanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine, and 8-hydroxyadenine. For example, the concentration of total identified base modifications represented a more than 9-fold increase over the control value. Base modifications of this type, which arise from radical-induced hydroxylation and cleavage reactions of the purine ring, likely play a major role in initiation and probably contribute to the further transformation of neoplastic cells in cancer of the female breast.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Malins DC,Haimanot Rsubject
Has Abstractpub_date
1991-10-01 00:00:00pages
5430-2issue
19eissn
0008-5472issn
1538-7445journal_volume
51pub_type
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