Abstract：
:With the publishing of the first complete whole genome of a human cancer and its paired normal, we have passed a key milestone in the cancer genome sequencing strategy. The generation of such data will, thanks to technical advances, soon become commonplace. As a significant number of proof-of-concept studies have been published, it is important to analyze now the likely implications of these data and how this information might frame cancer research in the near future. The diversity of genes mutated within individual tumor types, the most striking feature of all studies reported to date, challenges gene-centric models of tumorigenesis. Although cancer genome sequencing will revolutionize certain aspects of personalized care, the value of these studies in facilitating the development of new therapies, their primary goal, seems less promising. Most significantly, however, the cancer genome sequencing strategy, as currently applied, fails to characterize the most relevant genomic features of cancer-the mutational heterogeneity within individual tumors.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Fox EJ,Salk JJ,Loeb LAdoi
10.1158/0008-5472.CAN-09-1231subject
Has Abstractpub_date
2009-06-15 00:00:00pages
4948-50issue
12eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-09-1231journal_volume
69pub_type
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