Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer.

abstract：:Successful chemotherapy accounts for both tumor-related factors and host immune response. Compelling evidence suggests that some chemotherapeutic agents can induce an immunogenic type of cell death stimulating tumor-specific immunity. Here, we show that cyclophosphamide (CTX) exerts two types of actions relevant for t...

journal_title：Cancer research

authors： Schiavoni G,Sistigu A,Valentini M,Mattei F,Sestili P,Spadaro F,Sanchez M,Lorenzi S,D'Urso MT,Belardelli F,Gabriele L,Proietti E,Bracci L

更新日期：2011-02-01 00:00:00

abstract：:Chronic exposure to UV radiation (UVR), especially in the UVA (315-400 nm) and UVB (280-315 nm) spectrum of sunlight, is the major risk factor for the development of nonmelanoma skin cancer. UVR is a complete carcinogen, which both initiates and promotes carcinogenesis. We found that protein kinase C epsilon (PKCepsil...

journal_title：Cancer research

authors： Wheeler DL,Martin KE,Ness KJ,Li Y,Dreckschmidt NE,Wartman M,Ananthaswamy HN,Mitchell DL,Verma AK

更新日期：2004-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs, thought to be involved in physiologic and developmental processes by negatively regulating expression of target genes. We have previously reported frequent down-regulation of the let-7 miRNA family in lung cancers and, in the present study, assessed alteration in a panel of...

journal_title：Cancer research

authors： Hayashita Y,Osada H,Tatematsu Y,Yamada H,Yanagisawa K,Tomida S,Yatabe Y,Kawahara K,Sekido Y,Takahashi T

更新日期：2005-11-01 00:00:00

abstract：:The numbers of ultraviolet light (UV)-induced pyrimidine dimers in the DNA of neonatal BALB/c mouse skin were measured by assessing the sensitivity of the DNA to Micrococcus luteus UV endonuclease. Irradiation of neonatal BALB/c mice with FS40 sunlamps caused a dose-dependent induction of endonuclease-sensitive sites ...

journal_title：Cancer research

authors： Ananthaswamy HN,Fisher MS

更新日期：1981-05-01 00:00:00

abstract：:The potential to heighten the efficacy of antiangiogenic agents was explored in this study based on active targeting of tumor cells overexpressing the gonadotropin-releasing hormone receptor (GnRH-R). The rational design pursued focused on five analogues of a clinically established antiangiogenic compound (sunitinib),...

journal_title：Cancer research

authors： Argyros O,Karampelas T,Asvos X,Varela A,Sayyad N,Papakyriakou A,Davos CH,Tzakos AG,Fokas D,Tamvakopoulos C

更新日期：2016-03-01 00:00:00

abstract：:Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in breast cancer cell resistance to cytotoxic natural killer (NK) cells. A ...

journal_title：Cancer research

authors： Al Absi A,Wurzer H,Guerin C,Hoffmann C,Moreau F,Mao X,Brown-Clay J,Petrolli R,Casellas CP,Dieterle M,Thiery JP,Chouaib S,Berchem G,Janji B,Thomas C

更新日期：2018-10-01 00:00:00

abstract：:Estrogen-related receptor alpha (ERRalpha) was identified as a gene related to estrogen receptor alpha (ERalpha) and belongs to a class of nuclear orphan receptors. ERRalpha binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significa...

journal_title：Cancer research

authors： Suzuki T,Miki Y,Moriya T,Shimada N,Ishida T,Hirakawa H,Ohuchi N,Sasano H

更新日期：2004-07-01 00:00:00

abstract：:Testicular germ cell tumors (TGCT) are the most common solid tumors of 15- to 35-year-old men. TGCT patients are frequently cured with cytotoxic cisplatin-based therapy. However, TGCT patients refractory to cisplatin-based chemotherapy have a poor prognosis, as do those having a late relapse. Pluripotent embryonal car...

journal_title：Cancer research

authors： Beyrouthy MJ,Garner KM,Hever MP,Freemantle SJ,Eastman A,Dmitrovsky E,Spinella MJ

更新日期：2009-12-15 00:00:00

abstract：:The cytochrome P-450 in hepatic microsomes prepared from rats pretreated with hematoporphyrin derivative was shown to be rapidly destroyed in the presence of long-wave ultraviolet light. The photocatalytic destruction of the heme-protein was dependent on both the dose of ultraviolet light and of hematoporphyrin deriva...

journal_title：Cancer research

authors： Das M,Dixit R,Mukhtar H,Bickers DR

更新日期：1985-02-01 00:00:00

abstract：:The role of oxygen free radicals in the toxicity and antitumor effect of tumor necrosis factor was investigated in vivo. Treatment of non-tumor-bearing mice and mice bearing methylcholanthrene-induced sarcomas with bovine CuZn superoxide dismutase or recombinant human CuZn superoxide dismutase afforded significant pro...

journal_title：Cancer research

authors： Hauser GJ,McIntosh JK,Travis WD,Rosenberg SA

更新日期：1990-06-15 00:00:00

abstract：:A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analyzed its coding sequenc...

journal_title：Cancer research

authors： Resta N,Simone C,Mareni C,Montera M,Gentile M,Susca F,Gristina R,Pozzi S,Bertario L,Bufo P,Carlomagno N,Ingrosso M,Rossini FP,Tenconi R,Guanti G

更新日期：1998-11-01 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumor in children. Osteosarcoma patients who respond poorly to chemotherapy are at a higher risk of relapse and adverse outcome. Therefore, it was the aim of this study to identify prognostic factors at the time of diagnosis to characterize the genes predictive of poor su...

journal_title：Cancer research

authors： Mintz MB,Sowers R,Brown KM,Hilmer SC,Mazza B,Huvos AG,Meyers PA,Lafleur B,McDonough WS,Henry MM,Ramsey KE,Antonescu CR,Chen W,Healey JH,Daluski A,Berens ME,Macdonald TJ,Gorlick R,Stephan DA

更新日期：2005-03-01 00:00:00

abstract：:DNA-dependent RNA polymerase A (or 1) was purified from murine myeloma MOPC 21 by diethylaminoethyl Sephadex chromatography. Further separation from DNA polymerases, protein kinase and DNA endonuclease was accomplished by polyriboadenylate-Sepharose affinity chromatography followed by gradient centrifugation. Yields f...

journal_title：Cancer research

authors： Hall SH,Smuckler EA

更新日期：1976-03-01 00:00:00

abstract：:Ionizing radiation is a major tool for cancer treatment. The response of eukaryotic cells to ionizing radiation includes apoptosis, a process which requires activation of multiple genes. We sought to determine whether radiation-induced gene expression plays a role in radiation-induced apoptosis. We found Apo2 ligand (...

journal_title：Cancer research

authors： Gong B,Almasan A

更新日期：2000-10-15 00:00:00

abstract：:Regulation of the expression of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) has been investigated in a number of human lymphoblastoid cell lines. In a number of Mex- cell lines that do not express methyltransferase activity, CpG sequences in the mgmt gene were hypomethylated with respect to met...

journal_title：Cancer research

authors： Cairns-Smith S,Karran P

更新日期：1992-10-01 00:00:00

abstract：:A potent modifying locus of intestinal tumorigenesis in the mouse was recently identified as secretory phospholipase A2 (sPLA2). The human homologue of sPLA2 maps to chromosome 1p35, a region frequently lost in human tumors. To evaluate the possibility that sPLA2 was a tumor suppressor gene that was the target of the ...

journal_title：Cancer research

authors： Riggins GJ,Markowitz S,Wilson JK,Vogelstein B,Kinzler KW

更新日期：1995-11-15 00:00:00

abstract：:Epithelial to mesenchymal transition occurs during embryologic development to allow tissue remodeling and is proposed to be a key step in the metastasis of epithelial-derived tumors. The miR-200 family of microRNAs plays a major role in specifying the epithelial phenotype by preventing expression of the transcription ...

journal_title：Cancer research

authors： Bracken CP,Gregory PA,Kolesnikoff N,Bert AG,Wang J,Shannon MF,Goodall GJ

更新日期：2008-10-01 00:00:00

abstract：:The effects of taxol on antitubulin immunofluorescent staining patterns, cellular DNA content, and labeling with [3H]thymidine were measured for the taxol-sensitive HL60 and taxol-resistant K562 cell lines after exposures for 0, 4, 12, and 24 h. Taxol caused a relative increase in the fraction of 4C interphase and met...

journal_title：Cancer research

authors： Roberts JR,Allison DC,Donehower RC,Rowinsky EK

更新日期：1990-02-01 00:00:00

abstract：:The treatment of HL-60 promyelocytic leukemia cells with phorbol esters (12-O-tetradecanoylphorbol-13-acetate) results in the appearance of cell substrate adhesion and the release of a Mr 94,000 gelatin-degrading metalloprotease. The appearance of the metalloprotease in the culture medium directly correlates with the ...

journal_title：Cancer research

authors： Davis GE,Martin BM

更新日期：1990-02-15 00:00:00

abstract：:Forestomach papillomas and skin papillomas were induced very efficiently by a single dose administration of the chemical carcinogen methylnitrosourea (MNU) in transgenic mice (rasH2 line) carrying human hybrid c-Ha-ras genes, which encode the prototype p21 gene product. The incidence of forestomach papillomas was dose...

journal_title：Cancer research

authors： Ando K,Saitoh A,Hino O,Takahashi R,Kimura M,Katsuki M

更新日期：1992-02-15 00:00:00

abstract：:The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain we...

journal_title：Cancer research

authors： Lin EY,Pollard JW

更新日期：2007-06-01 00:00:00

abstract：:Cell suspensions derived from 2 specimens of normal human urothelium and 13 human transitional cell carcinomas were studied by discontinuous density gradient centrifugation. The histochemical and proliferative properties of the fractions were evaluated. In normal urothelium, DNA synthesis was restricted to a subpopula...

journal_title：Cancer research

authors： Mackillop WJ,Bizarri JP,Ward GK

更新日期：1985-09-01 00:00:00

abstract：:Suspensions of an oxygen-sensitive (MT-7) and of an oxygen-insensitive(M109) tumor cell line were injected i.v. into BALB/c mice. Exposure to 100% O2 after injection of the cells did not modify the initial arrest of either cell line in the lung. Exposure of animals given injections of MT-7 cells for 60 h to 100% oxyge...

journal_title：Cancer research

authors： Margaretten NC,Witschi H

更新日期：1988-05-15 00:00:00

abstract：:Twenty-eight patients with metastatic malignant melanoma received anti-p97 murine monoclonal antibody (96.5) infused over 2 h at doses between 1 and 20 mg coupled to either 2.5 or 5.0 mCi of 111In by the bifunctional chelating agent diethyltriaminepentaacetic acid. Clearance of 111In from plasma closely fit an open, o...

journal_title：Cancer research

authors： Rosenblum MG,Murray JL,Haynie TP,Glenn HJ,Jahns MF,Benjamin RS,Frincke JM,Carlo DJ,Hersh EM

更新日期：1985-05-01 00:00:00

abstract：:The tumor suppressor gene p53 regulates G1 checkpoint prior to the initiation of DNA synthesis, which can either induce G1 arrest or signal apoptosis. The involvement of p53 in apoptosis may also be related to its ability to down-regulate transcription of the bcl-2 gene. The bcl-2 gene product prevents most types of a...

journal_title：Cancer research

authors： Upadhyay S,Li G,Liu H,Chen YQ,Sarkar FH,Kim HR

更新日期：1995-10-15 00:00:00

abstract：:Increase in dietary fat intake has been reported to be associated with progression of hormone-dependent cancers. To explore its mechanism, we examined the effects of fatty acids on the growth of androgen-dependent SC-3 cells cloned from mouse mammary cancer (Shionogi carcinoma 115). Their androgen-dependent growth was...

journal_title：Cancer research

authors： Kasayama S,Koga M,Kouhara H,Sumitani S,Wada K,Kishimoto T,Sato B

更新日期：1994-12-15 00:00:00

abstract：:The rTSbeta protein has been hypothesized to synthesize signaling molecules that can down-regulate thymidylate synthase. These molecules share biological and chemical properties with acyl-homoserine lactones (AHL), suggesting some AHLs might act as rTS signaling mimics and down-regulate thymidylate synthase. We have d...

journal_title：Cancer research

authors： Dolnick R,Wu Q,Angelino NJ,Stephanie LV,Chow KC,Sufrin JR,Dolnick BJ

更新日期：2005-07-01 00:00:00

abstract：:Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular and clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2, 12, and 31, we stratified 77 primary CRC...

journal_title：Cancer research

authors： Whitehall VL,Wynter CV,Walsh MD,Simms LA,Purdie D,Pandeya N,Young J,Meltzer SJ,Leggett BA,Jass JR

更新日期：2002-11-01 00:00:00

abstract：:Epidemiological and animal studies suggest a role for calcium in the chemoprevention of colorectal neoplasia. This study was designed to investigate whether supplemental oral calcium has a suppressant effect on colonic mucosal ornithine decarboxylase (ODC) and tyrosine kinase activities in patients with adenomatous po...

journal_title：Cancer research

authors： Lans JI,Jaszewski R,Arlow FL,Tureaud J,Luk GD,Majumdar AP

更新日期：1991-07-01 00:00:00

abstract：:In female nude mice, epidermal growth factor (EGF) was present at a mean concentration of 42.8 +/- 16.9 (SD) ng/mg wet tissue in the submandibular gland and 0.28 +/- 0.13 ng/ml in the plasma. Sialoadenectomy (removal of the submandibular glands) decreased circulating EGF to undetectable levels (less than 0.1 ng/ml). T...

journal_title：Cancer research

authors： Tsutsumi O,Tsutsumi A,Oka T

更新日期：1987-09-01 00:00:00