Importance of epidermal growth factor in implantation and growth of mouse mammary tumor in female nude mice.

abstract：:Multifunctional cytokines play important and only partially defined roles in mammary tumor development and progression. Normal human mammary epithelia] cells (MECs) constitutively produce interleukin (IL) 6, IL8, and a nonsecreted form of tumor necrosis factor. MEC transformation by different oncogenes is frequently a...

journal_title：Cancer research

authors： Basolo F,Fiore L,Fontanini G,Conaldi PG,Calvo S,Falcone V,Toniolo A

更新日期：1996-07-01 00:00:00

abstract：:The structural features of the free prostate-specific antigen (F-PSA) present in human blood have not been clarified up to now, and it is, therefore, not known why F-PSA is not complexed by the protease inhibitors that are present in human blood in large amounts. This lack of information is mainly attributable to the ...

journal_title：Cancer research

authors： Peter J,Unverzagt C,Krogh TN,Vorm O,Hoesel W

更新日期：2001-02-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) functions primarily as an inhibitory neurotransmitter in the mature central nervous system, and GABA/GABA receptors are also present in nonneural tissues, including cancer, but their precise function in nonneuronal or cancerous cells has thus far been poorly defined. Through the genome-w...

journal_title：Cancer research

authors： Takehara A,Hosokawa M,Eguchi H,Ohigashi H,Ishikawa O,Nakamura Y,Nakagawa H

更新日期：2007-10-15 00:00:00

abstract：:Batracylin (8-aminoisoindolo [1,2-b]quinazolin-10(12H)-one; NSC320846) is an investigational clinical anticancer agent. Previous animal studies showed activity against solid tumors and Adriamycin-resistant leukemia. We initially sought to test the proposed Top2-mediated DNA cleavage activity of batracylin and identify...

journal_title：Cancer research

authors： Rao VA,Agama K,Holbeck S,Pommier Y

更新日期：2007-10-15 00:00:00

abstract：:Clinical and pathological studies of cutaneous T-cell lymphomas (CTCL) reveal variations in tumor cell morphology and surface membrane phenotype that are of diagnostic and prognostic importance. Our study investigates blastic transformation and surface antigen change on CTCL cells in vitro under the influence of tumor...

journal_title：Cancer research

authors： Kadin ME,Nasu K,Sako D,Su IJ

更新日期：1984-08-01 00:00:00

abstract：:Immunity to infectious agents involves a coordinated response of innate and adaptive immune cells working in concert, with many feed-forward and regulatory interactions between both arms of the immune system. In contrast, many therapeutic strategies to augment immunity against tumors have focused predominantly on stim...

journal_title：Cancer research

authors： Moynihan KD,Irvine DJ

更新日期：2017-10-01 00:00:00

abstract：:The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, a major barrier imposed on tumor cells early in tumorigenesis. MYC is a key factor in suppression of RAS/BRAF(V600E)-induced senescence in vitro. However, it is still unclear whether MYC has the same rol...

journal_title：Cancer research

authors： Tabor V,Bocci M,Alikhani N,Kuiper R,Larsson LG

更新日期：2014-08-15 00:00:00

abstract：:Murine sarcoma virus (Moloney strain) (MSV-M)-induced tumors are unusual in that they regularly appear less than 2 weeks after virus inoculation, progress for 1 to 2 weeks, and are rejected by normal adult BALB/c mice. Rejectio leaves the animals immune to tumor induction. In the present study, presensitization of nor...

journal_title：Cancer research

authors： Wood GW

更新日期：1976-12-01 00:00:00

abstract：:Antibodies were produced against 220,000-molecular-weight proteins of Syrian hamster embryo cells. The antiserum containing these antibodies is capable of immunologically staining the surfaces and a fibrillar network around untransformed Syrian hamster embryo cells. The staining is removed by adsorption of the antiser...

journal_title：Cancer research

authors： Clarke SM,Fink LM

更新日期：1977-09-01 00:00:00

abstract：:We evaluated whether treatment of orthotopic human prostate cancer in nude mice with pegylated IFN-alpha-2b (PEG-IFN-alpha-2b) and docetaxel could represent a two-compartment targeting of primary tumor (tumor cells and tumor-associated endothelial cells) and inhibition of regional lymph node metastasis. The antiangiog...

journal_title：Cancer research

authors： Huang SF,Kim SJ,Lee AT,Karashima T,Bucana C,Kedar D,Sweeney P,Mian B,Fan D,Shepherd D,Fidler IJ,Dinney CP,Killion JJ

更新日期：2002-10-15 00:00:00

abstract：:It had been shown previously that the ribonucleotide reductase from mouse tumor consisted of two nonidentical components (Tris and dye fractions, each prepared from the 20 to 40% (NH/)2SO4 protein fraction containing the ribonucleotide reductase activity by blue dextran-Sepharose chromatography). The individual compon...

journal_title：Cancer research

authors： Cory JG,Fleischer AE

更新日期：1979-11-01 00:00:00

abstract：:High expression of VEGFC predicts adverse prognosis in acute myeloid leukemia (AML). We therefore explored VEGFC-targeting efficacy as an AML therapy using a VEGFC mAb. VEGFC antibody therapy enforced myelocytic differentiation of clonal CD34+ AML blasts. Treatment of CD34+ AML blasts with the antibody reduced expansi...

journal_title：Cancer research

authors： Kampen KR,Scherpen FJG,Mahmud H,Ter Elst A,Mulder AB,Guryev V,Verhagen HJMP,De Keersmaecker K,Smit L,Kornblau SM,De Bont ESJM

更新日期：2018-10-15 00:00:00

abstract：:The idea of using oncolytic viruses for the treatment of cancers was proposed a century ago. During the last two decades, viruses able to replicate specifically in cancer cells and to induce their lysis were identified and were genetically modified to improve their viro-oncolytic properties. More recently, a new appro...

journal_title：Cancer research

authors： Gillet L,Dewals B,Farnir F,de Leval L,Vanderplasschen A

更新日期：2005-10-15 00:00:00

abstract：:Pyrazine diazohydroxide (PZDH) is a novel antineoplastic agent that appears to form DNA adducts via the reactive pyrazine diazonium ion and produces substantial antitumor activity in preclinical models. We conducted a phase I trial to determine the maximally tolerated dose of PZDH that could be administered as a 5-min...

journal_title：Cancer research

authors： Vogelzang NJ,Mick R,Janisch L,Berezin F,Schilsky RL,Ratain MJ

更新日期：1994-01-01 00:00:00

abstract：:Hereditary renal carcinoma (RC) in the rat, originally reported by Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. We previously reported that ionizing radiation induces additional tumors in a linear dose-response relationship, suggesting that in heter...

journal_title：Cancer research

authors： Kubo Y,Mitani H,Hino O

更新日期：1994-05-15 00:00:00

abstract：:The effect of Adriamycin on the invasive capacity of rat ascites hepatoma cells, W1, was studied. The invasive capacity of W1 cells was estimated in vitro by counting the number of penetrated single tumor cells and tumor cell colonies formed from the penetrated cells underneath a cultured mesothelial cell monolayer (H...

journal_title：Cancer research

authors： Imamura F,Horai T,Mukai M,Shinkai K,Akedo H

更新日期：1990-04-01 00:00:00

abstract：:A new double-label histochemical method is described which permits accurate quantitation of macrophage recruitment into neoplastic lesions in situ. Intratumoral macrophages are identified by their capacity to ingest colloidal iron particles from the interstitial fluid. Since colloidal iron is retained in a stable form...

journal_title：Cancer research

authors： Bugelski PJ,Kirsh RL,Poste G

更新日期：1983-11-01 00:00:00

abstract：:The long latency period of cancer would suggest that timely measures to reduce the risk of cancer, such as dietary guidelines to the public, be an integral component of policy on cancer. Although criteria for acceptability of scientific evidence are often defined, judgment its required in interpreting the significance...

journal_title：Cancer research

authors： Palmer S

更新日期：1983-05-01 00:00:00

abstract：:Heteroantisera were produced in rabbits by immunization with cultivated cells from rat intestinal carcinomas. The sera were made specific by in vivo absorption in syngeneic rats. On immunofluorescence, these sera recognized a membrane-associated antigen common to five different intestinal carcinomas and to fetal intes...

journal_title：Cancer research

authors： Martin F,Knobel S,Martin M,Bordes M

更新日期：1975-02-01 00:00:00

abstract：:In vitro cell-mediated cytotoxicity (CMC) assays have been carried out in human melanoma system with blood effector lymphocytes on [3H]proline-labeled target cells in a 48-hr microcytotoxicity technique. Three lymphocyte purification procedures (Ficoll:Hypaque gradient, plasma gel sedimentation followed by nylon colum...

journal_title：Cancer research

authors： Mukherji B,Vassos D,Flowers A,Binder SC,Nathanson L

更新日期：1975-12-01 00:00:00

abstract：:Metronomic chemotherapy refers to the close, regular administration of comparatively low doses of cytotoxic drugs, with minimal or no drug-free breaks, over prolonged periods. It is thought to have an antiangiogenic basis. However, whereas surprisingly durable and potent tumor responses have been observed in a number ...

journal_title：Cancer research

authors： Shaked Y,Emmenegger U,Francia G,Chen L,Lee CR,Man S,Paraghamian A,Ben-David Y,Kerbel RS

更新日期：2005-08-15 00:00:00

abstract：:The nonhistone chromosomal protein, high mobility group 1 (HMG1), which is ubiquitously expressed in higher eukaryotic cells, preferentially binds to cisplatin-modified DNA. The observation that HMG1 is overexpressed in cisplatin-resistant human cancer cells suggests that cisplatin resistance may be closely associated...

journal_title：Cancer research

authors： Nagatani G,Nomoto M,Takano H,Ise T,Kato K,Imamura T,Izumi H,Makishima K,Kohno K

更新日期：2001-02-15 00:00:00

abstract：:Because of its relatively indolent clinical course, chronic lymphocytic leukemia (CLL) offers a versatile model for testing novel therapeutic regimens and drug combinations. Nicotinamide is the main NAD(+) precursor and a direct inhibitor of four classes of enzymes, including the sirtuins. SIRT1, the main member of th...

journal_title：Cancer research

authors： Audrito V,Vaisitti T,Rossi D,Gottardi D,D'Arena G,Laurenti L,Gaidano G,Malavasi F,Deaglio S

更新日期：2011-07-01 00:00:00

abstract：:The thymidylate synthase inhibitor 5-fluorouracil (5-FU) continues to play a pivotal role in the treatment of cancer. A downstream event of thymidylate synthase inhibition involves the induction of a self-defeating base excision repair process. With the depletion of TTP pools, there is also an increase in dUMP. Metabo...

journal_title：Cancer research

authors： Fischer JA,Muller-Weeks S,Caradonna SJ

更新日期：2006-09-01 00:00:00

abstract：:Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRβ has been identified as a key player of this process and is considered a promising target for bre...

journal_title：Cancer research

authors： D'Ippolito E,Plantamura I,Bongiovanni L,Casalini P,Baroni S,Piovan C,Orlandi R,Gualeni AV,Gloghini A,Rossini A,Cresta S,Tessari A,De Braud F,Di Leva G,Tripodo C,Iorio MV

更新日期：2016-09-15 00:00:00

abstract：:The adhesion molecules E-selectin (ELAM-1) and P-selectin (GMP-140/CD62) recognize the carbohydrate motives sialyl-Le(x), sialyl-diLe(x), or sialyl-Lea, though with different affinity. We found that the melanoma cell line NKI-4 bound to E-selectin, but not to P-selectin. This melanoma cell line did not express sialyl-...

journal_title：Cancer research

authors： Kunzendorf U,Krüger-Krasagakes S,Notter M,Hock H,Walz G,Diamantstein T

更新日期：1994-02-15 00:00:00

abstract：:We developed a novel orthotopic mouse tumor model of renal cell carcinoma to collect and characterize cells spontaneously shed from SN12C (renal cell carcinoma) and SN12L1 (high metastatic variant of SN12C) tumors grown in kidneys of severe combined immunodeficient mice. Viability of the shed cell population was great...

journal_title：Cancer research

authors： Bockhorn M,Roberge S,Sousa C,Jain RK,Munn LL

更新日期：2004-04-01 00:00:00

abstract：:In an effort to achieve high concentrations of 5-fluorouracil (5-FUra) in the hepatic circulation while minimizing systemic exposure, several routes of intrahepatic administration were compared in the canine model. To ascertain these data, 5-FUra (30 mg/kg) was given as a bolus into either a systemic vein (femoral vei...

journal_title：Cancer research

authors： Didolkar MS,Covell DG,Jackson AJ,Walker AP,Kalidindi SR

更新日期：1984-11-01 00:00:00

abstract：:A mouse IgG2a monoclonal antibody, SWA20, defining a tumor-associated cell surface antigen on small cell carcinoma of the lung (SCC) was generated. The reactivity of the antibody with cell lines was examined by indirect immunofluorescence staining and solid phase radioimmunoassay and the reactivity with tissues by imm...

journal_title：Cancer research

authors： Waibel R,O'Hara CJ,Smith A,Stahel RA

更新日期：1988-08-01 00:00:00

abstract：:Brain tumors such as medulloblastoma (MB) and glioblastoma multiforme (GBM) can derive from neural precursors. For instance, many MBs are thought to arise from the uncontrolled proliferation of cerebellar granule neuron precursors (GNP). GNPs normally proliferate in early postnatal stages in mice but then they become ...

journal_title：Cancer research

authors： Tatard VM,Xiang C,Biegel JA,Dahmane N

更新日期：2010-02-01 00:00:00