Distinctive phorbol ester-induced morphological and surface antigen changes in mycosis fungoides, the Sézary syndrome, and adult T-cell leukemia.

abstract：:Enhanced glucose and lipid metabolism is one of the most common properties of malignant cells. ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate. To evaluate its role in lung cancer progression, we here analyzed ACLY expression in ...

journal_title：Cancer research

authors： Migita T,Narita T,Nomura K,Miyagi E,Inazuka F,Matsuura M,Ushijima M,Mashima T,Seimiya H,Satoh Y,Okumura S,Nakagawa K,Ishikawa Y

更新日期：2008-10-15 00:00:00

abstract：:Nitromidazole and nitrofuran derivatives comprise a large family of compounds, some of which have been shown to be hypoxic cell specific radiosensitizers in vivo and in vitro. The effects of metronidazole (2-methyl-5-nitroimidazole-1-ethanol) and nitrofurazone (5-nitro-2-furaldehyde semicarbazone) were studied on cell...

journal_title：Cancer research

authors： Mohindra JK,Rauth AM

更新日期：1976-03-01 00:00:00

abstract：:Phosphorylation of heat shock protein 27 (HSP27) has been suggested to play an important role in the regulation of F-actin dynamics in response to growth factors and stress. Because the microfilament network is one of the earliest targets of oxidative stress and because phosphorylation of HSP27 is strongly induced by ...

journal_title：Cancer research

authors： Huot J,Houle F,Spitz DR,Landry J

更新日期：1996-01-15 00:00:00

abstract：:The human papillomavirus (HPV) 16 E7 oncoprotein has been reported previously to stimulate DNA damage and to activate host cell DNA damage checkpoints. How HPV-16 E7 maintains proliferation despite activated DNA damage checkpoints is incompletely understood. Here, we provide evidence that cells expressing the HPV-16 E...

journal_title：Cancer research

authors： Spardy N,Covella K,Cha E,Hoskins EE,Wells SI,Duensing A,Duensing S

更新日期：2009-09-01 00:00:00

abstract：:Purines were long thought to be restricted to the intracellular compartment, where they are used for energy transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions. However, it is now clear that both adenosine and adenosine triphosphate are (i) abundant biochemical components of the tumor mic...

journal_title：Cancer research

authors： Di Virgilio F

更新日期：2012-11-01 00:00:00

abstract：:An animal lectin purified from loach (Misgurnus anguillicaudatus) eggs induced release of cytotoxin from fresh bone marrow cells from mice, although the other lectins tested, wheat germ agglutinin, concanavalin A, and phytohemagglutinin did not. The cytotoxin released from bone marrow cells was a heat-labile protein w...

journal_title：Cancer research

authors： Okutomi T,Nakajima Y,Sakakibara F,Kawauchi H,Yamazaki M

更新日期：1987-01-01 00:00:00

abstract：:The development of myeloid and lymphoid neoplasms related to overexpression of FGFR1 kinases as a result of chromosome translocations depends on the promotion of a stem cell phenotype, suppression of terminal differentiation, and resistance to apoptosis. These phenotypes are related to the stem cell leukemia/lymphoma ...

journal_title：Cancer research

authors： Hu T,Chong Y,Lu S,Wang R,Qin H,Silva J,Kitamura E,Chang CS,Hawthorn L,Cowell JK

更新日期：2018-07-01 00:00:00

abstract：:One hundred seven Chinese patients with primary hepatocellular carcinoma (PHC) were compared with 107 hospital controls for the presence of hepatitis B surface antigen and smoking, drinking, and dietary habits. Eighty-two % of PHC cases were hepatitis B surface antigen positive compared to 18% of controls (relative ri...

journal_title：Cancer research

authors： Lam KC,Yu MC,Leung JW,Henderson BE

更新日期：1982-12-01 00:00:00

abstract：:Copy number alterations are crucial for the development of colorectal cancer. Our whole-genome analysis identified tocopherol alpha transfer protein-like (TTPAL) as preferentially amplified in colorectal cancer. Here we demonstrate that frequent copy number gain of TTPAL leads to gene overexpression in colorectal canc...

journal_title：Cancer research

authors： Gou H,Liang JQ,Zhang L,Chen H,Zhang Y,Li R,Wang X,Ji J,Tong JH,To KF,Sung JJY,Chan FKL,Fang JY,Yu J

更新日期：2019-07-01 00:00:00

abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) is a master transcription factor that is critical for the regulation of a variety of cellular functions. HIF-1alpha is rapidly degraded under normoxic conditions by ubiquitin-mediated proteasome pathway controlled by the tumor suppressor von Hippel Lindau (VHL). Several rec...

journal_title：Cancer research

authors： Zhang D,Li J,Costa M,Gao J,Huang C

更新日期：2010-01-15 00:00:00

abstract：:An estrogen receptor immunocytochemical assay which uses monoclonal antibodies to the estrogen receptor protein [Nature (Lond.), 307: 745-747, 1984] was applied to several human tissues, including human breast tumors, and the results were compared to those of steroid-binding assays performed on cytosol extracts of the...

journal_title：Cancer research

authors： King WJ,DeSombre ER,Jensen EV,Greene GL

更新日期：1985-01-01 00:00:00

abstract：:There are many animal models of glioma, but few that represent the biology of low-grade tumors and allow the study of the genetic mechanisms of glial oncogenesis. We report the in vivo transformation of astrocytic cells in transgenic mice by the SV40 T antigen under the control of the 5'-flanking sequence of the murin...

journal_title：Cancer research

authors： Danks RA,Orian JM,Gonzales MF,Tan SS,Alexander B,Mikoshiba K,Kaye AH

更新日期：1995-10-01 00:00:00

abstract：:When SV40 tumor cells (F5-1) in culture were treated with dibutyryl cyclic adenylic acid (DbcAMP),marked alterations occurred in their growth and morphology. Additionally, the incorporation or uptake of labeled thymidine, uridine, phenylalanine, and choline were reduced by this treatment. These modifications with DbcA...

journal_title：Cancer research

authors： Hannon WH,Anderson NG,Coggin JH Jr

更新日期：1976-09-01 00:00:00

abstract：:Topotecan, a water-soluble semisynthetic analogue of camptothecin, is the first topoisomerase I inhibitor to undergo evaluation in pediatric patients with refractory malignancies. A phase I and pharmacokinetic study was performed to determine the maximum tolerated dose (MTD) and dose-limiting toxicities, the incidence...

journal_title：Cancer research

authors： Blaney SM,Balis FM,Cole DE,Craig C,Reid JM,Ames MM,Krailo M,Reaman G,Hammond D,Poplack DG

更新日期：1993-03-01 00:00:00

abstract：:Bisphosphonates are widely used clinically to treat bone diseases in which bone resorption is in excess. However, the mechanism of bisphosphonate action on bone is not fully understood. Studies of direct action of bisphosphonates on bone have been limited mainly to their effects on bone-resorbing osteoclast cells, wit...

journal_title：Cancer research

authors： Reinholz GG,Getz B,Pederson L,Sanders ES,Subramaniam M,Ingle JN,Spelsberg TC

更新日期：2000-11-01 00:00:00

abstract：:Ovarian and testicular tumors were induced in the offspring (F1 generation) of MRC rats that received single or multiple doses of N-nitrosobis(2-oxopropyl)amine on the 14th, 18th, and/or 20th days of pregnancy. The ovarian tumor incidence was significantly higher (46%) in the F1 generation exposed to the carcinogen a ...

journal_title：Cancer research

authors： Pour PM

更新日期：1986-08-01 00:00:00

abstract：:Chinese hamster V-79 cells were treated with high cytotoxic or low noncytotoxic concentrations of the highly carcinogenic and mutagenic (-)-(1R,2S,3S,4R)-3,4-dihydroxy-1, 2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene [(-)-B[c]PhDE; fjord-region diol epoxide] or its biologically less active (+)-(1S,2R,3R,4S) enantiome...

journal_title：Cancer research

authors： Wei SJ,Chang RL,Cui XX,Merkler KA,Wong CQ,Yagi H,Jerina DM,Conney AH

更新日期：1996-08-15 00:00:00

abstract：:Thioguanine and mercaptopurine are prodrugs requiring conversion into thiopurine nucleotides to exert cytotoxicity. Thiopurine S-methyltransferase (TPMT), an enzyme subject to genetic polymorphism, catabolizes thiopurines into inactive methylated bases, but also produces methylthioguanine nucleotides and methylmercapt...

journal_title：Cancer research

authors： Dervieux T,Blanco JG,Krynetski EY,Vanin EF,Roussel MF,Relling MV

更新日期：2001-08-01 00:00:00

abstract：:Dipeptidyl peptidase IV (DPPIV/CD26) is a multifunctional cell surface aminopeptidase that is widely expressed in different cell types. Our previous study demonstrated a possible link between DPPIV expression and decreased i.p. dissemination and loss of invasive potential of ovarian carcinoma. In this report, we exami...

journal_title：Cancer research

authors： Kajiyama H,Kikkawa F,Khin E,Shibata K,Ino K,Mizutani S

更新日期：2003-05-01 00:00:00

abstract：:Vigorous activity after diagnosis was recently reported to be inversely associated with prostate cancer-specific mortality. However, men with metastatic disease may decrease their activity due to their disease; thus, a causal interpretation is uncertain. We therefore prospectively examined vigorous activity and brisk ...

journal_title：Cancer research

authors： Richman EL,Kenfield SA,Stampfer MJ,Paciorek A,Carroll PR,Chan JM

更新日期：2011-06-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) functions as a tumor suppressor of the prostate through mechanisms that remain unresolved. Although TGF-beta receptors directly activate both Smads 2 and 3, to date, Smad3 has been shown to be the essential mediator of most Smad-dependent TGF-beta responses, including control...

journal_title：Cancer research

authors： Yang J,Wahdan-Alaswad R,Danielpour D

更新日期：2009-03-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major adult liver cancers. The existence of combined hepatocellular-cholangiocarcinoma (CHC), a histopathologic intermediate form between HCC and CC, suggests phenotypic overlap between these tumors. Here, we applied an integrative oncogenomic approach...

journal_title：Cancer research

authors： Woo HG,Lee JH,Yoon JH,Kim CY,Lee HS,Jang JJ,Yi NJ,Suh KS,Lee KU,Park ES,Thorgeirsson SS,Kim YJ

更新日期：2010-04-15 00:00:00

abstract：:The effects of single agent therapy with 1-(-chloroethyl)-3-cyclohexyl-1-nitrosourea, 5-fluorouracil, and 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide on a human malignant melanoma transplanted and passed serially in thymusless nude mouse were studied. Tumor response varied. A single dose of 1-(-chloroethyl)-3-...

journal_title：Cancer research

authors： Povlsen CO,Jacobsen GK

更新日期：1975-10-01 00:00:00

abstract：:We have analyzed the Fas-mediated death pathway in a panel of 11 Epstein-Barr virus (EBV)-negative and 10 EBV-positive Burkitt's lymphoma (BL) cell lines. We show that the increased expression of Fas in EBV-positive cell lines is mediated via LMP-1. Four of the 21 BL cell lines are readily responsive to Fas-mediated c...

journal_title：Cancer research

authors： Gutiérrez MI,Cherney B,Hussain A,Mostowski H,Tosato G,Magrath I,Bhatia K

更新日期：1999-02-01 00:00:00

abstract：:Most squamous cell carcinomas of the head and neck (HNSCC) overexpress ERBB1/EGFR, but EGF receptor (EGFR)-targeted therapies have yielded disappointing clinical results in treatment of this cancer. Here, we describe a novel interaction between EGFR and the ligand EphrinB1 (EFNB1), and we show that EFNB1 phosphorylati...

journal_title：Cancer research

authors： Vermeer PD,Colbert PL,Wieking BG,Vermeer DW,Lee JH

更新日期：2013-09-15 00:00:00

abstract：:Migration from the primary tumor is a crucial step in the metastatic cascade. Cells with various degrees of adhesion and motility migrate and are launched into the bloodstream as single circulating tumor cells (CTC) or multicellular CTC clusters. The frequency and size distributions of these clusters have been recentl...

journal_title：Cancer research

authors： Bocci F,Kumar Jolly M,Onuchic JN

更新日期：2019-11-01 00:00:00

abstract：:The human colon cancer cell line HCT does not express any detectable HLA class I antigens on the cell surface. RNA blot analyses showed that HCT cells synthesize easily detectable levels of heavy chains as well as beta 2-microglobulin (beta 2m) transcripts. Experiments of immunoprecipitation revealed the presence of i...

journal_title：Cancer research

authors： Gattoni-Celli S,Kirsch K,Timpane R,Isselbacher KJ

更新日期：1992-03-01 00:00:00

abstract：:The growth-inhibitory effect of 6-methylmercaptopurine riboside (MMPR) against leukemia L1210 cells in culture was dramatically potentiated by the addition of guanine nucleosides to the medium. In the presence of either deoxyguanosine or guanosine, the concentration of MMPR that caused 50% inhibition of growth was 35 ...

journal_title：Cancer research

authors： Grindey GB,Lowe JK,Divekar AY,Hakala MT

更新日期：1976-02-01 00:00:00

abstract：:Modern cancer therapy/care involves the integration of basic, clinical, and population-based research professionals using state-of-the-art science to achieve the best possible patient outcomes. A well-integrated team of basic, clinical, and population science professionals and educators working with a fully engaged gr...

journal_title：Cancer research

authors： Welch DR,Antalis TM,Burnstein K,Vona-Davis L,Jensen RA,Nakshatri H,Riegel AT,Spitz DR,Watson DK,Weiner GJ,Cancer Biology Training Consortium.

更新日期：2015-12-15 00:00:00

abstract：:Muscle-invasive bladder cancer (MIBC) generally responds poorly to treatment and tends to exhibit significant mortality. Here we show that expression of the tumor suppressor p14ARF (ARF) is upregulated in aggressive subtypes of MIBC. Accumulation of ARF in the nucleolus is associated with poor outcome and attenuated r...

journal_title：Cancer research

authors： Owczarek TB,Kobayashi T,Ramirez R,Rong L,Puzio-Kuter AM,Iyer G,Teo MY,Sánchez-Vega F,Wang J,Schultz N,Zheng T,Solit DB,Al-Ahmadie HA,Abate-Shen C

更新日期：2017-02-15 00:00:00