Chemotherapy of a human malignant melanoma transplanted in the nude mouse.

abstract：:The purpose of this study was to investigate the immunobiological characteristics of the tumor-specific cell surface antigen expressed by the UV-induced murine fibrosarcoma, UV-2240. UV-2240 is classified as a regressor UV tumor because it is immunologically rejected by normal syngeneic mice but grows in immunocomprom...

journal_title：Cancer research

authors： Simcik WJ,Kripke ML,Sheu TL,LeGrue SJ

更新日期：1988-12-15 00:00:00

abstract：:A series of 152 human bladder tumors, 14 bladder tumor cell lines, and 1 immortal urothelial cell line were examined by single-strand conformation polymorphism (SSCP) and designed restriction fragment.length polymorphism analyses for mutations in exons 1 and 2 of the H-ras gene. Nine tumors (6%) contained mutations. T...

journal_title：Cancer research

authors： Knowles MA,Williamson M

更新日期：1993-01-01 00:00:00

abstract：:The breakpoint of t(11;14)(q23;q32) chromosome translocation in a B-cell lymphoma line, RC-K8, was cloned. Immunoglobulin heavy chain (IGH) constant gene, C gamma 2 at the 5' end, was involved in this translocation, and the DNA segment juxtaposed to the C gamma 2 was proved to be derived from chromosome 11 by somatic ...

journal_title：Cancer research

authors： Akao Y,Seto M,Takahashi T,Kubonishi I,Miyoshi I,Nakazawa S,Tsujimoto Y,Croce CM,Ueda R

更新日期：1991-03-01 00:00:00

abstract：:The receptor-interacting protein kinase 1 (RIPK1) is an essential signaling molecule in pathways for cell survival, apoptosis, and necroptosis. We report here that RIPK1 is upregulated in human colorectal cancer and promotes cell proliferation when overexpressed in a colon cancer cell line. RIPK1 interacts with mitoch...

journal_title：Cancer research

authors： Zeng F,Chen X,Cui W,Wen W,Lu F,Sun X,Ma D,Yuan Y,Li Z,Hou N,Zhao H,Bi X,Zhao J,Zhou J,Zhang Y,Xiao RP,Cai J,Zhang X

更新日期：2018-06-01 00:00:00

abstract：:The c-Fes protein-tyrosine kinase exhibits strong expression in myeloid hematopoietic cells. Previous studies have shown that Fes induces differentiation in the chronic myelogenous leukemia-derived cell line K-562, suggesting that the Fes signal for differentiation is dominant to the Bcr-Abl signal for transformation ...

journal_title：Cancer research

authors： Lionberger JM,Smithgall TE

更新日期：2000-02-15 00:00:00

abstract：:Preexisting and acquired resistance to epidermal growth factor receptor (EGFR) inhibitors limits their clinical usefulness in patients with advanced non-small cell lung cancer (NSCLC). This study characterizes the efficacy and mechanisms of the combination of gefitinib or erlotinib with OSU-03012, a celecoxib-derived ...

journal_title：Cancer research

authors： Wang YC,Kulp SK,Wang D,Yang CC,Sargeant AM,Hung JH,Kashida Y,Yamaguchi M,Chang GD,Chen CS

更新日期：2008-04-15 00:00:00

abstract：:Elimination of both alleles of the gene that encodes the cyclin kinase inhibitor p21(WAF1/cip1) increases the frequency and size of intestinal tumors in Apc1638+/- mice that inherit a mutant allele of the Apc gene, and intermediate effects are seen if a single p21 allele is inactivated. The increased tumor formation i...

journal_title：Cancer research

authors： Yang WC,Mathew J,Velcich A,Edelmann W,Kucherlapati R,Lipkin M,Yang K,Augenlicht LH

更新日期：2001-01-15 00:00:00

abstract：:The N-glucuronidation of three carcinogenic aromatic amines (4-aminobiphenyl, alpha-naphthylamine, and beta-naphthylamine) was investigated in hepatic microsomal preparations from two rat strains. In preparations from Wistar rats, individual variability was observed for the glucuronidation of the arylamines. This vari...

journal_title：Cancer research

authors： Green MD,Tephly TR

更新日期：1987-04-15 00:00:00

abstract：:We recently identified the immunoglobulin-CAM CD155/PVR (the poliovirus receptor) as a regulator of cancer invasiveness and glioma migration, but the mechanism through which CD155/PVR controls these processes is unknown. Here, we show that expression of CD155/PVR in rat glioma cells that normally lack this protein enh...

journal_title：Cancer research

authors： Sloan KE,Stewart JK,Treloar AF,Matthews RT,Jay DG

更新日期：2005-12-01 00:00:00

abstract：:The effect of a number of steroids, growth factors, and peptides on aromatase activity in two estrogen receptor positive breast cancer cell lines (MCF7 and T47D) was investigated. The cells were incubated in Dulbecco's minimum essential medium containing phenol red and 10% fetal calf serum. Pronounced differences in b...

journal_title：Cancer research

authors： Ryde CM,Nicholls JE,Dowsett M

更新日期：1992-03-15 00:00:00

abstract：:Gastric and intestinal phenotypic expression in 37 surgically obtained primary signet ring cell carcinomas, five of their metastases to lymph nodes, and three signet ring cell carcinomas transplanted into nude mice were determined by biochemical, mucin, histochemical, and ultrastructural studies. Crude extracts of can...

journal_title：Cancer research

authors： Tatematsu M,Furihata C,Katsuyama T,Miki K,Honda H,Konishi Y,Ito N

更新日期：1986-09-01 00:00:00

abstract：:It is anticipated that this report will serve as a nucleus for stimulating meaningful studies of the biology of prostate cancer. Such studies will be essential for the control and ultimately the prevention of prostate cancer. The present focus was arrived at by consensus of an expert panel on prostate cancer. It is no...

journal_title：Cancer research

authors： Chiarodo A

更新日期：1991-05-01 00:00:00

abstract：:Human and mouse paralogues of the evolutionarily conserved mammalian HRAD9 and Mrad9 cell cycle checkpoint control genes have been isolated and called HRAD9B and Mrad9B, respectively. HRAD9B encodes a protein that is 414 amino acids long and is 55% similar and 35% identical to the HRAD9 gene product. The Mrad9B protei...

journal_title：Cancer research

authors： Hopkins KM,Wang X,Berlin A,Hang H,Thaker HM,Lieberman HB

更新日期：2003-09-01 00:00:00

abstract：:About two thirds of laryngeal cancers originate at the vocal cords. Early-stage detection of malignant vocal fold alterations, including a discrimination of premalignant lesions, represents a major challenge in laryngology as precancerous vocal fold lesions and small carcinomas are difficult to distinguish by means of...

journal_title：Cancer research

authors： Unger J,Lohscheller J,Reiter M,Eder K,Betz CS,Schuster M

更新日期：2015-01-01 00:00:00

abstract：:Medulloblastoma is frequently disseminated throughout the central nervous system by the time of diagnosis. Conventional therapeutic approaches have not reduced the high mortality associated with metastatic medulloblastoma and little is known regarding the molecular mechanisms that promote tumor invasion. Previously, w...

journal_title：Cancer research

authors： Hernan R,Fasheh R,Calabrese C,Frank AJ,Maclean KH,Allard D,Barraclough R,Gilbertson RJ

更新日期：2003-01-01 00:00:00

abstract：:Tissue phytosterol and cholesterol levels in 10 benign and 8 malignant breast tumors were quantitated to reexamine the hypothesis that malignant tumors had distinctive phytosterol content. Phytosterols were present in 9 of 10 benign and 7 of 8 malignant breast tumors. Mean (+/- S.E.) cholesterol, campesterol, stigmast...

journal_title：Cancer research

authors： Mellies MJ,Ishikawa TT,Glueck CJ,Crissman JD

更新日期：1977-09-01 00:00:00

abstract：:The detection of high-grade bladder tumors prior to invasion is crucial for a good prognosis. We recently found that the levels of hyaluronic acid (HA), a glycosaminoglycan, are elevated in the urine of bladder cancer patients, and small angiogenic HA fragments are present in the urine of high-grade bladder cancer pat...

journal_title：Cancer research

authors： Pham HT,Block NL,Lokeshwar VB

更新日期：1997-02-15 00:00:00

abstract：:The prodrug of 9-beta-D-arabinosylguanine (ara-G), nelarabine, demonstrated efficacy against T-cell acute lymphoblastic leukemia, and its effectiveness correlated with the accumulation of the triphosphate form (ara-GTP). Although in vitro investigations using purified deoxycytidine kinase (dCK) or deoxyguanosine kinas...

journal_title：Cancer research

authors： Rodriguez CO Jr,Mitchell BS,Ayres M,Eriksson S,Gandhi V

更新日期：2002-06-01 00:00:00

abstract：:Alterations in mitochondrial DNA (mtDNA) were once thought to be predominantly innocuous to cell growth. Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations and polymorphisms, which profoundly affect the cells in which they appear and contribute to a variety of diseases, in...

journal_title：Cancer research

authors： Bussard KM,Siracusa LD

更新日期：2017-11-15 00:00:00

abstract：:ABBV-075 is a potent and selective BET family bromodomain inhibitor that recently entered phase I clinical trials. Comprehensive preclinical characterization of ABBV-075 demonstrated broad activity across cell lines and tumor models, representing a variety of hematologic malignancies and solid tumor indications. In mo...

journal_title：Cancer research

authors： Bui MH,Lin X,Albert DH,Li L,Lam LT,Faivre EJ,Warder SE,Huang X,Wilcox D,Donawho CK,Sheppard GS,Wang L,Fidanze S,Pratt JK,Liu D,Hasvold L,Uziel T,Lu X,Kohlhapp F,Fang G,Elmore SW,Rosenberg SH,McDaniel KF,Kati

更新日期：2017-06-01 00:00:00

abstract：:Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system. We now show that this factor is also expressed in the lung, where it localizes in adults to a discrete population of tracheobronchial basal cells. To target the mouse gene, the first exon wa...

journal_title：Cancer research

authors： Tian J,Mahmood R,Hnasko R,Locker J

更新日期：2006-11-01 00:00:00

abstract：:Neuroblastomas are extremely aggressive, although heterogeneous, cancers with a poor prognosis upon metastasis. Some evidence has suggested a correlative silencing of caspase-8 with MYCN amplification in neuroblastoma. A prognostic effect of this silencing, however, has been disputed. We report here hitherto undescrib...

journal_title：Cancer research

authors： Finlay D,Vuori K

更新日期：2007-12-15 00:00:00

abstract：:Chromatin modification is pivotal to the epithelial-mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was inc...

journal_title：Cancer research

authors： He X,Yan B,Liu S,Jia J,Lai W,Xin X,Tang CE,Luo D,Tan T,Jiang Y,Shi Y,Liu Y,Xiao D,Chen L,Liu S,Mao C,Yin G,Cheng Y,Fan J,Cao Y,Muegge K,Tao Y

更新日期：2016-10-01 00:00:00

abstract：:Genetic instability, a hallmark feature of human cancers including prostatic adenocarcinomas, is considered a driver of metastasis. Somatic copy number alterations (CNA) are found in most aggressive primary human prostate cancers, and the overall number of such changes is increased in metastases. Chromosome 10q23 dele...

journal_title：Cancer research

authors： Hubbard GK,Mutton LN,Khalili M,McMullin RP,Hicks JL,Bianchi-Frias D,Horn LA,Kulac I,Moubarek MS,Nelson PS,Yegnasubramanian S,De Marzo AM,Bieberich CJ

更新日期：2016-01-15 00:00:00

abstract：:Tumor-derived cell lines are used as in vitro cancer models, but their ability to accurately reflect the phenotype and genotype of the parental histology remains questionable, given the prevalence of documented cell line-specific cytogenetic changes. We have addressed the issue of whether copy number alterations seen ...

journal_title：Cancer research

authors： Greshock J,Nathanson K,Martin AM,Zhang L,Coukos G,Weber BL,Zaks TZ

更新日期：2007-04-15 00:00:00

abstract：:The reactivities of two anti-bladder cancer monoclonal antibodies, AN43 and BB369, were characterized. AN43 and BB369 reacted with a majority (greater than 50%) of bladder cancer tissue sections tested by immunoperoxidase staining. When tested against a panel of 27 normal human tissues, AN43 and BB369 reacted only wit...

journal_title：Cancer research

authors： Liebert M,Wedemeyer GA,Stein JA,Washington RW Jr,Flint A,Ren LQ,Grossman HB

更新日期：1989-12-01 00:00:00

abstract：:In this study, we identified 53 aberrantly hypermethylated DNA sequences in adult T-cell leukemia (ATL) cells using methylated CpG island amplification/representational difference analysis method. We also observed a proportionate increase in the methylation density of these regions with disease progression. Seven gene...

journal_title：Cancer research

authors： Yasunaga J,Taniguchi Y,Nosaka K,Yoshida M,Satou Y,Sakai T,Mitsuya H,Matsuoka M

更新日期：2004-09-01 00:00:00

abstract：:DNA, isolated from two samples of human liver obtained from a suspected dimethylnitrosamine poisoning, contained 1363 to 1373 micromol of 7-methylguanine per mol of guanine and 273 to 317 micromol of O6-methylguanine per mol of guanine. Liver and kidney DNA obtained from unrelated cases contained no detectable methyla...

journal_title：Cancer research

authors： Herron DC,Shank RC

更新日期：1980-09-01 00:00:00

abstract：:The MAGE-1 gene codes for a tumor-specific antigen, MZ2-E, that elicited a cytotoxic T-lymphocyte response in the melanoma patient from whom it was derived. We have developed a simplified method, using polymerase chain reaction amplification of exon 3 followed by restriction enzyme pattern analysis, to distinguish exp...

journal_title：Cancer research

authors： Zakut R,Topalian SL,Kawakami Y,Mancini M,Eliyahu S,Rosenberg SA

更新日期：1993-01-01 00:00:00

abstract：:It is widely accepted that a major role of matrix metalloproteinases in the metastatic process is degradation of basement membrane during cancer cell invasion. We tested the hypothesis that the reduction in metastatic potential which has been demonstrated for B16F10 melanoma cells genetically engineered to overexpress...

journal_title：Cancer research

authors： Koop S,Khokha R,Schmidt EE,MacDonald IC,Morris VL,Chambers AF,Groom AC

更新日期：1994-09-01 00:00:00