Beta 2-microglobulin gene is mutated in a human colon cancer cell line (HCT) deficient in the expression of HLA class I antigens on the cell surface.

abstract：:We evaluated whether antibody response correlates with tumor therapy by cytokine gene-modified tumor cell vaccines. To characterize the antibody (Ab) response against a known antigen, colon carcinoma C26 cells and C26 variants engineered to produce interleukin (IL) 12 or IL-4 were further transduced to express the hum...

journal_title：Cancer research

authors： Rodolfo M,Melani C,Zilocchi C,Cappetti B,Luison E,Arioli I,Parenza M,Canevari S,Colombo MP

更新日期：1998-12-15 00:00:00

abstract：:The receptor Notch1 plays an important role in malignant progression of many cancers, but its regulation is not fully understood. In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7-dependent proteasomal degradation of Notch1 by phosphorylating its intracellular domain (Notch1-IC) w...

journal_title：Cancer research

authors： Ann EJ,Kim MY,Yoon JH,Ahn JS,Jo EH,Lee HJ,Lee HW,Kang HG,Choi DW,Chun KH,Lee JS,Choi CY,Ferrando AA,Lee K,Park HS

更新日期：2016-08-15 00:00:00

abstract：:The structure and distribution of microfilaments were examined by electron microscopy in uninfected normal rat kidney (NRK) cells, murine sarcoma virus (MSV)-transformed NRK cells, and NRK cells infected with a cold-sensitive transformation mutant of MSV, i.e., NRK (MSV-1b) cells, grown at both permissive (39 degrees)...

journal_title：Cancer research

authors： Altenburg BC,Somers K,Steiner S

更新日期：1976-01-01 00:00:00

abstract：:Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c+ myeloid cells. IL1β production is triggered by cancer cell membrane-derived TGFβ. Neutralizing TG...

journal_title：Cancer research

authors： Wu TC,Xu K,Martinek J,Young RR,Banchereau R,George J,Turner J,Kim KI,Zurawski S,Wang X,Blankenship D,Brookes HM,Marches F,Obermoser G,Lavecchio E,Levin MK,Bae S,Chung CH,Smith JL,Cepika AM,Oxley KL,Snipes GJ,B

更新日期：2018-09-15 00:00:00

abstract：:Microarray gene expression profiling is a powerful tool for generating molecular cancer classifications. However, elucidating biological insights from these large data sets has been challenging. Previously, we identified a gene expression-based classification of primary uveal melanomas that accurately predicts metasta...

journal_title：Cancer research

authors： Onken MD,Ehlers JP,Worley LA,Makita J,Yokota Y,Harbour JW

更新日期：2006-05-01 00:00:00

abstract：:Kinase inhibitors are used widely to treat various cancers, but adaptive reprogramming of kinase cascades and activation of feedback loop mechanisms often contribute to therapeutic resistance. Determining comprehensive, accurate maps of kinase circuits may therefore help elucidate mechanisms of response and resistance...

journal_title：Cancer research

authors： Olow A,Chen Z,Niedner RH,Wolf DM,Yau C,Pankov A,Lee EP,Brown-Swigart L,van 't Veer LJ,Coppé JP

更新日期：2016-04-01 00:00:00

abstract：:In an effort to achieve high concentrations of 5-fluorouracil (5-FUra) in the hepatic circulation while minimizing systemic exposure, several routes of intrahepatic administration were compared in the canine model. To ascertain these data, 5-FUra (30 mg/kg) was given as a bolus into either a systemic vein (femoral vei...

journal_title：Cancer research

authors： Didolkar MS,Covell DG,Jackson AJ,Walker AP,Kalidindi SR

更新日期：1984-11-01 00:00:00

abstract：:Hydroxyurea (HU) inhibited DNA synthesis in the livers of partially hepatectomized rats. After an i.v. infusion of HU begun in the late G1 phase and continued for periods of up to 30 hr, all hepatocytes scheduled to embark on DNA synthesis in a characteristic intralobular sequence during this time interval accumulated...

journal_title：Cancer research

authors： Rabes HM,Iseler G,Czichos S,Tuczek HV

更新日期：1977-04-01 00:00:00

abstract：:Recent studies of murine tumor models and certain human tumor cell lines have provided evidence for intratumor heterogeneity in expression of extracellular matrix receptors and in the elaboration of matrix-degrading enzymes. However, little is known about possible intratumoral heterogeneity in the production of matrix...

journal_title：Cancer research

authors： Crouch EC,Stone KR,Bloch M,McDivitt RW

更新日期：1987-11-15 00:00:00

abstract：:Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the tumor suppressor phosphatase and tensin homologue deleted from chromosome 10 or activating mutations of p110-alpha. These hotspot mutations result in oncogenic activity of the enzyme and cont...

journal_title：Cancer research

authors： Serra V,Markman B,Scaltriti M,Eichhorn PJ,Valero V,Guzman M,Botero ML,Llonch E,Atzori F,Di Cosimo S,Maira M,Garcia-Echeverria C,Parra JL,Arribas J,Baselga J

更新日期：2008-10-01 00:00:00

abstract：:There is no effective treatment for prostate cancer arising after androgen ablation. Previous studies have analyzed the short-term effects of androgen ablation on the immune system and suggest an abatement of immune suppression by hormone removal. Because castration-resistant disease can arise years after treatment, i...

journal_title：Cancer research

authors： Akins EJ,Moore ML,Tang S,Willingham MC,Tooze JA,Dubey P

更新日期：2010-05-01 00:00:00

abstract：:Successful antiestrogen treatment in patients with tamoxifen-responsive breast tumors is often followed by an outgrowth of tumors cells that are antiestrogen resistant, implying that estrogen-dependent tumors can become estrogen-independent. In an effect to mimic this progression, we have transfected fibroblast growth...

journal_title：Cancer research

authors： McLeskey SW,Kurebayashi J,Honig SF,Zwiebel J,Lippman ME,Dickson RB,Kern FG

更新日期：1993-05-01 00:00:00

abstract：:Complementary DNA (cDNA)-oligodeoxythmidylate-celluloses were prepared from cDNA copies of polysomal messenger RNA (mRNA) of Novikoff hepatoma, normal rat liver, and regenerating rat liver. cDNA synthesis with reverse transcriptase was approximately 46% with respect to input mRNA with oligodeoxythymidylate-cellulose p...

journal_title：Cancer research

authors： Hirsch FW,Nall KN,Hayes LC,Raju KS,Spohn WH,Busch H

更新日期：1977-10-01 00:00:00

abstract：:Eighty-five antibodies recognizing breast cancer-selective antigens were conjugated to ricin toxin A-chain using a disulfide linkage. The cytotoxicities of the resulting immunotoxins were determined on breast cancer cells and normal human fibroblasts. Twenty-four antibodies formed immunotoxins that were toxic to at le...

journal_title：Cancer research

authors： Bjorn MJ,Ring D,Frankel A

更新日期：1985-03-01 00:00:00

abstract：:To determine whether infection with a Helicobacter pylori strain possessing cagA is associated with an increased risk of development of adenocarcinoma of the stomach, we used a nested case-control study based on a cohort of 5443 Japanese-American men in Oahu, Hawaii, who had a physical examination and a phlebotomy dur...

journal_title：Cancer research

authors： Blaser MJ,Perez-Perez GI,Kleanthous H,Cover TL,Peek RM,Chyou PH,Stemmermann GN,Nomura A

更新日期：1995-05-15 00:00:00

abstract：:Intravesical mitomycin C (MMC) therapy is used to treat superficial bladder cancer. This study was to establish the intra- and intersubject variabilities in the systemic (plasma) and target site (bladder) exposure to the drug and to identify the factors which contribute to these variabilities. The pharmacokinetics of ...

journal_title：Cancer research

authors： Dalton JT,Wientjes MG,Badalament RA,Drago JR,Au JL

更新日期：1991-10-01 00:00:00

abstract：:Colon carcinoma cells overexpress c-myc due to defective Wnt signaling, but only patients whose tumors have an amplified c-myc gene show improved disease-free and overall survival in response to 5-fluoruracil (5FU). Here we show that in two colon carcinoma cell lines that do not have an amplified c-myc gene but differ...

journal_title：Cancer research

authors： Arango D,Corner GA,Wadler S,Catalano PJ,Augenlicht LH

更新日期：2001-06-15 00:00:00

abstract：:A molecular target associated with the progression of gastric cancer has not yet been uncovered. FBXW7 is a tumor suppressor gene transcriptionally controlled by p53 that plays a role in the regulation of cell cycle exit and reentry via c-Myc degradation. Few studies have addressed the clinical significance of FBXW7 e...

journal_title：Cancer research

authors： Yokobori T,Mimori K,Iwatsuki M,Ishii H,Onoyama I,Fukagawa T,Kuwano H,Nakayama KI,Mori M

更新日期：2009-05-01 00:00:00

abstract：:alphaVbeta3 integrin complexes are overexpressed in the growing, invading margins of human glioblastoma multiforme (GBM) and in the GBM vasculature, suggesting a key role for alphaVbeta3 in GBM growth and invasion. The function of alphaVbeta3 complexes in tumor formation, however, has been challenged by studies showin...

journal_title：Cancer research

authors： Kanamori M,Vanden Berg SR,Bergers G,Berger MS,Pieper RO

更新日期：2004-04-15 00:00:00

abstract：:The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains poor despite decades of effort. The abundant extracellular matrix (ECM) in PDAC comprises a major fraction of the tumor mass and plays various roles in promoting resistance to therapies. However, nonselective depletion of ECM has led to poor patient out...

journal_title：Cancer research

authors： Tian C,Öhlund D,Rickelt S,Lidström T,Huang Y,Hao L,Zhao RT,Franklin O,Bhatia SN,Tuveson DA,Hynes RO

更新日期：2020-04-01 00:00:00

abstract：:Toll-like receptors (TLR) expressed on inflammatory cells play a key role in host defense against pathogens, benefiting the host. TLR are also expressed on tumor cells. To evaluate the role of TLR in tumor cells, we investigated TLR4 signaling effects on human head and neck squamous cell carcinoma (HNSCC). Tumor tissu...

journal_title：Cancer research

authors： Szczepanski MJ,Czystowska M,Szajnik M,Harasymczuk M,Boyiadzis M,Kruk-Zagajewska A,Szyfter W,Zeromski J,Whiteside TL

更新日期：2009-04-01 00:00:00

abstract：:Plasma levels of luteinizing hormone, sex hormone binding globulin, and antithrombin III were measured in pre- and postmenopausal breast cancer patients receiving adjuvant combination chemotherapy or combination chemotherapy and long-term tamoxifen therapy. The aim was to determine the estrogen-like effects of tamoxif...

journal_title：Cancer research

authors： Jordan VC,Fritz NF,Tormey DC

更新日期：1987-08-15 00:00:00

abstract：:Systemic cisplatin-based chemotherapy cures > or =90% of patients with metastatic germ cell tumors (GCTs). The biological basis of this exquisite chemo-sensitivity and the resistant phenotype encountered in 10-15% of patients with GCT is yet unclear. A defective mismatch repair pathway leading to microsatellite instab...

journal_title：Cancer research

authors： Mayer F,Gillis AJ,Dinjens W,Oosterhuis JW,Bokemeyer C,Looijenga LH

更新日期：2002-05-15 00:00:00

abstract：:Cancer-associated retinopathy (CAR) is an ocular manifestation of a paraneoplastic syndrome whereby immunological reactions to retinal antigens aberrantly expressed in tumor cells lead to the degeneration of retinal photoreceptor cells. In our previous study (H. Ohguro et al., Invest. Ophthalmol. Vis. Sci., 40: 82-89,...

journal_title：Cancer research

authors： Maeda A,Ohguro H,Maeda T,Wada I,Sato N,Kuroki Y,Nakagawa T

更新日期：2000-04-01 00:00:00

abstract：:Melanoma is a disease characterized by lesions that activate ERK. Although 70% of cutaneous melanomas harbor activating mutations in the BRAF and NRAS genes, the alterations that drive tumor progression in the remaining 30% are largely undefined. Vemurafenib, a selective inhibitor of RAF kinases, has clinical utility ...

journal_title：Cancer research

authors： Nissan MH,Pratilas CA,Jones AM,Ramirez R,Won H,Liu C,Tiwari S,Kong L,Hanrahan AJ,Yao Z,Merghoub T,Ribas A,Chapman PB,Yaeger R,Taylor BS,Schultz N,Berger MF,Rosen N,Solit DB

更新日期：2014-04-15 00:00:00

abstract：:Cell aggregation is frequently impaired during the growth of primary tumors and the formation of metastatic lesions. Cell aggregation depends on cell-cell adhesion; however, no rigorous approach exists to monitor and quantify it accurately in the absence of the confounding factors of cell-substrate adhesion and the re...

journal_title：Cancer research

authors： Saias L,Gomes A,Cazales M,Ducommun B,Lobjois V

更新日期：2015-06-15 00:00:00

abstract：:Dietary calcium may reduce the risk of colon cancer, probably by precipitating cytotoxic surfactants, such as secondary bile acids, in the colonic lumen. We previously showed that milk mineral, an important source of calcium, decreases metabolic risk factors and colonic proliferation in rats. We now report the effects...

journal_title：Cancer research

authors： Govers MJ,Termont DS,Lapré JA,Kleibeuker JH,Vonk RJ,Van der Meer R

更新日期：1996-07-15 00:00:00

abstract：:The influence of phorbol diesters on the in vitro hydrolysis of diacylglycerols was examined using enzymes from rat serum, porcine pancreas, and Rhizopus delemar. Two main phenomena were observed: 12-O-tetradecanoylphorbol-13-acetate (TPA), when added to the enzyme assay system, stimulated 2- to 3-fold the hydrolysis ...

journal_title：Cancer research

authors： Zhang ZC,Cabot MC

更新日期：1987-01-01 00:00:00

abstract：:Loss of hSNF5 function is usually observed in malignant rhabdoid tumor (MRT), a highly aggressive pediatric neoplasm. Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A), p21(CIP1/WAF1), and cyclin D1 playing key roles in MRT cell growth control. However...

journal_title：Cancer research

authors： Kuwahara Y,Charboneau A,Knudsen ES,Weissman BE

更新日期：2010-03-01 00:00:00

abstract：:The effects of vascular endothelial growth factor-A (VEGF-A/VEGF) and its receptors on endothelial cells function have been studied extensively, but their effects on tumor cells are less well defined. Studies of human colorectal cancer cells where the VEGF gene has been deleted suggest an intracellular role of VEGF as...

journal_title：Cancer research

authors： Bhattacharya R,Ye XC,Wang R,Ling X,McManus M,Fan F,Boulbes D,Ellis LM

更新日期：2016-05-15 00:00:00