Role of active oxygen species in the photodestruction of microsomal cytochrome P-450 and associated monooxygenases by hematoporphyrin derivative in rats.

abstract：:Procarbazine, a chemotherapeutic hydrazine, is thought to be metabolized to an alkylating species similar to methyl carbonium ion by multistep reactions involving cytochrome P-450, monoamine oxidase, and cytosolic enzymes. The DNA-damaging and cytotoxic potential of procarbazine and its metabolites in murine L1210 leu...

journal_title：Cancer research

authors： Erikson JM,Tweedie DJ,Ducore JM,Prough RA

更新日期：1989-01-01 00:00:00

abstract：:Extravasation of tumor cells is a pivotal step in metastasis formation. This step is initiated by an interaction of extravasating tumor cells with endothelial cells. Among the molecules mediating tumor-endothelium interactions are selectins and their fucosylated ligands. In a previous study, we demonstrated that the f...

journal_title：Cancer research

authors： Zipin A,Israeli-Amit M,Meshel T,Sagi-Assif O,Yron I,Lifshitz V,Bacharach E,Smorodinsky NI,Many A,Czernilofsky PA,Morton DL,Witz IP

更新日期：2004-09-15 00:00:00

abstract：:von Hippel-Lindau (VHL) disease results from germline and somatic mutations in the VHL tumor suppressor gene and is characterized by highly vascularized tumors. VHL mutations lead to stabilization of hypoxia-inducible factor (HIF), which up-regulates proangiogenic factors such as vascular endothelial growth factor (VE...

journal_title：Cancer research

authors： Champion KJ,Guinea M,Dammai V,Hsu T

更新日期：2008-06-15 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death for women in the United States. Of the different subtypes, estrogen receptor-negative (ER(-)) tumors, which are ErbB2+ or triple-negative, carry a relatively poor prognosis. In this study, we used system-wide analysis of breast cancer proteomes to identify prot...

journal_title：Cancer research

authors： Geiger T,Madden SF,Gallagher WM,Cox J,Mann M

更新日期：2012-05-01 00:00:00

abstract：:The homologous proteins p68 and p72 are members of the DEAD box family of RNA helicases. Here, we show that expression of both of these helicases strongly increases during the polyp-->adenoma-->adenocarcinoma transition in the colon. Furthermore, p68 and p72 form complexes with beta-catenin and promote the ability of ...

journal_title：Cancer research

authors： Shin S,Rossow KL,Grande JP,Janknecht R

更新日期：2007-08-15 00:00:00

abstract：:Recently, loss or inactivation of genes at specific chromosomal loci has been considered to be one of the important mechanisms during the development of human tumors. In order to identify tumor suppressor genes for gastric carcinoma, we performed restriction fragment length polymorphism analysis on 48 human gastric ca...

journal_title：Cancer research

authors： Sano T,Tsujino T,Yoshida K,Nakayama H,Haruma K,Ito H,Nakamura Y,Kajiyama G,Tahara E

更新日期：1991-06-01 00:00:00

abstract：:Based on reports that both human and murine lymphoblastoid cell lines can effect lysis in antibody-dependent (ADCC) and mitogen-induced (MICC) cell-mediated cytotoxicity, 10 human lymphoblastoid cell lines were investigated for their ability to act as effector cells in these lytic reactions. Four cell lines promoted M...

journal_title：Cancer research

authors： Jordan TF,Ferrone S,Pellegrino MA,Dennert G

更新日期：1978-11-01 00:00:00

abstract：:In Drosophila melanogaster, the wings apart-like (wapl) gene encodes a protein that regulates heterochromatin structure. Here, we characterize a novel human homologue of wapl (termed human WAPL; hWAPL). The hWAPL mRNA was predominantly expressed in uterine cervical cancer, with weak expression in all other normal and ...

journal_title：Cancer research

authors： Oikawa K,Ohbayashi T,Kiyono T,Nishi H,Isaka K,Umezawa A,Kuroda M,Mukai K

更新日期：2004-05-15 00:00:00

abstract：:The levels of serum thymic factor(s) (STF), of Thy-1.2 positivity of splenocytes [as measured by their azathioprine (AZ) sensitivity], and of Thy-1.2-positive "spontaneous" spleen rosette-forming cells (SSRFCs), as well as the presence of infectious virus in the thymus, were assessed as a function of time after virus ...

journal_title：Cancer research

authors： Tonietti G,Rossi GB,Del Gobbo V,Accinni L,Ranucci A,Titti F,Premrov MG,Garaci E

更新日期：1983-09-01 00:00:00

abstract：:Aryl hydrocarbon hydroxylase (AHH) and microsomal cytochromes were measured in tissues of human features aborted by prostaglandins. Cytochrome P-450 concentrations and AHH activity were about 4 times higher in adrenal glands than in liver. AHH was present in testes, ovaries, and vagina and uterus at levels equal to or...

journal_title：Cancer research

authors： Rifkind AB,Tseng L,Hirsch MB,Lauersen NH

更新日期：1978-06-01 00:00:00

abstract：:Mesothelioma is a unique and insidious tumor associated historically with occupational exposure to asbestos. The transcription factor, activator protein-1 (AP-1) is a major target of asbestos-induced signaling pathways. Here, we demonstrate that asbestos-induced mesothelial cell transformation is linked to increases i...

journal_title：Cancer research

authors： Ramos-Nino ME,Timblin CR,Mossman BT

更新日期：2002-11-01 00:00:00

abstract：:Sulindac is the most extensively investigated clinically relevant chemopreventive nonsteroidal anti-inflammatory drug. Sulindac sulfide is one of the major metabolites of sulindac that is believed to mediate its antitumorigenic effects by inducing apoptosis. Recent evidence suggests that sulindac sulfide engages the m...

journal_title：Cancer research

authors： Huang Y,He Q,Hillman MJ,Rong R,Sheikh MS

更新日期：2001-09-15 00:00:00

abstract：:Cell cycle arrest in G2 phase is a common response to a variety of DNA-damaging agents. The coupling between DNA damage and G2 arrest was studied in synchronized HeLa cells using camptothecin, a highly specific inhibitor of topoisomerase I that damages DNA through the formation of reversible topoisomerase I-DNA cleava...

journal_title：Cancer research

authors： Tsao YP,D'Arpa P,Liu LF

更新日期：1992-04-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] inhibited the secretion of gamma-interferon from human T-lymphocytes activated by the calcium ionophore, A23187, or phytohemagglutinin with or without 12-O-tetradecanoylphorbol-13-acetate. The agent also inhibited cell proliferation and interleukin 2 secretion by these cells. Th...

journal_title：Cancer research

authors： Matsui T,Takahashi R,Nakao Y,Koizumi T,Katakami Y,Mihara K,Sugiyama T,Fujita T

更新日期：1986-11-01 00:00:00

abstract：:Estrogen-related receptor alpha (ERRalpha) was identified as a gene related to estrogen receptor alpha (ERalpha) and belongs to a class of nuclear orphan receptors. ERRalpha binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significa...

journal_title：Cancer research

authors： Suzuki T,Miki Y,Moriya T,Shimada N,Ishida T,Hirakawa H,Ohuchi N,Sasano H

更新日期：2004-07-01 00:00:00

abstract：:We have previously described the neoplastic transformation of immortalized human bronchial epithelial cells (BEAS-2B) by the combination of the c-raf-1 and c-myc protooncogenes and the concomitant induction of neuron-specific enolase mRNA expression (A. Pfeifer et al., Proc. Natl. Acad. Sci. USA, 86: 10075-10079, 1989...

journal_title：Cancer research

authors： Pfeifer AM,Jones RT,Bowden PE,Mann D,Spillare E,Klein-Szanto AJ,Trump BF,Harris CC

更新日期：1991-07-15 00:00:00

abstract：:Coho salmon (Oncorhynchus kisutch) and chinook salmon (Oncorhynchus tshawytscha) from Lakes Ontario, Michigan, Erie, or Huron were found to suffer epizootics of thyroid hyperplasia and goiters which appeared to have an environmental etiology. There were 13-fold differences in goiter prevalence within the Great Lakes, ...

journal_title：Cancer research

authors： Moccia RD,Leatherland JF,Sonstegard RA

更新日期：1981-06-01 00:00:00

abstract：:The distribution of alkylated deoxynucleosides and bases has been determined in the DNA of a sensitive and a resistant human glioma-derived cell line exposed to therapeutic levels of [3H]N-(2-chloroethyl)-N-nitrosourea in vitro. The resistant cell line is 5-fold less sensitive to the cytotoxic effects of N-(2-chloroet...

journal_title：Cancer research

authors： Bodell WJ,Tokuda K,Ludlum DB

更新日期：1988-08-15 00:00:00

abstract：:The base excision repair protein MED1 (also known as MBD4), an interactor with the mismatch repair protein MLH1, has a central role in the maintenance of genomic stability with dual functions in DNA damage response and repair. MED1 acts as a thymine and uracil DNA N-glycosylase on T:G and U:G mismatches that occur at ...

journal_title：Cancer research

authors： Turner DP,Cortellino S,Schupp JE,Caretti E,Loh T,Kinsella TJ,Bellacosa A

更新日期：2006-08-01 00:00:00

abstract：:To test the hypothesis that genetic instability correlates with malignant potential, we compared the rate of generation of marker chromosomal abnormalities in clones of B16 F1 and B16 F10 murine melanoma. These rates were estimated through an adaptation of fluctuation analysis of Luria and Delbruck (S. E. Luria and M....

journal_title：Cancer research

authors： Kendal WS,Wang RY,Hsu TC,Frost P

更新日期：1987-07-15 00:00:00

abstract：:The A-240T and I/D polymorphisms in the angiotensin I-converting enzyme (ACE) gene are markers of circulating ACE levels and have been associated with numerous cardiovascular disease outcomes. More recently, the low-activity A and I alleles at these polymorphic sites have been inversely related with breast cancer risk...

journal_title：Cancer research

authors： Haiman CA,Henderson SO,Bretsky P,Kolonel LN,Henderson BE

更新日期：2003-10-15 00:00:00

abstract：:Deletion of the chromosome 5q [del(5q)] is one of the most common cytogenetic abnormalities observed in patients with de novo myelodysplastic syndromes (MDS) and therapy-related MDS or acute myeloid leukemia (t-MDS/tAML). Emerging evidence indicates that activation of the Wnt/β-catenin pathway contributes to the devel...

journal_title：Cancer research

authors： Li L,Sheng Y,Li W,Hu C,Mittal N,Tohyama K,Seba A,Zhao YY,Ozer H,Zhu T,Qian Z

更新日期：2017-08-01 00:00:00

abstract：:Immunophotodiagnosis uses a fluorescence-labeled monoclonal antibody (MAb) that recognizes a tumor-associated antigen to image the fluorescence emitted from the fluorophore-bound MAb that has localized in the tissue. It may be used to diagnose malignant or precancerous lesions, to delineate the margins for tumor resec...

journal_title：Cancer research

authors： Soukos NS,Hamblin MR,Keel S,Fabian RL,Deutsch TF,Hasan T

更新日期：2001-06-01 00:00:00

abstract：:Mitotic and labeling indices of bone marrow tumor cells were determined from patients with disseminated neuroblastoma. Although pretreatment values were variable, the median indices indicated that only a small proportion of tumor cells were proliferating. The pretreatment indices could not be correlated with presentin...

journal_title：Cancer research

authors： Hayes FA,Green AA,Mauer AM

更新日期：1977-10-01 00:00:00

abstract：:Patient-derived xenografts (PDX) are tumor-in-mouse models for cancer. PDX collections, such as the NCI PDXNet, are powerful resources for preclinical therapeutic testing. However, variations in experimental and analysis procedures have limited interpretability. To determine the robustness of PDX studies, the PDXNet t...

journal_title：Cancer research

authors： Evrard YA,Srivastava A,Randjelovic J,Doroshow JH,Dean DA 2nd,Morris JS,Chuang JH,NCI PDXNet Consortium.

更新日期：2020-06-01 00:00:00

abstract：:Human embryonic lung fibroblasts (F-136-35-56) capable of growing in medium containing DL-homocysteine instead of L-methionine and human acute lymphoblastic leukemia cells (CCRF-HSB-2) with absolute methionine requirement exhibited dose-dependent growth inhibition when semipurified L-methionine-degrading enzyme (L-met...

journal_title：Cancer research

authors： Kreis W,Baker A,Ryan V,Bertasso A

更新日期：1980-03-01 00:00:00

abstract：:Hypoxic conditions exist within pancreatic adenocarcinoma, yet pancreatic cancer cells survive and replicate within this environment. To understand the mechanisms involved in pancreatic cancer adaptation to hypoxia, we analyzed expression of a regulator of hypoxia-induced cell death, Bcl-2/adenovirus E1B 19 kDa intera...

journal_title：Cancer research

authors： Okami J,Simeone DM,Logsdon CD

更新日期：2004-08-01 00:00:00

abstract：:Fourteen suspected hereditary nonpolyposis colorectal carcinoma cases with microsatellite unstable(microsatellite instability-high; MSI-H) tumors but no germ-line MSH2, MSH6, or MLH1 mutations were examined for hypermethylation of CpG sites in the critical promoter region of MLH1. The methylation patterns were determi...

journal_title：Cancer research

authors： Gazzoli I,Loda M,Garber J,Syngal S,Kolodner RD

更新日期：2002-07-15 00:00:00

abstract：:MicroRNAs (miRNA) are negative regulators of gene expression at the posttranscriptional level, which are involved in tumorigenesis. Two miRNAs, miR-15a and miR-16, which are located at chromosome 13q14, have been implicated in cell cycle control and apoptosis, but little information is available about their role in so...

journal_title：Cancer research

authors： Bandi N,Zbinden S,Gugger M,Arnold M,Kocher V,Hasan L,Kappeler A,Brunner T,Vassella E

更新日期：2009-07-01 00:00:00

abstract：:: TRIM29 (tripartite motif-containing protein 29) is a TRIM family protein that has been implicated in breast, colorectal, and pancreatic cancers. However, its role in stratified squamous epithelial cells and tumors has not been elucidated. Here, we investigate the expression of TRIM29 in cutaneous head and neck squam...

journal_title：Cancer research

authors： Yanagi T,Watanabe M,Hata H,Kitamura S,Imafuku K,Yanagi H,Homma A,Wang L,Takahashi H,Shimizu H,Hatakeyama S

更新日期：2018-12-15 00:00:00