Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression.

abstract：:Human kallikrein 10 (hK10) is a secreted serine protease that is highly expressed in ovarian tissue. We hypothesized that hK10 might represent a novel serological marker for ovarian cancer. We quantified by immunoassay, hK10 in sera from 97 normal women (controls), 141 patients with benign gynecologic diseases, and 14...

journal_title：Cancer research

authors： Luo LY,Katsaros D,Scorilas A,Fracchioli S,Bellino R,van Gramberen M,de Bruijn H,Henrik A,Stenman UH,Massobrio M,van der Zee AG,Vergote I,Diamandis EP

更新日期：2003-02-15 00:00:00

abstract：:Toll-like receptor (TLR) agonists are considered adjuvants in clinical trials of cancer immunotherapy. Here, we investigated the modulation of gammadelta T cell-mediated tumor cell lysis by TLR ligands. gammadelta T-cell cytotoxicity and granzyme A/B production were enhanced after pretreatment of tumor cells with TLR3...

journal_title：Cancer research

authors： Shojaei H,Oberg HH,Juricke M,Marischen L,Kunz M,Mundhenke C,Gieseler F,Kabelitz D,Wesch D

更新日期：2009-11-15 00:00:00

abstract：:A cell line (NCE-G28) was established from the biopsy material of a human gliosarcoma of low histological differentiation. The initial cultures showed a mixed population of cells which in later stages became more uniform due to loss of slower growing constituents. The cells have been growing steadily for 20 months. A ...

journal_title：Cancer research

authors： Westphal M,Haensel M,Mueller D,Laas R,Kunzmann R,Rohde E,Koenig A,Hoelzel F,Herrmann HD

更新日期：1988-02-01 00:00:00

abstract：:We measured the tissue concentration of human urokinase receptor (uPAR) in 22 breast carcinomas and 9 benign breast lesions using in vitro quantitative autoradiography. Tissue sections were incubated with increasing concentrations of 125I-pro-urokinase in the presence or absence of unlabeled competitor. Breast carcino...

journal_title：Cancer research

authors： Del Vecchio S,Stoppelli MP,Carriero MV,Fonti R,Massa O,Li PY,Botti G,Cerra M,D'Aiuto G,Esposito G

更新日期：1993-07-01 00:00:00

abstract：:The cytotoxicity of a diphtheria toxin-human epidermal growth factor fusion protein (DAB(389)EGF) was tested against 14 human glioma cell lines. After cells were cultured for 48 h with various concentrations of DAB(389)EGF, the percentage reduction in thymidine incorporation was determined. For 13 of 14 cell lines, po...

journal_title：Cancer research

authors： Liu TF,Cohen KA,Ramage JG,Willingham MC,Thorburn AM,Frankel AE

更新日期：2003-04-15 00:00:00

abstract：:Cancer-associated retinopathy (CAR) is an ocular manifestation of a paraneoplastic syndrome whereby immunological reactions to retinal antigens aberrantly expressed in tumor cells lead to the degeneration of retinal photoreceptor cells. In our previous study (H. Ohguro et al., Invest. Ophthalmol. Vis. Sci., 40: 82-89,...

journal_title：Cancer research

authors： Maeda A,Ohguro H,Maeda T,Wada I,Sato N,Kuroki Y,Nakagawa T

更新日期：2000-04-01 00:00:00

abstract：:Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all three markers (triple negative or basal-like). While targeted therapies for ER+/PR+ and HER2+ tumors have revolutionized...

journal_title：Cancer research

authors： McCleland ML,Adler AS,Shang Y,Hunsaker T,Truong T,Peterson D,Torres E,Li L,Haley B,Stephan JP,Belvin M,Hatzivassiliou G,Blackwood EM,Corson L,Evangelista M,Zha J,Firestein R

更新日期：2012-11-15 00:00:00

abstract：:miRNAs (miR) are a critical class of small (21-25 nucleotides) noncoding endogenous RNAs implicated in gene expression regulation. We identified miR-23b and miR-27b as miRNAs that are highly upregulated in human breast cancer. We found that engineered knockdown of miR-23b and miR-27b substantially repressed breast can...

journal_title：Cancer research

authors： Jin L,Wessely O,Marcusson EG,Ivan C,Calin GA,Alahari SK

更新日期：2013-05-01 00:00:00

abstract：:The effect of type (corn oil or lard) and quantity (5 or 20%) of dietary fat and 1,2-dimethylhydrazine (DMH) on the composition of biliary bile acids, fecal bile acids, and neutral sterols was studied in rats exposed to a given regimen for two generations prior to s.c. treatment with DMH for 20 weeks. Biliary excretio...

journal_title：Cancer research

authors： Reddy BS,Mangat S,Sheinfil A,Weisburger JH,Wynder EL

更新日期：1977-07-01 00:00:00

abstract：:After 5 or 20 mg cyclophosphamide per kg body weight, given once i.v., the output in thoracic duct lymph of small and large lymphoid cells, cells incorporating [3H]lymidine in vitro, mitotic cells, pyknotic cells, and/or the number of lymphocytes and neutrophils in peripheral blood were measured in six calves. The med...

journal_title：Cancer research

authors： Wagner JP,Chanana AD,Cottier H,Cronkite EP,Gassmann A,Joel DD,Laissue JA

更新日期：1976-09-01 00:00:00

abstract：:The Notch signaling pathway is required in both nonneoplastic neural stem cells and embryonal brain tumors, such as medulloblastoma, which are derived from such cells. We investigated the effects of Notch pathway inhibition on medulloblastoma growth using pharmacologic inhibitors of gamma-secretase. Notch blockade sup...

journal_title：Cancer research

authors： Fan X,Matsui W,Khaki L,Stearns D,Chun J,Li YM,Eberhart CG

更新日期：2006-08-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its agonistic antibodies, which are currently in early clinical trials for treating various malignancies, induce apoptosis through triggering of either TRAIL-R1 or TRAIL-R2. Based on studies using agonistic monoclonal antibodies, we recently proposed ...

journal_title：Cancer research

authors： MacFarlane M,Kohlhaas SL,Sutcliffe MJ,Dyer MJ,Cohen GM

更新日期：2005-12-15 00:00:00

abstract：:A synthetic DNA template has been constructed that is suitable for the quantitation of mRNAs encoding gastrin, transforming growth factor alpha (TGF alpha), cholecystokinin, and the 78-kDa gastrin-binding protein. The template was used to measure levels of gastrin and TGF alpha mRNA in 7 colonic and 2 gastric carcinom...

journal_title：Cancer research

authors： Baldwin GS,Zhang QX

更新日期：1992-04-15 00:00:00

abstract：:Emerging evidence indicates the presence of tumor-initiating cells (TIC) or cancer stem cells in osteosarcoma. However, no study has shown specific markers to identify osteosarcoma TICs with in vivo tumor formation ability. Additionally, there has been a lack of investigations gauging the contribution of osteosarcoma ...

journal_title：Cancer research

authors： Adhikari AS,Agarwal N,Wood BM,Porretta C,Ruiz B,Pochampally RR,Iwakuma T

更新日期：2010-06-01 00:00:00

abstract：:The BCR-ABL oncogene is responsible for most cases of chronic myelogenous leukemia and some acute lymphoblastic leukemias. The fusion protein encoded by BCR-ABL possesses an aberrantly regulated tyrosine kinase activity. Imatinib mesylate (Gleevec, STI-571) is an inhibitor of ABL tyrosine kinase activity that has been...

journal_title：Cancer research

authors： Kharas MG,Fruman DA

更新日期：2005-03-15 00:00:00

abstract：:Normal and transformed rat liver epithelial cell lines exhibited differences in the ability to survive in the aggregate form. Normal rat liver epithelial cells in the aggregate form underwent a rapid decline in the number of viable cells, while counterpart transformed epithelial cells exhibited an ability to survive a...

journal_title：Cancer research

authors： Steuer AF,Hentosh PM,Diamond L,Ting RC

更新日期：1977-06-01 00:00:00

abstract：:Multimodal therapy is generally more effective than single-agent treatment for cancer. rRp450 is an engineered herpes simplex viral mutant that replicates in and kills tumor cells in a relatively selective fashion. It also expresses, in infected cells, the cyclophosphamide (CPA)-sensitive rat cytochrome P450 2B1 (CYP2...

journal_title：Cancer research

authors： Aghi M,Chou TC,Suling K,Breakefield XO,Chiocca EA

更新日期：1999-08-15 00:00:00

abstract：:Cyclins and cyclin-dependent kinases regulate the cell cycle. Cyclin A has a dual role in cell proliferation. It is essential in the S phase for DNA replication, and it is also involved in G2-M-phase transition, signifying actively dividing cells. The expression of cyclin A was determined by immunohistochemistry in pa...

journal_title：Cancer research

authors： Huuhtanen RL,Blomqvist CP,Böhling TO,Wiklund TA,Tukiainen EJ,Virolainen M,Tribukait B,Andersson LC

更新日期：1999-06-15 00:00:00

abstract：:A large number of epidemiological studies have shown that regular use of aspirinor other nonsteroidal anti-inflammatory drugs (NSAIDs) results in a 40-50% reduced risk of colorectal cancer (CRC). Furthermore, NSAIDs cause the regression of preexisting adenomas in patients with familial adenomatous polyposis and signif...

journal_title：Cancer research

authors： Yao M,Kargman S,Lam EC,Kelly CR,Zheng Y,Luk P,Kwong E,Evans JF,Wolfe MM

更新日期：2003-02-01 00:00:00

abstract：:Studies demonstrate that some colon cancers possess receptors for various gastrointestinal hormones or neurotransmitters, the occupation of which can affect growth. These results are limited because frequently only a small number of tumors are studied, only 1 or 2 receptors are sought, and the effect on cell function ...

journal_title：Cancer research

authors： Frucht H,Gazdar AF,Park JA,Oie H,Jensen RT

更新日期：1992-03-01 00:00:00

abstract：:Enhanced glucose and lipid metabolism is one of the most common properties of malignant cells. ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate. To evaluate its role in lung cancer progression, we here analyzed ACLY expression in ...

journal_title：Cancer research

authors： Migita T,Narita T,Nomura K,Miyagi E,Inazuka F,Matsuura M,Ushijima M,Mashima T,Seimiya H,Satoh Y,Okumura S,Nakagawa K,Ishikawa Y

更新日期：2008-10-15 00:00:00

abstract：:Enhancement of specific transplantation resistance to a syngeneic tumor (KMT-17) was observed in WKA rats by treatment with the antileukemia drug busulfan (BU) (15 mg/kg) 5 days before and 5 days after immunization with X-irradiated KMT-17 tumor cells. Rats immunized with X-irradiated KMT-17 cells and then treated wit...

journal_title：Cancer research

authors： Mizushima Y,Sendo F,Takeichi N,Hosohawa M,Kobayashi H

更新日期：1981-07-01 00:00:00

abstract：:Mutations of the p53 gene constitute one of the most frequent genetic alterations in squamous cell carcinoma of the head and neck (SCCHN). In this study, we introduced wild-type p53 into two separate SCCHN cell lines via a recombinant adenoviral vector, Ad5CMV-p53. Northern blotting showed that following infection by ...

journal_title：Cancer research

authors： Liu TJ,Zhang WW,Taylor DL,Roth JA,Goepfert H,Clayman GL

更新日期：1994-07-15 00:00:00

abstract：:Helicobacter pylori-induced gastritis is the strongest singular risk factor for gastric adenocarcinoma. Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and H. pylori stimulates expression of MMP-7 in gastric epitheli...

journal_title：Cancer research

authors： Ogden SR,Noto JM,Allen SS,Patel DA,Romero-Gallo J,Washington MK,Fingleton B,Israel DA,Lewis ND,Wilson KT,Chaturvedi R,Zhao Z,Shyr Y,Peek RM Jr

更新日期：2010-01-01 00:00:00

abstract：:Preincubation of murine colon 26 colon adenocarcinoma cells with gamma-interferon (IFN-gamma), but not alpha-interferon, produced a significant increase in experimental pulmonary metastases in syngeneic BALB/c and T-cell-deficient BALB/c nude mice. The enhancement was seen after as little as 1 h of exposure to 1 unit/...

journal_title：Cancer research

authors： Kelly SA,Gschmeissner S,East N,Balkwill FR

更新日期：1991-08-01 00:00:00

abstract：:Immunotherapy with high-dose interleukin (IL) 2 has been shown to successfully treat tumors in animal models and cause dramatic tumor regressions in some patients with metastatic melanoma, renal cell carcinoma, and non-Hodgkin's lymphoma. However, toxicity associated with IL-2 administration has compromised its widesp...

journal_title：Cancer research

authors： Wang G,Tschoi M,Spolski R,Lou Y,Ozaki K,Feng C,Kim G,Leonard WJ,Hwu P

更新日期：2003-12-15 00:00:00

abstract：:Astrocytes, the most abundant type of glial cells in the brain, play critical roles in supporting neuronal development and brain function. Although astrocytes have been frequently detected in brain tumors, including medulloblastoma (MB), their functions in tumorigenesis are not clear. Here, we demonstrate that astrocy...

journal_title：Cancer research

authors： Liu Y,Yuelling LW,Wang Y,Du F,Gordon RE,O'Brien JA,Ng JMY,Robins S,Lee EH,Liu H,Curran T,Yang ZJ

更新日期：2017-12-01 00:00:00

abstract：:Bleomycin treatment produced dose-dependent changes in lung collagen content and in several measurable histopathological parameters. NIH/Swiss mice were treated twice weekly for 6 weeks with bleomycin, 0, 1, 20, or 40 mg/kg s.c. The two highest doses produced mortalities of 35 and 100%, respectively, as well as loss o...

journal_title：Cancer research

authors： Sikic BI,Young DM,Mimnaugh EG,Gram TE

更新日期：1978-03-01 00:00:00

abstract：:Data are presented indicating marked antineoplastic activity for cis-dichlorodiammineplatinum(II) in MOPC 104E myeloma. One-eighteenth of the dose that produced 100% cures can be combined with noncurative, low doses of cyclophosphamide and 1,3-bis(2-chloroethyl)-1-nitrosourea to produce antineoplastic activity of the ...

journal_title：Cancer research

authors： Ghanta VK,Jones MT,Woodard DA,Durant JR,Hiramoto RN

更新日期：1977-03-01 00:00:00

abstract：:We are in an era where the potential exists for deriving comprehensive profiles of DNA alterations characterizing each form of human cancer. Such profiles would provide invaluable insight into mechanisms underlying the evolution of each tumor type and will provide molecular markers, which could radically improve cance...

journal_title：Cancer research

authors： Esteller M,Corn PG,Baylin SB,Herman JG

更新日期：2001-04-15 00:00:00