Survival differences exhibited by normal and transformed rat liver epithelial cell lines in the aggregate form.

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease that is characterized by a particularly marked resistance to chemotherapy. We previously showed an association between decreased expression of BNIP3 and chemoresistance in PDAC cell lines. To further explore the molecular basis of chemoresistance in PDAC...

journal_title：Cancer research

authors： Mahon PC,Baril P,Bhakta V,Chelala C,Caulee K,Harada T,Lemoine NR

更新日期：2007-07-15 00:00:00

abstract：:Determining to what degree chemicals and environmental agents contribute to the development of cancer would be materially enhanced by the ability to distinguish chemically induced tumors from those that arise spontaneously. Using DNA fingerprinting as an assay, we investigated whether somatic DNA rearrangements are mo...

journal_title：Cancer research

authors： Ledwith BJ,Storer RD,Prahalada S,Manam S,Leander KR,van Zwieten MJ,Nichols WW,Bradley MO

更新日期：1990-09-01 00:00:00

abstract：:Receptor protein-tyrosine kinases (RPTKs) are tightly regulated during normal cellular processes including cell growth, differentiation, and metabolism. Recently, a RPTK-like molecule named novel oncogene with kinase-domain (NOK) has been cloned and characterized. Overexpression of NOK caused severe cellular transform...

journal_title：Cancer research

authors： Chen Y,Li YH,Chen XP,Gong LM,Zhang SP,Chang ZJ,Zhang XF,Fu XY,Liu L

更新日期：2005-12-01 00:00:00

abstract：:Recent work on a variety of normal and malignant cell lines has shown that induction and secretion of biologically active TGF-beta may occur after exposure to all-trans-retinoic acid (RA), coincident with decreased growth rate and/or differentiation. This study evaluates the expression and regulation of transforming g...

journal_title：Cancer research

authors： Cohen PS,Letterio JJ,Gaetano C,Chan J,Matsumoto K,Sporn MB,Thiele CJ

更新日期：1995-06-01 00:00:00

abstract：:The effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth of epithelial cells from rat, hamster, and human respiratory tract has been measured by monitoring colony formation and cross-linked envelope formation in culture. TPA and its active derivatives stimulated colony formation of rat...

journal_title：Cancer research

authors： Beeman DK,Siegfried JM,Mass MJ

更新日期：1987-01-15 00:00:00

abstract：:This study was undertaken to determine the extent of apoptosis in lung carcinoma and to evaluate it as a prognostic marker. A series of 75 lung carcinomas (47 squamous cell carcinomas, 24 adenocarcinomas, 3 small cell carcinomas, and 1 large cell carcinoma) was analyzed for the extent of apoptosis by using the 3' end-...

journal_title：Cancer research

authors： Törmänen U,Eerola AK,Rainio P,Vähäkangas K,Soini Y,Sormunen R,Bloigu R,Lehto VP,Pääkkö P

更新日期：1995-12-01 00:00:00

abstract：:A lymphocyte blastogenesis inhibitory factor (LBIF) has been characterized as an immunoregulatory molecule, especially on the T-lymphocyte proliferation. Using fast protein liquid chromatography-purified LBIF, we examined the effect of LBIF on the proliferation of various 18 tumor cell lines in vitro in comparison wit...

journal_title：Cancer research

authors： Sugimura K,Ohno T,Fukuda S,Wada Y,Kimura T,Azuma I

更新日期：1990-01-15 00:00:00

abstract：:The effects of various forms of tocopherol (vitamin E) on the growth and differentiation of mouse melanoma (B-16) and mouse fibroblast (L-cells) cells in culture were studied. D-alpha-tocopherol acid succinate induced morphological alterations and growth inhibition in melanoma cells. When vitamin E acid succinate was ...

journal_title：Cancer research

authors： Prasad KN,Edwards-Prasad J

更新日期：1982-02-01 00:00:00

abstract：:N-4-Hydroxyphenylretinamide (fenretinide or 4HPR), a derivative of retinoic acid, has been demonstrated to decrease the development of prostate cancer in a rat carcinogenesis model. This study was undertaken to determine if 4HPR is an effective agent for the treatment of established prostate cancer. In vitro, 4HPR was...

journal_title：Cancer research

authors： Pienta KJ,Nguyen NM,Lehr JE

更新日期：1993-01-15 00:00:00

abstract：:A detailed analysis of the gamma-glutamylation of methotrexate has been conducted in primary cultures of rat hepatic parenchymal cells in monolayer culture. The rates of glutamylation are concentration dependent and saturable when measured over a 6-h period at concentrations between 2 and 50 microM. The removal of fol...

journal_title：Cancer research

authors： Galivan J,Pupons A,Rhee MS

更新日期：1986-02-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) is currently being used as a target antigen in the radioimmunodetection of cancer. Circulating CEA may adversely affect the outcome of such studies by formation of intravascular immune complexes. The following studies were undertaken to expand our knowledge of the production, secretion, ...

journal_title：Cancer research

authors： Martin KW,Halpern SE

更新日期：1984-12-01 00:00:00

abstract：:Types I and II cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinases were compared in extracts from untransformed rat 3Y1 cells and 3Y1 cells transformed by the highly oncogenic human adenovirus type 12. Analysis of the kinases through diethylaminoethyl Sepharose column chromatography showed a signific...

journal_title：Cancer research

authors： Ledinko N,Chan IJ

更新日期：1984-06-01 00:00:00

abstract：:Development of resistance to tamoxifen is a serious problem in treatment of breast cancer patients. Although the mechanisms for development of resistance are unclear, an altered expression of alternatively spliced estrogen receptor (ER) mRNA has been suggested to be involved. We have looked for differential expression...

journal_title：Cancer research

authors： Madsen MW,Reiter BE,Larsen SS,Briand P,Lykkesfeldt AE

更新日期：1997-02-15 00:00:00

abstract：:Rational therapeutic approaches based on synthetic lethality may improve cancer management. On the basis of a high-throughput drug screen, we provide preclinical proof of concept that targeting the mitochondrial Hsp90 chaperone network (mtHsp90) and inhibition of Bcl-2, Bcl-xL, and Mcl-1 is sufficient to elicit synthe...

journal_title：Cancer research

authors： Karpel-Massler G,Ishida CT,Bianchetti E,Shu C,Perez-Lorenzo R,Horst B,Banu M,Roth KA,Bruce JN,Canoll P,Altieri DC,Siegelin MD

更新日期：2017-07-01 00:00:00

abstract：:Squamous cell carcinoma (SCC) and keratoacanthoma (KA; SCC/KA) research has been hampered mainly by our lack of understanding the underlying genetic and epigenetic alterations associated with SCC/KA development, as well as the lack of animal models that faithfully recapitulate histopathologic features of human SCC/KA....

journal_title：Cancer research

authors： Lee JH,Lee JH,Lee SH,Do SI,Cho SD,Forslund O,Inn KS,Lee JS,Deng FM,Melamed J,Jung JU,Jeong JH

更新日期：2016-11-15 00:00:00

abstract：:The role of glutathione (GSH) as a determinant of cellular sensitivity to the cytotoxic and DNA-damaging effects of cyclophosphamide (CP) was studied in a dual culture system of rat hepatocytes and K562 human chronic myeloid leukemia cells, which have elevated aldehyde dehydrogenase activity with a corresponding insen...

journal_title：Cancer research

authors： Crook TR,Souhami RL,Whyman GD,McLean AE

更新日期：1986-10-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) expression by human breast cancer has been shown to predict poor patient outcome, as has amplification of the c-erbB-2 proto-oncogene. We have developed a quantitative immunohistochemical method for measuring protein levels of both receptors and have applied this to a series of ...

journal_title：Cancer research

authors： Robertson KW,Reeves JR,Smith G,Keith WN,Ozanne BW,Cooke TG,Stanton PD

更新日期：1996-08-15 00:00:00

abstract：:Bleomycin inhibits cellular RNA synthesis and the inhibition is nonspecific. The ratio of polyadenylate- [poly(A)] containing RNA to non-poly(A)-containing RNA in the drug-treated human lymphocytic cells, line Wil2, was the same as that in untreated cells. Poly(A) RNA isolated from untreated cells was used as a templa...

journal_title：Cancer research

authors： Kuo MT,Auger LT,Saunders GF,Haidle CW

更新日期：1977-05-01 00:00:00

abstract：:Individual human infiltrating ductal carcinomas and fibroadenomas were sectioned frozen to yield an alternating sequence of stained and lyophilized material. Stained preparations were used as references permitting microdissection of regions of tumor involvement in the corresponding dried sections. Tissues quantities o...

journal_title：Cancer research

authors： Larner EH,Rutherford CL

更新日期：1982-05-01 00:00:00

abstract：:Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules. To establish a biochemical efficacy end point for overcoming alkylguanine DNA alkyltransferase (AGT)-mediated tumor cell resistance to 1,3-bis(2-...

journal_title：Cancer research

authors： Spiro TP,Gerson SL,Liu L,Majka S,Haaga J,Hoppel CL,Ingalls ST,Pluda JM,Willson JK

更新日期：1999-05-15 00:00:00

abstract：:Infiltrating macrophages are a key component of inflammation during tumorigenesis, but the direct evidence of such linkage remains unclear. We report here that persistent coculturing of immortalized prostate epithelial cells with macrophages, without adding any carcinogens, induces prostate tumorigenesis and that indu...

journal_title：Cancer research

authors： Fang LY,Izumi K,Lai KP,Liang L,Li L,Miyamoto H,Lin WJ,Chang C

更新日期：2013-09-15 00:00:00

abstract：:Our previous studies have defined reactive stroma in human prostate cancer and have developed the differential reactive stroma (DRS) xenograft model to evaluate mechanisms of how reactive stroma promotes carcinoma tumorigenesis. Analysis of several normal human prostate stromal cell lines in the DRS model showed that ...

journal_title：Cancer research

authors： Yang F,Tuxhorn JA,Ressler SJ,McAlhany SJ,Dang TD,Rowley DR

更新日期：2005-10-01 00:00:00

abstract：:Two subclones of L1210 murine leukemia (L1210-46.1 and L1210-56.3) were isolated in the absence of selective agents. Subclone 56.3 appeared to be more sensitive than was subclone 46.1 to treatment with dexamethasone, 1-beta-D-arabinofuranosyl cytosine, vincristine, and X-irradiation. No differences between the parent ...

journal_title：Cancer research

authors： Brouwer M,Smets LA,Jongsma AP

更新日期：1983-06-01 00:00:00

abstract：:The majority of colorectal cancers have lost/inactivated the p53 tumor suppressor gene. Using isogenic human colon cancer cells that differ only in their p53 status, we demonstrate that loss of p53 renders tumor cells relatively resistant to the topoisomerase I inhibitor, irinotecan. Whereas irinotecan-induced up-regu...

journal_title：Cancer research

authors： Ravi R,Jain AJ,Schulick RD,Pham V,Prouser TS,Allen H,Mayer EG,Yu H,Pardoll DM,Ashkenazi A,Bedi A

更新日期：2004-12-15 00:00:00

abstract：:We recently reported the isolation of the K-sam complementary DNA (cDNA), which was amplified preferentially in poorly differentiated types of stomach cancer and codes for one of the heparin-binding growth factor or fibroblast growth factor (FGF) receptor families. The K-sam-related gene, N-sam (NCC-IT-cell-derived sa...

journal_title：Cancer research

authors： Hattori Y,Odagiri H,Katoh O,Sakamoto H,Morita T,Shimotohno K,Tobinai K,Sugimura T,Terada M

更新日期：1992-06-15 00:00:00

abstract：:OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and ...

journal_title：Cancer research

authors： Curti BD,Kovacsovics-Bankowski M,Morris N,Walker E,Chisholm L,Floyd K,Walker J,Gonzalez I,Meeuwsen T,Fox BA,Moudgil T,Miller W,Haley D,Coffey T,Fisher B,Delanty-Miller L,Rymarchyk N,Kelly T,Crocenzi T,Bernstein E,

更新日期：2013-12-15 00:00:00

abstract：:Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all three markers (triple negative or basal-like). While targeted therapies for ER+/PR+ and HER2+ tumors have revolutionized...

journal_title：Cancer research

authors： McCleland ML,Adler AS,Shang Y,Hunsaker T,Truong T,Peterson D,Torres E,Li L,Haley B,Stephan JP,Belvin M,Hatzivassiliou G,Blackwood EM,Corson L,Evangelista M,Zha J,Firestein R

更新日期：2012-11-15 00:00:00

abstract：:All mammalian cells express 3 closely related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogenesis when they are mutationally activated at codon 12, 13, or 61. Although there is a high degree of similarity among the isoforms, K-Ras mutations are far more frequently observed in cancer, and each isofor...

journal_title：Cancer research

authors： Prior IA,Lewis PD,Mattos C

更新日期：2012-05-15 00:00:00

abstract：:A common feature of mammalian cell lines selected for multiple drug resistance is the overexpression of a high-molecular-weight surface membrane glycoprotein(s). While its amount has been shown to be related to the degree of resistance of such cells, its function in this phenomenon remains obscure. Because there are s...

journal_title：Cancer research

authors： Beck WT,Cirtain MC,Ashmun RA,Mirro J

更新日期：1986-09-01 00:00:00

abstract：:Preincubation of murine colon 26 colon adenocarcinoma cells with gamma-interferon (IFN-gamma), but not alpha-interferon, produced a significant increase in experimental pulmonary metastases in syngeneic BALB/c and T-cell-deficient BALB/c nude mice. The enhancement was seen after as little as 1 h of exposure to 1 unit/...

journal_title：Cancer research

authors： Kelly SA,Gschmeissner S,East N,Balkwill FR

更新日期：1991-08-01 00:00:00