Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice.

abstract：:Rapid or accelerated tumor cell repopulation after significant tumor cell killing induced by various cytotoxic agents often compromises the expected therapeutic benefit of such tumor responses. Here, we discuss the concept that tumor cell repopulation after certain cytotoxic therapies, using vascular disrupting agents...

journal_title：Cancer research

authors： Shaked Y,Kerbel RS

更新日期：2007-08-01 00:00:00

abstract：:3-phosphoinositide-dependent protein kinase-1 (PDK1) plays a pivotal role in coupling growth factor receptor signaling to tumor cell proliferation, survival, and invasion. Protein kinase C (PKC) alpha, but not Akt1, was found previously to be downstream of PDK1-mediated transformation of mammary epithelial cells. To d...

journal_title：Cancer research

authors： Xie Z,Zeng X,Waldman T,Glazer RI

更新日期：2003-09-01 00:00:00

abstract：:Human intraepithelial lymphocytes (IEL), predominantly CD8+ T-lymphocytes located between intestinal epithelial cells (EC), may represent the first-line immune defense against colon cancer. The mechanism by which IEL bind to the colon cancer line, DLD-1, was evaluated. A larger fraction of IEL than peripheral blood mo...

journal_title：Cancer research

authors： Roberts AI,O'Connell SM,Ebert EC

更新日期：1993-04-01 00:00:00

abstract：:Lipid peroxidation is considered a unifying mechanistic pathway through which known risk factors induce renal cell carcinoma (RCC). We hypothesized that genes selected a priori for their role in lipid peroxidation would modify cancer risk. We genotyped 635 single nucleotide polymorphisms (SNP) in 38candidate genes in ...

journal_title：Cancer research

authors： Moore LE,Brennan P,Karami S,Menashe I,Berndt SI,Dong LM,Meisner A,Yeager M,Chanock S,Colt J,Schwartz K,Davis F,Zaridze D,Mattveev V,Janout V,Kollarova H,Bencko V,Navratilova M,Szeszenia-Dabrowska N,Mates D,Holcato

更新日期：2009-10-15 00:00:00

abstract：:To identify mechanisms of camptothecin (CPT) resistance and the relationship between CPT-resistant cells and other anticancer agents, a CPT-resistant cell line (CPT30) and its partial revertant cell line (CPT30R) were established from a human nasopharyngeal carcinoma cell line (HONE-1). CPT30 and CPT30R cells displaye...

journal_title：Cancer research

authors： Chang JY,Liu JF,Juang SH,Liu TW,Chen LT

更新日期：2002-07-01 00:00:00

abstract：:We showed recently that Helicobacter infection induces expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in the mouse stomach, and that transgenic mice expressing both cyclooxygenase-2 and microsomal prostaglandin E synthase-1 (K19-C2mE mice) develop hyperplastic gastric tumors with inflammatory...

journal_title：Cancer research

authors： Oshima M,Oshima H,Matsunaga A,Taketo MM

更新日期：2005-10-15 00:00:00

abstract：:Tumor-suppressors have commanded attention due to the selection for their inactivating mutations in human tumors. However, relatively little is understood about the inverse, namely, that tumors do not select for a large proportion of seemingly favorable mutations in tumor-suppressor genes. This could be explained by a...

journal_title：Cancer research

authors： Cunningham SC,Gallmeier E,Hucl T,Dezentje DA,Calhoun ES,Falco G,Abdelmohsen K,Gorospe M,Kern SE

更新日期：2006-06-01 00:00:00

abstract：:The fusion transcript AML1/ETO was detected in the bone marrow of two t(8;21)-negative acute myelogenous leukemia (AML) patients by means of reverse transcription-polymerase chain reaction. This fusion transcript is identical to the one transcribed from the t(8;21) translocation base, as deduced from (a) the size and ...

journal_title：Cancer research

authors： Maruyama F,Yang P,Stass SA,Cork A,Freireich EJ,Lee MS,Chang KS

更新日期：1993-10-01 00:00:00

abstract：:Eight analogues of 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone have been synthesized and tested for cytotoxicity against four different leukemic and lymphomic cell lines. For K562 and BSM cells, the toxicity could be correlated with the ease of reduction of the compounds as determined by the one-electr...

journal_title：Cancer research

authors： Dzielendziak A,Butler J,Hoey BM,Lea JS,Ward TH

更新日期：1990-04-01 00:00:00

abstract：:A modified method was developed for measuring the frequency of variant erythrocytes at the glycophorin A locus using a single beam cell sorter (SBS). Fluorescein- or phycoerythrin-labeled monoclonal antibodies specific for the M or N glycophorin A alleles were used for the SBS assay. To prevent contamination of nuclea...

journal_title：Cancer research

authors： Kyoizumi S,Nakamura N,Hakoda M,Awa AA,Bean MA,Jensen RH,Akiyama M

更新日期：1989-02-01 00:00:00

abstract：:The biological activity of two novel 14-epi-analogues of 1,25(OH)2D3, 19-nor-14-epi-23-yne-1,25(OH)2D3 (TX 522) and 19-nor-14,20-bisepi-23-yne-1,25(OH)2D3 (TX 527), is described. Both analogues were at least 10 times more potent than 1,25(OH)2D3 in inhibiting in vitro cell proliferation and had much lower in vivo calc...

journal_title：Cancer research

authors： Verlinden L,Verstuyf A,Van Camp M,Marcelis S,Sabbe K,Zhao XY,De Clercq P,Vandewalle M,Bouillon R

更新日期：2000-05-15 00:00:00

abstract：:Amyloid fibrils from two cases of cancer-associated, systemic amyloidosis with renal cell carcinoma and mesothelioma as the respective underlying disorders were studied. The immunochemical studies suggested strongly that amyloid A comprised a principal fibril component in both cases of cancer-associated amyloidosis. T...

journal_title：Cancer research

authors： Husby G,Marhaug G,Sletten K

更新日期：1982-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)-C is a lymphangiogenic factor implicated in lymphatic metastasis. In this study, we investigated the role of the type I insulin-like growth factor receptor (IGF-IR) in the regulation of VEGF-C expression. We used Lewis lung carcinoma subline M-27 cells transfected with human I...

journal_title：Cancer research

authors： Tang Y,Zhang D,Fallavollita L,Brodt P

更新日期：2003-03-15 00:00:00

abstract：:The expression of the major glycoprotein, gp71, of murine leukemia virus was studied on the surfaces of a variety of normal murine cell lines with a monospecific rabbit antiserum raised against purified Friend murine leukemia virus gp71. Using viable cell membrane immunofluorescence, most established and early passage...

journal_title：Cancer research

authors： Cloyd MW,Bolognesi DP,Bigner DD

更新日期：1977-03-01 00:00:00

abstract：:Pentraxin-3 (PTX3) is a member of the pentraxin family of innate immune regulators, which includes C-reactive protein (CRP). PTX3 has been implicated in angiogenesis, proliferation, and immune escape in cancer. In the present study, we evaluated PTX3 tissue expression and serum concentration as a biomarker to discrimi...

journal_title：Cancer research

authors： Stallone G,Cormio L,Netti GS,Infante B,Selvaggio O,Fino GD,Ranieri E,Bruno F,Prattichizzo C,Sanguedolce F,Tortorella S,Bufo P,Grandaliano G,Carrieri G

更新日期：2014-08-15 00:00:00

abstract：:The activity of gemcitabine (dFdC), an effective agent against solid tumors, depends on the incorporation of its triphosphate into DNA. In vitro investigations demonstrated that, depending on the sequence of template DNA, polymerases may pause after incorporation of gemcitabine nucleotide at either the 3'-terminal or ...

journal_title：Cancer research

authors： Gandhi V,Legha J,Chen F,Hertel LW,Plunkett W

更新日期：1996-10-01 00:00:00

abstract：:The aim of this study was to determine whether buccal mucosa would provide an alternate source of tissue for human biomonitoring. Samples of clinically normal oral biopsies were excised, and buccal mucosa were scraped or brushed from patients while they were undergoing surgery for the excision of intra-oral squamous c...

journal_title：Cancer research

authors： Stone JG,Jones NJ,McGregor AD,Waters R

更新日期：1995-03-15 00:00:00

abstract：:Toward the identification of steps in the multiphasic process of human pancreas carcinogenesis we have developed a panel of monoclonal antibodies to normal and carcinogen-treated human pancreas cells. One of these, an IgG3 with strong affinity for a membrane-associated Mr 78,000 protein in fetal and adult parenchymal ...

journal_title：Cancer research

authors： Parsa I

更新日期：1988-04-15 00:00:00

abstract：:Structural and functional abnormalities in tumor blood vessels impact the delivery of oxygen and nutrients to solid tumors, resulting in chronic and cycling hypoxia. Although chronically hypoxic regions exhibit treatment resistance, more recently it has been shown that cycling hypoxic regions acquire prosurvival pathw...

journal_title：Cancer research

authors： Matsumoto S,Batra S,Saito K,Yasui H,Choudhuri R,Gadisetti C,Subramanian S,Devasahayam N,Munasinghe JP,Mitchell JB,Krishna MC

更新日期：2011-10-15 00:00:00

abstract：:The sonic hedgehog (SHH) receptor Patched 1 (Ptch1) is critical for embryonic development, and its loss is linked to tumorigenesis. Germ line inactivation of one copy of Ptch1 predisposes to basal cell carcinoma and medulloblastoma in mouse and man. In many cases, medulloblastoma arising from perturbations of Ptch1 fu...

journal_title：Cancer research

authors： Lee Y,Miller HL,Russell HR,Boyd K,Curran T,McKinnon PJ

更新日期：2006-07-15 00:00:00

abstract：:Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue culture models are extremely useful in understanding the biology of prostate cancer, they cannot recapitulate the complex cellular interactions within the tumor m...

journal_title：Cancer research

authors： Ittmann M,Huang J,Radaelli E,Martin P,Signoretti S,Sullivan R,Simons BW,Ward JM,Robinson BD,Chu GC,Loda M,Thomas G,Borowsky A,Cardiff RD

更新日期：2013-05-01 00:00:00

abstract：:Although ethanol has generally not been found to induce cancer in experimental animals, the consumption of alcoholic beverages has been linked to increased risks of several cancers in humans. Risks of oral, pharyngeal, laryngeal, esophageal, and liver cancer are elevated among drinkers, typically in proportion to the ...

journal_title：Cancer research

authors： Blot WJ

更新日期：1992-04-01 00:00:00

abstract：:We have measured the 31P nuclear magnetic resonance spectra of EMT6/Ro multicellular tumor spheroids over a wide range of sizes under constant nutrient conditions which matched those used for culturing the spheroids. The amount of nucleotide triphosphate per cell decreased with spheroid growth, roughly in proportion t...

journal_title：Cancer research

authors： Freyer JP,Schor PL,Jarrett KA,Neeman M,Sillerud LO

更新日期：1991-08-01 00:00:00

abstract：:The LeY determinant, a difucosylated type 2 blood group-related antigen, is a positional isomer of the Leb blood group antigen and a fucosylated derivative of the LeX antigen. The LeX antigen behaves like an oncodevelopmental tumor-associated antigen in human colon cancer, and extended polyfucosyl LeX antigens are mor...

journal_title：Cancer research

authors： Kim YS,Yuan M,Itzkowitz SH,Sun QB,Kaizu T,Palekar A,Trump BF,Hakomori S

更新日期：1986-11-01 00:00:00

abstract：:Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "bacterial" ancestry, these antibiotics also target mitochondrial ...

journal_title：Cancer research

authors： Chatzispyrou IA,Held NM,Mouchiroud L,Auwerx J,Houtkooper RH

更新日期：2015-11-01 00:00:00

abstract：:Clinical and pathological studies of cutaneous T-cell lymphomas (CTCL) reveal variations in tumor cell morphology and surface membrane phenotype that are of diagnostic and prognostic importance. Our study investigates blastic transformation and surface antigen change on CTCL cells in vitro under the influence of tumor...

journal_title：Cancer research

authors： Kadin ME,Nasu K,Sako D,Su IJ

更新日期：1984-08-01 00:00:00

abstract：:Mouse C1 line cells are megakaryoblastic cells established by coinfection of Abelson murine leukemia virus and recombinant simian virus 40. We examined the effects of various compounds on growth and differentiation of these cells. Megakaryocytic differentiation of C1 cells was not induced by cytokines that stimulate m...

journal_title：Cancer research

authors： Honma Y,Okabe-Kado J,Kasukabe T,Hozumi M,Kajigaya S,Suda T,Miura Y

更新日期：1991-09-01 00:00:00

abstract：:Mortality surveys and death certificate studies have suggested an association between leukemia and farming. To investigate whether exposure to carcinogens in an agricultural setting is related to risk of leukemia, the authors conducted a population-based case-control interview study of 578 white men with leukemia and ...

journal_title：Cancer research

authors： Brown LM,Blair A,Gibson R,Everett GD,Cantor KP,Schuman LM,Burmeister LF,Van Lier SF,Dick F

更新日期：1990-10-15 00:00:00

abstract：:N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) metabolism was examined in vitro using microsomes prepared from rat liver and renal cortex and from rabbit liver and renal cortex and outer and inner medulla. NFTA nitroreduction was observed with each tissue. Three mol of NADPH were used per mol of NFTA reduced. Sub...

journal_title：Cancer research

authors： Mattammal MB,Zenser TV,Palmier MO,Davis BB

更新日期：1985-01-01 00:00:00

abstract：:A prominent feature of glioblastoma is its resistance to death from Fas pathway activation. In this study, we explored the modulation of Fas-induced glioblastoma death with chemotherapeutic agents. Camptothecin significantly increased the glioblastoma cell death response to Fas receptor activation regardless of p53 st...

journal_title：Cancer research

authors： Xia S,Rosen EM,Laterra J

更新日期：2005-06-15 00:00:00