Detection of somatic mutations at the glycophorin A locus in erythrocytes of atomic bomb survivors using a single beam flow sorter.

abstract：:Colorectal tumorigenesis is accompanied by the generation of oxidative stress, but how this controls tumor development is poorly understood. Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures. GPx2 silencing...

journal_title：Cancer research

authors： Emmink BL,Laoukili J,Kipp AP,Koster J,Govaert KM,Fatrai S,Verheem A,Steller EJ,Brigelius-Flohé R,Jimenez CR,Borel Rinkes IH,Kranenburg O

更新日期：2014-11-15 00:00:00

abstract：:Retinoids have been found to be promising chemopreventive agents that play an important role in regulating cell growth, differentiation, and apoptosis. The action of retinoids is mediated by retinoid receptors (retinoic acid receptors and retinoid X receptors), which are nuclear transcription factors that, when bound ...

journal_title：Cancer research

authors： Kim HT,Kong G,Denardo D,Li Y,Uray I,Pal S,Mohsin S,Hilsenbeck SG,Bissonnette R,Lamph WW,Johnson K,Brown PH

更新日期：2006-12-15 00:00:00

abstract：:Glucuronidation is an important pathway in the metabolism of nicotine, with previous studies suggesting that ∼22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine gl...

journal_title：Cancer research

authors： Chen G,Giambrone NE Jr,Dluzen DF,Muscat JE,Berg A,Gallagher CJ,Lazarus P

更新日期：2010-10-01 00:00:00

abstract：:IA-1 is a recently isolated novel complementary DNA which encodes a protein of 510 amino acids that contains both a zinc finger DNA-binding domain and a putative prohormone domain. mRNA expression of IA-1 has been found thus far only in tumors of neuroendocrine origin. In this report we describe the expression of IA-1...

journal_title：Cancer research

authors： Lan MS,Russell EK,Lu J,Johnson BE,Notkins AL

更新日期：1993-09-15 00:00:00

abstract：:Irinotecan hydrochloride (CPT-11), an antitumor camptothecin derivative, causes severe forms of diarrhea clinically. We characterized CPT-11-induced diarrhea histologically and enzymologically and assessed the relationships between intestinal toxicity and the activity of the enzymes that play a key role in the major m...

journal_title：Cancer research

authors： Takasuna K,Hagiwara T,Hirohashi M,Kato M,Nomura M,Nagai E,Yokoi T,Kamataki T

更新日期：1996-08-15 00:00:00

abstract：:Estramustine is an estradiol-based antimicrotubule agent that accumulates in malignant glioma cells, resulting in a concentration-dependent inhibition of proliferation. This agent has been shown to synchronize human glioma cells at G2-M consistent with its known effects on the mitotic spindle and potentially could be ...

journal_title：Cancer research

authors： Yoshida D,Piepmeier J,Weinstein M

更新日期：1994-03-15 00:00:00

abstract：:We have previously described the neoplastic transformation of immortalized human bronchial epithelial cells (BEAS-2B) by the combination of the c-raf-1 and c-myc protooncogenes and the concomitant induction of neuron-specific enolase mRNA expression (A. Pfeifer et al., Proc. Natl. Acad. Sci. USA, 86: 10075-10079, 1989...

journal_title：Cancer research

authors： Pfeifer AM,Jones RT,Bowden PE,Mann D,Spillare E,Klein-Szanto AJ,Trump BF,Harris CC

更新日期：1991-07-15 00:00:00

abstract：:Elevation of the DNA-unwinding helicase RECQL4, which participates in various DNA repair pathways, has been suggested to contribute to the pathogenicity of various human cancers, including gastric cancer. In this study, we addressed the prognostic and chemotherapeutic significance of RECQL4 in human gastric cancer, wh...

journal_title：Cancer research

authors： Mo D,Fang H,Niu K,Liu J,Wu M,Li S,Zhu T,Aleskandarany MA,Arora A,Lobo DN,Madhusudan S,Balajee AS,Chi Z,Zhao Y

更新日期：2016-05-15 00:00:00

abstract：:The transcription factor B-Myb plays a critical role in regulating gene expression and is implicated in controlling carcinogenesis and cellular senescence. Transcription of the B-Myb gene is regulated by retinoblastoma proteins acting directly on the B-Myb promoter. Recently, we found that microRNAs also control the a...

journal_title：Cancer research

authors： Martinez I,Dimaio D

更新日期：2011-08-15 00:00:00

abstract：:The present study with N-methyl-N-nitrosourea and rat brain DNA was performed in order to study the distribution of alkylated products and the difference in the removal of these products from DNase I-sensitive and -resistant regions of DNA. Nuclei were isolated from N-[3H]methyl-N-nitrosourea-treated rats and incubate...

journal_title：Cancer research

authors： Cox R

更新日期：1979-07-01 00:00:00

abstract：:Aromatase plays a critical role in breast cancer development by converting androgen to estrogen. In this report, results are presented to demonstrate that estrogen, the product of aromatase, can up-regulate its expression. Estrogen receptor (ER) transient transfection experiments were performed using the SK-BR-3 breas...

journal_title：Cancer research

authors： Kinoshita Y,Chen S

更新日期：2003-07-01 00:00:00

abstract：:The role of the cyclin-dependent kinase (CDK) inhibitor p21 as a mediator of p53-induced growth arrest is well established. In addition, recent data provide strong evidence for new emerging functions of p21, including a role as a modulator of apoptosis. The mechanisms, however, by which p21 interferes with the death m...

journal_title：Cancer research

authors： Sohn D,Essmann F,Schulze-Osthoff K,Jänicke RU

更新日期：2006-12-01 00:00:00

abstract：:SOX9 is a transcription factor that plays a critical role in the development of multiple tissues. We previously reported that SOX9 in normal human adult prostate was restricted to basal epithelium. SOX9 was also expressed in a subset of prostate cancer (PCa) cells and was increased in relapsed hormone-refractory PCa. ...

journal_title：Cancer research

authors： Wang H,Leav I,Ibaragi S,Wegner M,Hu GF,Lu ML,Balk SP,Yuan X

更新日期：2008-03-15 00:00:00

abstract：:Mutations of the tumor suppressor E-cadherin and overexpression of the receptor tyrosine kinase epidermal growth factor receptor (EGFR) are among the most frequent genetic alterations associated with diffuse-type gastric carcinoma. Accumulating evidence suggests a functional relationship between E-cadherin and EGFR th...

journal_title：Cancer research

authors： Bremm A,Walch A,Fuchs M,Mages J,Duyster J,Keller G,Hermannstädter C,Becker KF,Rauser S,Langer R,von Weyhern CH,Höfler H,Luber B

更新日期：2008-02-01 00:00:00

abstract：:Recently, we demonstrated that an androgen-regulated cell adhesion molecule, C-CAM, acts as a tumor suppressor in prostate cancer development. In this study, we further explored the possibility of applying C-CAM as a potential agent for developing prostate cancer gene therapy using an adenoviral delivery system. We fo...

journal_title：Cancer research

authors： Kleinerman DI,Zhang WW,Lin SH,Nguyen TV,von Eschenbach AC,Hsieh JT

更新日期：1995-07-01 00:00:00

abstract：:Proteasome inhibitors sensitize tumor cells to DNA-damaging agents, including ionizing radiation (IR), and DNA cross-linking agents (melphalan and cisplatin) through unknown mechanisms. The Fanconi anemia pathway is a DNA damage-activated signaling pathway, which regulates cellular resistance to DNA cross-linking agen...

journal_title：Cancer research

authors： Jacquemont C,Taniguchi T

更新日期：2007-08-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer syndrome characterized by early age of onset colorectal cancer (mean 45 years) as well as endometrial, urinary tract, and upper gastrointestinal adenocarcinomas. The HNPCC phenotype has been shown to segregate with germline mutations in ...

journal_title：Cancer research

authors： Weber TK,Conlon W,Petrelli NJ,Rodriguez-Bigas M,Keitz B,Pazik J,Farrell C,O'Malley L,Oshalim M,Abdo M,Anderson G,Stoler D,Yandell D

更新日期：1997-09-01 00:00:00

abstract：:Cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF) are significantly associated with tumor growth and metastasis. Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)). This cyclop...

journal_title：Cancer research

authors： Grau R,Iñiguez MA,Fresno M

更新日期：2004-08-01 00:00:00

abstract：:In estrogen-induced cancer, catechol formation from administered steroids has been postulated to be a necessary event for estrogen activation and subsequent damage to cellular macromolecules. In the present study, this hypothesis has been tested using two homologous series of structurally related estrogens: estradiol,...

journal_title：Cancer research

authors： Liehr JG,Purdy RH,Baran JS,Nutting EF,Colton F,Randerath E,Randerath K

更新日期：1987-05-15 00:00:00

abstract：:Functional studies using freshly isolated tumor-infiltrating B lymphocytes(TIB) are difficult to perform and interpret. Here we document a novel function of TIB using fresh human lung cancer tissues engrafted in SCID mice; they are at activated state and produce tumor-specific antibodies in tumor microenvironment: (a)...

journal_title：Cancer research

authors： Yasuda M,Takenoyama M,Obata Y,Sugaya M,So T,Hanagiri T,Sugio K,Yasumoto K

更新日期：2002-03-15 00:00:00

abstract：:Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat. Wi...

journal_title：Cancer research

authors： Ying TS,Sarma DS,Farber E

更新日期：1981-06-01 00:00:00

abstract：:DNA methyltransferase 1 (DNMT1)-deficient mice are tumor-prone, and this has been proposed to result from the induction of genomic instability. To address whether loss of DNMT1, or the related protein DNMT3b, results in genomic instability in human cancer cells, we used a near-diploid human colorectal cancer cell line...

journal_title：Cancer research

authors： Karpf AR,Matsui S

更新日期：2005-10-01 00:00:00

abstract：:Galectin-1 (Gal1), an evolutionarily conserved glycan-binding protein, contributes to the creation of an immunosuppressed microenvironment at sites of tumor growth. In spite of considerable progress in elucidating its role in tumor-immune escape, the mechanisms underlying the inhibitory functions of Gal1 remain obscur...

journal_title：Cancer research

authors： Dalotto-Moreno T,Croci DO,Cerliani JP,Martinez-Allo VC,Dergan-Dylon S,Méndez-Huergo SP,Stupirski JC,Mazal D,Osinaga E,Toscano MA,Sundblad V,Rabinovich GA,Salatino M

更新日期：2013-02-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSC) aid in tissue maintenance and repair by differentiating into specialized cell types. Due to this ability, hMSC are currently being evaluated for cell-based therapies of tissue injury and degenerative diseases. However, extensive expansion ex vivo is a prerequisite to obtain the cell...

journal_title：Cancer research

authors： Røsland GV,Svendsen A,Torsvik A,Sobala E,McCormack E,Immervoll H,Mysliwietz J,Tonn JC,Goldbrunner R,Lønning PE,Bjerkvig R,Schichor C

更新日期：2009-07-01 00:00:00

abstract：:Induction of mRNA for BIK proapoptotic protein by doxorubicin or gamma-irradiation requires the DNA-binding transcription factor activity of p53. In MCF7 cells, pure antiestrogen fulvestrant also induces BIK mRNA and apoptosis. Here, we provide evidence that, in contrast to doxorubicin or gamma-irradiation, fulvestran...

journal_title：Cancer research

authors： Hur J,Bell DW,Dean KL,Coser KR,Hilario PC,Okimoto RA,Tobey EM,Smith SL,Isselbacher KJ,Shioda T

更新日期：2006-10-15 00:00:00

abstract：:Genomic analyses of late-stage human cancers have uncovered deletions encompassing 1p36, thereby providing an extensive body of literature supporting the idea that a potent tumor suppressor resides in this interval. Although several genes have been proposed as 1p36 candidate tumor suppressors, convincing evidence that...

journal_title：Cancer research

authors： Bagchi A,Mills AA

更新日期：2008-04-15 00:00:00

abstract：:The tachykinin family of neuropeptides, including substance P and neurokinins A and B, induce a transient increase in intracellular free calcium concentration in human small cell lung carcinoma (SCLC) cells, as measured with a calcium indicator fura-2. The effects are dose dependent and even greater than that of bombe...

journal_title：Cancer research

authors： Takuwa N,Takuwa Y,Ohue Y,Mukai H,Endoh K,Yamashita K,Kumada M,Munekata E

更新日期：1990-01-15 00:00:00

abstract：:Glutathione S-transferases have been purified to homogeneity from Chinese hamster liver. Three enzyme forms were separated and designated Forms I, II, and III in order of their elution from carboxymethylcellulose columns. The forms exhibit close physical similarities to glutathione S-transferases B (ligandin) of rat l...

journal_title：Cancer research

authors： Smith GJ,Ohl VS,Litwack G

更新日期：1980-06-01 00:00:00

abstract：:The binding of labeled insulin to dissociated R3230AC mammary adenocarcinoma cells from diabetic and intact rats was investigated in vitro. At 20 degrees, specific binding (total binding minus binding in the presence of 1000-fold excess or 10(-6) M unlabeled insulin) reached a plateau at 45 to 60 min and was directly ...

journal_title：Cancer research

authors： Harmon JT,Hilf R

更新日期：1976-11-01 00:00:00

abstract：:Multi-targeting strategies improve the efficacy of antibody and immunotoxin therapies but have not yet been thoroughly explored for HER2-based cancer treatments. We investigated multi-epitope HER2 targeting to boost photosensitizer immunoconjugate uptake as a way of enhancing photoimmunotherapy. Photoimmunotherapy may...

journal_title：Cancer research

authors： Savellano MD,Pogue BW,Hoopes PJ,Vitetta ES,Paulsen KD

更新日期：2005-07-15 00:00:00