Regulation of expression of BIK proapoptotic protein in human breast cancer cells: p53-dependent induction of BIK mRNA by fulvestrant and proteasomal degradation of BIK protein.

abstract：:Epithelial to mesenchymal transition occurs during embryologic development to allow tissue remodeling and is proposed to be a key step in the metastasis of epithelial-derived tumors. The miR-200 family of microRNAs plays a major role in specifying the epithelial phenotype by preventing expression of the transcription ...

journal_title：Cancer research

authors： Bracken CP,Gregory PA,Kolesnikoff N,Bert AG,Wang J,Shannon MF,Goodall GJ

更新日期：2008-10-01 00:00:00

abstract：:Homogeneously staining regions (HSRs) were found in hypodiploid cells (40%) of a subline of the human melanoma cell line, MeWo, (MeWo-C) but were absent from the hypotetraploid cells (60%). Another subline (MeWo-B) was also shown to contain two populations of cells, 70% hypodiploid and 30% hypotetraploid. None of the ...

journal_title：Cancer research

authors： Shtromas I,White BN,Holden JJ,Reimer DL,Roder JC

更新日期：1985-02-01 00:00:00

abstract：:Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by aggregating FcγRIIIA/CD16, contributing significantly to the therapeutic effect of CD20 monoclonal antibodies (mAb). In this study, we show that CD16 ligation on primary human NK cells by the anti-CD20 mAb rituximab or ofatumum...

journal_title：Cancer research

authors： Capuano C,Romanelli M,Pighi C,Cimino G,Rago A,Molfetta R,Paolini R,Santoni A,Galandrini R

更新日期：2015-10-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are the main producers of a key T-cell-stimulatory cytokine, IFNα, and critical regulators of antiviral immunity. Chronic myeloid leukemia (CML) is caused by BCR-ABL, which is an oncogenic tyrosine kinase that can be effectively inhibited with ABL-selective tyrosine kinase inhibitors...

journal_title：Cancer research

authors： Inselmann S,Wang Y,Saussele S,Fritz L,Schütz C,Huber M,Liebler S,Ernst T,Cai D,Botschek S,Brendel C,Calogero RA,Pavlinic D,Benes V,Liu ET,Neubauer A,Hochhaus A,Burchert A

更新日期：2018-11-01 00:00:00

abstract：:Membrane type-1 matrix metalloproteinase (MT1-MMP) is a promising drug target in malignancy. The structure of MT1-MMP includes the hemopexin domain (PEX) that is distinct from and additional to the catalytic domain. Current MMP inhibitors target the conserved active site in the catalytic domain and, as a result, repre...

journal_title：Cancer research

authors： Remacle AG,Golubkov VS,Shiryaev SA,Dahl R,Stebbins JL,Chernov AV,Cheltsov AV,Pellecchia M,Strongin AY

更新日期：2012-05-01 00:00:00

abstract：:Monoclonal antibody (MAb) B72.3 was generated using a membrane-enriched fraction of a human mammary carcinoma biopsy. It has demonstrated reactivity to the majority of human adenocarcinomas including colorectal, gastric, pancreatic, ovarian, endometrial, mammary, and non-small cell lung cancer and no or weak reactivit...

journal_title：Cancer research

authors： Muraro R,Kuroki M,Wunderlich D,Poole DJ,Colcher D,Thor A,Greiner JW,Simpson JF,Molinolo A,Noguchi P

更新日期：1988-08-15 00:00:00

abstract：:Identification of proteins that are involved in the sensitivity of radiotherapy of cancers is important to enhance the response to cancer treatment. Expression of TAp73 is associated with the sensitivity of radiotherapy in cervical cancer patients, suggesting it plays an important role in controlling radiosensitivity....

journal_title：Cancer research

authors： Leung TH,Ngan HY

更新日期：2010-08-15 00:00:00

abstract：:MLN4924 is a first-in-class experimental cancer drug that inhibits the NEDD8-activating enzyme, thereby inhibiting cullin-RING E3 ubiquitin ligases and stabilizing many cullin substrates. The mechanism by which MLN4924 inhibits cancer cell proliferation has not been defined, although it is accompanied by DNA rereplica...

journal_title：Cancer research

authors： Lin JJ,Milhollen MA,Smith PG,Narayanan U,Dutta A

更新日期：2010-12-15 00:00:00

abstract：:There is increasing evidence that high doses of radiotherapy, like those delivered in stereotactic body radiotherapy (SBRT), trigger indirect mechanisms of cell death. Such effect seems to be two-fold. High doses may trigger an immune response and may cause vascular damage, leading to cell starvation and death. Develo...

journal_title：Cancer research

authors： Rodríguez-Barbeito P,Díaz-Botana P,Gago-Arias A,Feijoo M,Neira S,Guiu-Souto J,López-Pouso Ó,Gómez-Caamaño A,Pardo-Montero J

更新日期：2019-12-01 00:00:00

abstract：:Therapeutic inhibition of mammalian target of rapamycin (mTOR) in cancer is complicated by the existence of a negative feedback loop linking mTOR to the phosphatidylinositol 3-kinase (PI3K)-Akt pathway. Thus, mTOR inhibition by rapamycin or TSC1/2 results in increased PI3K-Akt activation. The death domain kinase recep...

journal_title：Cancer research

authors： Park S,Zhao D,Hatanpaa KJ,Mickey BE,Saha D,Boothman DA,Story MD,Wong ET,Burma S,Georgescu MM,Rangnekar VM,Chauncey SS,Habib AA

更新日期：2009-05-15 00:00:00

abstract：:[D-Arg1,D-Trp5,7,9,Leu11]Substance P (SP) was identified out of a panel of novel SP analogues as the most potent inhibitor of small cell lung cancer (SCLC) cell growth. This analogue inhibited proliferation of H-510 and H-69 SCLC cells in liquid culture and in semisolid media (IC50, 5 microM). Colony formation stimula...

journal_title：Cancer research

authors： Seckl MJ,Higgins T,Widmer F,Rozengurt E

更新日期：1997-01-01 00:00:00

abstract：:The inhibitor of caspase-3-activated DNase (ICAD) is a caspase-3 substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of M(r) 45,000, ICAD-L/DNA fragmentation factor (DFF) 45; and a M(r) 35,000 isoform, ICAD-S/DFF35. ICAD-deficient murine cells display resistance to apoptotic stimuli ...

journal_title：Cancer research

authors： Charrier L,Jarry A,Toquet C,Bou-Hanna C,Chedorge M,Denis M,Vallette G,Laboisse CL

更新日期：2002-04-01 00:00:00

abstract：:Immunodiffusion, immunofluorescence, and flow cytometric techniques were used to characterize the expression of murine gamma-glutamyltranspeptidase (gamma GT) on normal and cervical cancer tissue. In immunodiffusion tests, the rabbit antiserum produced against highly purified murine kidney gamma GT formed two lines ag...

journal_title：Cancer research

authors： Chen YF,Haskill S

更新日期：1984-10-01 00:00:00

abstract：:Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD) could function as a cell surface sensor for cell density, controlling the transition between local cell proliferation and tissue invasion in melanoma progression. We have tested the hypothesis that progressive cell clustering controls the proteolytic cascad...

journal_title：Cancer research

authors： Lunter PC,van Kilsdonk JW,van Beek H,Cornelissen IM,Bergers M,Willems PH,van Muijen GN,Swart GW

更新日期：2005-10-01 00:00:00

abstract：:alphaVbeta3 integrin complexes are overexpressed in the growing, invading margins of human glioblastoma multiforme (GBM) and in the GBM vasculature, suggesting a key role for alphaVbeta3 in GBM growth and invasion. The function of alphaVbeta3 complexes in tumor formation, however, has been challenged by studies showin...

journal_title：Cancer research

authors： Kanamori M,Vanden Berg SR,Bergers G,Berger MS,Pieper RO

更新日期：2004-04-15 00:00:00

abstract：:Lipoblastomas are pediatric neoplasms resulting from transformation of adipocytes. These benign tumors are typically composed of adipose cells in different stages of maturation within a variably myxoid matrix, and they contain clonal rearrangements of chromosome band 8q12. Because lipoblastomas resemble embryonic adip...

journal_title：Cancer research

authors： Hibbard MK,Kozakewich HP,Dal Cin P,Sciot R,Tan X,Xiao S,Fletcher JA

更新日期：2000-09-01 00:00:00

abstract：:We used three techniques to examine excision repair in human cells treated with ultraviolet radiation, N-acetoxy-2-acetylaminofluorene, and a combination of the two. The three techniques gave similar results. Two types of human cells were used: (a) excision repair proficient (normal human fibroblasts and xeroderma pig...

journal_title：Cancer research

authors： Ahmed FE,Setlow RB

更新日期：1979-02-01 00:00:00

abstract：:We have cloned an alternatively spliced form of cyclin-dependent kinase (CDK) inhibitor p15 from human placenta. The alternative splice arises from an alternative 5' donor site in intron 1. An in-frame stop codon within the new exon, called exon 1beta, leads to translation of a Mr 10,000 protein identical to the NH2 t...

journal_title：Cancer research

authors： Tsubari M,Tiihonen E,Laiho M

更新日期：1997-07-15 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are highly aggressive, lack FDA-approved targeted therapies, and frequently recur, making the discovery of novel therapeutic targets for this disease imperative. Our previous analysis of the molecular mechanisms of action of bromodomain and extraterminal protein inhibitors (BETi) ...

journal_title：Cancer research

authors： Sahni JM,Gayle SS,Webb BM,Weber-Bonk KL,Seachrist DD,Singh S,Sizemore ST,Restrepo NA,Bebek G,Scacheri PC,Varadan V,Summers MK,Keri RA

更新日期：2017-10-01 00:00:00

abstract：:It has been shown that the systemic administration of lymphokine-activated killer (LAK) cells with recombinant interleukin 2 (RIL-2) is effective in reducing the number of established pulmonary and hepatic metastases in murine models. Similarly, this modality of therapy has been proven effective against certain select...

journal_title：Cancer research

authors： Lafreniere R,Borkenhagen K,Bryant LD,Huchcroft S

更新日期：1989-05-01 00:00:00

abstract：:A synthetic peptide from the inner globule of the B1 chain of laminin, termed peptide F-9 (RYVVLPRPVCFEKGMNYTVR; residues 641-660), has been shown to have heparin-binding and cell adhesion-promoting activities for diverse cell types (Charonis et al., J. Cell. Biol., 107: 1253-1260, 1988). In this study, the metastatic...

journal_title：Cancer research

authors： Skubitz AP,McCarthy JB,Zhao Q,Yi XY,Furcht LT

更新日期：1990-12-01 00:00:00

abstract：:The Lewis lung carcinoma is a transplantable metastatic tumor of the C57BL mouse strain. When cells derived from this tumor are inoculated onto the chorioallantoic membrane (CAM) of 9- to 11-day-old chick embryos, large tumors are produced. Although most of these tumors contain mouse cells, they can no longer be trans...

journal_title：Cancer research

authors： Belin D,Ossowski L

更新日期：1983-07-01 00:00:00

abstract：:Spy1A is a unique cell cycle activator known to mediate cell cycle progression and override the DNA damage response. This study focused on determining the role of this protein on postnatal mammary gland morphogenesis and neoplasia. Herein, we show that Spy1A levels are tightly regulated during mammary gland developmen...

journal_title：Cancer research

authors： Golipour A,Myers D,Seagroves T,Murphy D,Evan GI,Donoghue DJ,Moorehead RA,Porter LA

更新日期：2008-05-15 00:00:00

abstract：:Despite esophageal adenocarcinoma (EAC) being the most widespread among gastrointestinal cancers, with an 11-fold increase in the risk of cancer for patients with Barrett esophagus (BE), its prognosis is still poor. There is a critical need to better perceive the biology of cancer progression and identification of spe...

journal_title：Cancer research

authors： Urbanska AM,Ponnazhagan S,Mozafari M

更新日期：2018-07-15 00:00:00

abstract：:Linomide is a p.o. active antiangiogenic agent that has been demonstrated to be effective in suppressing the in vivo growth of rat and human prostatic cancer xenografts. The present studies were conducted to determine whether the angiogenic molecules, vascular endothelial growth factor/vascular permeability factor (VE...

journal_title：Cancer research

authors： Joseph IB,Isaacs JT

更新日期：1997-03-15 00:00:00

abstract：:The presence of a quinone group in the structure of a series of model compounds was shown to produce cell kill by a mechanism involving free radicals and active oxygen species. Furthermore, the ability of the compound to bind to DNA appeared to enhance its cytocidal activity. The same model compounds were used to inve...

journal_title：Cancer research

authors： Begleiter A,Blair GW

更新日期：1984-01-01 00:00:00

abstract：:The fibroblast growth factors (FGF) play diverse roles in development, wound healing, and angiogenesis. The intracellular signal transduction pathways, which mediate these pleiotropic activities, remain incompletely understood. We show here that the proangiogenic factors FGF2 and FGF8b can activate signal transducers ...

journal_title：Cancer research

authors： Yang X,Qiao D,Meyer K,Friedl A

更新日期：2009-02-15 00:00:00

abstract：:CXCL10 was recently shown to exert antimalignancy functions by influencing the tumor microenvironment. Here, we have taken a different approach, investigating the effects of CXCL10 directly on tumor-promoting functions in colorectal carcinoma (CRC) cells. CXCL10 expression was detected in preferred metastatic sites of...

journal_title：Cancer research

authors： Zipin-Roitman A,Meshel T,Sagi-Assif O,Shalmon B,Avivi C,Pfeffer RM,Witz IP,Ben-Baruch A

更新日期：2007-04-01 00:00:00

abstract：:Whole-slide histology images contain information that is valuable for clinical and basic science investigations of cancer, but extracting quantitative measurements from these images is challenging for researchers who are not image analysis specialists. In this paper, we describe HistomicsML2, a software tool for learn...

journal_title：Cancer research

authors： Lee S,Amgad M,Mobadersany P,McCormick M,Pollack BP,Elfandy H,Hussein H,Gutman DA,Cooper LA

更新日期：2020-12-21 00:00:00

abstract：:Glioblastoma multiforme lacks effective therapy options. Although deregulated kinase pathways are drivers of malignant progression in glioblastoma multiforme, glioma cells exhibit intrinsic resistance toward many kinase inhibitors, and the molecular basis of this resistance remains poorly understood. Here, we show tha...

journal_title：Cancer research

authors： Kaur A,Denisova OV,Qiao X,Jumppanen M,Peuhu E,Ahmed SU,Raheem O,Haapasalo H,Eriksson J,Chalmers AJ,Laakkonen P,Westermarck J

更新日期：2016-12-01 00:00:00