PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells.

abstract：:C/EBPα is an essential transcription factor involved in regulating the expression or function of certain cell-cycle regulators, including in breast cancer cells. Although protein arginine methyltransferases have been shown to play oncogenic roles in a variety of cancers, little is known about the role of arginine meth...

journal_title：Cancer research

authors： Liu LM,Sun WZ,Fan XZ,Xu YL,Cheng MB,Zhang Y

更新日期：2019-06-01 00:00:00

abstract：:Synovial sarcomas are aggressive spindle cell sarcomas containing in some cases areas of epithelial differentiation. They consistently show a specific t(X;18;p11;q11), which usually represents either of two gene fusions, SYT-SSX1 or SYT-SSX2, encoding putative transcriptional proteins differing at 13 amino acid positi...

journal_title：Cancer research

authors： Ladanyi M,Antonescu CR,Leung DH,Woodruff JM,Kawai A,Healey JH,Brennan MF,Bridge JA,Neff JR,Barr FG,Goldsmith JD,Brooks JS,Goldblum JR,Ali SZ,Shipley J,Cooper CS,Fisher C,Skytting B,Larsson O

更新日期：2002-01-01 00:00:00

abstract：:Anguidine, a protein synthesis inhibitor, has been shown to induce a reversible cell cycle arrest in exponentially growing Chinese hamster ovary cells. The effect of pretreatment with anguidine on the cytotoxicity of subsequently administered various chemotherapeutic agents, hyperthermia, and radiation was investigate...

journal_title：Cancer research

authors： Hromas R,Barlogie B,Swartzendruber D,Drewinko B

更新日期：1983-07-01 00:00:00

abstract：:The ability of the vitamin E (RRR-alpha-tocopherol) derivatives alpha-tocopheryl succinate (alpha-TOS) and alpha-tocopheryloxyacetic acid (alpha-TEA) to suppress tumor growth in preclinical animal models has recently led to increased interest in their potential use for treating human cancer. To make the use of these v...

journal_title：Cancer research

authors： Hahn T,Szabo L,Gold M,Ramanathapuram L,Hurley LH,Akporiaye ET

更新日期：2006-10-01 00:00:00

abstract：:The fate of circulating tumor cells is an important determinant of their ability to form distant metastasis. Here, we demonstrate the use of in vivo flow cytometry as a powerful new method for detecting quantitatively circulating cancer cells. We specifically examine the circulation kinetics of two prostate cancer cel...

journal_title：Cancer research

authors： Georgakoudi I,Solban N,Novak J,Rice WL,Wei X,Hasan T,Lin CP

更新日期：2004-08-01 00:00:00

abstract：:Previous work in our laboratory has demonstrated that antisera to proteins found in the urine of bladder cancer patients can distinguish between urine samples from these patients and those from normal individuals when tested by a complement-fixation assay. Antisera which were reactive with individual tumor-associated ...

journal_title：Cancer research

authors： De Fazio SR,Gozzo JJ,Monaco AP

更新日期：1982-07-01 00:00:00

abstract：:CD38 is a leukocyte differentiation antigen that has been thought to be a phenotypic marker of different subpopulations of T- and B-lymphocytes. In myeloid cells, CD38 is expressed during early stages of differentiation. Virtually no information is available on regulation and functions of CD38. Recently we reported th...

journal_title：Cancer research

authors： Drach J,McQueen T,Engel H,Andreeff M,Robertson KA,Collins SJ,Malavasi F,Mehta K

更新日期：1994-04-01 00:00:00

abstract：:Iodine-131-labeled anti-CD45 antibody has been added to conventional hematopoietic stem cell transplant preparative regimens to deliver targeted radiation to hematopoietic tissues, with the goal of decreasing relapse rates without increasing toxicity. However, higher radiation doses could be delivered to leukemia cell...

journal_title：Cancer research

authors： Ruffner KL,Martin PJ,Hussell S,Nourigat C,Fisher DR,Bernstein ID,Matthews DC

更新日期：2001-07-01 00:00:00

abstract：:The radiation response of autochthonous tumors induced by s.c. injection of 3-methylcholanthrene in ICR/JCL mice was studied. The tumors were mostly fibrosarcomas and grew with an average volume-doubling time of 2.6 days, independently of the time tumor appearance or dose of the chemical used. The tumors were locally ...

journal_title：Cancer research

authors： Tanooka H,Hoshino H,Tanaka K,Nagase M

更新日期：1980-07-01 00:00:00

abstract：:Aluminum sulfonated phthalocyanine has potential as a suitable photosensitizer for use in the photodynamic therapy of cancer. In the present study, cellular uptake and retention of the individual mono-, di-, tri-, and tetrasulfonated derivatives (AlS1-4Pc) were examined in tissue culture and in normal and neoplastic t...

journal_title：Cancer research

authors： Chan WS,Marshall JF,Svensen R,Bedwell J,Hart IR

更新日期：1990-08-01 00:00:00

abstract：:It has been reported that HLA-DR is a potent inducer of thrombin generation. Human colorectal cells (GEO, WiDr, DLD-1, and MIP) that lack the constitutive expression of HLA-DR cause platelet aggregation through a thrombin-dependent mechanism. Treatment with recombinant human gamma-interferon induced the expression of ...

journal_title：Cancer research

authors： Ferroni P,Guadagni F,Spila A,Martini F,Gazzaniga PP

更新日期：1994-02-01 00:00:00

abstract：:Migration from the primary tumor is a crucial step in the metastatic cascade. Cells with various degrees of adhesion and motility migrate and are launched into the bloodstream as single circulating tumor cells (CTC) or multicellular CTC clusters. The frequency and size distributions of these clusters have been recentl...

journal_title：Cancer research

authors： Bocci F,Kumar Jolly M,Onuchic JN

更新日期：2019-11-01 00:00:00

abstract：:Patient-derived xenografts (PDX) are tumor-in-mouse models for cancer. PDX collections, such as the NCI PDXNet, are powerful resources for preclinical therapeutic testing. However, variations in experimental and analysis procedures have limited interpretability. To determine the robustness of PDX studies, the PDXNet t...

journal_title：Cancer research

authors： Evrard YA,Srivastava A,Randjelovic J,Doroshow JH,Dean DA 2nd,Morris JS,Chuang JH,NCI PDXNet Consortium.

更新日期：2020-06-01 00:00:00

abstract：:The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem-like cells. However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood. Here, we report that Nestin binds the hedgehog pathway transcription factor Gli3 to ...

journal_title：Cancer research

authors： Li P,Lee EH,Du F,Gordon RE,Yuelling LW,Liu Y,Ng JM,Zhang H,Wu J,Korshunov A,Pfister SM,Curran T,Yang ZJ

更新日期：2016-09-15 00:00:00

abstract：:The relevance of cysteine metabolism in cancer has gained considerable interest in recent years, largely focusing on its role in generating the antioxidant glutathione. Through metabolomic profiling using a combination of high-throughput liquid and gas chromatography-based mass spectrometry on a total of 69 patient-de...

journal_title：Cancer research

authors： Prabhu A,Sarcar B,Kahali S,Yuan Z,Johnson JJ,Adam KP,Kensicki E,Chinnaiyan P

更新日期：2014-02-01 00:00:00

abstract：:Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions have yet to be understood with any mechanistic clarity. In this study, we evaluated the proteomic spectrum of interactions made by Nm23-H1 in 4T1 murine breast cancer cells derived from tissue culture, primary mammary tumors, and...

journal_title：Cancer research

authors： Marino N,Marshall JC,Collins JW,Zhou M,Qian Y,Veenstra T,Steeg PS

更新日期：2013-10-01 00:00:00

abstract：:50C10 and 52H10 are two DNA clones previously reported by us to be overexpressed in human colonic mucosa at high risk for development of colonic tumors. This report presents sequencing data that reveal that these clones contain repetitive Alu elements. Each Alu sequence is associated with a 3'-oligoadenylate [oligo(A)...

journal_title：Cancer research

authors： Chen J,Heerdt BG,Augenlicht LH

更新日期：1995-01-01 00:00:00

abstract：:Salvage of preformed nucleosides requires transport across the plasma membrane by sodium-dependent (concentrative) and sodium-independent (equilibrative) mechanisms. These transport systems are also the route of cellular uptake for nucleoside analogues, including gemcitabine (2',2'-difluorodeoxycytidine), a deoxycytid...

journal_title：Cancer research

authors： Rauchwerger DR,Firby PS,Hedley DW,Moore MJ

更新日期：2000-11-01 00:00:00

abstract：:The glutathione transferase P (GST-P) gene is known for its specific expression during chemical hepatocarcinogenesis of the rat and is used as a tumor marker for hepatocellular carcinoma. We have shown recently that the upstream 2.9-kb region of the GST-P gene is sufficient for conferring tumor-specific expression of ...

journal_title：Cancer research

authors： Suzuki T,Imagawa M,Hirabayashi M,Yuki A,Hisatake K,Nomura K,Kitagawa T,Muramatsu M

更新日期：1995-06-15 00:00:00

abstract：:We have previously described an MCF-7 breast cancer cell variant, MCF-7TAM, which is stimulated to grow in athymic mice by tamoxifen (TAM) (M. M. Gottardis and V. C. Jordan, Cancer Res., 48:5183-5187, 1988). Earlier experiments have shown that TAM exhibits some profound estrogen-like effects in mice whereas TAM is les...

journal_title：Cancer research

authors： Gottardis MM,Wagner RJ,Borden EC,Jordan VC

更新日期：1989-09-01 00:00:00

abstract：:Rational therapeutic approaches based on synthetic lethality may improve cancer management. On the basis of a high-throughput drug screen, we provide preclinical proof of concept that targeting the mitochondrial Hsp90 chaperone network (mtHsp90) and inhibition of Bcl-2, Bcl-xL, and Mcl-1 is sufficient to elicit synthe...

journal_title：Cancer research

authors： Karpel-Massler G,Ishida CT,Bianchetti E,Shu C,Perez-Lorenzo R,Horst B,Banu M,Roth KA,Bruce JN,Canoll P,Altieri DC,Siegelin MD

更新日期：2017-07-01 00:00:00

abstract：:The presence of succinyl-coenzyme A:acetoacetate CoA transferase (CoA transferase) (EC 2.8.3.5), an initiator of ketone body utilization in nonhepatic tissue, was examined in liver from normal, partly hepatectomized, neonatal, and tumor-bearing rats, as well as in a series of transplantable rat hepatomas ranging widel...

journal_title：Cancer research

authors： Fenselau A,Wallis K,Morris HP

更新日期：1975-09-01 00:00:00

abstract：:Lung carcinoma cell lines were analyzed in culture and in nude mouse xenograft for both morphological appearance and expression of specific proteins that participate in cross-linked envelope formation during normal squamous cell terminal differentiation. Cross-linked envelope formation, induced by artificial influx of...

journal_title：Cancer research

authors： Levitt ML,Gazdar AF,Oie HK,Schuller H,Thacher SM

更新日期：1990-01-01 00:00:00

abstract：:Many vaccines are dependent on adjuvants to augment the immunizing process. The vaccines being developed for active specific immunotherapy of cancer have also usually included an adjuvant in the clinical studies. Several cytokines have been identified which are participants in the immune response to new antigenic stim...

journal_title：Cancer research

authors： McCune CS,Marquis DM

更新日期：1990-02-15 00:00:00

abstract：:We previously reported that the thermosensitivity of tumor cells can be increased when the intracellular pH is lowered by inhibiting Na+/H+ exchange through the plasma membrane with amiloride (3,5-diamino-6-chloro-N-(diamino methylene)pyrazinecarboxamide) or its analogues and HCO3-/Cl-exchange with 4,4-diiothiocyanato...

journal_title：Cancer research

authors： Song CW,Lyons JC,Griffin RJ,Makepeace CM,Cragoe EJ Jr

更新日期：1993-04-01 00:00:00

abstract：:Calf thymus DNA was modified in vitro by cis-diamminedichloroplatinum(II) (cisDDP), complexed with methylated bovine serum albumin and used to immunize rabbits. The anti-cisDDP-DNA antiserum obtained was applied in a double peroxidase-antiperoxidase staining procedure to localize cisDDP-DNA and cis-diammine(1,1-cyclob...

journal_title：Cancer research

authors： Terheggen PM,Floot BG,Scherer E,Begg AC,Fichtinger-Schepman AM,den Engelse L

更新日期：1987-12-15 00:00:00

abstract：:SNAI2 overexpression appears to be associated with poor prognosis in breast cancer, yet it remains unclear in which breast cancer subtypes this occurs. Here we show that excess SNAI2 is associated with a poor prognosis of luminal B HER2+/ERBB2+ breast cancers in which SNAI2 expression in the stroma but not the epithel...

journal_title：Cancer research

authors： Blanco-Gómez A,Hontecillas-Prieto L,Corchado-Cobos R,García-Sancha N,Salvador N,Castellanos-Martín A,Sáez-Freire MDM,Mendiburu-Eliçabe M,Alonso-López D,De Las Rivas J,Lorente M,García-Casas A,Del Carmen S,Abad-Hernández MDM,C

更新日期：2020-12-01 00:00:00

abstract：:Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation of miRNAs has been associated with the pa...

journal_title：Cancer research

authors： Park EY,Chang E,Lee EJ,Lee HW,Kang HG,Chun KH,Woo YM,Kong HK,Ko JY,Suzuki H,Song E,Park JH

更新日期：2014-12-15 00:00:00

abstract：:The effect of the AC33 tumor on protein synthesis in Lewis-Wistar rats was investigated under four different dietary regimens. The four diets used were: (a) 1.25 g amino acids plus 12.5 g glucose per day, (b) 1.25 g amino acids, (c) 1.25 g glucose per day, and (d) 12.5 g glucose per day. The rats were maintained on th...

journal_title：Cancer research

authors： Stein TP,Oram-Smith JC,Leskiw MJ,Wallace HW,Miller EE

更新日期：1976-11-01 00:00:00

abstract：:Ionizing radiation is a major tool for cancer treatment. The response of eukaryotic cells to ionizing radiation includes apoptosis, a process which requires activation of multiple genes. We sought to determine whether radiation-induced gene expression plays a role in radiation-induced apoptosis. We found Apo2 ligand (...

journal_title：Cancer research

authors： Gong B,Almasan A

更新日期：2000-10-15 00:00:00