当前位置： SCI文献检索 > CANCER RESEARCH期刊下所有文献 > CXCL10 promotes invasion-related properties in human colorectal carcinoma cells.

CXCL10 promotes invasion-related properties in human colorectal carcinoma cells.

Abstract：

:CXCL10 was recently shown to exert antimalignancy functions by influencing the tumor microenvironment. Here, we have taken a different approach, investigating the effects of CXCL10 directly on tumor-promoting functions in colorectal carcinoma (CRC) cells. CXCL10 expression was detected in preferred metastatic sites of CRC (liver, lungs, and lymph nodes), and its CXCR3 receptor was expressed by eight CRC cell lines (detected: reverse transcription-PCR and/or flow cytometry). Detailed analysis was done on two cell lines derived from primary CRC tumors (SW480, KM12C) and their metastatic descendents (SW620 and KM12SM). The three known variants of CXCR3 (CXCR3-A, CXCR3-B, and CXCR3-alt) were detected in all four cell lines. CXCR3 expression was also observed on colorectal tumor cells in biopsies of CRC patients (immunohistochemistry). CXCL10 and CXCR3 expression were potently induced in CRC cells by Interferon gamma and all four CRC cell lines responded to CXCL10 by extracellular signal-regulated kinase 1/2 dephosphorylation. The chemokine did not affect tumor cell growth or angiogenesis-related functions in the tumor cells, such as CXCL8 and vascular endothelial growth factor secretion. Importantly, CXCL10 significantly up-regulated invasion-related properties in CRC cells: It promoted matrix metalloproteinase 9 expression and induced CRC cell migration. Of note, CXCL10-induced migration was detected only in the two metastatic cells and not in their primary counterparts. Also, CXCL10 promoted the adhesion of metastatic cells to laminin. These results suggest that CXCL10 can be exploited by CRC cells toward their progression, thus possibly antagonizing the antimalignancy effects of the chemokine on the tumor microenvironment. Therefore, care should be taken when considering CXCL10 as a therapeutic antitumor modality for CRC treatment.

journal_name

Cancer Res

journal_title

Cancer research

authors

Zipin-Roitman A,Meshel T,Sagi-Assif O,Shalmon B,Avivi C,Pfeffer RM,Witz IP,Ben-Baruch A

doi

10.1158/0008-5472.CAN-06-3087

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

3396-405

issue

7

eissn

0008-5472

issn

1538-7445

pii

67/7/3396

journal_volume

67

pub_type

杂志文章

相关文献

CANCER RESEARCH文献大全
  • Influence of pH on the thermal sensitivity of cultured human glioblastoma cells.

    abstract：:The hyperthermic sensitivity of cultured human glioblastoma cells was determined in 1 degree increments from 42 through 46 degrees over the pH range of 6.1 to 7.4. These cells were 5 to 10 times less heat sensitive than were Chinese hamster ovary cells and are among the most resistant cells examined in cell culture. A...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Gerweck LE,Richards B

    更新日期：1981-03-01 00:00:00

  • Effects of the antitumor agent 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one on the DNA of mouse L1210 cells.

    abstract：:L1210 murine leukemia cells were treated in vitro with the novel antineoplastic agent 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one (M&B 39565), and its interaction with cellular DNA was assessed by alkaline elution. DNA interstrand cross-link and DNA-protein cross-link formation was quantifi...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Gibson NW,Erickson LC,Hickman JA

    更新日期：1984-05-01 00:00:00

  • Genetic variation in angiotensin I-converting enzyme (ACE) and breast cancer risk: the multiethnic cohort.

    abstract：:The A-240T and I/D polymorphisms in the angiotensin I-converting enzyme (ACE) gene are markers of circulating ACE levels and have been associated with numerous cardiovascular disease outcomes. More recently, the low-activity A and I alleles at these polymorphic sites have been inversely related with breast cancer risk...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Haiman CA,Henderson SO,Bretsky P,Kolonel LN,Henderson BE

    更新日期：2003-10-15 00:00:00

  • Quinone-induced DNA damage and its relationship to antitumor activity in L5178Y lymphoblasts.

    abstract：:The presence of a quinone group in the structure of a series of model compounds was shown to produce cell kill by a mechanism involving free radicals and active oxygen species. Furthermore, the ability of the compound to bind to DNA appeared to enhance its cytocidal activity. The same model compounds were used to inve...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Begleiter A,Blair GW

    更新日期：1984-01-01 00:00:00

  • Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice.

    abstract：:Tumor-specific immune tolerance limits the effectiveness of cancer vaccines. In addition, tumor vaccines alone have a limited potential for the treatment of measurable tumor burdens. This highlights the importance of identifying more potent cancer vaccine strategies for clinical testing. We tested immune-modulating do...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Machiels JP,Reilly RT,Emens LA,Ercolini AM,Lei RY,Weintraub D,Okoye FI,Jaffee EM

    更新日期：2001-05-01 00:00:00

  • Epidermal growth factor protects epithelial-derived cells from tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by inhibiting cytochrome c release.

    abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in combination with chemotherapeutic drugs induces a synergistic apoptotic response in cancer cells. TRAIL death receptors have also been implicated in chemotherapeutic drug-induced apoptosis. This has lead to TRAIL being proposed as a potential cancer tr...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Gibson EM,Henson ES,Haney N,Villanueva J,Gibson SB

    更新日期：2002-01-15 00:00:00

  • Heme-oxygenase-1 Production by Intestinal CX3CR1+ Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis.

    abstract：:CX3CR1+ macrophages in the intestinal lamina propria contribute to gut homeostasis through the immunomodulatory interleukin IL10, but there is little knowledge on how these cells or the CX3CR1 receptor may affect colorectal carcinogenesis. In this study, we show that CX3CR1-deficient mice fail to resolve gut inflammat...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-16-2501

    authors： Marelli G,Erreni M,Anselmo A,Taverniti V,Guglielmetti S,Mantovani A,Allavena P

    更新日期：2017-08-15 00:00:00

  • Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells.

    abstract：:The treatment of glioblastoma (GBM) remains challenging in part due to the presence of stem-like tumor-propagating cells that are resistant to standard therapies consisting of radiation and temozolomide. Among the novel and targeted agents under evaluation for the treatment of GBM are BRAF/MAPK inhibitors, but their e...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-14-3689

    authors： Lerner RG,Grossauer S,Kadkhodaei B,Meyers I,Sidorov M,Koeck K,Hashizume R,Ozawa T,Phillips JJ,Berger MS,Nicolaides T,James CD,Petritsch CK

    更新日期：2015-12-15 00:00:00

  • Multiple hormone receptors in the adenylate cyclase of human adrenocortical tumors.

    abstract：:Adenylate cyclase responses to pituitary hormones including adrenocorticotropic hormone (ACTH), biogenetic amines, prostaglandin E1 (PGE1), angiotensin II, and glucagon were evaluated in adrenocortical tumors and hyperplastic adrenal tissues, obtained from patients with Cushing's syndrome at surgery, and in normal adr...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Matsukura S,Kakita T,Sueoka S,Yoshimi H,Hirata Y,Yokota M,Fujita T

    更新日期：1980-10-01 00:00:00

  • The vitamin E analogue α-TEA stimulates tumor autophagy and enhances antigen cross-presentation.

    abstract：:The semisynthetic vitamin E derivative alpha-tocopheryloxyacetic acid (α-TEA) induces tumor cell apoptosis and may offer a simple adjuvant supplement for cancer therapy if its mechanisms can be better understood. Here we report that α-TEA also triggers tumor cell autophagy and that it improves cross-presentation of tu...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-11-3103

    authors： Li Y,Hahn T,Garrison K,Cui ZH,Thorburn A,Thorburn J,Hu HM,Akporiaye ET

    更新日期：2012-07-15 00:00:00

  • A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2.

    abstract：:Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways that drive disease aggressiveness in tumors with high MIF expression, we analyzed the expression of coding and noncoding genes in high and low MIF-expressing tumor...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-15-2841

    authors： Yang S,He P,Wang J,Schetter A,Tang W,Funamizu N,Yanaga K,Uwagawa T,Satoskar AR,Gaedcke J,Bernhardt M,Ghadimi BM,Gaida MM,Bergmann F,Werner J,Ried T,Hanna N,Alexander HR,Hussain SP

    更新日期：2016-07-01 00:00:00

  • Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression.

    abstract：:Hepatocellular carcinoma is among the most common and lethal cancers in humans. Hepatocellular carcinoma is commonly associated with physical or functional inactivation of the p53 tumor suppressor, high levels of chromosomal instability, and disease conditions causing chronic cycles of hepatocyte death and regeneratio...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-05-4608

    authors： Farazi PA,Glickman J,Horner J,Depinho RA

    更新日期：2006-05-01 00:00:00

  • Immune reactivity to Thomsen-Friedenreich antigen in patients with lung cancer detected by superoxide assay-leukocyte adherence inhibition test.

    abstract：:The immune reactivity to partially purified Thomsen-Friedenreich antigen was investigated in patients with lung cancer. The modified method of original leukocyte adherence inhibition test, termed superoxide assay-leukocyte adherence inhibition test, was used to detect the reactivity. The coded peripheral mononuclear c...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Ichinose Y,Yagawa K,Kaku M,Hara N,Ohta M

    更新日期：1985-09-01 00:00:00

  • Efficient repair of O6-ethylguanine, but not O4-ethylthymine or O2-ethylthymine, is dependent upon O6-alkylguanine-DNA alkyltransferase and nucleotide excision repair activities in human cells.

    abstract：:The formation and persistence of O6-ethylguanine, O4-ethylthymine, and O2-ethylthymine were quantitated in the genomic DNA of human lymphoblasts exposed to 1.0 mM N-ethyl-N-nitrosourea using immunoslot-blot. The three cell lines used included one which lacks O6-alkylguanine-DNA alkyltransferase, one deficient in nucle...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Bronstein SM,Skopek TR,Swenberg JA

    更新日期：1992-04-01 00:00:00

  • Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells.

    abstract：:Androgens via their receptor (AR) may play a role in prostate cancer etiology. This study focuses on the inhibitory effects of resveratrol on androgen action in the LNCaP prostate cancer cell line. We found that resveratrol represses different classes of androgen up-regulated genes at the protein or mRNA level includi...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Mitchell SH,Zhu W,Young CY

    更新日期：1999-12-01 00:00:00

  • Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome.

    abstract：:Glial tumors progress to malignant grades by heightened proliferation and relentless dispersion throughout the central nervous system. Understanding genetic and biochemical processes that foster these behaviors is likely to reveal specific and effective targets for therapeutic intervention. Our current report shows th...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-06-0418

    authors： Tran NL,McDonough WS,Savitch BA,Fortin SP,Winkles JA,Symons M,Nakada M,Cunliffe HE,Hostetter G,Hoelzinger DB,Rennert JL,Michaelson JS,Burkly LC,Lipinski CA,Loftus JC,Mariani L,Berens ME

    更新日期：2006-10-01 00:00:00

  • Characterization of the receptor protein tyrosine phosphatase gene product PTP gamma: binding and activation by triphosphorylated nucleosides.

    abstract：:A full-length cDNA for a novel isoform of the human receptor tyrosine phosphatase gamma gene (PTPRG) was overexpressed in Sf9 insect cells, and the gene product, PTP gamma, was purified and characterized. The protein was expressed as a M(r) approximately 185,000 protein accompanied by a M(r) approximately 120,000 puta...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Sorio C,Mendrola J,Lou Z,LaForgia S,Croce CM,Huebner K

    更新日期：1995-11-01 00:00:00

  • Photosensitizing effects of Photofrin II on the site-selected mitochondrial enzymes adenylate kinase and monoamine oxidase.

    abstract：:The response to Photofrin II-induced photosensitization on the activities of mitochondrial monoamine oxidase (MAO) and adenylate kinase (AK) were studied in order to gain further insight into site specific effects. Utilizing intact mitochondria in vitro, both MAO, located on the cytoplasmic side of the outer mitochond...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Murant RS,Gibson SL,Hilf R

    更新日期：1987-08-15 00:00:00

  • p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma.

    abstract：:Loss of genetic material on the short arm of chromosome 17 is observed in approximately 40% of human astrocytomas (WHO grades II and III) and in approximately 30% of cases of glioblastoma multiforme (WHO grade IV). Previous studies of glioblastoma multiforme have shown that the p53 gene, located on the short arm of ch...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： von Deimling A,Eibl RH,Ohgaki H,Louis DN,von Ammon K,Petersen I,Kleihues P,Chung RY,Wiestler OD,Seizinger BR

    更新日期：1992-05-15 00:00:00

  • Chemical quantification of unscheduled DNA synthesis in cultured hepatocytes as an assay for the rapid screening of potential chemical carcinogens.

    abstract：:Technical modifications of the quantitative determination of unscheduled DNA synthesis in cultured hepatocytes are described which allow for the rapid identification of potentially carcinogenic chemicals on a large-scale screening basis. The test is based on the biochemical quantification of [methyl-3H]thymidine incor...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Althaus FR,Lawrence SD,Sattler GL,Longfellow DG,Pitot HC

    更新日期：1982-08-01 00:00:00

  • Cargo from tumor-expressed albumin inhibits T-cell activation and responses.

    abstract：:In this study, we show that rodent albumin is expressed by and cell surface localized on at least some murine tumor cells. We have been able to purify this tumor-expressed albumin from in vivo grown tumor masses. The tumor-expressed albumin, unlike normal serum albumin purified from blood, is capable of inhibiting T-c...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-04-1871

    authors： Graner MW,Likhacheva A,Davis J,Raymond A,Brandenberger J,Romanoski A,Thompson S,Akporiaye E,Katsanis E

    更新日期：2004-11-01 00:00:00

  • Cancer in first and second generation Americans.

    abstract：:Mortality or incidence rates of ten major neoplasms in migrants from several countries, their respective countries of origin, their American-born offspring, and United States whites were compared. Rates in succeeding generations of Americans increased most rapidly for colon cancer and most slowly for breast cancer, wi...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Thomas DB,Karagas MR

    更新日期：1987-11-01 00:00:00

  • Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas.

    abstract：:Expression of some members of the cadherin family is reduced in several human tumors, and CDH13 (H-cadherin), located on chromosome 16q24.2-3, may function as a tumor suppressor gene. In human tumors, loss of expression of many tumor suppressor genes occurs by aberrant promoter region methylation. We examined the meth...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Toyooka KO,Toyooka S,Virmani AK,Sathyanarayana UG,Euhus DM,Gilcrease M,Minna JD,Gazdar AF

    更新日期：2001-06-01 00:00:00

  • DNA binding and transactivation activity of A-myb, a c-myb-related gene.

    abstract：:A partial-length A-myb complementary DNA recently cloned by low-stringency hybridization with a c-myb probe to complementary DNA libraries derived from human cell lines showed a high degree of homology with the DNA-binding domain of c-myb and B-myb, suggesting that A-myb also encoded a DNA-binding protein. We report h...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Ma XP,Calabretta B

    更新日期：1994-12-15 00:00:00

  • Histological comparison of the growth of rat bladder carcinoma R-4909 observed for two years in vitro and in vivo.

    abstract：:A transplantable bladder tumor (Chapman R-4909) of the rat, when first received in our laboratory, grew with a complex histopathology. The predominant component was transitional cell carcinoma, but there were foci of keratinization, including pearl formation, and foci of a less well-defined cystic appearance. We repor...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Toyoshima K,Abaza N,Leighton J

    更新日期：1976-08-01 00:00:00

  • Dose-dependent differences in the mutational profiles of (-)-(1R,2S,3S,4R)-3,4-dihydroxy-1, 2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene and its less carcinogenic enantiomer.

    abstract：:Chinese hamster V-79 cells were treated with high cytotoxic or low noncytotoxic concentrations of the highly carcinogenic and mutagenic (-)-(1R,2S,3S,4R)-3,4-dihydroxy-1, 2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene [(-)-B[c]PhDE; fjord-region diol epoxide] or its biologically less active (+)-(1S,2R,3R,4S) enantiome...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Wei SJ,Chang RL,Cui XX,Merkler KA,Wong CQ,Yagi H,Jerina DM,Conney AH

    更新日期：1996-08-15 00:00:00

  • Tumor dormancy and MYC inactivation: pushing cancer to the brink of normalcy.

    abstract：:Upon MYC inactivation, tumors variously undergo proliferative arrest, cellular differentiation, and apoptosis and in some cases, apparently permanently revoking tumorigenesis. In liver tumor cells, we recently showed that MYC inactivation uncovers stem cell properties and triggers differentiation, but in this case, th...

    journal_title：Cancer research

    pub_type： 杂志文章,评审

    doi：10.1158/0008-5472.CAN-05-1172

    authors： Shachaf CM,Felsher DW

    更新日期：2005-06-01 00:00:00

  • Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a 17.1A chlorin(e6) immunoconjugate.

    abstract：:Photoimmunotherapy (using a monoclonal antibody-targeted photosensitizer and red light) may be a strategy to overcome the limitations inherent in photodynamic therapy of liver tumors. The aims of this study were (a) to test the efficacy of selective treatment of hepatic metastases of colorectal cancer in an orthotopic...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Del Governatore M,Hamblin MR,Shea CR,Rizvi I,Molpus KG,Tanabe KK,Hasan T

    更新日期：2000-08-01 00:00:00

  • Combination of anastrozole with fulvestrant in the intratumoral aromatase xenograft model.

    abstract：:Although the aromatase inhibitor anastrozole has been shown to be very effective in the treatment of hormone-dependent postmenopausal breast cancer, some patients with advanced disease will develop resistance to treatment. To investigate therapeutic strategies to overcome resistance to anastrozole treatment, we have u...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-07-6807

    authors： Macedo LF,Sabnis GJ,Goloubeva OG,Brodie A

    更新日期：2008-05-01 00:00:00

  • ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients.

    abstract：:Identification and reversal of treatment resistance mechanisms of clinically refractory tumor cells is critical for successful cancer therapy. Here we show that ATP-binding cassette member B5 (ABCB5) identifies therapy-refractory tumor cells in colorectal cancer patients following fluorouracil (5-FU)-based chemoradiat...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-11-0221

    authors： Wilson BJ,Schatton T,Zhan Q,Gasser M,Ma J,Saab KR,Schanche R,Waaga-Gasser AM,Gold JS,Huang Q,Murphy GF,Frank MH,Frank NY

    更新日期：2011-08-01 00:00:00