Effects of the antitumor agent 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one on the DNA of mouse L1210 cells.

abstract：:Monoclonal antibody SM 92 is involved in the immunophenotype of gastrointestinal and liver cells, SM 43 in ovarian cells, and SM 13 in lung cells. Based on a study of 61 breast adenocarcinoma patients, we found that tumors reacting with SM 92 appear associated with liver metastases, SM 43 with ovarian metastases, and ...

journal_title：Cancer research

authors： Gioanni JC,Mazeau C,Zanghellini E,Hecht F,Gugenheim J,Crafa F,Granon C,Namer M,Ettore F,Schneider M

更新日期：1994-10-15 00:00:00

abstract：:Children with the tumor predisposition syndrome, neurofibromatosis 1 (NF1), develop optic pathway gliomas. The NF1 gene product, neurofibromin, functions as a negative regulator of RAS, such that NF1 inactivation results in RAS hyperactivation. Recent studies have highlighted the divergent biological and biochemical p...

journal_title：Cancer research

authors： Dasgupta B,Li W,Perry A,Gutmann DH

更新日期：2005-01-01 00:00:00

abstract：:Angiogenesis is characteristic of solid tumor growth and a surrogate marker for metastasis in many human cancers. Inhibition of tumor angiogenesis using antiangiogenic drugs and gene transfer approaches has suggested the potential of this form of therapy in controlling tumor growth. However, for long-term tumor-free s...

journal_title：Cancer research

authors： Ponnazhagan S,Mahendra G,Kumar S,Shaw DR,Stockard CR,Grizzle WE,Meleth S

更新日期：2004-03-01 00:00:00

abstract：:Cancer vaccine feasibility would benefit from reducing the number and duration of vaccinations without diminishing efficacy. However, the duration of in vivo studies and the huge number of possible variations in vaccination protocols have discouraged their optimization. In this study, we employed an established mouse ...

journal_title：Cancer research

authors： Palladini A,Nicoletti G,Pappalardo F,Murgo A,Grosso V,Stivani V,Ianzano ML,Antognoli A,Croci S,Landuzzi L,De Giovanni C,Nanni P,Motta S,Lollini PL

更新日期：2010-10-15 00:00:00

abstract：:Small hydrophobic peptides were studied as possible substrates of the multidrug resistance protein (MRP)-1 (ABCC1) transmembrane transporter molecule. As observed earlier for P-glycoprotein- (Pgp; ABCB1) overexpressing cells, MRP1-overexpressing cells, including cells stably transfected with the MRP1 cDNA, showed dist...

journal_title：Cancer research

authors： de Jong MC,Slootstra JW,Scheffer GL,Schroeijers AB,Puijk WC,Dinkelberg R,Kool M,Broxterman HJ,Meloen RH,Scheper RJ

更新日期：2001-03-15 00:00:00

abstract：:We have recently demonstrated that many cancer cell lines produce a novel trypsinogen isoenzyme called tumor-associated trypsinogen 2 (TAT-2). It was found during a search of the target protease for tumor-associated trypsin inhibitor (TATI). We now show that degradation of subendothelial cell extracellular matrix (ECM...

journal_title：Cancer research

authors： Koivunen E,Ristimäki A,Itkonen O,Osman S,Vuento M,Stenman UH

更新日期：1991-04-15 00:00:00

abstract：:Dysregulation of Wnt/β-catenin signaling is frequently observed in human gastric cancer. Elucidation of the tumor immune microenvironment is essential for understanding tumorigenesis and for the development of immunotherapeutic strategies. However, it remains unclear how β-catenin signaling regulates the tumor immune ...

journal_title：Cancer research

authors： Ji L,Qian W,Gui L,Ji Z,Yin P,Lin GN,Wang Y,Ma B,Gao WQ

更新日期：2020-05-15 00:00:00

abstract：:PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies the end stage of human disease. To identify additional pathway ...

journal_title：Cancer research

authors： Mulholland DJ,Kobayashi N,Ruscetti M,Zhi A,Tran LM,Huang J,Gleave M,Wu H

更新日期：2012-04-01 00:00:00

abstract：:Several well characterized murine T-lymphoma cell lines were used in somatic cell hybridization experiments to study the genetic regulation of glucocorticoid-induced lysis. Cell fusions were carried out among the SL12-derived cloned lines and between the W7 and SAK8 lines all of which have functional hormone receptors...

journal_title：Cancer research

authors： Weinroth SE,MacLeod CL,Minning L,Hays EF

更新日期：1985-10-01 00:00:00

abstract：:The interaction of dietary fat and the thymus in the induction of mammary tumors by dimethylbenz(a)anthracene has been examined in female Sprague-Dawley rats. In these experiments, rats fed diets of 0.5% (low fat), 5% (normal fat), or 20% (high fat) corn oil from weaning (21 days of age) were thymectomized or sham thy...

journal_title：Cancer research

authors： Wagner DA,Naylor PH,Kim U,Shea W,Ip C,Ip MM

更新日期：1982-04-01 00:00:00

abstract：:Centrosome amplification is a hallmark of virtually all types of cancers, including solid tumors and hematologic malignancies. Cancer cells with extra centrosomes use centrosome clustering (CC) to allow for successful division. Because normal cells do not rely on this mechanism, CC is regarded as a promising target to...

journal_title：Cancer research

authors： Konotop G,Bausch E,Nagai T,Turchinovich A,Becker N,Benner A,Boutros M,Mizuno K,Krämer A,Raab MS

更新日期：2016-11-15 00:00:00

abstract：:Prognostic tests for patients with early-stage lung cancer may provide needed guidance on postoperative surveillance and therapeutic decisions. We used a novel strategy to develop and validate a prognostic classifier for early-stage lung cancer. Specifically, we focused on 42 genes with roles in lung cancer or cancer ...

journal_title：Cancer research

authors： Akagi I,Okayama H,Schetter AJ,Robles AI,Kohno T,Bowman ED,Kazandjian D,Welsh JA,Oue N,Saito M,Miyashita M,Uchida E,Takizawa T,Takenoshita S,Skaug V,Mollerup S,Haugen A,Yokota J,Harris CC

更新日期：2013-07-01 00:00:00

abstract：:Disruption of one allele for the cytosine-DNA methyltransferase 1 (DNMT1) gene in mice with a germ-line mutation in a tumor suppressor gene was shown previously to reduce tumor formation in juvenile animals. This effect is now reproduced in our studies of mature mice where this genetic DNMT1 reduction leads to a 50% d...

journal_title：Cancer research

authors： Belinsky SA,Klinge DM,Stidley CA,Issa JP,Herman JG,March TH,Baylin SB

更新日期：2003-11-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (Stat3) is activated by cytokines and growth factors in lung cancers and regulates expression of genes implicated in cell growth, survival, and transformation. Previously, we found that mice with a deletion of the G protein-coupled receptor, family C, group 5, membe...

journal_title：Cancer research

authors： Chen Y,Deng J,Fujimoto J,Kadara H,Men T,Lotan D,Lotan R

更新日期：2010-11-01 00:00:00

abstract：:The alternative reading frame (ARF) tumor suppressor exerts both p53-dependent and p53-independent activities critical to the prevention of cancer in mice and humans. Recent evidence from mouse models suggests that when p53 is absent, further loss of ARF can widen the tumor spectrum, and potentiate invasion and metast...

journal_title：Cancer research

authors： Paliwal S,Kovi RC,Nath B,Chen YW,Lewis BC,Grossman SR

更新日期：2007-10-01 00:00:00

abstract：:Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors, hypoxia is associated with aggressive disease course and poor clinical outcomes. Furthermore, many aggressive tumors have been shown to display gene expression signatures characteristic of human embryonic stem cells (hESC). We now...

journal_title：Cancer research

authors： Mathieu J,Zhang Z,Zhou W,Wang AJ,Heddleston JM,Pinna CM,Hubaud A,Stadler B,Choi M,Bar M,Tewari M,Liu A,Vessella R,Rostomily R,Born D,Horwitz M,Ware C,Blau CA,Cleary MA,Rich JN,Ruohola-Baker H

更新日期：2011-07-01 00:00:00

abstract：:"Self" melanocyte differentiation antigens are potential targets for specific melanoma immunotherapy. Vaccination against murine tyrosinase-related protein (TRP)-1/gp75 was shown recently to cause melanoma rejection, which was accompanied by autoimmune skin depigmentation (vitiligo). To further explore the linkage bet...

journal_title：Cancer research

authors： Bronte V,Apolloni E,Ronca R,Zamboni P,Overwijk WW,Surman DR,Restifo NP,Zanovello P

更新日期：2000-01-15 00:00:00

abstract：:To study antitumor functions of T-lymphocyte subpopulations in the blood [peripheral blood lymphocytes (PBLs)] and tumor-draining lymph nodes (LNs) of patients (n = 26) with squamous cell carcinoma of the head and neck (SCCHN), antibody-coated devices were used to positively select CD8+ or CD4+ cells. The mean percent...

journal_title：Cancer research

authors： Letessier EM,Heo DS,Okarma T,Johnson JT,Herberman RB,Whiteside TL

更新日期：1991-08-01 00:00:00

abstract：:The tumorigenicities of 7-methylbenz[c]acridine (7MB[c]ACR) and its five metabolically possible trans-dihydrodiols were determined in two mouse tumor models. In initiation-promotion studies on mouse skin, a single topical application of 0.15 to 0.75 mumol of compound was followed 9 days later by twice weekly applicati...

journal_title：Cancer research

authors： Chang RL,Levin W,Wood AW,Shirai N,Ryan AJ,Duke CC,Jerina DM,Holder GM,Conney AH

更新日期：1986-09-01 00:00:00

abstract：:Emerging evidence indicates the presence of tumor-initiating cells (TIC) or cancer stem cells in osteosarcoma. However, no study has shown specific markers to identify osteosarcoma TICs with in vivo tumor formation ability. Additionally, there has been a lack of investigations gauging the contribution of osteosarcoma ...

journal_title：Cancer research

authors： Adhikari AS,Agarwal N,Wood BM,Porretta C,Ruiz B,Pochampally RR,Iwakuma T

更新日期：2010-06-01 00:00:00

abstract：:Radiation therapy combined with adjuvant hyperthermia has the potential to provide outstanding local-regional control for refractory disease. However, achieving therapeutic thermal dose can be problematic. In the current investigation, we used a chemistry-driven approach with the goal of designing and synthesizing nov...

journal_title：Cancer research

authors： Sekhar KR,Sonar VN,Muthusamy V,Sasi S,Laszlo A,Sawani J,Horikoshi N,Higashikubo R,Bristow RG,Borrelli MJ,Crooks PA,Lepock JR,Roti Roti JL,Freeman ML

更新日期：2007-01-15 00:00:00

abstract：:The intranuclear mitosis of the plasmodial nuclei of myxomycetes permits the observation of defects in chromosomal repartition which would probably be lethal in other eukaryotic cells with open mitosis. We found that antitumoral platinum-amine compounds perturbed late mitotic events and induced the formation of giant ...

journal_title：Cancer research

authors： Wright M,Lacorre-Arescaldino I,Macquet JP,Daffé M

更新日期：1984-02-01 00:00:00

abstract：:Sixty % of clones isolated from HeLa cells treated with toxic concentrations of a methylating carcinogen showed increased resistance to the cytotoxicity of N-methyl-N-nitrosourea. D37 values were 6- to 100-fold higher than in the parental cell population. The absence of detectable levels of the repair enzyme O6-methyl...

journal_title：Cancer research

authors： Aquilina G,Hess P,Fiumicino S,Ceccotti S,Bignami M

更新日期：1995-06-15 00:00:00

abstract：:Analysis of human fibrosarcoma cells exposed to radiolabeled monoclonal antibody 19-24, which recognizes sarcoma-associated antigen p102, revealed that over 54% of the cell surface-bound radioactivity was internalized. No modulation of cell surface p102 antigen by monoclonal antibody 19-24 was observed in human fibros...

journal_title：Cancer research

authors： Stastny JJ,Das Gupta TK

更新日期：1993-12-01 00:00:00

abstract：:Cross-coupling of active protein-1 (AP-1) and nuclear factor (NF)-kappaB has been reported. In the present study, we investigated the possibility that both of these two transcription factors might contribute to the process of tumor promoter-induced transformation. To establish a stable reporter cell system, two report...

journal_title：Cancer research

authors： Li JJ,Westergaard C,Ghosh P,Colburn NH

更新日期：1997-08-15 00:00:00

abstract：:Accumulation of sulfolipids associated with elevated levels of glycolipid sulfotransferase activities has previously been demonstrated in renal cell carcinoma cells. To investigate the role of protein kinase C in the synthesis of sulfolipids, the effects of 12-O-tetradecanoylphorbol-13-acetate and protein kinase C inh...

journal_title：Cancer research

authors： Kobayashi T,Honke K,Gasa S,Sugiura M,Miyazaki T,Ishizuka I,Makita A

更新日期：1993-06-01 00:00:00

abstract：:miRNAs that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNAs (mitomiR). mitomiRs have been shown to modulate the translational activity of the mitochondrial genome, yet their role in mitochondrial DNA (mtDNA) transcription remains to be determined. Here we report that the mitomiR...

journal_title：Cancer research

authors： Fan S,Tian T,Chen W,Lv X,Lei X,Zhang H,Sun S,Cai L,Pan G,He L,Ou Z,Lin X,Wang X,Perez MF,Tu Z,Ferrone S,Tannous BA,Li J

更新日期：2019-03-15 00:00:00

abstract：:8-Chloro-cAMP (8-Cl-cAMP) is a novel agent that is able to inhibit the growth of a wide variety of cancer cell types in vitro and in vivo and, at doses devoid of toxicity, to achieve plasma concentrations in cancer patients in a range effective for cancer cell growth inhibition. In this study, we have demonstrated tha...

journal_title：Cancer research

authors： Tortora G,di Isernia G,Sandomenico C,Bianco R,Pomatico G,Pepe S,Bianco AR,Ciardiello F

更新日期：1997-11-15 00:00:00

abstract：:In principle, the inhibition of candidate gain-of-function genes defined through genomic analyses of large patient cohorts offers an attractive therapeutic strategy. In this study, we focused on changes in expression of CD24, a well-validated clinical biomarker of poor prognosis and a driver of tumor growth and metast...

journal_title：Cancer research

authors： Agarwal N,Dancik GM,Goodspeed A,Costello JC,Owens C,Duex JE,Theodorescu D

更新日期：2016-09-01 00:00:00

abstract：:The interaction of the activating receptor NKG2D with its ligands plays an important role in immunosurveillance of tumors and infectious pathogens, but dysregulation of this system may lead to autoimmunity. The expression of NKG2D ligands is induced by cellular "stress." However, the regulation of expression of these ...

journal_title：Cancer research

authors： Valés-Gómez M,Chisholm SE,Cassady-Cain RL,Roda-Navarro P,Reyburn HT

更新日期：2008-03-01 00:00:00