Genetic complexity of glucocorticoid-induced lysis of murine T-lymphoma cells.

abstract：:The effect of the adenosine diphosphoribosyltransferase inhibitors, the substituted benzamides, on the cytotoxicity of 6-thioguanine (6TG) was investigated. Nontoxic concentrations of benzamides potentiated the cytotoxicity of 6TG with a dose enhancement factor of 2, producing a 6-fold increase in cell killing at 10% ...

journal_title：Cancer research

authors： Moses K,Harris AL,Durkacz BW

更新日期：1988-10-15 00:00:00

abstract：:FET cells, derived from an early-stage colon carcinoma, are nontumorigenic in athymic mice. Stable transfection of a dominant-negative transforming growth factor beta (TGFbeta) type II receptor (DNRII) into FET cells that express autocrine TGFbeta shows loss of TGFbeta signaling and increased tumorigenicity in vivo in...

journal_title：Cancer research

authors： Wang J,Yang L,Yang J,Kuropatwinski K,Wang W,Liu XQ,Hauser J,Brattain MG

更新日期：2008-05-01 00:00:00

abstract：:Cytogenetic analysis of tumor cells from a human malignant melanoma was performed on both the primary tumor colony-forming cells and a cell line (HA-A) established subsequently from the clonogenic population. Chromosome-banding analysis demonstrated identical karyotypic alterations in both the tumor colony-forming cel...

journal_title：Cancer research

authors： Trent JM,Thompson FH,Ludwig C

更新日期：1984-01-01 00:00:00

abstract：:Thrombin-mediated proteolysis is a major determinant of metastasis, but is not universally important for primary tumor growth. Here, we report that colorectal adenocarcinoma represents one important exception whereby thrombin-mediated functions support both primary tumor growth and metastasis. In contrast with studies...

journal_title：Cancer research

authors： Adams GN,Rosenfeldt L,Frederick M,Miller W,Waltz D,Kombrinck K,McElhinney KE,Flick MJ,Monia BP,Revenko AS,Palumbo JS

更新日期：2015-10-01 00:00:00

abstract：:Regional measurements of blood flow (F) were performed in transplanted intracerebral RG-2 rat gliomas using [14C]iodoantipyrine, Kety-Schmidt blood flow equations, and quantitative autoradiography. Twenty-nine intracranial tumors in ten rats were analyzed by location; 18 intraparenchymal, seven meningeal, two third-ve...

journal_title：Cancer research

authors： Groothuis DR,Pasternak JF,Fischer JM,Blasberg RG,Bigner DD,Vick NA

更新日期：1983-07-01 00:00:00

abstract：:The effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth of epithelial cells from rat, hamster, and human respiratory tract has been measured by monitoring colony formation and cross-linked envelope formation in culture. TPA and its active derivatives stimulated colony formation of rat...

journal_title：Cancer research

authors： Beeman DK,Siegfried JM,Mass MJ

更新日期：1987-01-15 00:00:00

abstract：:Potent luteinizing hormone-releasing hormone analogues are known to cause regression of hormone-dependent mammary tumors. We have observed that high and long-lasting serum levels of a potent luteinizing hormone-releasing hormone analogue [desglycyl10-(D-leucyl6) luteinizing hormone-releasing hormone ethylamide, leupro...

journal_title：Cancer research

authors： Okada H,Sakura Y,Kawaji H,Yashiki T,Mima H

更新日期：1983-04-01 00:00:00

abstract：:Previous studies have shown that enforced expression of IFN-beta suppressed tumor growth and metastasis. In this report, we determined whether the induction of nitric oxide synthase II (NOS II) gene is required for IFN-beta-mediated antitumor activity using syngeneic mice with intact (NOS II+/+) or genetically disrupt...

journal_title：Cancer research

authors： Wang B,Xiong Q,Shi Q,Le X,Abbruzzese JL,Xie K

更新日期：2001-01-01 00:00:00

abstract：:Mutated ras genes are powerful transforming agents in vitro and are found in a wide variety of human tumors in vivo. We characterized the histopathology and p21 protein expression associated with tumorigenesis in line 69 transgenic mice carrying an activated, human c-Ha-ras gene on the Y-chromosome (A. C. Andres, C. A...

journal_title：Cancer research

authors： Nielsen LL,Discafani CM,Gurnani M,Tyler RD

更新日期：1991-07-15 00:00:00

abstract：:Individual human infiltrating ductal carcinomas and fibroadenomas were sectioned frozen to yield an alternating sequence of stained and lyophilized material. Stained preparations were used as references permitting microdissection of regions of tumor involvement in the corresponding dried sections. Tissues quantities o...

journal_title：Cancer research

authors： Larner EH,Rutherford CL

更新日期：1982-05-01 00:00:00

abstract：:The DNA damage response kinase ATR and its effector kinase CHEK1 are required for cancer cells to survive oncogene-induced replication stress. ATR inhibitors exhibit synthetic lethal interactions, with deficiencies in the DNA damage response enzymes ATM and XRCC1 and with overexpression of the cell cycle kinase cyclin...

journal_title：Cancer research

authors： Mohni KN,Kavanaugh GM,Cortez D

更新日期：2014-05-15 00:00:00

abstract：:L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the expression of LAT1 and LAT3 to maintain sufficient levels of leucine needed for mTORC1 signaling and cell growth. Inhibiting LAT function was sufficient to decreas...

journal_title：Cancer research

authors： Wang Q,Bailey CG,Ng C,Tiffen J,Thoeng A,Minhas V,Lehman ML,Hendy SC,Buchanan G,Nelson CC,Rasko JE,Holst J

更新日期：2011-12-15 00:00:00

abstract：:Three human colon cancer lines (SW 480, SW 620, WIDR) were characterized as to their production of molecules with transforming growth factor (TGF)-like activity. Production of both TGF alpha-like and TGF beta-like activity was quantitated, as were cellular receptors for these molecules, and growth response in soft aga...

journal_title：Cancer research

authors： Coffey RJ Jr,Shipley GD,Moses HL

更新日期：1986-03-01 00:00:00

abstract：:The cell surface molecules controlling apoptosis in cortical neurons are largely unknown. A monoclonal antibody was derived that induces cultured neocortical neurons to undergo apoptosis. A Fab fragment of the antibody, however, lacked the ability to induce cell death. The antigen was purified, and characterized by co...

journal_title：Cancer research

authors： Zhong LT,Manzi A,Skowronski E,Notterpek L,Fluharty AL,Faull KF,Masada I,Rabizadeh S,Varsanyi-Nagy M,Ruan Y,Oh JD,Butcher LL,Bredesen DE

更新日期：2001-08-01 00:00:00

abstract：:We have investigated the effect of partial hepatectomy (HEP) on tumor growth. MH-134 hepatoma cells, which were inoculated in syngeneic C3H/He mice from 3 to 10 days after HEP, grew with a linear increase in size until 7 days, began to regress, and disappeared 14 days after the inoculation. The survival rate was 100%,...

journal_title：Cancer research

authors： Ono M,Tanaka N,Orita K

更新日期：1986-10-01 00:00:00

abstract：:It has been postulated that the expression of the ribonucleoprotein telomerase is necessary to overcome cellular senescence and that malignant tumors must express telomerase to maintain their immortality. In most human adult tissues, telomerase activity is not detected. In contrast, several murine tissues express vari...

journal_title：Cancer research

authors： Bednarek A,Budunova I,Slaga TJ,Aldaz CM

更新日期：1995-10-15 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death for women in the United States. Of the different subtypes, estrogen receptor-negative (ER(-)) tumors, which are ErbB2+ or triple-negative, carry a relatively poor prognosis. In this study, we used system-wide analysis of breast cancer proteomes to identify prot...

journal_title：Cancer research

authors： Geiger T,Madden SF,Gallagher WM,Cox J,Mann M

更新日期：2012-05-01 00:00:00

abstract：:Deleted in colorectal cancer (DCC), the receptor for the multifunctional cue netrin-1, acts as a tumor suppressor in intestinal cancer and lung metastasis by triggering cancer cell death when netrin-1 is lowly expressed. Recent genomic data highlighted that DCC is the third most frequently mutated gene in melanoma; we...

journal_title：Cancer research

authors： Boussouar A,Tortereau A,Manceau A,Paradisi A,Gadot N,Vial J,Neves D,Larue L,Battistella M,Leboeuf C,Lebbé C,Janin A,Mehlen P

更新日期：2020-02-15 00:00:00

abstract：:Despite its function as an inhibitor of urokinase and tissue-type plasminogen activator (PA), PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting angiogenesis and tumor cell survival. In this review, we summarize preclinical evidence in support of the protumorigenic function of PAI-1 that...

journal_title：Cancer research

authors： Placencio VR,DeClerck YA

更新日期：2015-08-01 00:00:00

abstract：:It is currently widely accepted that genetic instability is key to cancer development. Many types of cancers arise as a consequence of a gradual accumulation of nucleotide aberrations, each mutation conferring growth and/or survival advantage. Genetic instability could also proceed in sudden bursts leading to a more d...

journal_title：Cancer research

authors： Bavoux C,Leopoldino AM,Bergoglio V,O-Wang J,Ogi T,Bieth A,Judde JG,Pena SD,Poupon MF,Helleday T,Tagawa M,Machado C,Hoffmann JS,Cazaux C

更新日期：2005-01-01 00:00:00

abstract：:Thioguanine and mercaptopurine are prodrugs requiring conversion into thiopurine nucleotides to exert cytotoxicity. Thiopurine S-methyltransferase (TPMT), an enzyme subject to genetic polymorphism, catabolizes thiopurines into inactive methylated bases, but also produces methylthioguanine nucleotides and methylmercapt...

journal_title：Cancer research

authors： Dervieux T,Blanco JG,Krynetski EY,Vanin EF,Roussel MF,Relling MV

更新日期：2001-08-01 00:00:00

abstract：:Two mutations of the ATM gene were recently suggested to confer breast cancer risks similar to mutations of BRCA1 or BRCA2. Here, we set out to confirm these findings in 961 families with non-BRCA1/BRCA2 breast cancer from diverse geographical regions. We did not detect the ATM 7271T-->G mutation in any family. The AT...

journal_title：Cancer research

authors： Szabo CI,Schutte M,Broeks A,Houwing-Duistermaat JJ,Thorstenson YR,Durocher F,Oldenburg RA,Wasielewski M,Odefrey F,Thompson D,Floore AN,Kraan J,Klijn JG,van den Ouweland AM,Wagner TM,Devilee P,Simard J,van 't Veer LJ,G

更新日期：2004-02-01 00:00:00

abstract：:Here, we report the molecular regulation of interleukin (IL)-8 expression in human melanoma cells. The inflammatory cytokines IL-1beta and tumor necrosis factor-alpha (TNF-alpha) up-regulated IL-8 expression, in a time- and concentration-dependent manner, in three metastatic melanoma variants, SBC-2 (nonmetastatic), A...

journal_title：Cancer research

authors： Singh RK,Varney ML

更新日期：1998-04-01 00:00:00

abstract：:To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-drug conjugates, respectively, represent a second revolution in antibody-mediated cancer therapy. Thu...

journal_title：Cancer research

authors： FitzGerald DJ,Wayne AS,Kreitman RJ,Pastan I

更新日期：2011-10-15 00:00:00

abstract：:Despite the impressive results obtained in animal models, the clinical use of tumor necrosis factor-alpha (TNF) as an anticancer drug is limited by severe toxicity. We have shown previously that targeted delivery of TNF to aminopeptidase N (CD13), a marker of angiogenic vessels, improved the therapeutic index of this ...

journal_title：Cancer research

authors： Curnis F,Gasparri A,Sacchi A,Longhi R,Corti A

更新日期：2004-01-15 00:00:00

abstract：:We investigated primary human lung cancers resected surgically or obtained at autopsy. Included were squamous cell carcinoma (SQC) (five cases), adenocarcinoma (ADC) (six cases), large cell carcinoma (LCC) (four cases), and small cell carcinoma (SCC) (two cases). The objective of the study was to search for the presen...

journal_title：Cancer research

authors： Shigematsu K,Kataoka Y,Kamio T,Kurihara M,Niwa M,Tsuchiyama H

更新日期：1990-04-15 00:00:00

abstract：:The expression of the chemokine CC-chemokine ligand 20 (CCL20)/macrophage inflammatory protein (MIP)-3alpha and its receptor CC-chemokine receptor 6 (CCR6) by multiple myeloma (MM) and microenvironment cells and their potential relationship with osteoclast (OC) formation and osteolytic bone lesions in MM patients was ...

journal_title：Cancer research

authors： Giuliani N,Lisignoli G,Colla S,Lazzaretti M,Storti P,Mancini C,Bonomini S,Manferdini C,Codeluppi K,Facchini A,Rizzoli V

更新日期：2008-08-15 00:00:00

abstract：:Radiation leukemia virus-induced leukemia of a male C57BL/6 mouse, B6RV2, is immunogenic to female BALB/c X C57BL/6 F1 mice. In these mice, B6RV2 tumors regressed after initial growth, and after tumor regression the mice were resistant to repeated inocula of up to 10(8) B6RV2 cells. Serum from these mice reacted with ...

journal_title：Cancer research

authors： Nakayama E,Uenaka A,Stockert E,Obata Y

更新日期：1984-11-01 00:00:00

abstract：:Exposure to the carcinogen asbestos is a major factor in the development of malignant mesothelioma. However, not all mesotheliomas are associated with asbestos exposure, and only a small minority of people exposed to asbestos develop mesothelioma. Therefore, the identification of the cofactors that render certain indi...

journal_title：Cancer research

authors： Testa JR,Carbone M,Hirvonen A,Khalili K,Krynska B,Linnainmaa K,Pooley FD,Rizzo P,Rusch V,Xiao GH

更新日期：1998-10-15 00:00:00

abstract：:The murine monoclonal antibodies TURP-27 and HNK-1 have been shown to detect antigens which are heavily expressed by benign prostatic hyperplasia and carcinoma of the prostate. Western blot analysis of prostate extracts showed that monoclonal antibodies TURP-27 and HNK-1 bound glycoproteins with molecular weights of 1...

journal_title：Cancer research

authors： Lipford GB,Wright GL Jr

更新日期：1991-05-01 00:00:00