Abstract:
:Despite its function as an inhibitor of urokinase and tissue-type plasminogen activator (PA), PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting angiogenesis and tumor cell survival. In this review, we summarize preclinical evidence in support of the protumorigenic function of PAI-1 that has led to the testing of small-molecule PAI-1 inhibitors, initially developed as antithrombotic agents, in animal models of cancer. The review discusses the challenges and the opportunities that lay ahead to the development of efficacious and nontoxic PAI-1 inhibitors as anticancer agents.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Placencio VR,DeClerck YAdoi
10.1158/0008-5472.CAN-15-0876subject
Has Abstractpub_date
2015-08-01 00:00:00pages
2969-74issue
15eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-15-0876journal_volume
75pub_type
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