Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients.

abstract：:Inflammatory pathways may mediate preparation of the "metastatic soil" in the lungs. Some of these pathways--activation and/or the recruitment of certain inflammatory cells--might depend on vascular endothelial growth factor receptor 1 (VEGFR1) activity. Thus, blocking the activity of VEGFR1 (or the interaction with i...

journal_title：Cancer research

authors： Duda DG,Jain RK

更新日期：2010-07-15 00:00:00

abstract：:FET cells, derived from an early-stage colon carcinoma, are nontumorigenic in athymic mice. Stable transfection of a dominant-negative transforming growth factor beta (TGFbeta) type II receptor (DNRII) into FET cells that express autocrine TGFbeta shows loss of TGFbeta signaling and increased tumorigenicity in vivo in...

journal_title：Cancer research

authors： Wang J,Yang L,Yang J,Kuropatwinski K,Wang W,Liu XQ,Hauser J,Brattain MG

更新日期：2008-05-01 00:00:00

abstract：:Reduced expression of neural cell adhesion molecule (NCAM) has been implicated in the progression to tumor malignancy in cancer patients. Previously, we have shown that the loss of NCAM function causes the formation of lymph node metastasis in a transgenic mouse model of pancreatic beta cell carcinogenesis (Rip1Tag2)....

journal_title：Cancer research

authors： Crnic I,Strittmatter K,Cavallaro U,Kopfstein L,Jussila L,Alitalo K,Christofori G

更新日期：2004-12-01 00:00:00

abstract：:A malignant hamster melanoma cell line HM-1 derived from the heterogenous malignant hamster melanoma MM1 contains a specific, high affinity binding protein for estrogens. Partial purification of the binding protein with ammonium sulfate (40% saturation) increased mean binding content (3.1 +/- 1.2 (SD) fmol/mg protein)...

journal_title：Cancer research

authors： Schleicher RL,Hitselberger MH,Beattie CW

更新日期：1987-01-15 00:00:00

abstract：:We have investigated the effect of a combined chemoimmunotherapy protocol with liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE), 5-fluorouracil (5-FU), and 5-formyltetrahydrofolate (leucovorin) on the growth of hepatic metastases using carcinoma H-59, a liver-homing subline of the Lewis lung carcinoma (P...

journal_title：Cancer research

authors： Asao T,Shibata HR,Batist G,Brodt P

更新日期：1992-11-15 00:00:00

abstract：:Dysregulation in patterns of alternative RNA splicing in cancer cells is emerging as a significant factor in cancer pathophysiology. In this study, we investigated the little known alternative splice isoform survivin-3B (S-3B) that is overexpressed in a tumor-specific manner. Ectopic overexpression of S-3B drove tumor...

journal_title：Cancer research

authors： Végran F,Mary R,Gibeaud A,Mirjolet C,Collin B,Oudot A,Charon-Barra C,Arnould L,Lizard-Nacol S,Boidot R

更新日期：2013-09-01 00:00:00

abstract：:We have found that reversible differentiation into the myoepithelial cells of a human salivary gland adenocarcinoma cell line (HSG) occurs in growth medium containing dibutyryl cAMP (dB-cAMP). In the current study, the relationship between intracellular cAMP levels and anchorage-dependent and -independent growth or ra...

journal_title：Cancer research

authors： Azuma M,Yoshida H,Kawamata H,Yanagawa T,Furumoto N,Sato M

更新日期：1988-05-15 00:00:00

abstract：:The in vitro antiproliferative effect of highly purified recombinant human gamma-interferon was studied with special reference to specific binding to tumor cells of interferon (IFN) labeled with 125I. Recombinant human gamma-interferon markedly suppressed the growth of 6 of 10 human epidermal tumor cell lines tested; ...

journal_title：Cancer research

authors： Nagao S,Sato K,Osada Y

更新日期：1986-07-01 00:00:00

abstract：:Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has been associated with increased growth, metastasis, and angiogenesis of some tumors. Because myeloma tumor cells express high levels of the syndecan-1 heparan sulfate proteoglycan and because these tumors grow as highly...

journal_title：Cancer research

authors： Kelly T,Miao HQ,Yang Y,Navarro E,Kussie P,Huang Y,MacLeod V,Casciano J,Joseph L,Zhan F,Zangari M,Barlogie B,Shaughnessy J,Sanderson RD

更新日期：2003-12-15 00:00:00

abstract：:Determination of neopterin [D-erythro-6-(1',2',3'-trihydroxypropyl)pterin] in body fluids is a powerful diagnostic tool in a variety of diseases in which activation of cellular immune mechanisms is involved, such as certain malignancies, allograft rejection, and autoimmune and infectious diseases. In vitro, neopterin ...

journal_title：Cancer research

authors： Werner-Felmayer G,Werner ER,Fuchs D,Hausen A,Reibnegger G,Wachter H

更新日期：1990-05-15 00:00:00

abstract：:Single-chain Fv antibody fragments from the CD20-specific murine monoclonal antibody B9E9 were genetically engineered as streptavidin fusions [single-chain Fv-streptavidin (scFvSA) fusion protein] for use in pretargeted radioimmunotherapy. The scFvSA constructs were expressed as soluble, tetrameric species in the peri...

journal_title：Cancer research

authors： Schultz J,Lin Y,Sanderson J,Zuo Y,Stone D,Mallett R,Wilbert S,Axworthy D

更新日期：2000-12-01 00:00:00

abstract：:Three Burkitt's lymphoma cell lines were studied for their response to cis-diamminedichloroplatinum(II) (cis-DDP) and L-phenylalanine mustard (L-PAM) with the objective of relating cytotoxicity to DNA cross-linking in human cells. Cytotoxicity was measured by cell proliferation and colony formation assays. DNA interst...

journal_title：Cancer research

authors： Ducore JM,Erickson LC,Zwelling LA,Laurent G,Kohn KW

更新日期：1982-03-01 00:00:00

abstract：:MUC1 is a heterodimeric transmembrane glycoprotein that is overexpressed and aberrantly glycosylated in ductal adenocarcinomas. Differential phosphorylation of the MUC1 cytoplasmic tail (MUC1CT) has been associated with signaling events that influence the proliferation and metastasis of cancer cells. We identified a n...

journal_title：Cancer research

authors： Singh PK,Wen Y,Swanson BJ,Shanmugam K,Kazlauskas A,Cerny RL,Gendler SJ,Hollingsworth MA

更新日期：2007-06-01 00:00:00

abstract：:We have previously shown that mice simultaneously infected with the murine mammary tumor virus (MuMTV) and with certain slow murine leukemia viruses (MLV) have an increased resistance to the pathological effects of both agents. Here we report that milk-transmitted MuMTV also delays the development of the acute erythro...

journal_title：Cancer research

authors： Basolo F,Toniolo A,Bistocchi M,Fontanini G,Squartini F

更新日期：1986-08-01 00:00:00

abstract：:To understand the skeletal metastatic pattern of non-small cell lung cancer, we developed a stable high-expression green fluorescent protein (GFP) transductant of human lung cancer cell line H460 (H460-GFP). The GFP-expressing lung cancer was visualized to metastasize widely throughout the skeleton when implanted orth...

journal_title：Cancer research

authors： Yang M,Hasegawa S,Jiang P,Wang X,Tan Y,Chishima T,Shimada H,Moossa AR,Hoffman RM

更新日期：1998-10-01 00:00:00

abstract：:Barrett's esophagus, a columnar metaplasia of the lower esophagus epithelium related to gastroesophageal reflux disease, is the strongest known risk factor for the development of esophageal adenocarcinoma (EAC). Understanding the signal transduction events involved in esophageal epithelium carcinogenesis may provide i...

journal_title：Cancer research

authors： Yen CJ,Izzo JG,Lee DF,Guha S,Wei Y,Wu TT,Chen CT,Kuo HP,Hsu JM,Sun HL,Chou CK,Buttar NS,Wang KK,Huang P,Ajani J,Hung MC

更新日期：2008-04-15 00:00:00

abstract：:The long-term effects on mammary glands of 5beta-dihydrotestosterone, considered to be biologically inactive, were studied in female SHN mice with mammary tumor, virus. 5beta-Dihydrotestosterone was adminstered to mothers for 4 days from Day 12 to Day 15 of pregnancy (prenatal treatment) and to pups for 5 days of post...

journal_title：Cancer research

authors： Yanai R,Mori T,Nagasawa H

更新日期：1977-12-01 00:00:00

abstract：:A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analyzed its coding sequenc...

journal_title：Cancer research

authors： Resta N,Simone C,Mareni C,Montera M,Gentile M,Susca F,Gristina R,Pozzi S,Bertario L,Bufo P,Carlomagno N,Ingrosso M,Rossini FP,Tenconi R,Guanti G

更新日期：1998-11-01 00:00:00

abstract：:The fate of circulating tumor cells is an important determinant of their ability to form distant metastasis. Here, we demonstrate the use of in vivo flow cytometry as a powerful new method for detecting quantitatively circulating cancer cells. We specifically examine the circulation kinetics of two prostate cancer cel...

journal_title：Cancer research

authors： Georgakoudi I,Solban N,Novak J,Rice WL,Wei X,Hasan T,Lin CP

更新日期：2004-08-01 00:00:00

abstract：:Targeting the tyrosine kinase activity of Bcr-Abl is an attractive therapeutic strategy in chronic myeloid leukemia (CML) and in Bcr-Abl-positive acute lymphoblastic leukemia. Whereas imatinib, a selective inhibitor of Bcr-Abl tyrosine kinase, is now used in frontline therapy for CML, second-generation inhibitors of B...

journal_title：Cancer research

authors： Mahon FX,Hayette S,Lagarde V,Belloc F,Turcq B,Nicolini F,Belanger C,Manley PW,Leroy C,Etienne G,Roche S,Pasquet JM

更新日期：2008-12-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer death globally. An improved risk stratification strategy can increase efficiency of low-dose computed tomography (LDCT) screening. Here we assessed whether individual's genetic background has clinical utility for risk stratification in the context of LDCT screening. Based on ...

journal_title：Cancer research

authors： Hung RJ,Warkentin MT,Brhane Y,Chatterjee N,Christiani DC,Landi MT,Caporaso NE,Liu G,Johansson M,Albanes D,Le Marchand L,Tardon A,Rennert G,Bojesen SE,Chen C,Field JK,Kiemeney LA,Lazarus P,Zienolddiny S,Lam S,Andre

更新日期：2021-01-20 00:00:00

abstract：:The effect of dietary intake of different levels of Menhaden fish oil on azoxymethane-induced carcinogenesis was examined in male F344 rats fed the semipurified diets. Starting at 5 weeks of age, groups of animals were fed the 5% corn oil (low corn oil) diet. At 7 weeks of age, all animals except the vehicle-treated c...

journal_title：Cancer research

authors： Reddy BS,Maruyama H

更新日期：1986-07-01 00:00:00

abstract：:The relation of in vitro properties to tumorigenicity was studied using eight sublines of the human breast cancer cell line MCF-7. Four of the eight were tumorigenic in estrogen-treated nude mice. The sublines differed for each of the in vitro properties measured, and no property correlated perfectly with tumorigenici...

journal_title：Cancer research

authors： Butler WB,Berlinski PJ,Hillman RM,Kelsey WH,Toenniges MM

更新日期：1986-12-01 00:00:00

abstract：:Phenotypic variability of the human neuroblastoma cell line SK-N-SH was studied with the use of three subclones that interconvert at a slower rate than the parent cell line, i.e., a neuroblast-type subclone (SH-SY5Y), a nonneuronal, strongly substrate adherent subclone (SH-EP), and an intermediate type subclone (SH-IN...

journal_title：Cancer research

authors： Sadée W,Yu VC,Richards ML,Preis PN,Schwab MR,Brodsky FM,Biedler JL

更新日期：1987-10-01 00:00:00

abstract：:Carcinomas of the exocrine pancreas are poorly understood and have a poor prognosis because of their highly malignant nature. Using two human pancreatic cancer cell lines, AsPc-1 and Capan-2, we have investigated avenues that might be useful in targeting the delivery of antineoplastic agents to such cancers. Qualitati...

journal_title：Cancer research

authors： Gonzalez DE,Covitz KM,Sadée W,Mrsny RJ

更新日期：1998-02-01 00:00:00

abstract：:Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb) trastuzumab. In a prospective, randomized phase III clinical trial ev...

journal_title：Cancer research

authors： Turcotte M,Allard D,Mittal D,Bareche Y,Buisseret L,José V,Pommey S,Delisle V,Loi S,Joensuu H,Kellokumpu-Lehtinen PL,Sotiriou C,Smyth MJ,Stagg J

更新日期：2017-10-15 00:00:00

abstract：:During therapy for chronic myeloid leukemia (CML), decline of the number of BCR-ABL transcripts has been shown to follow a biphasic pattern, with a fast phase followed by a slower phase. Hence, sustained remission requires a long phase of therapy. Data indicate that a combination of different available targeted drugs ...

journal_title：Cancer research

authors： Komarova NL,Wodarz D

更新日期：2009-06-01 00:00:00

abstract：:Metastasis is complex, involving multiple genetic, epigenetic, biochemical, and physical changes in the cancer cell and its microenvironment. Cells with metastatic potential are often characterized by altered cellular contractility and deformability, lending them the flexibility to disseminate and navigate through dif...

journal_title：Cancer research

authors： Surcel A,Schiffhauer ES,Thomas DG,Zhu Q,DiNapoli KT,Herbig M,Otto O,West-Foyle H,Jacobi A,Kräter M,Plak K,Guck J,Jaffee EM,Iglesias PA,Anders RA,Robinson DN

更新日期：2019-09-15 00:00:00

abstract：:The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem-like cells. However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood. Here, we report that Nestin binds the hedgehog pathway transcription factor Gli3 to ...

journal_title：Cancer research

authors： Li P,Lee EH,Du F,Gordon RE,Yuelling LW,Liu Y,Ng JM,Zhang H,Wu J,Korshunov A,Pfister SM,Curran T,Yang ZJ

更新日期：2016-09-15 00:00:00

abstract：:Options for skin cancer treatment currently include surgery, radiotherapy, topical chemotherapy, cryosurgery, curettage, and electrodessication. Although effective, surgery is costly and unsuitable for certain patients. Radiotherapy can leave a poor cosmetic effect, and current chemotherapy is limited by low cure rate...

journal_title：Cancer research

authors： Ogbourne SM,Suhrbier A,Jones B,Cozzi SJ,Boyle GM,Morris M,McAlpine D,Johns J,Scott TM,Sutherland KP,Gardner JM,Le TT,Lenarczyk A,Aylward JH,Parsons PG

更新日期：2004-04-15 00:00:00