Abstract：
:The fate of circulating tumor cells is an important determinant of their ability to form distant metastasis. Here, we demonstrate the use of in vivo flow cytometry as a powerful new method for detecting quantitatively circulating cancer cells. We specifically examine the circulation kinetics of two prostate cancer cell lines with different metastatic potential in mice and rats. We find that the cell line and the host environment affect the circulation kinetics of prostate cancer cells, with the intrinsic cell line properties determining the initial rate of cell depletion from the circulation and the host affecting cell circulation at later time points.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Georgakoudi I,Solban N,Novak J,Rice WL,Wei X,Hasan T,Lin CPdoi
10.1158/0008-5472.CAN-04-1058subject
Has Abstractpub_date
2004-08-01 00:00:00pages
5044-7issue
15eissn
0008-5472issn
1538-7445pii
64/15/5044journal_volume
64pub_type
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