Retinoic acid receptor beta induces terminal differentiation of squamous cell carcinoma lines in the absence of cyclin-dependent kinase inhibitor expression.

abstract：:Hematogenous carcinoma metastasis is supported by aggregated platelets and leukocytes, forming tumor cell emboli. Early tumor cell-platelet interactions can be mediated by P-selectin binding to tumor cell surface ligands and this process is blocked by heparin. We previously showed that L-selectin deficiency also atten...

journal_title：Cancer research

authors： Läubli H,Stevenson JL,Varki A,Varki NM,Borsig L

更新日期：2006-02-01 00:00:00

abstract：:The pharmacokinetics of UCN-01 after administration as a 72- or 3-h infusion to cancer patients in initial Phase I trials displayed distinctive features that could not have been predicted from preclinical data. The distribution volumes (0.0796-0.158 liters/kg) and the systemic clearance (0.0407-0.252 ml/h/kg) were ext...

journal_title：Cancer research

authors： Fuse E,Tanii H,Kurata N,Kobayashi H,Shimada Y,Tamura T,Sasaki Y,Tanigawara Y,Lush RD,Headlee D,Figg WD,Arbuck SG,Senderowicz AM,Sausville EA,Akinaga S,Kuwabara T,Kobayashi S

更新日期：1998-08-01 00:00:00

abstract：:In Drosophila melanogaster, the wings apart-like (wapl) gene encodes a protein that regulates heterochromatin structure. Here, we characterize a novel human homologue of wapl (termed human WAPL; hWAPL). The hWAPL mRNA was predominantly expressed in uterine cervical cancer, with weak expression in all other normal and ...

journal_title：Cancer research

authors： Oikawa K,Ohbayashi T,Kiyono T,Nishi H,Isaka K,Umezawa A,Kuroda M,Mukai K

更新日期：2004-05-15 00:00:00

abstract：:The antiestrogen tamoxifen is used in the treatment of breast cancer and has recently been recommended as a chemopreventive drug for women at high risk for breast cancer. However, women treated with the drug have an increased incidence of endometrial cancer. It has been suggested that this endometrial cancer might res...

journal_title：Cancer research

authors： Shibutani S,Reardon JT,Suzuki N,Sancar A

更新日期：2000-05-15 00:00:00

abstract：:High levels of anti-phosphatidylinositol (PtdIns) autoantibodies (autoAb) have been previously described in sera of cancer patients and in plasma of dimethylbenzanthracene-treated female Sprague-Dawley rats. The presence of anti-PtdIns autoAb was tested in a model of highly malignant sarcomas induced by a single dose ...

journal_title：Cancer research

authors： Faiderbe S,Chagnaud JL,Geffard M

更新日期：1992-05-15 00:00:00

abstract：:The renal uptake of radiolabeled antibody fragments and peptides is a problem in radioimmunodetection and radioimmunotherapy, especially with intracellular retained radiometals. The aim of this study was to develop suitable methods to reduce this kidney uptake. BALB/c mice or nude mice bearing the human GW-39 colon ca...

journal_title：Cancer research

authors： Behr TM,Sharkey RM,Juweid ME,Blumenthal RD,Dunn RM,Griffiths GL,Bair HJ,Wolf FG,Becker WS,Goldenberg DM

更新日期：1995-09-01 00:00:00

abstract：:The oxidation of the bladder carcinogen 2-naphthylamine (2-NA) by prostaglandin H synthase (PHS) in vitro was examined. Oxygen uptake studies of 2-NA oxidation in the presence of glutathione, as well as extensive product analysis data, are consistent with a one-electron mechanism of 2-NA oxidation by PHS. The formatio...

journal_title：Cancer research

authors： Boyd JA,Eling TE

更新日期：1987-08-01 00:00:00

abstract：:Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) is an angiogenic cytokine expressed by many human and animal tumors. Hypoxia often up-regulates VPF/VEGF expression further. To better define the role of VPF/VEGF in tumor biology, we screened tumorigenic lines for those expressing minimal co...

journal_title：Cancer research

authors： Claffey KP,Brown LF,del Aguila LF,Tognazzi K,Yeo KT,Manseau EJ,Dvorak HF

更新日期：1996-01-01 00:00:00

abstract：:Although dendritic cell (DC) function is impaired in pancreatic cancer patients, the underlying mechanisms are unknown. This study analyzed the soluble factors released by pancreatic cancer cells responsible for inhibiting DC differentiation and activation. Medium conditioned by a highly metastatic human pancreatic ca...

journal_title：Cancer research

authors： Bharadwaj U,Li M,Zhang R,Chen C,Yao Q

更新日期：2007-06-01 00:00:00

abstract：:Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic drivers of medulloblastoma and CNS-PNET. Cross-species gene expressi...

journal_title：Cancer research

authors： Beckmann PJ,Larson JD,Larsson AT,Ostergaard JP,Wagner S,Rahrmann EP,Shamsan GA,Otto GM,Williams RL,Wang J,Lee C,Tschida BR,Das P,Dubuc AM,Moriarity BS,Picard D,Wu X,Rodriguez FJ,Rosemarie Q,Krebs RD,Molan AM,Dem

更新日期：2019-03-01 00:00:00

abstract：:Multimodal therapy is generally more effective than single-agent treatment for cancer. rRp450 is an engineered herpes simplex viral mutant that replicates in and kills tumor cells in a relatively selective fashion. It also expresses, in infected cells, the cyclophosphamide (CPA)-sensitive rat cytochrome P450 2B1 (CYP2...

journal_title：Cancer research

authors： Aghi M,Chou TC,Suling K,Breakefield XO,Chiocca EA

更新日期：1999-08-15 00:00:00

abstract：:Methyl-CpG binding domain (MBD) proteins have been shown to couple DNA methylation to transcriptional repression. This biological property suggests a role for MBD proteins in the silencing of tumor suppressor genes that are hypermethylated at their promoter CpG islands in cancer cells. Despite the demonstration of the...

journal_title：Cancer research

authors： Lopez-Serra L,Ballestar E,Fraga MF,Alaminos M,Setien F,Esteller M

更新日期：2006-09-01 00:00:00

abstract：:A slight induction of granulocytic differentiation of HL-60 cells occurred after treatment with antileukemia chemotherapeutic agents Adriamycin (ADM) and daunomycin (DM). Addition of an inhibitor (sphinganine, SP) of protein kinase C (PKC) enhanced 2-4-fold the ADM or DM-induced differentiation. This phenomenon was ac...

journal_title：Cancer research

authors： Yung BY,Luo KJ,Hui EK

更新日期：1992-07-01 00:00:00

abstract：:Although accumulating evidence indicates that chronic lymphocytic leukemia (CLL) is a disease with appreciable cell dynamics, it remains uncertain whether this also applies to patients with stable disease. In this study, (2)H(2)O was administered to a clinically homogeneous cohort of nine stable, untreated CLL patient...

journal_title：Cancer research

authors： van Gent R,Kater AP,Otto SA,Jaspers A,Borghans JA,Vrisekoop N,Ackermans MA,Ruiter AF,Wittebol S,Eldering E,van Oers MH,Tesselaar K,Kersten MJ,Miedema F

更新日期：2008-12-15 00:00:00

abstract：:The heterogeneity of the surface material released by trypsin in isolated cells of melanotic and amelanotic melanomas was studied by the method of separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The electrophoretic patterns of the surface material derived from two kinds of melanoma showed some...

journal_title：Cancer research

authors： Kozłowska K,Zurawska-Czupa B

更新日期：1983-03-01 00:00:00

abstract：:Two human breast carcinoma cell lines, EP and MW, were established in culture from malignant pleural effusions. In addition to producing tumors in antithymocyte serum-immunosuppressed mice, both cell lines showed epithelial characteristics and anchorage-independent growth in soft agar. EP and MW differed in morphology...

journal_title：Cancer research

authors： Chu MY,Hagerty MG,Wiemann MC,Tibbetts LM,Sato S,Cummings FJ,Bogaars HA,Leduc EH,Calabresi P

更新日期：1985-03-01 00:00:00

abstract：:In this issue of Cancer Research, Rozeveld and colleagues present intriguing evidence of the importance of lipid droplets and hormone-sensitive lipase (HSL) in regulating the aggressive nature of pancreatic cancer. Initially demonstrating a dependency of preloaded lipids on an invasive phenotype, the authors then esta...

journal_title：Cancer research

authors： Man J,Pajic M,Joshua AM

更新日期：2020-11-15 00:00:00

abstract：:A lymphocyte blastogenesis inhibitory factor (LBIF) has been characterized as an immunoregulatory molecule, especially on the T-lymphocyte proliferation. Using fast protein liquid chromatography-purified LBIF, we examined the effect of LBIF on the proliferation of various 18 tumor cell lines in vitro in comparison wit...

journal_title：Cancer research

authors： Sugimura K,Ohno T,Fukuda S,Wada Y,Kimura T,Azuma I

更新日期：1990-01-15 00:00:00

abstract：:Deletion of the distal short arm of chromosome 1 occurs in 35% of primary neuroblastomas (NBs). These deletions tend to be large and extend to the telomere, but a common region within sub-band 1p36.3 is consistently lost. Despite intensive investigation, no candidate tumor suppressor gene within this region has been s...

journal_title：Cancer research

authors： Hogarty MD,Winter CL,Liu X,Guo C,White PS,Look AT,Brodeur GM,Maris JM

更新日期：2002-11-15 00:00:00

abstract：:BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets. There is accumulating evidence that overexpression of BAG-1 may play an important role in breast cancer; however, the functional consequences of BAG-1 expression and its mechanism of action in breast cancer cells have not been stu...

journal_title：Cancer research

authors： Townsend PA,Cutress RI,Sharp A,Brimmell M,Packham G

更新日期：2003-07-15 00:00:00

abstract：:Prostate cancer has become epidemic, and environmental factors such as cadmium may be partly responsible. This study reports malignant transformation of the nontumorigenic human prostatic epithelial cell line RWPE-1 by in vitro cadmium exposure. The cadmium-transformed cells exhibited a loss of contact inhibition in v...

journal_title：Cancer research

authors： Achanzar WE,Diwan BA,Liu J,Quader ST,Webber MM,Waalkes MP

更新日期：2001-01-15 00:00:00

abstract：:Methylation-mediated silencing of G0-G1 switch gene 2 (G0S2) has been detected in a variety of solid tumors, whereas G0S2 induction is associated with remissions in patients with acute promyelocytic leukemia, implying that G0S2 may possess tumor suppressor activity. In this study, we clearly demonstrate that G0S2 oppo...

journal_title：Cancer research

authors： Yim CY,Sekula DJ,Hever-Jardine MP,Liu X,Warzecha JM,Tam J,Freemantle SJ,Dmitrovsky E,Spinella MJ

更新日期：2016-03-01 00:00:00

abstract：:Silybin, a main component of the milk thistle of Silybum marianum, has been reported to possess anticancer activity. We investigated the effects of IdB 1016, a complex of silybin with phosphatidylcholine, on the development of mammary tumors appearing spontaneously in HER-2/neu transgenic mice. The mechanisms involved...

journal_title：Cancer research

authors： Provinciali M,Papalini F,Orlando F,Pierpaoli S,Donnini A,Morazzoni P,Riva A,Smorlesi A

更新日期：2007-03-01 00:00:00

abstract：:B-cell precursor acute lymphoblastic leukemia (BCP-ALL/B-precursor ALL) is characterized by a high rate of tissue infiltration. The mechanism of BCP-ALL cell extravasation is not fully understood. In the present study, we have investigated the major carrier of carbohydrate selectin ligands in the BCP-ALL cell line NAL...

journal_title：Cancer research

authors： Nonomura C,Kikuchi J,Kiyokawa N,Ozaki H,Mitsunaga K,Ando H,Kanamori A,Kannagi R,Fujimoto J,Muroi K,Furukawa Y,Nakamura M

更新日期：2008-02-01 00:00:00

abstract：:The expression of the chemokine CC-chemokine ligand 20 (CCL20)/macrophage inflammatory protein (MIP)-3alpha and its receptor CC-chemokine receptor 6 (CCR6) by multiple myeloma (MM) and microenvironment cells and their potential relationship with osteoclast (OC) formation and osteolytic bone lesions in MM patients was ...

journal_title：Cancer research

authors： Giuliani N,Lisignoli G,Colla S,Lazzaretti M,Storti P,Mancini C,Bonomini S,Manferdini C,Codeluppi K,Facchini A,Rizzoli V

更新日期：2008-08-15 00:00:00

abstract：:The novel antineoplastic drug taxol has been shown to be active clinically against several types of human tumors. With improvement in treatment strategy and the number of long-term survivors increasing, a question that needs to be addressed is the potential carcinogenic effect of the treatment in the induction of seco...

journal_title：Cancer research

authors： Hei TK,Hall EJ

更新日期：1993-03-15 00:00:00

abstract：:Based on reports that both human and murine lymphoblastoid cell lines can effect lysis in antibody-dependent (ADCC) and mitogen-induced (MICC) cell-mediated cytotoxicity, 10 human lymphoblastoid cell lines were investigated for their ability to act as effector cells in these lytic reactions. Four cell lines promoted M...

journal_title：Cancer research

authors： Jordan TF,Ferrone S,Pellegrino MA,Dennert G

更新日期：1978-11-01 00:00:00

abstract：:The underlying mechanism regulating the expression of the cancer stem cell/tumor-initiating cell marker CD133/prominin-1 in cancer cells remains largely unclear, although knowledge of this mechanism would likely provide important biological information regarding cancer stem cells. Here, we found that the inhibition of...

journal_title：Cancer research

authors： Matsumoto K,Arao T,Tanaka K,Kaneda H,Kudo K,Fujita Y,Tamura D,Aomatsu K,Tamura T,Yamada Y,Saijo N,Nishio K

更新日期：2009-09-15 00:00:00

abstract：:A monoclonal antibody (5E8) has been used to identify and structurally characterize a previously unreported macromolecule present on the surface of human lung tumors. This antibody was derived from a hybrid clone that was produced using spleen cells of mice immunized with a surgically excised squamous cell carcinoma. ...

journal_title：Cancer research

authors： Zylstra S,Chen FA,Ghosh SK,Repasky EA,Rao U,Takita H,Bankert RB

更新日期：1986-12-01 00:00:00

abstract：:Preexisting and acquired resistance to epidermal growth factor receptor (EGFR) inhibitors limits their clinical usefulness in patients with advanced non-small cell lung cancer (NSCLC). This study characterizes the efficacy and mechanisms of the combination of gefitinib or erlotinib with OSU-03012, a celecoxib-derived ...

journal_title：Cancer research

authors： Wang YC,Kulp SK,Wang D,Yang CC,Sargeant AM,Hung JH,Kashida Y,Yamaguchi M,Chang GD,Chen CS

更新日期：2008-04-15 00:00:00