CC-chemokine ligand 20/macrophage inflammatory protein-3α and CC-chemokine receptor 6 are overexpressed in myeloma microenvironment related to osteolytic bone lesions.

abstract：:Antibodies to formalin-fixed, syngeneic melanoma cells were prepared in mice, purified by immunoaffinity chromatography, and tested for binding activity to viable melanoma cells. The radiolabeled antibodies detected congruent to 9 X 10(6) melanoma antigenic sites/cell. The calculated average association constant (Ka) ...

journal_title：Cancer research

authors： Winkelhake JL,Elcombe BM,Hodach A

更新日期：1979-08-01 00:00:00

abstract：:Recent reports suggest that expression of an activated c-Ha-ras oncogene is associated with cisplatin resistance in NIH-3T3 fibroblasts. To investigate the generality of these observations, cisplatin cytotoxicity was determined in a series of clonal Rat-1 fibroblast and rat ovarian surface epithelial (ROSE) cell lines...

journal_title：Cancer research

authors： Perez RP,Hamaguchi K,Tracey PA,Handel LM,Hamilton TC,Godwin AK

更新日期：1993-08-15 00:00:00

abstract：:We established a cisplatin-resistant human ovarian cancer cell line (HAC2/0.1) from the parent cell line (HAC2/P) by continuous exposure of HAC2/P to 0.1 microgram of cisplatin/ml. Drug sensitivity determined by colony assay revealed that HAC2/0.1 was 2.4 times as resistant to cisplatin as the parental cell line. HAC2...

journal_title：Cancer research

authors： Niimi S,Nakagawa K,Sugimoto Y,Nishio K,Fujiwara Y,Yokoyama S,Terashima Y,Saijo N

更新日期：1992-01-15 00:00:00

abstract：:A new human myeloma cell line, OPM-6, was established from the peripheral blood of a patient with advanced IgG-kappa plasma cell leukemia. Cytogenetic and phenotypic analysis confirmed that the cells were derived from the patient's leukemic cells. Insulin-like growth factor-1 (IGF-1) acts as an autocrine growth factor...

journal_title：Cancer research

authors： Ogawa M,Nishiura T,Oritani K,Yoshida H,Yoshimura M,Okajima Y,Ishikawa J,Hashimoto K,Matsumura I,Tomiyama Y,Matsuzawa Y

更新日期：2000-08-01 00:00:00

abstract：:Recently, we developed a nutritionally optimal medium for rapid clonal growth (greater than 1 population doubling/day) of normal human bronchial epithelial (NHBE) cells. Adding fetal bovine or adult human blood-derived serum to this medium depresses the clonal growth rate of NHBE cells in a dose-dependent fashion. In ...

journal_title：Cancer research

authors： Lechner JF,McClendon IA,LaVeck MA,Shamsuddin AM,Harris CC

更新日期：1983-12-01 00:00:00

abstract：:DNA polymerase beta (Polbeta) is a DNA repair protein that functions in base excision repair and meiosis. The enzyme has deoxyribose phosphate lyase and polymerase activity, but it is error prone because it bears no proofreading activity. Errors in DNA repair can lead to the accumulation of mutations and consequently ...

journal_title：Cancer research

authors： Fotiadou P,Henegariu O,Sweasy JB

更新日期：2004-06-01 00:00:00

abstract：:Monoclonal antibodies (mAb) are widely used in the treatment of non-Hodgkin's lymphoma and autoimmune diseases. Although the mechanism of action in vivo is not always known, the therapeutic activity of several approved mAbs depends on the binding of the Fcgamma regions to low-affinity Fcgamma receptors (FcgammaR) expr...

journal_title：Cancer research

authors： Stavenhagen JB,Gorlatov S,Tuaillon N,Rankin CT,Li H,Burke S,Huang L,Vijh S,Johnson S,Bonvini E,Koenig S

更新日期：2007-09-15 00:00:00

abstract：:Early growth-response (EGR) genes are nuclear transcription factors that are implicated in regulating cell proliferation. Because these genes show divergent expression in various human tumors, we sought to determine their expression in nonmalignant and malignant prostate tissues. Total RNA extracted from prostate tiss...

journal_title：Cancer research

authors： Eid MA,Kumar MV,Iczkowski KA,Bostwick DG,Tindall DJ

更新日期：1998-06-01 00:00:00

abstract：:There is still insufficient knowledge of the distribution of drinking habits in human populations, and more descriptive surveys are needed. Both prospective and retrospective epidemiological studies indicate that alcohol consumption is a cancer hazard. Prospective studies on excessive drinkers have shown an increased ...

journal_title：Cancer research

authors： Tuyns AJ

更新日期：1979-07-01 00:00:00

abstract：:Thirty patients with cisplatin-refractory germ cell tumor were treated with high-dose carboplatin, etoposide, and cyclophosphamide and autologous bone marrow transplantation. The total dose of carboplatin was 1500 mg/m2, etoposide 1200 mg/m2, and cyclophosphamide was increased by increments from 60 to 150 mg/kg. Twent...

journal_title：Cancer research

authors： Motzer RJ,Gulati SC,Tong WP,Menendez-Botet C,Lyn P,Mazumdar M,Vlamis V,Lin S,Bosl GJ

更新日期：1993-08-15 00:00:00

abstract：:Chicken chondrocytes isolated from 11-day-old chicken vertebrate cartilage were transformed by Rous sarcoma virus ts LA24 of the Prague strain as well as by the wild-type Prague strain of Rous sarcoma virus. The morphology of chondrocytes transformed by Rous sarcoma virus ts LA 24 was dependent on the temperature, and...

journal_title：Cancer research

authors： Okayama M,Yoshimura M,Muto M,Chi J,Roth S,Kaji A

更新日期：1977-03-01 00:00:00

abstract：:The effects of taxol on antitubulin immunofluorescent staining patterns, cellular DNA content, and labeling with [3H]thymidine were measured for the taxol-sensitive HL60 and taxol-resistant K562 cell lines after exposures for 0, 4, 12, and 24 h. Taxol caused a relative increase in the fraction of 4C interphase and met...

journal_title：Cancer research

authors： Roberts JR,Allison DC,Donehower RC,Rowinsky EK

更新日期：1990-02-01 00:00:00

abstract：:Cultures of adult mouse epidermal keratinocytes (MEKs) were utilized to determine whether the metabolism and metabolic activation of polycyclic aromatic hydrocarbons varied as a function of extracellular calcium (Ca2+) concentration. MEKs grown in low Ca2+-containing medium (0.05-0.10 mM) maintain basal cell morpholog...

journal_title：Cancer research

authors： DiGiovanni J,Gill RD,Nettikumara AN,Colby AB,Reiners JJ Jr

更新日期：1989-10-15 00:00:00

abstract：:Screening of the entire let-7 family of microRNAs (miRNA) by in situ hybridization identified let-7g as the only member, the diminished expression of which was significantly associated with lymph node metastasis and poor survival in breast cancer patients. Abrogation of let-7g expression in otherwise nonmetastatic mam...

journal_title：Cancer research

authors： Qian P,Zuo Z,Wu Z,Meng X,Li G,Wu Z,Zhang W,Tan S,Pandey V,Yao Y,Wang P,Zhao L,Wang J,Wu Q,Song E,Lobie PE,Yin Z,Zhu T

更新日期：2011-10-15 00:00:00

abstract：:Culturing DOV 13 ovarian carcinoma cells on three-dimensional collagen lattice but not on thin-layer collagen induces processing of promatrix metalloproteinase (MMP)-2 to a M(r) 62,000 form, suggesting that multivalent integrin aggregation may participate in proteinase regulation. To address the role of collagen-bindi...

journal_title：Cancer research

authors： Ellerbroek SM,Fishman DA,Kearns AS,Bafetti LM,Stack MS

更新日期：1999-04-01 00:00:00

abstract：:The role of the insulin-like growth factor I receptor (IGF-IR) in programmed cell death has been investigated in vivo in a biodiffusion chamber, where the extent of cell death could be determined quantitatively. We found that a decrease in the number of IGF-IRs causes massive apoptosis in vivo in several transplantabl...

journal_title：Cancer research

authors： Resnicoff M,Abraham D,Yutanawiboonchai W,Rotman HL,Kajstura J,Rubin R,Zoltick P,Baserga R

更新日期：1995-06-01 00:00:00

abstract：:Two human breast carcinoma cell lines, EP and MW, were established in culture from malignant pleural effusions. In addition to producing tumors in antithymocyte serum-immunosuppressed mice, both cell lines showed epithelial characteristics and anchorage-independent growth in soft agar. EP and MW differed in morphology...

journal_title：Cancer research

authors： Chu MY,Hagerty MG,Wiemann MC,Tibbetts LM,Sato S,Cummings FJ,Bogaars HA,Leduc EH,Calabresi P

更新日期：1985-03-01 00:00:00

abstract：:We performed parallel array comparative genomic hybridization and array expression analysis of the 12p11-p12 amplicon in human testicular seminomas and an ovarian carcinoma cell line using an expressed sequence tags (ESTs) array spotted with 8254 ESTs. The data were normalized using a robust statistical modeling and t...

journal_title：Cancer research

authors： Bourdon V,Naef F,Rao PH,Reuter V,Mok SC,Bosl GJ,Koul S,Murty VV,Kucherlapati RS,Chaganti RS

更新日期：2002-11-01 00:00:00

abstract：:Inflammation plays a role in the progression to cancer and it is linked to the presence of senescent cells. Ulcerative colitis (UC) is a chronic inflammatory disease that predisposes to colorectal cancer. Tumorigenesis in this setting is associated with telomere shortening that can be observed in the nondysplastic epi...

journal_title：Cancer research

authors： Risques RA,Lai LA,Himmetoglu C,Ebaee A,Li L,Feng Z,Bronner MP,Al-Lahham B,Kowdley KV,Lindor KD,Rabinovitch PS,Brentnall TA

更新日期：2011-03-01 00:00:00

abstract：:We previously found that a minor subfraction of the human genomic DNA, corresponding to 2500-3000 nonrepetitive sequences of 3 kilobases each and designated as tumor-activated DNA (TaDNA) was transcriptionally active in Burkitt's lymphoma cells and almost inactive in normal lymphocytes growing in vitro following integ...

journal_title：Cancer research

authors： Hanania N,Castagna M,Shaool D,Zeliszewski D,Harel J

更新日期：1985-12-01 00:00:00

abstract：:It is well established that small cell lung carcinomas (SCLCs) express receptors for acetylcholine (ACh) and that stimulation of these receptors by nicotine or other cholinergic agonists stimulates cell growth via activation of nicotinic cholinergic receptors (nAChRs) and/or muscarinic cholinergic receptors (mAChRs). ...

journal_title：Cancer research

authors： Song P,Sekhon HS,Jia Y,Keller JA,Blusztajn JK,Mark GP,Spindel ER

更新日期：2003-01-01 00:00:00

abstract：:An assay has been developed and measurements of aryl hydrocarbon [benzo(a)pyrene] hydroxylase have been made in peripheral blood monocytes from a human population. Treatment with benz(a)anthracene in cell culture increased aryl hydrocarbon hydroxylase activity from 6.5 to 37-fold in monocytes from each of 25 apparentl...

journal_title：Cancer research

authors： Bast RC Jr,Okuda T,Plotkin E,Tarone R,Rapp HJ,Gelboin HV

更新日期：1976-06-01 00:00:00

abstract：:A case-control study was undertaken to evaluate the roles of the hepatitis B virus (HBV), cigarette smoking, and alcohol use in the etiology of hepatocellular carcinoma (HCC). A major purpose of the study was to evaluate the effect of cigarette smoking on HCC among hepatitis B surface antigen (HBsAg)-negative persons,...

journal_title：Cancer research

authors： Austin H,Delzell E,Grufferman S,Levine R,Morrison AS,Stolley PD,Cole P

更新日期：1986-02-01 00:00:00

abstract：:Nerve growth factor-like substance(s) were identified in both conditioned media of a human prostatic tumor epithelial cell line (TSU-pr1) and a human prostatic stromal cell line (HPS) by Western blot analysis and bioassay of neurite outgrowth of PC12 cells. Nerve growth factor-beta (NGF) immunofluorescence was also lo...

journal_title：Cancer research

authors： Djakiew D,Delsite R,Pflug B,Wrathall J,Lynch JH,Onoda M

更新日期：1991-06-15 00:00:00

abstract：:Human carcinoembryonic antigen (CEA) is an oncofetal glycoprotein overexpression of which by gastrointestinal carcinomas is well known. Expression of CEA in head and neck cancer (HNC) is not widely recognized. It is important to note that most of these studies used polyclonal antibodies that may have cross-reactivity ...

journal_title：Cancer research

authors： Kass ES,Greiner JW,Kantor JA,Tsang KY,Guadagni F,Chen Z,Clark B,De Pascalis R,Schlom J,Van Waes C

更新日期：2002-09-01 00:00:00

abstract：:A possible involvement of gender-dependent factors has been postulated in development of human non-small-cell lung cancers (NSCLC), but its details remain unclear. In this study, we examined biological significance of progesterone receptor in NSCLCs. Progesterone receptor immunoreactivity was detected in 106 of 228 NS...

journal_title：Cancer research

authors： Ishibashi H,Suzuki T,Suzuki S,Niikawa H,Lu L,Miki Y,Moriya T,Hayashi S,Handa M,Kondo T,Sasano H

更新日期：2005-07-15 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) gamma is an important signaling molecule in cells of mesenchymal origin, inducing differentiation and regulating cell proliferation in several cell types such as vascular smooth muscle cells. Leiomyomas arise from smooth muscle cells of the uterine myometrium with an i...

journal_title：Cancer research

authors： Houston KD,Copland JA,Broaddus RR,Gottardis MM,Fischer SM,Walker CL

更新日期：2003-03-15 00:00:00

abstract：:An extremely rapid blood clearance rate of murine IgG2a antibodies was found in all strains tested of outbred Swiss nu/nu mice, including mice from the major commercial suppliers. The clearance half-life was less than 5 h, in comparison to a 4-5-day half-life in BALB/c mice. Therefore, most of the IgG2a antibody injec...

journal_title：Cancer research

authors： Sharkey RM,Natale A,Goldenberg DM,Mattes MJ

更新日期：1991-06-15 00:00:00

abstract：:Cellular motility is a critical function in embryonic development, tissue repair, and tumor invasion. We used assays of scattering (epithelial colony dispersion), cell migration, and cell invasion to study cytokine-regulated motility in epithelial and carcinoma cell lines. Tumor necrosis factor (TNF) stimulated motili...

journal_title：Cancer research

authors： Rosen EM,Goldberg ID,Liu D,Setter E,Donovan MA,Bhargava M,Reiss M,Kacinski BM

更新日期：1991-10-01 00:00:00

abstract：:The release of cardiac troponin T (cTnT) as a biomarker of doxorubicin-induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT and decreased immunohistochemical staining of heart sections for this protein were noted in SHRs treated with cumulat...

journal_title：Cancer research

authors： Herman EH,Lipshultz SE,Rifai N,Zhang J,Papoian T,Yu ZX,Takeda K,Ferrans VJ

更新日期：1998-01-15 00:00:00