Abstract：
:The release of cardiac troponin T (cTnT) as a biomarker of doxorubicin-induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT and decreased immunohistochemical staining of heart sections for this protein were noted in SHRs treated with cumulative doses of doxorubicin (7 mg/kg) that induced only minimal histological alterations in myocytes. Concentrations of cTnT were further elevated, coincident with reduced immunohistochemical staining, in SHRs given 10-12 mg/kg doxorubicin. Thus, monitoring serum levels of cTnT can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Herman EH,Lipshultz SE,Rifai N,Zhang J,Papoian T,Yu ZX,Takeda K,Ferrans VJsubject
Has Abstractpub_date
1998-01-15 00:00:00pages
195-7issue
2eissn
0008-5472issn
1538-7445journal_volume
58pub_type
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