RIPK1 Binds MCU to Mediate Induction of Mitochondrial Ca2+ Uptake and Promotes Colorectal Oncogenesis.

abstract：:The development of molecular dosimetry methods will simplify the identification of people at high risk for cancer. A combined monoclonal antibody immunoaffinity chromatography/high performance liquid chromatography method has been devised to isolate and quantify aflatoxin-DNA adducts and other metabolites in rat urine...

journal_title：Cancer research

authors： Groopman JD,Hasler JA,Trudel LJ,Pikul A,Donahue PR,Wogan GN

更新日期：1992-01-15 00:00:00

abstract：:More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has been identified. Also, the chronological order in which the aberrations appear during disease progression is not well k...

journal_title：Cancer research

authors： Höglund M,Gisselsson D,Hansen GB,Säll T,Mitelman F,Nilbert M

更新日期：2002-10-15 00:00:00

abstract：:We examined whether herpes simplex virus thymidine kinase (HSV-TK) gene expression driven by the promoter of the vascular endothelial growth factor (VEGF) gene that is activated by hypoxia is effective in killing highly metastatic Lewis lung carcinoma A11 cells under hypoxic conditions. We isolated the promoter region...

journal_title：Cancer research

authors： Koshikawa N,Takenaga K,Tagawa M,Sakiyama S

更新日期：2000-06-01 00:00:00

abstract：:Expression of the pro-oncogenic mucin MUC1 is elevated by inflammation in airway epithelial cells, but the contributions of MUC1 to the development of lung cancer are uncertain. In this study, we developed our finding that cigarette smoke increases Muc1 expression in mouse lung macrophages, where we hypothesized MUC1 ...

journal_title：Cancer research

authors： Xu X,Padilla MT,Li B,Wells A,Kato K,Tellez C,Belinsky SA,Kim KC,Lin Y

更新日期：2014-01-15 00:00:00

abstract：:Testicular germ cell tumors (TGCT) are the most common solid tumors of 15- to 35-year-old men. TGCT patients are frequently cured with cytotoxic cisplatin-based therapy. However, TGCT patients refractory to cisplatin-based chemotherapy have a poor prognosis, as do those having a late relapse. Pluripotent embryonal car...

journal_title：Cancer research

authors： Beyrouthy MJ,Garner KM,Hever MP,Freemantle SJ,Eastman A,Dmitrovsky E,Spinella MJ

更新日期：2009-12-15 00:00:00

abstract：:p63, a recently identified member of the p53 gene family, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. To explore the penetrance of p63 in bladder carcinogenesis, we performed expression and mutation analyses of two major isotypes, TAp63 and deltaNp63, in 63 bladder...

journal_title：Cancer research

authors： Park BJ,Lee SJ,Kim JI,Lee SJ,Lee CH,Chang SG,Park JH,Chi SG

更新日期：2000-07-01 00:00:00

abstract：:Adenylate cyclase responses to pituitary hormones including adrenocorticotropic hormone (ACTH), biogenetic amines, prostaglandin E1 (PGE1), angiotensin II, and glucagon were evaluated in adrenocortical tumors and hyperplastic adrenal tissues, obtained from patients with Cushing's syndrome at surgery, and in normal adr...

journal_title：Cancer research

authors： Matsukura S,Kakita T,Sueoka S,Yoshimi H,Hirata Y,Yokota M,Fujita T

更新日期：1980-10-01 00:00:00

abstract：:The intention of this study was to estimate the pharmacological advantage of a clinically applicable method of isolated liver perfusion (ILP) over hepatic artery infusion (HAI) administering various doses of 5-fluorouracil (FUra). FUra concentrations were measured using high-performance liquid chromatography in liver ...

journal_title：Cancer research

authors： de Brauw LM,Marinelli A,van de Velde CJ,Hermans J,Tjaden UR,Erkelens C,de Bruijn EA

更新日期：1991-03-15 00:00:00

abstract：:Acute promyelocytic leukemia is associated with a t(15;17) translocation that generates a fusion product between PML and the retinoic acid receptor alpha. Recently, PML was shown to concentrate within subnuclear domains, referred to as nuclear bodies, that are disorganized in acute promyelocytic leukemia cells. This o...

journal_title：Cancer research

authors： Terris B,Baldin V,Dubois S,Degott C,Flejou JF,Hénin D,Dejean A

更新日期：1995-04-01 00:00:00

abstract：:MCT-1 is an oncogene that was initially identified in a human T cell lymphoma and has been shown to induce cell proliferation as well as activate survival-related pathways. MCT-1 contains the PUA domain, a recently described RNA-binding domain that is found in several tRNA and rRNA modification enzymes. Here, we estab...

journal_title：Cancer research

authors： Reinert LS,Shi B,Nandi S,Mazan-Mamczarz K,Vitolo M,Bachman KE,He H,Gartenhaus RB

更新日期：2006-09-15 00:00:00

abstract：:Strategies for the prevention of cancer include those aimed at reducing the incidence of cancer (primary prevention) and cancer mortality through early detection of tumors (secondary prevention). The efficacy of prevention interventions is evaluated by clinical trials. The conduct of clinical trials is aided by the us...

journal_title：Cancer research

authors： Helzlsouer KJ

更新日期：1994-04-01 00:00:00

abstract：:To understand the biological basis of resistance to endocrine therapy is of utmost importance in patients with steroid hormone receptor-positive breast cancer. Not only will this allow us prediction of therapy success, it may also lead to novel therapies for patients resistant to current endocrine therapy. DNA methyla...

journal_title：Cancer research

authors： Martens JW,Nimmrich I,Koenig T,Look MP,Harbeck N,Model F,Kluth A,Bolt-de Vries J,Sieuwerts AM,Portengen H,Meijer-Van Gelder ME,Piepenbrock C,Olek A,Höfler H,Kiechle M,Klijn JG,Schmitt M,Maier S,Foekens JA

更新日期：2005-05-15 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) plays critical roles in many biological processes and in tumorigenesis. Here, we show that two mutated EGFRs found in lung and other malignancies, EGFR-G719S and EGFR-L858R, could transform Ba/F3 cells to interleukin-3 (IL-3)-independent growth, in a ligand-independent manner, a...

journal_title：Cancer research

authors： Jiang J,Greulich H,Jänne PA,Sellers WR,Meyerson M,Griffin JD

更新日期：2005-10-01 00:00:00

abstract：:The role of active oxygen species and lipid peroxidation in the antitumor effect of hyperthermia was studied in an experimental rabbit model. VX2 tumors were transplanted into rabbit hind legs, and the effect of hyperthermia on tumor growth was measured at 7 and 14 days after heating. As an index of lipid peroxidation...

journal_title：Cancer research

authors： Yoshikawa T,Kokura S,Tainaka K,Itani K,Oyamada H,Kaneko T,Naito Y,Kondo M

更新日期：1993-05-15 00:00:00

abstract：:Human genes expressed exclusively in tumors and male germ line cells, such as those of the MAGE, BAGE, and GAGE families, encode antigens recognized by T lymphocytes, which are potentially useful for antitumor immunotherapy. To identify new genes of this type, we generated cDNA populations enriched in sequences expres...

journal_title：Cancer research

authors： Lucas S,De Smet C,Arden KC,Viars CS,Lethé B,Lurquin C,Boon T

更新日期：1998-02-15 00:00:00

abstract：:The most deadly phase in cancer progression is attributed to the inappropriate acquisition of molecular machinery leading to metastatic transformation and spread of disease to distant organs. Although it is appreciated that metastasis involves epithelial-mesenchymal interplay, the underlying mechanism defining this pr...

journal_title：Cancer research

authors： Powell AE,Anderson EC,Davies PS,Silk AD,Pelz C,Impey S,Wong MH

更新日期：2011-02-15 00:00:00

abstract：:Global blood flow (TBF), tumor vascular resistance, laser Doppler flow in superficial tumor areas, and mean arterial blood pressure were evaluated in rats bearing s.c. DS sarcomas. Measurements were performed before and after i.v. administration of rhTNF-alpha 2 or recombinant human lymphotoxin (rhLT) (1 mg/kg). Upon ...

journal_title：Cancer research

authors： Kluge M,Elger B,Engel T,Schaefer C,Seega J,Vaupel P

更新日期：1992-04-15 00:00:00

abstract：:Lymphocytes can be stimulated to proliferate in vitro by mitogens such as concanavalin A. The tumor-promoting phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) can enhance this proliferation, partly because of an increase in interleukin 2 (IL-2) production. However, if lymphocytes are treated with TPA for 24 h...

journal_title：Cancer research

authors： Grove DS,Mastro AM

更新日期：1991-01-01 00:00:00

abstract：:The in vivo activation of aflatoxin B1 (AFB1) was assessed by using two transgenic mouse lines, M2 and M10, in which the human fetus-specific CYP3A7 was expressed in the kidney (M2) and the liver (M10), respectively. Male mice of 8 weeks old from these two lines were treated with a single i.p. injection of AFB1 (4 mg/...

journal_title：Cancer research

authors： Li Y,Yokoi T,Katsuki M,Wang JS,Groopman JD,Kamataki T

更新日期：1997-02-15 00:00:00

abstract：:We have analyzed genomic DNA sequences from 125 prospectively collected single unilateral primary breast carcinoma samples for the presence of alterations of c-myc, c-erbB-1, c-erbB-2, c-Ki-ras and c-Ha-ras protooncogenes. Amplification of the c-myc gene was found in 18% of the samples, and in one sample a non-germ li...

journal_title：Cancer research

authors： Garcia I,Dietrich PY,Aapro M,Vauthier G,Vadas L,Engel E

更新日期：1989-12-01 00:00:00

abstract：:We have demonstrated the intracellular expression of sex hormone-binding globulin (SHBG) exon VII splicing variant mRNA in human uterine endometrial cancer using the reverse transcription-PCR-Southern blot and DNA sequencing analyses. Analysis of the missing base pairs proved that they corresponded to the entire exon ...

journal_title：Cancer research

authors： Misao R,Nakanishi Y,Fujimoto J,Tamaya T

更新日期：1997-12-15 00:00:00

abstract：:Microsomal epoxide hydrolase (mEH) is involved in the metabolism of tobacco-derived carcinogens. Polymorphisms in exons 3 and 4 of the EPHX gene have been reported to be associated with variations in mEH activity. We examined whether the predicted mEH activity modified the lung cancer risk among 150 cases and 172 cont...

journal_title：Cancer research

authors： Benhamou S,Reinikainen M,Bouchardy C,Dayer P,Hirvonen A

更新日期：1998-12-01 00:00:00

abstract：:Bloom syndrome is an autosomal recessive disorder whose characteristics include an increased risk for many types of cancers. In contrast to the homozygous mutations of Bloom syndrome, heterozygous carriers of BLM mutations may be at increased risk for developing colorectal cancer. We have screened 2,333 Jewish individ...

journal_title：Cancer research

authors： Cleary SP,Zhang W,Di Nicola N,Aronson M,Aube J,Steinman A,Haddad R,Redston M,Gallinger S,Narod SA,Gryfe R

更新日期：2003-04-15 00:00:00

abstract：:Two human breast carcinoma cell lines, EP and MW, were established in culture from malignant pleural effusions. In addition to producing tumors in antithymocyte serum-immunosuppressed mice, both cell lines showed epithelial characteristics and anchorage-independent growth in soft agar. EP and MW differed in morphology...

journal_title：Cancer research

authors： Chu MY,Hagerty MG,Wiemann MC,Tibbetts LM,Sato S,Cummings FJ,Bogaars HA,Leduc EH,Calabresi P

更新日期：1985-03-01 00:00:00

abstract：:The role of the NKG2D immunoreceptor and its ligands in antitumor immune response is incompletely understood. Here, we report that effector immune cells infiltrating ovarian carcinoma are mostly CD8+ lymphocytes lacking CD28 but expressing the NKG2D costimulatory receptor. Human ovarian carcinoma expresses the novel N...

journal_title：Cancer research

authors： Conejo-Garcia JR,Benencia F,Courreges MC,Gimotty PA,Khang E,Buckanovich RJ,Frauwirth KA,Zhang L,Katsaros D,Thompson CB,Levine B,Coukos G

更新日期：2004-03-15 00:00:00

abstract：:The pharmacology of high-dose 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) has been studied by radiochemical and chromatographic techniques in eight patients. Plasma disappearance of FT was exponential, with a half-life of 8.8 hr. Plasma concentrations of 5-fluorouracil (FUra) were sustained at 12.8 nmol/ml (1.7 micro...

journal_title：Cancer research

authors： Benvenuto JA,Lu K,Hall SW,Benjamin RS,Loo TL

更新日期：1978-11-01 00:00:00

abstract：:Transcription factor PAX3 has seven isoforms of which PAX3c has been studied extensively whereas the functions of the other isoforms are less well known. Here, we found that PAX3 isoforms in a stable transfection system have different biological functions in mouse melanocytes in vitro. PAX3a and PAX3b had negative eff...

journal_title：Cancer research

authors： Wang Q,Kumar S,Slevin M,Kumar P

更新日期：2006-09-01 00:00:00

abstract：:We analyzed the karyotype of 27 B-cell lymphomas of human origin that developed in mice with severe combined immunodeficiency disease following the injection of peripheral blood leukocytes from Epstein-Barr virus-seropositive donors. Three tumors had clonal abnormalities detected with conventional techniques, 2 had tr...

journal_title：Cancer research

authors： Thangavelu M,Snyder L,Anastasi J,Le Beau MM,Kirven M,Picchio G,Mosier DE,Rowley JD

更新日期：1992-09-01 00:00:00

abstract：:The biosynthesis, structure, and topology of a melanoma-associated antigen, previously defined with the monoclonal antibody NKI/C-3 was studied. A polyclonal rabbit antiserum was raised against the antigen with a broader reactivity than the previously used monoclonal antibody NKI/C-3. The antigen was shown to consist ...

journal_title：Cancer research

authors： Gruters RA,Calafat J,Vennegoor CJ,Jansen H,Ploegh HL

更新日期：1989-01-15 00:00:00

abstract：:Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation of miRNAs has been associated with the pa...

journal_title：Cancer research

authors： Park EY,Chang E,Lee EJ,Lee HW,Kang HG,Chun KH,Woo YM,Kong HK,Ko JY,Suzuki H,Song E,Park JH

更新日期：2014-12-15 00:00:00