Functional analysis of alternative isoforms of the transcription factor PAX3 in melanocytes in vitro.

abstract：:Procarbazine, a chemotherapeutic hydrazine, is thought to be metabolized to an alkylating species similar to methyl carbonium ion by multistep reactions involving cytochrome P-450, monoamine oxidase, and cytosolic enzymes. The DNA-damaging and cytotoxic potential of procarbazine and its metabolites in murine L1210 leu...

journal_title：Cancer research

authors： Erikson JM,Tweedie DJ,Ducore JM,Prough RA

更新日期：1989-01-01 00:00:00

abstract：:Technical modifications of the quantitative determination of unscheduled DNA synthesis in cultured hepatocytes are described which allow for the rapid identification of potentially carcinogenic chemicals on a large-scale screening basis. The test is based on the biochemical quantification of [methyl-3H]thymidine incor...

journal_title：Cancer research

authors： Althaus FR,Lawrence SD,Sattler GL,Longfellow DG,Pitot HC

更新日期：1982-08-01 00:00:00

abstract：:Inflammation plays a role in the progression to cancer and it is linked to the presence of senescent cells. Ulcerative colitis (UC) is a chronic inflammatory disease that predisposes to colorectal cancer. Tumorigenesis in this setting is associated with telomere shortening that can be observed in the nondysplastic epi...

journal_title：Cancer research

authors： Risques RA,Lai LA,Himmetoglu C,Ebaee A,Li L,Feng Z,Bronner MP,Al-Lahham B,Kowdley KV,Lindor KD,Rabinovitch PS,Brentnall TA

更新日期：2011-03-01 00:00:00

abstract：:We recently reported the isolation of the K-sam complementary DNA (cDNA), which was amplified preferentially in poorly differentiated types of stomach cancer and codes for one of the heparin-binding growth factor or fibroblast growth factor (FGF) receptor families. The K-sam-related gene, N-sam (NCC-IT-cell-derived sa...

journal_title：Cancer research

authors： Hattori Y,Odagiri H,Katoh O,Sakamoto H,Morita T,Shimotohno K,Tobinai K,Sugimura T,Terada M

更新日期：1992-06-15 00:00:00

abstract：:We evaluated whether treatment of orthotopic human prostate cancer in nude mice with pegylated IFN-alpha-2b (PEG-IFN-alpha-2b) and docetaxel could represent a two-compartment targeting of primary tumor (tumor cells and tumor-associated endothelial cells) and inhibition of regional lymph node metastasis. The antiangiog...

journal_title：Cancer research

authors： Huang SF,Kim SJ,Lee AT,Karashima T,Bucana C,Kedar D,Sweeney P,Mian B,Fan D,Shepherd D,Fidler IJ,Dinney CP,Killion JJ

更新日期：2002-10-15 00:00:00

abstract：:The effects of an altered content of dietary iodine and fat on the development of N-nitrosomethylurea-induced mammary tumors in rats were studied and correlated with thyroid and pituitary function studies. In three separate experiments, animals fed a semisynthetic diet containing 11.8% fat had an earlier time of tumor...

journal_title：Cancer research

authors： Cave WT Jr,Dunn JT,MacLeod RM

更新日期：1979-03-01 00:00:00

abstract：:Chinese hamster V-79 cells were treated with high cytotoxic or low noncytotoxic concentrations of the highly carcinogenic and mutagenic (-)-(1R,2S,3S,4R)-3,4-dihydroxy-1, 2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene [(-)-B[c]PhDE; fjord-region diol epoxide] or its biologically less active (+)-(1S,2R,3R,4S) enantiome...

journal_title：Cancer research

authors： Wei SJ,Chang RL,Cui XX,Merkler KA,Wong CQ,Yagi H,Jerina DM,Conney AH

更新日期：1996-08-15 00:00:00

abstract：:Vaccine strategies for treatment of human papillomavirus-induced cervical cancer are based on either the recombinant E7 fusion oncoprotein or E7 CTL peptides. The therapeutic potential of the E7-based vaccine depends on the use of different adjuvants. In this study, we describe for the first time the expression of the...

journal_title：Cancer research

authors： Franconi R,Di Bonito P,Dibello F,Accardi L,Muller A,Cirilli A,Simeone P,Donà MG,Venuti A,Giorgi C

更新日期：2002-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a new class of short noncoding regulatory RNAs (18-25 nucleotides) that are involved in diverse developmental and pathologic processes. Altered miRNA expression has been associated with several types of human cancer. However, most studies did not establish whether miRNA expression changes occurr...

journal_title：Cancer research

authors： Sempere LF,Christensen M,Silahtaroglu A,Bak M,Heath CV,Schwartz G,Wells W,Kauppinen S,Cole CN

更新日期：2007-12-15 00:00:00

abstract：:Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called "oncogene addiction," provides a rationale for molecular targeted therapy. The efficacy of this strategy require...

journal_title：Cancer research

authors： Weinstein IB,Joe A

更新日期：2008-05-01 00:00:00

abstract：:Estrogen receptor α (ERα) is a key regulator of breast growth and breast cancer development. Here, we report how ERα impacts these processes by reprogramming metabolism in malignant breast cells. We employed an integrated approach, combining genome-wide mapping of chromatin-bound ERα with estrogen-induced transcript a...

journal_title：Cancer research

authors： Jia M,Andreassen T,Jensen L,Bathen TF,Sinha I,Gao H,Zhao C,Haldosen LA,Cao Y,Girnita L,Moestue SA,Dahlman-Wright K

更新日期：2016-10-01 00:00:00

abstract：:The pathogenetic relationship between high-grade prostatic intraepithelial neoplasia (PIN), prostatic carcinoma, and metastases is poorly understood. We used fluorescence in situ hybridization (FISH) with centromere-specific probes for chromosomes 7, 8, 10, 12, and Y to evaluate numeric chromosomal anomalies in PIN (6...

journal_title：Cancer research

authors： Qian J,Bostwick DG,Takahashi S,Borell TJ,Herath JF,Lieber MM,Jenkins RB

更新日期：1995-11-15 00:00:00

abstract：:alpha(v)beta(3) integrin was investigated in multiple myeloma in relation to the in vitro osteoclast-like activity of malignant plasma cells. Myeloma cells from patients with skeleton involvement overexpressed alpha(v)beta(3) and produced erosion pits on bone substrates, whereas this effect was not observed by cells f...

journal_title：Cancer research

authors： Tucci M,De Palma R,Lombardi L,Rodolico G,Berrino L,Dammacco F,Silvestris F

更新日期：2009-08-15 00:00:00

abstract：:It has been well established that overexpression of Cyclooxygenase-2 (Cox-2) in epithelial cells inhibits apoptosis and increases the invasiveness of malignant cells, favoring tumorigenesis and metastasis. However, the molecular mechanism that regulates Cox-2 expression has not been well defined in gastric carcinoma. ...

journal_title：Cancer research

authors： Song SH,Jong HS,Choi HH,Inoue H,Tanabe T,Kim NK,Bang YJ

更新日期：2001-06-01 00:00:00

abstract：:Deletion of the distal short arm of chromosome 1 occurs in 35% of primary neuroblastomas (NBs). These deletions tend to be large and extend to the telomere, but a common region within sub-band 1p36.3 is consistently lost. Despite intensive investigation, no candidate tumor suppressor gene within this region has been s...

journal_title：Cancer research

authors： Hogarty MD,Winter CL,Liu X,Guo C,White PS,Look AT,Brodeur GM,Maris JM

更新日期：2002-11-15 00:00:00

abstract：:Modest clinical outcomes of dendritic cell (DC) vaccine trials call for novel strategies. In this study, we have created a chimeric CD40 molecule that incorporates a single chain Fv (scFv) molecule specific for human ErbB2 antigen and fusing to the membrane spanning and cytosolic domains of murine CD40. After adenovir...

journal_title：Cancer research

authors： Wei H,Wang H,Lu B,Li B,Hou S,Qian W,Fan K,Dai J,Zhao J,Guo Y

更新日期：2008-05-15 00:00:00

abstract：:We have studied the lipid composition and the acyl group composition, transport, and metabolism of doxorubicin-sensitive and -resistant rat glioblastoma cells in monolayer cultures (C6 clone). No difference in lipid composition was evidenced; the acyl group composition was, in contrast, highly modified in resistant ce...

journal_title：Cancer research

authors： Vrignaud P,Montaudon D,Londos-Gagliardi D,Robert J

更新日期：1986-07-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma is a treatment refractory malignancy with a high mortality and an increasing incidence worldwide. Recent studies have observed that activation of Notch and AKT signaling within mature hepatocytes is able to induce the formation of tumors displaying biliary lineage markers, thereby raisi...

journal_title：Cancer research

authors： Guest RV,Boulter L,Kendall TJ,Minnis-Lyons SE,Walker R,Wigmore SJ,Sansom OJ,Forbes SJ

更新日期：2014-02-15 00:00:00

abstract：:In this paper, we describe the role of chemokine receptor CXCR4 activation by its natural ligand, the chemokine stromal cell-derived factor (SDF-1) (CXCL12), in glioblastoma cell growth in vitro. We show that both CXC chemokine receptor 4 (CXCR4) and SDF-1 mRNA are expressed in several human glioblastoma multiforme tu...

journal_title：Cancer research

authors： Barbero S,Bonavia R,Bajetto A,Porcile C,Pirani P,Ravetti JL,Zona GL,Spaziante R,Florio T,Schettini G

更新日期：2003-04-15 00:00:00

abstract：:Four hr after either a single injection or continuous infusion of methotrexate (MTX) plus purified [3',5',9(n)-3H]MTX in cynomolgus or rhesus monkeys, 80 to 98% of the 3H radioactivity present in the plasma was found not to represent intact MTX. The percentage of 3H-containing MTX products in the urine after 4 hr was ...

journal_title：Cancer research

authors： Kimelberg HK,Biddlecome SM,Bourke RS

更新日期：1977-01-01 00:00:00

abstract：:The human colon cancer cell line HCT does not express any detectable HLA class I antigens on the cell surface. RNA blot analyses showed that HCT cells synthesize easily detectable levels of heavy chains as well as beta 2-microglobulin (beta 2m) transcripts. Experiments of immunoprecipitation revealed the presence of i...

journal_title：Cancer research

authors： Gattoni-Celli S,Kirsch K,Timpane R,Isselbacher KJ

更新日期：1992-03-01 00:00:00

abstract：:We previously reported that intetumumab (CNTO 95), a fully human anti-αv integrin monoclonal antibody, is a radiosensitizer in mice with xenograft tumors. Because intetumumab does not cross-react with mouse integrins, but has cross-reactivity with rat integrins, we next studied the potential combined use of radiation ...

journal_title：Cancer research

authors： Ning S,Tian J,Marshall DJ,Knox SJ

更新日期：2010-10-01 00:00:00

abstract：:We studied N-myc RNA by in situ hybridization and S1 nuclease protection analysis in human fetal cerebrum, retina, lung, liver, and placenta during the second trimester. High levels of N-myc RNA were found in the early fetal cerebral germinal layer and the primordial cortex, with lower levels in the intermediate layer...

journal_title：Cancer research

authors： Grady EF,Schwab M,Rosenau W

更新日期：1987-06-01 00:00:00

abstract：:Progression of well differentiated rat mammary adenocarcinomas to very anaplastic phenotypes was found to correlate with a systematic and significant amplification of a mutant HRAS allele. Tumors with high amplification levels of this oncogene were analyzed by chromosomal in situ hybridization; in four of the cases th...

journal_title：Cancer research

authors： Aldaz CM,Gollahon LS,Chen A

更新日期：1993-11-15 00:00:00

abstract：:Aberrant methylation of promoter CpG islands (CGI) is involved in silencing of tumor suppressor genes and is also a potential cancer biomarker. Here, to identify CGIs aberrantly methylated in human melanomas, we did a genome-wide search using methylation-sensitive representational difference analysis. CGIs in putative...

journal_title：Cancer research

authors： Furuta J,Nobeyama Y,Umebayashi Y,Otsuka F,Kikuchi K,Ushijima T

更新日期：2006-06-15 00:00:00

abstract：:Phosphoglucose isomerase (PGI) is a multifunctional enzyme that functions in glucose metabolism as a glycolytic enzyme catalyzing an interconversion between glucose and fructose inside the cell, while it acts as cytokine outside the cell, with properties that include autocrine motility factor (AMF)-regulating tumor ce...

journal_title：Cancer research

authors： Niinaka Y,Harada K,Fujimuro M,Oda M,Haga A,Hosoki M,Uzawa N,Arai N,Yamaguchi S,Yamashiro M,Raz A

更新日期：2010-11-15 00:00:00

abstract：:We have analyzed genomic DNA sequences from 125 prospectively collected single unilateral primary breast carcinoma samples for the presence of alterations of c-myc, c-erbB-1, c-erbB-2, c-Ki-ras and c-Ha-ras protooncogenes. Amplification of the c-myc gene was found in 18% of the samples, and in one sample a non-germ li...

journal_title：Cancer research

authors： Garcia I,Dietrich PY,Aapro M,Vauthier G,Vadas L,Engel E

更新日期：1989-12-01 00:00:00

abstract：:The ability to accurately distinguish remaining or recurrent high-grade astrocytoma from necrosis or edema following treatment is essential to optimal patient management. Thallium 201 planar gamma-camera imaging has been shown to be helpful in detecting recurrent high-grade astrocytoma; however, due to tissue heteroge...

journal_title：Cancer research

authors： Mountz JM,Raymond PA,McKeever PE,Modell JG,Hood TW,Barthel LK,Stafford-Schuck KA

更新日期：1989-07-15 00:00:00

abstract：:The macrophage content of spontaneous metastases has been quantified morphometrically for a panel of rodent tumors at different stages of metastatic tumor growth. Using a histochemical technique to selectively stain macrophages, we have evaluated the relative content of macrophages in spontaneous pulmonary metastases ...

journal_title：Cancer research

authors： Bugelski PJ,Corwin SP,North SM,Kirsh RL,Nicolson GL,Poste G

更新日期：1987-08-01 00:00:00

abstract：:Nitric oxide (NO) in nanomolar (nmol/L) concentrations is consistently detected in tumor microenvironment and has been found to promote tumorigenesis. The mechanism by which NO enhances tumor progression is largely unknown. In this study, we investigated the possible mechanisms and identified cellular targets by which...

journal_title：Cancer research

authors： Pervin S,Singh R,Hernandez E,Wu G,Chaudhuri G

更新日期：2007-01-01 00:00:00